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Q8N4W6

- DJC22_HUMAN

UniProt

Q8N4W6 - DJC22_HUMAN

Protein

DnaJ homolog subfamily C member 22

Gene

DNAJC22

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    May function as a co-chaperone.

    Keywords - Molecular functioni

    Chaperone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DnaJ homolog subfamily C member 22
    Gene namesi
    Name:DNAJC22
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:25802. DNAJC22.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162383905.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 341341DnaJ homolog subfamily C member 22PRO_0000325862Add
    BLAST

    Proteomic databases

    PaxDbiQ8N4W6.
    PRIDEiQ8N4W6.

    PTM databases

    PhosphoSiteiQ8N4W6.

    Expressioni

    Gene expression databases

    BgeeiQ8N4W6.
    CleanExiHS_DNAJC22.
    GenevestigatoriQ8N4W6.

    Organism-specific databases

    HPAiHPA039953.
    HPA040012.

    Interactioni

    Protein-protein interaction databases

    BioGridi123031. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N4W6.
    SMRiQ8N4W6. Positions 279-335.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei30 – 5021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei81 – 10121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei105 – 12521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei185 – 20521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei218 – 23821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini277 – 34165JPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 J domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0484.
    HOGENOMiHOG000007152.
    HOVERGENiHBG107813.
    InParanoidiQ8N4W6.
    OMAiWHPDHNL.
    OrthoDBiEOG7TMZS5.
    PhylomeDBiQ8N4W6.
    TreeFamiTF324581.

    Family and domain databases

    Gene3Di1.10.287.110. 1 hit.
    InterProiIPR001623. DnaJ_domain.
    IPR007829. TM2.
    [Graphical view]
    PfamiPF00226. DnaJ. 1 hit.
    PF05154. TM2. 1 hit.
    [Graphical view]
    PRINTSiPR00625. JDOMAIN.
    SMARTiSM00271. DnaJ. 1 hit.
    [Graphical view]
    SUPFAMiSSF46565. SSF46565. 1 hit.
    PROSITEiPS50076. DNAJ_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N4W6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKGLLVTYA LWAVGGPAGL HHLYLGRDSH ALLWMLTLGG GGLGWLWEFW    50
    KLPSFVAQAN RAQGQRQSPR GVTPPLSPIR FAAQVIVGIY FGLVALISLS 100
    SMVNFYIVAL PLAVGLGVLL VAAVGNQTSD FKNTLGSAFL TSPIFYGRPI 150
    AILPISVAAS ITAQRHRRYK ALVASEPLSV RLYRLGLAYL AFTGPLAYSA 200
    LCNTAATLSY VAETFGSFLN WFSFFPLLGR LMEFVLLLPY RIWRLLMGET 250
    GFNSSCFQEW AKLYEFVHSF QDEKRQLAYQ VLGLSEGATN EEIHRSYQEL 300
    VKVWHPDHNL DQTEEAQRHF LEIQAAYEVL SQPRKPWGSR R 341
    Length:341
    Mass (Da):38,086
    Last modified:October 1, 2002 - v1
    Checksum:i0246AFCB12D09917
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055747 mRNA. Translation: BAG51566.1.
    CH471111 Genomic DNA. Translation: EAW58066.1.
    BC033236 mRNA. Translation: AAH33236.1.
    CCDSiCCDS8785.1.
    RefSeqiNP_079178.2. NM_024902.2.
    XP_005269210.1. XM_005269153.1.
    XP_005269211.1. XM_005269154.1.
    UniGeneiHs.659300.

    Genome annotation databases

    EnsembliENST00000395069; ENSP00000378508; ENSG00000178401.
    ENST00000549441; ENSP00000446830; ENSG00000178401.
    GeneIDi79962.
    KEGGihsa:79962.
    UCSCiuc001rua.3. human.

    Polymorphism databases

    DMDMi74728914.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055747 mRNA. Translation: BAG51566.1 .
    CH471111 Genomic DNA. Translation: EAW58066.1 .
    BC033236 mRNA. Translation: AAH33236.1 .
    CCDSi CCDS8785.1.
    RefSeqi NP_079178.2. NM_024902.2.
    XP_005269210.1. XM_005269153.1.
    XP_005269211.1. XM_005269154.1.
    UniGenei Hs.659300.

    3D structure databases

    ProteinModelPortali Q8N4W6.
    SMRi Q8N4W6. Positions 279-335.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123031. 1 interaction.

    PTM databases

    PhosphoSitei Q8N4W6.

    Polymorphism databases

    DMDMi 74728914.

    Proteomic databases

    PaxDbi Q8N4W6.
    PRIDEi Q8N4W6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000395069 ; ENSP00000378508 ; ENSG00000178401 .
    ENST00000549441 ; ENSP00000446830 ; ENSG00000178401 .
    GeneIDi 79962.
    KEGGi hsa:79962.
    UCSCi uc001rua.3. human.

    Organism-specific databases

    CTDi 79962.
    GeneCardsi GC12P049740.
    HGNCi HGNC:25802. DNAJC22.
    HPAi HPA039953.
    HPA040012.
    neXtProti NX_Q8N4W6.
    PharmGKBi PA162383905.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0484.
    HOGENOMi HOG000007152.
    HOVERGENi HBG107813.
    InParanoidi Q8N4W6.
    OMAi WHPDHNL.
    OrthoDBi EOG7TMZS5.
    PhylomeDBi Q8N4W6.
    TreeFami TF324581.

    Miscellaneous databases

    ChiTaRSi DNAJC22. human.
    GenomeRNAii 79962.
    NextBioi 69965.
    PROi Q8N4W6.

    Gene expression databases

    Bgeei Q8N4W6.
    CleanExi HS_DNAJC22.
    Genevestigatori Q8N4W6.

    Family and domain databases

    Gene3Di 1.10.287.110. 1 hit.
    InterProi IPR001623. DnaJ_domain.
    IPR007829. TM2.
    [Graphical view ]
    Pfami PF00226. DnaJ. 1 hit.
    PF05154. TM2. 1 hit.
    [Graphical view ]
    PRINTSi PR00625. JDOMAIN.
    SMARTi SM00271. DnaJ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46565. SSF46565. 1 hit.
    PROSITEi PS50076. DNAJ_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiDJC22_HUMAN
    AccessioniPrimary (citable) accession number: Q8N4W6
    Secondary accession number(s): B3KP54
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3