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Protein

Synaptic vesicle 2-related protein

Gene

SVOP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle 2-related protein
Short name:
SV2-related protein
Gene namesi
Name:SVOP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:25417. SVOP.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8787CytoplasmicSequence analysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence analysisAdd
BLAST
Topological domaini109 – 12214VesicularSequence analysisAdd
BLAST
Transmembranei123 – 14321HelicalSequence analysisAdd
BLAST
Topological domaini144 – 15613CytoplasmicSequence analysisAdd
BLAST
Transmembranei157 – 17721HelicalSequence analysisAdd
BLAST
Topological domaini178 – 1803VesicularSequence analysis
Transmembranei181 – 20121HelicalSequence analysisAdd
BLAST
Topological domaini202 – 2098CytoplasmicSequence analysis
Transmembranei210 – 23021HelicalSequence analysisAdd
BLAST
Topological domaini231 – 2388VesicularSequence analysis
Transmembranei239 – 25921HelicalSequence analysisAdd
BLAST
Topological domaini260 – 31657CytoplasmicSequence analysisAdd
BLAST
Transmembranei317 – 33721HelicalSequence analysisAdd
BLAST
Topological domaini338 – 37336VesicularSequence analysisAdd
BLAST
Transmembranei374 – 39421HelicalSequence analysisAdd
BLAST
Topological domaini395 – 4017CytoplasmicSequence analysis
Transmembranei402 – 42221HelicalSequence analysisAdd
BLAST
Topological domaini423 – 4242VesicularSequence analysis
Transmembranei425 – 44521HelicalSequence analysisAdd
BLAST
Topological domaini446 – 45712CytoplasmicSequence analysisAdd
BLAST
Transmembranei458 – 47821HelicalSequence analysisAdd
BLAST
Topological domaini479 – 48911VesicularSequence analysisAdd
BLAST
Transmembranei490 – 51021HelicalSequence analysisAdd
BLAST
Topological domaini511 – 54838CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670848.

Polymorphism and mutation databases

BioMutaiSVOP.
DMDMi74751007.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548Synaptic vesicle 2-related proteinPRO_0000279452Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251PhosphoserineBy similarity
Modified residuei31 – 311PhosphoserineBy similarity
Modified residuei542 – 5421PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8N4V2.
PRIDEiQ8N4V2.

PTM databases

iPTMnetiQ8N4V2.
PhosphoSiteiQ8N4V2.

Expressioni

Gene expression databases

BgeeiQ8N4V2.
CleanExiHS_SVOP.
ExpressionAtlasiQ8N4V2. baseline and differential.
GenevisibleiQ8N4V2. HS.

Organism-specific databases

HPAiHPA016573.

Interactioni

Protein-protein interaction databases

BioGridi120701. 2 interactions.
STRINGi9606.ENSP00000299134.

Structurei

3D structure databases

ProteinModelPortaliQ8N4V2.
SMRiQ8N4V2. Positions 130-281.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0253. Eukaryota.
KOG0255. Eukaryota.
ENOG410ZVDQ. LUCA.
GeneTreeiENSGT00550000074384.
HOGENOMiHOG000114543.
HOVERGENiHBG057057.
InParanoidiQ8N4V2.
OMAiKEDYMDL.
OrthoDBiEOG718KCS.
PhylomeDBiQ8N4V2.
TreeFamiTF313465.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR004749. Orgcat_transp/SVOP.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N4V2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEDLFQLRQ LPVVKFRRTG ESARSEDDTA SGEHEVQIEG VHVGLEAVEL
60 70 80 90 100
DDGAAVPKEF ANPTDDTFMV EDAVEAIGFG KFQWKLSVLT GLAWMADAME
110 120 130 140 150
MMILSILAPQ LHCEWRLPSW QVALLTSVVF VGMMSSSTLW GNISDQYGRK
160 170 180 190 200
TGLKISVLWT LYYGILSAFA PVYSWILVLR GLVGFGIGGV PQSVTLYAEF
210 220 230 240 250
LPMKARAKCI LLIEVFWAIG TVFEVVLAVF VMPSLGWRWL LILSAVPLLL
260 270 280 290 300
FAVLCFWLPE SARYDVLSGN QEKAIATLKR IATENGAPMP LGKLIISRQE
310 320 330 340 350
DRGKMRDLFT PHFRWTTLLL WFIWFSNAFS YYGLVLLTTE LFQAGDVCGI
360 370 380 390 400
SSRKKAVEAK CSLACEYLSE EDYMDLLWTT LSEFPGVLVT LWIIDRLGRK
410 420 430 440 450
KTMALCFVIF SFCSLLLFIC VGRNVLTLLL FIARAFISGG FQAAYVYTPE
460 470 480 490 500
VYPTATRALG LGTCSGMARV GALITPFIAQ VMLESSVYLT LAVYSGCCLL
510 520 530 540
AALASCFLPI ETKGRGLQES SHREWGQEMV GRGMHGAGVT RSNSGSQE
Length:548
Mass (Da):60,769
Last modified:October 1, 2002 - v1
Checksum:i666116BD99516567
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC033587 mRNA. Translation: AAH33587.1.
BC094722 mRNA. Translation: AAH94722.1.
AL359592 mRNA. Translation: CAB94878.3.
CCDSiCCDS73520.1.
PIRiT50622.
RefSeqiNP_061181.1. NM_018711.4.
UniGeneiHs.27226.
Hs.4221.
Hs.595078.

Genome annotation databases

EnsembliENST00000610966; ENSP00000479104; ENSG00000166111.
GeneIDi55530.
KEGGihsa:55530.
UCSCiuc031zmo.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC033587 mRNA. Translation: AAH33587.1.
BC094722 mRNA. Translation: AAH94722.1.
AL359592 mRNA. Translation: CAB94878.3.
CCDSiCCDS73520.1.
PIRiT50622.
RefSeqiNP_061181.1. NM_018711.4.
UniGeneiHs.27226.
Hs.4221.
Hs.595078.

3D structure databases

ProteinModelPortaliQ8N4V2.
SMRiQ8N4V2. Positions 130-281.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120701. 2 interactions.
STRINGi9606.ENSP00000299134.

PTM databases

iPTMnetiQ8N4V2.
PhosphoSiteiQ8N4V2.

Polymorphism and mutation databases

BioMutaiSVOP.
DMDMi74751007.

Proteomic databases

PaxDbiQ8N4V2.
PRIDEiQ8N4V2.

Protocols and materials databases

DNASUi55530.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000610966; ENSP00000479104; ENSG00000166111.
GeneIDi55530.
KEGGihsa:55530.
UCSCiuc031zmo.2. human.

Organism-specific databases

CTDi55530.
GeneCardsiSVOP.
H-InvDBHIX0021720.
HGNCiHGNC:25417. SVOP.
HPAiHPA016573.
MIMi611699. gene.
neXtProtiNX_Q8N4V2.
PharmGKBiPA142670848.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0253. Eukaryota.
KOG0255. Eukaryota.
ENOG410ZVDQ. LUCA.
GeneTreeiENSGT00550000074384.
HOGENOMiHOG000114543.
HOVERGENiHBG057057.
InParanoidiQ8N4V2.
OMAiKEDYMDL.
OrthoDBiEOG718KCS.
PhylomeDBiQ8N4V2.
TreeFamiTF313465.

Miscellaneous databases

ChiTaRSiSVOP. human.
GenomeRNAii55530.
PROiQ8N4V2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N4V2.
CleanExiHS_SVOP.
ExpressionAtlasiQ8N4V2. baseline and differential.
GenevisibleiQ8N4V2. HS.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR004749. Orgcat_transp/SVOP.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 405-548.
    Tissue: Amygdala.
  3. "Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family."
    Jacobsson J.A., Haitina T., Lindblom J., Fredriksson R.
    Genomics 90:595-609(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiSVOP_HUMAN
AccessioniPrimary (citable) accession number: Q8N4V2
Secondary accession number(s): Q9NPW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.