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Protein

T-complex protein 11-like protein 2

Gene

TCP11L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 11-like protein 2
Gene namesi
Name:TCP11L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:28627. TCP11L2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670825.

Polymorphism and mutation databases

BioMutaiTCP11L2.
DMDMi74728903.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519T-complex protein 11-like protein 2PRO_0000313750Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N4U5.
MaxQBiQ8N4U5.
PaxDbiQ8N4U5.
PeptideAtlasiQ8N4U5.
PRIDEiQ8N4U5.

PTM databases

iPTMnetiQ8N4U5.
PhosphoSiteiQ8N4U5.

Expressioni

Gene expression databases

BgeeiQ8N4U5.
CleanExiHS_TCP11L2.
ExpressionAtlasiQ8N4U5. baseline and differential.
GenevisibleiQ8N4U5. HS.

Organism-specific databases

HPAiHPA039483.
HPA042188.

Interactioni

Protein-protein interaction databases

BioGridi129100. 10 interactions.
STRINGi9606.ENSP00000299045.

Structurei

3D structure databases

ProteinModelPortaliQ8N4U5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi16 – 5540Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the TCP11 family.Curated

Phylogenomic databases

eggNOGiKOG1981. Eukaryota.
ENOG410ZDEH. LUCA.
GeneTreeiENSGT00390000008958.
HOGENOMiHOG000231350.
HOVERGENiHBG008348.
InParanoidiQ8N4U5.
OMAiRQLVEYE.
PhylomeDBiQ8N4U5.
TreeFamiTF313385.

Family and domain databases

InterProiIPR008862. Tcp11.
[Graphical view]
PANTHERiPTHR12832. PTHR12832. 1 hit.
PfamiPF05794. Tcp11. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N4U5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPFNGEKQCV GEDQPSDSDS SRFSESMASL SDYECSRQSF ASDSSSKSSS
60 70 80 90 100
PASTSPPRVV TFDEVMATAR NLSNLTLAHE IAVNENFQLK QEALPEKSLA
110 120 130 140 150
GRVKHIVHQA FWDVLDSELN ADPPEFEHAI KLFEEIREIL LSFLTPGGNR
160 170 180 190 200
LRNQICEVLD TDLIRQQAEH SAVDIQGLAN YVISTMGKLC APVRDNDIRE
210 220 230 240 250
LKATGNIVEV LRQIFHVLDL MQMDMANFTI MSLRPHLQRQ LVEYERTKFQ
260 270 280 290 300
EILEETPSAL DQTTEWIKES VNEELFSLSE SALTPGAENT SKPSLSPTLV
310 320 330 340 350
LNNSYLKLLQ WDYQKKELPE TLMTDGARLQ ELTEKLNQLK IIACLSLITN
360 370 380 390 400
NMVGAITGGL PELASRLTRI SAVLLEGMNK ETFNLKEVLN SIGIQTCVEV
410 420 430 440 450
NKTLMERGLP TLNAEIQANL IGQFSSIEEE DNPIWSLIDK RIKLYMRRLL
460 470 480 490 500
CLPSPQKCMP PMPGGLAVIQ QELEALGSQY ANIVNLNKQV YGPFYANILR
510
KLLFNEEAMG KVDASPPTN
Length:519
Mass (Da):58,091
Last modified:October 1, 2002 - v1
Checksum:iDB21CEDFECA17900
GO
Isoform 2 (identifier: Q8N4U5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-266: SALDQTTEW → RKAEVAGAS
     267-519: Missing.

Note: Gene prediction based on EST data.
Show »
Length:266
Mass (Da):29,870
Checksum:i733885D7A8C4339F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti137 – 1371R → G in BAG36762 (PubMed:14702039).Curated
Sequence conflicti158 – 1581V → A in BAG36762 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti41 – 411A → T.1 Publication
Corresponds to variant rs4964460 [ dbSNP | Ensembl ].
VAR_037728
Natural varianti82 – 821A → S.
Corresponds to variant rs11837375 [ dbSNP | Ensembl ].
VAR_037729
Natural varianti261 – 2611D → N.
Corresponds to variant rs17218950 [ dbSNP | Ensembl ].
VAR_037730

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei258 – 2669SALDQTTEW → RKAEVAGAS in isoform 2. CuratedVSP_055736
Alternative sequencei267 – 519253Missing in isoform 2. CuratedVSP_055737Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK314055 mRNA. Translation: BAG36762.1.
AC079174 Genomic DNA. No translation available.
AC080012 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97774.1.
CH471054 Genomic DNA. Translation: EAW97775.1.
BC033617 mRNA. Translation: AAH33617.1.
CCDSiCCDS66456.1. [Q8N4U5-2]
CCDS9104.1. [Q8N4U5-1]
RefSeqiNP_001273191.1. NM_001286262.1. [Q8N4U5-2]
NP_689985.1. NM_152772.2. [Q8N4U5-1]
XP_005268824.1. XM_005268767.3. [Q8N4U5-1]
XP_005268825.1. XM_005268768.3. [Q8N4U5-1]
XP_011536431.1. XM_011538129.1. [Q8N4U5-1]
XP_011536432.1. XM_011538130.1. [Q8N4U5-1]
UniGeneiHs.696047.
Hs.736922.

Genome annotation databases

EnsembliENST00000299045; ENSP00000299045; ENSG00000166046. [Q8N4U5-1]
ENST00000547153; ENSP00000448952; ENSG00000166046. [Q8N4U5-2]
GeneIDi255394.
KEGGihsa:255394.
UCSCiuc001tlm.5. human. [Q8N4U5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK314055 mRNA. Translation: BAG36762.1.
AC079174 Genomic DNA. No translation available.
AC080012 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97774.1.
CH471054 Genomic DNA. Translation: EAW97775.1.
BC033617 mRNA. Translation: AAH33617.1.
CCDSiCCDS66456.1. [Q8N4U5-2]
CCDS9104.1. [Q8N4U5-1]
RefSeqiNP_001273191.1. NM_001286262.1. [Q8N4U5-2]
NP_689985.1. NM_152772.2. [Q8N4U5-1]
XP_005268824.1. XM_005268767.3. [Q8N4U5-1]
XP_005268825.1. XM_005268768.3. [Q8N4U5-1]
XP_011536431.1. XM_011538129.1. [Q8N4U5-1]
XP_011536432.1. XM_011538130.1. [Q8N4U5-1]
UniGeneiHs.696047.
Hs.736922.

3D structure databases

ProteinModelPortaliQ8N4U5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129100. 10 interactions.
STRINGi9606.ENSP00000299045.

PTM databases

iPTMnetiQ8N4U5.
PhosphoSiteiQ8N4U5.

Polymorphism and mutation databases

BioMutaiTCP11L2.
DMDMi74728903.

Proteomic databases

EPDiQ8N4U5.
MaxQBiQ8N4U5.
PaxDbiQ8N4U5.
PeptideAtlasiQ8N4U5.
PRIDEiQ8N4U5.

Protocols and materials databases

DNASUi255394.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299045; ENSP00000299045; ENSG00000166046. [Q8N4U5-1]
ENST00000547153; ENSP00000448952; ENSG00000166046. [Q8N4U5-2]
GeneIDi255394.
KEGGihsa:255394.
UCSCiuc001tlm.5. human. [Q8N4U5-1]

Organism-specific databases

CTDi255394.
GeneCardsiTCP11L2.
HGNCiHGNC:28627. TCP11L2.
HPAiHPA039483.
HPA042188.
neXtProtiNX_Q8N4U5.
PharmGKBiPA142670825.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1981. Eukaryota.
ENOG410ZDEH. LUCA.
GeneTreeiENSGT00390000008958.
HOGENOMiHOG000231350.
HOVERGENiHBG008348.
InParanoidiQ8N4U5.
OMAiRQLVEYE.
PhylomeDBiQ8N4U5.
TreeFamiTF313385.

Miscellaneous databases

GenomeRNAii255394.
PROiQ8N4U5.

Gene expression databases

BgeeiQ8N4U5.
CleanExiHS_TCP11L2.
ExpressionAtlasiQ8N4U5. baseline and differential.
GenevisibleiQ8N4U5. HS.

Family and domain databases

InterProiIPR008862. Tcp11.
[Graphical view]
PANTHERiPTHR12832. PTHR12832. 1 hit.
PfamiPF05794. Tcp11. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-41.
    Tissue: Thymus.
  2. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiT11L2_HUMAN
AccessioniPrimary (citable) accession number: Q8N4U5
Secondary accession number(s): B2RA65, G3V1Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.