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Protein

DnaJ homolog subfamily C member 22

Gene

DNAJC22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a co-chaperone.

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178401-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 22
Gene namesi
Name:DNAJC22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:25802. DNAJC22.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178401.
PharmGKBiPA162383905.

Polymorphism and mutation databases

BioMutaiDNAJC22.
DMDMi74728914.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003258621 – 341DnaJ homolog subfamily C member 22Add BLAST341

Proteomic databases

PaxDbiQ8N4W6.
PeptideAtlasiQ8N4W6.
PRIDEiQ8N4W6.

PTM databases

iPTMnetiQ8N4W6.
PhosphoSitePlusiQ8N4W6.

Expressioni

Gene expression databases

BgeeiENSG00000178401.
CleanExiHS_DNAJC22.
ExpressionAtlasiQ8N4W6. baseline and differential.
GenevisibleiQ8N4W6. HS.

Organism-specific databases

HPAiHPA039953.

Interactioni

Protein-protein interaction databases

IntActiQ8N4W6. 1 interactor.
STRINGi9606.ENSP00000378508.

Structurei

3D structure databases

ProteinModelPortaliQ8N4W6.
SMRiQ8N4W6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini277 – 341JPROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0714. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00390000012136.
HOGENOMiHOG000007152.
HOVERGENiHBG107813.
InParanoidiQ8N4W6.
KOiK19370.
OMAiLASAWWT.
OrthoDBiEOG091G0GZ6.
PhylomeDBiQ8N4W6.
TreeFamiTF324581.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR007829. TM2.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF05154. TM2. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N4W6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKGLLVTYA LWAVGGPAGL HHLYLGRDSH ALLWMLTLGG GGLGWLWEFW
60 70 80 90 100
KLPSFVAQAN RAQGQRQSPR GVTPPLSPIR FAAQVIVGIY FGLVALISLS
110 120 130 140 150
SMVNFYIVAL PLAVGLGVLL VAAVGNQTSD FKNTLGSAFL TSPIFYGRPI
160 170 180 190 200
AILPISVAAS ITAQRHRRYK ALVASEPLSV RLYRLGLAYL AFTGPLAYSA
210 220 230 240 250
LCNTAATLSY VAETFGSFLN WFSFFPLLGR LMEFVLLLPY RIWRLLMGET
260 270 280 290 300
GFNSSCFQEW AKLYEFVHSF QDEKRQLAYQ VLGLSEGATN EEIHRSYQEL
310 320 330 340
VKVWHPDHNL DQTEEAQRHF LEIQAAYEVL SQPRKPWGSR R
Length:341
Mass (Da):38,086
Last modified:October 1, 2002 - v1
Checksum:i0246AFCB12D09917
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055747 mRNA. Translation: BAG51566.1.
CH471111 Genomic DNA. Translation: EAW58066.1.
BC033236 mRNA. Translation: AAH33236.1.
CCDSiCCDS8785.1.
RefSeqiNP_001291873.1. NM_001304944.1.
NP_079178.2. NM_024902.3.
UniGeneiHs.659300.

Genome annotation databases

EnsembliENST00000395069; ENSP00000378508; ENSG00000178401.
ENST00000549441; ENSP00000446830; ENSG00000178401.
GeneIDi79962.
KEGGihsa:79962.
UCSCiuc001rua.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055747 mRNA. Translation: BAG51566.1.
CH471111 Genomic DNA. Translation: EAW58066.1.
BC033236 mRNA. Translation: AAH33236.1.
CCDSiCCDS8785.1.
RefSeqiNP_001291873.1. NM_001304944.1.
NP_079178.2. NM_024902.3.
UniGeneiHs.659300.

3D structure databases

ProteinModelPortaliQ8N4W6.
SMRiQ8N4W6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8N4W6. 1 interactor.
STRINGi9606.ENSP00000378508.

PTM databases

iPTMnetiQ8N4W6.
PhosphoSitePlusiQ8N4W6.

Polymorphism and mutation databases

BioMutaiDNAJC22.
DMDMi74728914.

Proteomic databases

PaxDbiQ8N4W6.
PeptideAtlasiQ8N4W6.
PRIDEiQ8N4W6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395069; ENSP00000378508; ENSG00000178401.
ENST00000549441; ENSP00000446830; ENSG00000178401.
GeneIDi79962.
KEGGihsa:79962.
UCSCiuc001rua.4. human.

Organism-specific databases

CTDi79962.
GeneCardsiDNAJC22.
HGNCiHGNC:25802. DNAJC22.
HPAiHPA039953.
neXtProtiNX_Q8N4W6.
OpenTargetsiENSG00000178401.
PharmGKBiPA162383905.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0714. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00390000012136.
HOGENOMiHOG000007152.
HOVERGENiHBG107813.
InParanoidiQ8N4W6.
KOiK19370.
OMAiLASAWWT.
OrthoDBiEOG091G0GZ6.
PhylomeDBiQ8N4W6.
TreeFamiTF324581.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178401-MONOMER.

Miscellaneous databases

ChiTaRSiDNAJC22. human.
GenomeRNAii79962.
PROiQ8N4W6.

Gene expression databases

BgeeiENSG00000178401.
CleanExiHS_DNAJC22.
ExpressionAtlasiQ8N4W6. baseline and differential.
GenevisibleiQ8N4W6. HS.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR007829. TM2.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF05154. TM2. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDJC22_HUMAN
AccessioniPrimary (citable) accession number: Q8N4W6
Secondary accession number(s): B3KP54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.