Q8N4W3 (Q8N4W3_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Colony stimulating factor 3 (Granulocyte) EMBL AAH33245.1

Submitted name:
Colony stimulating factor 3 (Granulocyte), isoform CRA_a EMBL EAW60626.1
Submitted name:
Granulocyte colony-stimulating factor Ensembl ENSP00000327766
Submitted name:
cDNA FLJ76606, highly similar to Homo sapiens colony stimulating factor 3 (granulocyte) (CSF3), transcript variant 3, mRNA EMBL BAF82936.1

Gene names

Name:	CSF3 Ensembl ENSP00000327766 EMBL AAH33245.1
ORF Names:	hCG_30013 EMBL EAW60626.1

Organism

Homo sapiens (Human) [Reference proteome] EMBL AAH33245.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	200 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8N4W3 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 8648AA55B329A96C	FASTA	200	21,543
	10 20 30 40 50 60 MSPEPALSPA LQLLLWHSAL WTVQEATPLG PASSLPQSFL LKCLEQVRKI QGDGAALQEK 70 80 90 100 110 120 LCATYKLCHP EELVLLGHSL GIPWAPLSSC PSQALQLAGC LSQLHSGLFL YQGLLQALEG 130 140 150 160 170 180 ISPELGPTLD TLQLDVADFA TTIWQQMEEL GMAPALQPTQ GAMPAFASAF QRRAGGVLVA 190 200 SHLQSFLEVS YRVLRHLAQP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin EMBL AAH33245.1.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"NEDO human cDNA sequencing project." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Cervix EMBL BAF82936.1.
[5]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC090844 Genomic DNA. No translation available. BC033245 mRNA. Translation: AAH33245.1. AK290247 mRNA. Translation: BAF82936.1. CH471152 Genomic DNA. Translation: EAW60626.1.
IPI	IPI00172504.
RefSeq	NP_000750.1. NM_000759.3. NP_001171618.1. NM_001178147.1. NP_757373.1. NM_172219.2. NP_757374.2. NM_172220.2.
UniGene	Hs.2233.
3D structure databases
HSSP	HSSP built from PDB template 1GNC based on UniProtKB P09919.
SMR	Q8N4W3. Positions 30-200.
ModBase	Search...
Protein family/group databases
Allergome	8367. Hom s G-CSF.
Protocols and materials databases
DNASU	1440.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000331769; ENSP00000327766; ENSG00000108342.
GeneID	1440.
KEGG	hsa:1440.
UCSC	uc002htq.3. human.
Organism-specific databases
CTD	1440.
HGNC	HGNC:2438. CSF3.
PharmGKB	PA26941.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000015371.
HOVERGEN	HBG005411.
KO	K05423.
Gene expression databases
ArrayExpress	Q8N4W3.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR003573. IL6_MGF_GCSF. [Graphical view]
Pfam	PF00489. IL6. 1 hit. [Graphical view]
PIRSF	PIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTS	PR00433. IL6GCSFMGF.
SMART	SM00126. IL6. 1 hit. [Graphical view]
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
PROSITE	PS00254. INTERLEUKIN_6. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	1440.
NextBio	5893.
PMAP-CutDB	Q8N4W3.

Entry information

Entry name

Q8N4W3_HUMAN

Accession

Primary (citable) accession number: Q8N4W3

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.