Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8N4W6

- DJC22_HUMAN

UniProt

Q8N4W6 - DJC22_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

DnaJ homolog subfamily C member 22

Gene

DNAJC22

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

May function as a co-chaperone.

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 22
Gene namesi
Name:DNAJC22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:25802. DNAJC22.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162383905.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341DnaJ homolog subfamily C member 22PRO_0000325862Add
BLAST

Proteomic databases

PaxDbiQ8N4W6.
PRIDEiQ8N4W6.

PTM databases

PhosphoSiteiQ8N4W6.

Expressioni

Gene expression databases

BgeeiQ8N4W6.
CleanExiHS_DNAJC22.
GenevestigatoriQ8N4W6.

Organism-specific databases

HPAiHPA039953.
HPA040012.

Interactioni

Protein-protein interaction databases

BioGridi123031. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8N4W6.
SMRiQ8N4W6. Positions 279-335.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence AnalysisAdd
BLAST
Transmembranei30 – 5021HelicalSequence AnalysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence AnalysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence AnalysisAdd
BLAST
Transmembranei138 – 15821HelicalSequence AnalysisAdd
BLAST
Transmembranei185 – 20521HelicalSequence AnalysisAdd
BLAST
Transmembranei218 – 23821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini277 – 34165JPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0484.
GeneTreeiENSGT00390000012136.
HOGENOMiHOG000007152.
HOVERGENiHBG107813.
InParanoidiQ8N4W6.
OMAiWHPDHNL.
OrthoDBiEOG7TMZS5.
PhylomeDBiQ8N4W6.
TreeFamiTF324581.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR007829. TM2.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF05154. TM2. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N4W6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKGLLVTYA LWAVGGPAGL HHLYLGRDSH ALLWMLTLGG GGLGWLWEFW
60 70 80 90 100
KLPSFVAQAN RAQGQRQSPR GVTPPLSPIR FAAQVIVGIY FGLVALISLS
110 120 130 140 150
SMVNFYIVAL PLAVGLGVLL VAAVGNQTSD FKNTLGSAFL TSPIFYGRPI
160 170 180 190 200
AILPISVAAS ITAQRHRRYK ALVASEPLSV RLYRLGLAYL AFTGPLAYSA
210 220 230 240 250
LCNTAATLSY VAETFGSFLN WFSFFPLLGR LMEFVLLLPY RIWRLLMGET
260 270 280 290 300
GFNSSCFQEW AKLYEFVHSF QDEKRQLAYQ VLGLSEGATN EEIHRSYQEL
310 320 330 340
VKVWHPDHNL DQTEEAQRHF LEIQAAYEVL SQPRKPWGSR R
Length:341
Mass (Da):38,086
Last modified:October 1, 2002 - v1
Checksum:i0246AFCB12D09917
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK055747 mRNA. Translation: BAG51566.1.
CH471111 Genomic DNA. Translation: EAW58066.1.
BC033236 mRNA. Translation: AAH33236.1.
CCDSiCCDS8785.1.
RefSeqiNP_079178.2. NM_024902.2.
XP_005269210.1. XM_005269153.1.
XP_005269211.1. XM_005269154.1.
UniGeneiHs.659300.

Genome annotation databases

EnsembliENST00000395069; ENSP00000378508; ENSG00000178401.
ENST00000549441; ENSP00000446830; ENSG00000178401.
GeneIDi79962.
KEGGihsa:79962.
UCSCiuc001rua.3. human.

Polymorphism databases

DMDMi74728914.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK055747 mRNA. Translation: BAG51566.1 .
CH471111 Genomic DNA. Translation: EAW58066.1 .
BC033236 mRNA. Translation: AAH33236.1 .
CCDSi CCDS8785.1.
RefSeqi NP_079178.2. NM_024902.2.
XP_005269210.1. XM_005269153.1.
XP_005269211.1. XM_005269154.1.
UniGenei Hs.659300.

3D structure databases

ProteinModelPortali Q8N4W6.
SMRi Q8N4W6. Positions 279-335.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123031. 1 interaction.

PTM databases

PhosphoSitei Q8N4W6.

Polymorphism databases

DMDMi 74728914.

Proteomic databases

PaxDbi Q8N4W6.
PRIDEi Q8N4W6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000395069 ; ENSP00000378508 ; ENSG00000178401 .
ENST00000549441 ; ENSP00000446830 ; ENSG00000178401 .
GeneIDi 79962.
KEGGi hsa:79962.
UCSCi uc001rua.3. human.

Organism-specific databases

CTDi 79962.
GeneCardsi GC12P049740.
HGNCi HGNC:25802. DNAJC22.
HPAi HPA039953.
HPA040012.
neXtProti NX_Q8N4W6.
PharmGKBi PA162383905.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0484.
GeneTreei ENSGT00390000012136.
HOGENOMi HOG000007152.
HOVERGENi HBG107813.
InParanoidi Q8N4W6.
OMAi WHPDHNL.
OrthoDBi EOG7TMZS5.
PhylomeDBi Q8N4W6.
TreeFami TF324581.

Miscellaneous databases

ChiTaRSi DNAJC22. human.
GenomeRNAii 79962.
NextBioi 69965.
PROi Q8N4W6.

Gene expression databases

Bgeei Q8N4W6.
CleanExi HS_DNAJC22.
Genevestigatori Q8N4W6.

Family and domain databases

Gene3Di 1.10.287.110. 1 hit.
InterProi IPR001623. DnaJ_domain.
IPR007829. TM2.
[Graphical view ]
Pfami PF00226. DnaJ. 1 hit.
PF05154. TM2. 1 hit.
[Graphical view ]
PRINTSi PR00625. JDOMAIN.
SMARTi SM00271. DnaJ. 1 hit.
[Graphical view ]
SUPFAMi SSF46565. SSF46565. 1 hit.
PROSITEi PS50076. DNAJ_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiDJC22_HUMAN
AccessioniPrimary (citable) accession number: Q8N4W6
Secondary accession number(s): B3KP54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3