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Q8N4W6 (DJC22_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DnaJ homolog subfamily C member 22
Gene names
Name:DNAJC22
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length341 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May function as a co-chaperone.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Contains 1 J domain.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionChaperone
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 341341DnaJ homolog subfamily C member 22
PRO_0000325862

Regions

Transmembrane5 – 2521Helical; Potential
Transmembrane30 – 5021Helical; Potential
Transmembrane81 – 10121Helical; Potential
Transmembrane105 – 12521Helical; Potential
Transmembrane138 – 15821Helical; Potential
Transmembrane185 – 20521Helical; Potential
Transmembrane218 – 23821Helical; Potential
Domain277 – 34165J

Sequences

Sequence LengthMass (Da)Tools
Q8N4W6 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 0246AFCB12D09917

FASTA34138,086
        10         20         30         40         50         60 
MAKGLLVTYA LWAVGGPAGL HHLYLGRDSH ALLWMLTLGG GGLGWLWEFW KLPSFVAQAN 

        70         80         90        100        110        120 
RAQGQRQSPR GVTPPLSPIR FAAQVIVGIY FGLVALISLS SMVNFYIVAL PLAVGLGVLL 

       130        140        150        160        170        180 
VAAVGNQTSD FKNTLGSAFL TSPIFYGRPI AILPISVAAS ITAQRHRRYK ALVASEPLSV 

       190        200        210        220        230        240 
RLYRLGLAYL AFTGPLAYSA LCNTAATLSY VAETFGSFLN WFSFFPLLGR LMEFVLLLPY 

       250        260        270        280        290        300 
RIWRLLMGET GFNSSCFQEW AKLYEFVHSF QDEKRQLAYQ VLGLSEGATN EEIHRSYQEL 

       310        320        330        340 
VKVWHPDHNL DQTEEAQRHF LEIQAAYEVL SQPRKPWGSR R 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK055747 mRNA. Translation: BAG51566.1.
CH471111 Genomic DNA. Translation: EAW58066.1.
BC033236 mRNA. Translation: AAH33236.1.
RefSeqNP_079178.2. NM_024902.2.
XP_005269210.1. XM_005269153.1.
XP_005269211.1. XM_005269154.1.
UniGeneHs.659300.

3D structure databases

ProteinModelPortalQ8N4W6.
SMRQ8N4W6. Positions 249-336.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123031. 1 interaction.

PTM databases

PhosphoSiteQ8N4W6.

Polymorphism databases

DMDM74728914.

Proteomic databases

PaxDbQ8N4W6.
PRIDEQ8N4W6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000395069; ENSP00000378508; ENSG00000178401.
ENST00000549441; ENSP00000446830; ENSG00000178401.
GeneID79962.
KEGGhsa:79962.
UCSCuc001rua.3. human.

Organism-specific databases

CTD79962.
GeneCardsGC12P049740.
HGNCHGNC:25802. DNAJC22.
HPAHPA039953.
HPA040012.
neXtProtNX_Q8N4W6.
PharmGKBPA162383905.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0484.
HOGENOMHOG000007152.
HOVERGENHBG107813.
InParanoidQ8N4W6.
OMAWHPDHNL.
OrthoDBEOG7TMZS5.
PhylomeDBQ8N4W6.
TreeFamTF324581.

Gene expression databases

BgeeQ8N4W6.
CleanExHS_DNAJC22.
GenevestigatorQ8N4W6.

Family and domain databases

Gene3D1.10.287.110. 1 hit.
InterProIPR001623. DnaJ_domain.
IPR007829. TM2.
[Graphical view]
PfamPF00226. DnaJ. 1 hit.
PF05154. TM2. 1 hit.
[Graphical view]
PRINTSPR00625. JDOMAIN.
SMARTSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMSSF46565. SSF46565. 1 hit.
PROSITEPS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSDNAJC22. human.
GenomeRNAi79962.
NextBio69965.
PROQ8N4W6.

Entry information

Entry nameDJC22_HUMAN
AccessionPrimary (citable) accession number: Q8N4W6
Secondary accession number(s): B3KP54
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2002
Last modified: March 19, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM