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Protein

MARVEL domain-containing protein 2

Gene

MARVELD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the formation of the epithelial barriers. The separation of the endolymphatic and perilymphatic spaces of the organ of Corti from one another by epithelial barriers is required for normal hearing.1 Publication

GO - Biological processi

  • bicellular tight junction assembly Source: UniProtKB
  • cell-cell junction organization Source: MGI
  • establishment of endothelial barrier Source: UniProtKB
  • sensory perception of sound Source: MGI
Complete GO annotation...

Keywords - Biological processi

Hearing

Names & Taxonomyi

Protein namesi
Recommended name:
MARVEL domain-containing protein 2
Alternative name(s):
Tricellulin
Gene namesi
Name:MARVELD2
Synonyms:TRIC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:26401. MARVELD2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 194194CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei195 – 21521HelicalSequence AnalysisAdd
BLAST
Topological domaini216 – 2238ExtracellularSequence Analysis
Transmembranei224 – 24421HelicalSequence AnalysisAdd
BLAST
Topological domaini245 – 25410CytoplasmicSequence Analysis
Transmembranei255 – 27521HelicalSequence AnalysisAdd
BLAST
Topological domaini276 – 29116ExtracellularSequence AnalysisAdd
BLAST
Transmembranei292 – 31221HelicalSequence AnalysisAdd
BLAST
Topological domaini313 – 3197CytoplasmicSequence Analysis
Transmembranei320 – 33718HelicalSequence AnalysisAdd
BLAST
Topological domaini338 – 3414ExtracellularSequence Analysis
Transmembranei342 – 36221HelicalSequence AnalysisAdd
BLAST
Topological domaini363 – 558196CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • basolateral plasma membrane Source: UniProtKB
  • bicellular tight junction Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • cytoplasmic vesicle Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • paranodal junction Source: Ensembl
  • Schmidt-Lanterman incisure Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal recessive, 49 (DFNB49)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

See also OMIM:610153

Keywords - Diseasei

Deafness, Non-syndromic deafness

Organism-specific databases

MIMi610153. phenotype.
Orphaneti90636. Autosomal recessive non-syndromic sensorineural deafness type DFNB.
PharmGKBiPA134954584.

Polymorphism and mutation databases

BioMutaiMARVELD2.
DMDMi317373387.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 558558MARVEL domain-containing protein 2PRO_0000271526Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei116 – 1161Phosphoserine2 Publications
Modified residuei120 – 1201Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8N4S9.
PaxDbiQ8N4S9.
PRIDEiQ8N4S9.

PTM databases

PhosphoSiteiQ8N4S9.

Expressioni

Gene expression databases

BgeeiQ8N4S9.
CleanExiHS_MARVELD2.
ExpressionAtlasiQ8N4S9. baseline and differential.
GenevisibleiQ8N4S9. HS.

Organism-specific databases

HPAiHPA018119.

Interactioni

Protein-protein interaction databases

BioGridi127502. 14 interactions.
IntActiQ8N4S9. 1 interaction.
STRINGi9606.ENSP00000323264.

Structurei

3D structure databases

ProteinModelPortaliQ8N4S9.
SMRiQ8N4S9. Positions 441-548.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini188 – 367180MARVELPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili466 – 49025Sequence AnalysisAdd
BLAST
Coiled coili524 – 54825Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi45 – 528Poly-Pro
Compositional biasi514 – 5174Poly-Lys

Sequence similaritiesi

Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG264085.
GeneTreeiENSGT00550000074378.
HOGENOMiHOG000155323.
HOVERGENiHBG079727.
InParanoidiQ8N4S9.
KOiK17291.
OMAiIHKDNEW.
PhylomeDBiQ8N4S9.
TreeFamiTF326161.

Family and domain databases

InterProiIPR031176. ELL/occludin.
IPR008253. Marvel.
IPR031177. MARVELD2.
IPR010844. Occludin_ELL.
[Graphical view]
PANTHERiPTHR23288. PTHR23288. 1 hit.
PTHR23288:SF3. PTHR23288:SF3. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
PF07303. Occludin_ELL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N4S9-1) [UniParc]FASTAAdd to basket

Also known as: A, TRIC

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNDGRSRNR DRRYDEVPSD LPYQDTTIRT HPTLHDSERA VSADPLPPPP
60 70 80 90 100
LPLQPPFGPD FYSSDTEEPA IAPDLKPVRR FVPDSWKNFF RGKKKDPEWD
110 120 130 140 150
KPVSDIRYIS DGVECSPPAS PARPNHRSPL NSCKDPYGGS EGTFSSRKEA
160 170 180 190 200
DAVFPRDPYG SLDRHTQTVR TYSEKVEEYN LRYSYMKSWA GLLRILGVVE
210 220 230 240 250
LLLGAGVFAC VTAYIHKDSE WYNLFGYSQP YGMGGVGGLG SMYGGYYYTG
260 270 280 290 300
PKTPFVLVVA GLAWITTIII LVLGMSMYYR TILLDSNWWP LTEFGINVAL
310 320 330 340 350
FILYMAAAIV YVNDTNRGGL CYYPLFNTPV NAVFCRVEGG QIAAMIFLFV
360 370 380 390 400
TMIVYLISAL VCLKLWRHEA ARRHREYMEQ QEINEPSLSS KRKMCEMATS
410 420 430 440 450
GDRQRDSEVN FKELRTAKMK PELLSGHIPP GHIPKPIVMP DYVAKYPVIQ
460 470 480 490 500
TDDERERYKA VFQDQFSEYK ELSAEVQAVL RKFDELDAVM SRLPHHSESR
510 520 530 540 550
QEHERISRIH EEFKKKKNDP TFLEKKERCD YLKNKLSHIK QRIQEYDKVM

NWDVQGYS
Length:558
Mass (Da):64,168
Last modified:January 11, 2011 - v2
Checksum:i04F3FCB2CFDB162B
GO
Isoform 2 (identifier: Q8N4S9-2) [UniParc]FASTAAdd to basket

Also known as: TRICbeta

The sequence of this isoform differs from the canonical sequence as follows:
     431-457: GHIPKPIVMPDYVAKYPVIQTDDERER → RPANFFVFLVEMGFHRVSQDDLDLLTS
     458-558: Missing.

Show »
Length:457
Mass (Da):51,839
Checksum:iAC283BB19827AFFE
GO
Isoform 3 (identifier: Q8N4S9-3) [UniParc]FASTAAdd to basket

Also known as: A1

The sequence of this isoform differs from the canonical sequence as follows:
     383-394: Missing.

Show »
Length:546
Mass (Da):62,796
Checksum:iF0BE767148439FCA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti356 – 3561L → P in BAF85651 (PubMed:14702039).Curated
Sequence conflicti435 – 4351K → R in BAF85651 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti33 – 331T → I.5 Publications
Corresponds to variant rs1185246 [ dbSNP | Ensembl ].
VAR_047436

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei383 – 39412Missing in isoform 3. 1 PublicationVSP_035760Add
BLAST
Alternative sequencei431 – 45727GHIPK…DERER → RPANFFVFLVEMGFHRVSQD DLDLLTS in isoform 2. 2 PublicationsVSP_022320Add
BLAST
Alternative sequencei458 – 558101Missing in isoform 2. 2 PublicationsVSP_022321Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB219936 mRNA. Translation: BAE54513.1.
AB219937 mRNA. Translation: BAE54514.1.
DQ682656 mRNA. Translation: ABG89104.1.
DQ682657 mRNA. Translation: ABG89105.1.
AK055094 mRNA. Translation: BAB70853.1.
AK292962 mRNA. Translation: BAF85651.1.
AC145146 Genomic DNA. No translation available.
CH471137 Genomic DNA. Translation: EAW51277.1.
BC033689 mRNA. Translation: AAH33689.1.
CCDSiCCDS34175.1. [Q8N4S9-1]
CCDS58956.1. [Q8N4S9-3]
RefSeqiNP_001033692.2. NM_001038603.2. [Q8N4S9-1]
NP_001231663.1. NM_001244734.1. [Q8N4S9-3]
XP_005248502.1. XM_005248445.3. [Q8N4S9-1]
XP_005248503.1. XM_005248446.3. [Q8N4S9-1]
XP_005248504.1. XM_005248447.3. [Q8N4S9-3]
XP_005276814.1. XM_005276757.3.
XP_005276815.1. XM_005276758.2.
XP_005276817.1. XM_005276760.3.
UniGeneiHs.657687.

Genome annotation databases

EnsembliENST00000325631; ENSP00000323264; ENSG00000152939.
ENST00000454295; ENSP00000396244; ENSG00000152939. [Q8N4S9-3]
ENST00000614617; ENSP00000480044; ENSG00000274671.
ENST00000622835; ENSP00000480068; ENSG00000274671.
GeneIDi153562.
KEGGihsa:153562.
UCSCiuc003jwq.3. human. [Q8N4S9-1]
uc010ixf.3. human. [Q8N4S9-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB219936 mRNA. Translation: BAE54513.1.
AB219937 mRNA. Translation: BAE54514.1.
DQ682656 mRNA. Translation: ABG89104.1.
DQ682657 mRNA. Translation: ABG89105.1.
AK055094 mRNA. Translation: BAB70853.1.
AK292962 mRNA. Translation: BAF85651.1.
AC145146 Genomic DNA. No translation available.
CH471137 Genomic DNA. Translation: EAW51277.1.
BC033689 mRNA. Translation: AAH33689.1.
CCDSiCCDS34175.1. [Q8N4S9-1]
CCDS58956.1. [Q8N4S9-3]
RefSeqiNP_001033692.2. NM_001038603.2. [Q8N4S9-1]
NP_001231663.1. NM_001244734.1. [Q8N4S9-3]
XP_005248502.1. XM_005248445.3. [Q8N4S9-1]
XP_005248503.1. XM_005248446.3. [Q8N4S9-1]
XP_005248504.1. XM_005248447.3. [Q8N4S9-3]
XP_005276814.1. XM_005276757.3.
XP_005276815.1. XM_005276758.2.
XP_005276817.1. XM_005276760.3.
UniGeneiHs.657687.

3D structure databases

ProteinModelPortaliQ8N4S9.
SMRiQ8N4S9. Positions 441-548.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127502. 14 interactions.
IntActiQ8N4S9. 1 interaction.
STRINGi9606.ENSP00000323264.

PTM databases

PhosphoSiteiQ8N4S9.

Polymorphism and mutation databases

BioMutaiMARVELD2.
DMDMi317373387.

Proteomic databases

MaxQBiQ8N4S9.
PaxDbiQ8N4S9.
PRIDEiQ8N4S9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325631; ENSP00000323264; ENSG00000152939.
ENST00000454295; ENSP00000396244; ENSG00000152939. [Q8N4S9-3]
ENST00000614617; ENSP00000480044; ENSG00000274671.
ENST00000622835; ENSP00000480068; ENSG00000274671.
GeneIDi153562.
KEGGihsa:153562.
UCSCiuc003jwq.3. human. [Q8N4S9-1]
uc010ixf.3. human. [Q8N4S9-3]

Organism-specific databases

CTDi153562.
GeneCardsiGC05P068746.
GeneReviewsiMARVELD2.
H-InvDBHIX0004923.
HGNCiHGNC:26401. MARVELD2.
HPAiHPA018119.
MIMi610153. phenotype.
610572. gene.
neXtProtiNX_Q8N4S9.
Orphaneti90636. Autosomal recessive non-syndromic sensorineural deafness type DFNB.
PharmGKBiPA134954584.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG264085.
GeneTreeiENSGT00550000074378.
HOGENOMiHOG000155323.
HOVERGENiHBG079727.
InParanoidiQ8N4S9.
KOiK17291.
OMAiIHKDNEW.
PhylomeDBiQ8N4S9.
TreeFamiTF326161.

Miscellaneous databases

ChiTaRSiMARVELD2. human.
GeneWikiiMARVELD2.
GenomeRNAii153562.
NextBioi87132.
PROiQ8N4S9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N4S9.
CleanExiHS_MARVELD2.
ExpressionAtlasiQ8N4S9. baseline and differential.
GenevisibleiQ8N4S9. HS.

Family and domain databases

InterProiIPR031176. ELL/occludin.
IPR008253. Marvel.
IPR031177. MARVELD2.
IPR010844. Occludin_ELL.
[Graphical view]
PANTHERiPTHR23288. PTHR23288. 1 hit.
PTHR23288:SF3. PTHR23288:SF3. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
PF07303. Occludin_ELL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells."
    Ikenouchi J., Furuse M., Furuse K., Sasaki H., Tsukita S., Tsukita S.
    J. Cell Biol. 171:939-945(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT ILE-33.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), INVOLVEMENT IN DFNB49, FUNCTION, VARIANT ILE-33.
    Tissue: Lung.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ILE-33.
    Tissue: Brain and Trachea.
  4. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-33.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-33.
    Tissue: Lung.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-116 AND SER-120, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-116 AND SER-120, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiMALD2_HUMAN
AccessioniPrimary (citable) accession number: Q8N4S9
Secondary accession number(s): A1BQX0
, A1BQX1, A8KA97, Q96NM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 11, 2011
Last modified: July 22, 2015
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.