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Protein

Progestin and adipoQ receptor family member 4

Gene

PAQR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. receptor activity Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Progestin and adipoQ receptor family member 4
Alternative name(s):
Progestin and adipoQ receptor family member IV
Gene namesi
Name:PAQR4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:26386. PAQR4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei52 – 7221HelicalSequence AnalysisAdd
BLAST
Transmembranei79 – 9921HelicalSequence AnalysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence AnalysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence AnalysisAdd
BLAST
Transmembranei185 – 20521HelicalSequence AnalysisAdd
BLAST
Transmembranei245 – 26521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134945614.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273Progestin and adipoQ receptor family member 4PRO_0000218848Add
BLAST

Proteomic databases

MaxQBiQ8N4S7.
PaxDbiQ8N4S7.
PRIDEiQ8N4S7.

Expressioni

Tissue specificityi

Relatively widely expressed in a range of tissues.1 Publication

Gene expression databases

BgeeiQ8N4S7.
CleanExiHS_PAQR4.
ExpressionAtlasiQ8N4S7. baseline and differential.
GenevestigatoriQ8N4S7.

Interactioni

Protein-protein interaction databases

BioGridi125857. 1 interaction.
STRINGi9606.ENSP00000321804.

Structurei

3D structure databases

ProteinModelPortaliQ8N4S7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1272.
GeneTreeiENSGT00530000062926.
HOGENOMiHOG000006893.
HOVERGENiHBG053505.
InParanoidiQ8N4S7.
OMAiCHQGGSP.
OrthoDBiEOG7PK905.
PhylomeDBiQ8N4S7.
TreeFamiTF323692.

Family and domain databases

InterProiIPR004254. AdipoR/HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N4S7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFLAGPRLL DWASSPPHLQ FNKFVLTGYR PASSGSGCLR SLFYLHNELG
60 70 80 90 100
NIYTHGLALL GFLVLVPMTM PWGQLGKDGW LGGTHCVACL APPAGSVLYH
110 120 130 140 150
LFMCHQGGSA VYARLLALDM CGVCLVNTLG ALPIIHCTLA CRPWLRPAAL
160 170 180 190 200
VGYTVLSGVA GWRALTAPST SARLRAFGWQ AAARLLVFGA RGVGLGSGAP
210 220 230 240 250
GSLPCYLRMD ALALLGGLVN VARLPERWGP GRFDYWGNSH QIMHLLSVGS
260 270
ILQLHAGVVP DLLWAAHHAC PRD
Length:273
Mass (Da):29,126
Last modified:May 1, 2007 - v3
Checksum:i147C445B5EFAFFFD
GO
Isoform 2 (identifier: Q8N4S7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-94: Missing.

Show »
Length:234
Mass (Da):25,152
Checksum:iEB378DE6BE387C0A
GO
Isoform 3 (identifier: Q8N4S7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-130: Missing.

Note: No experimental confirmation available.

Show »
Length:198
Mass (Da):21,357
Checksum:iC2B5709D29EFE9F9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541T → A in BAC03821. (PubMed:14702039)Curated
Sequence conflicti148 – 1481A → T in BAC03821. (PubMed:14702039)Curated
Sequence conflicti189 – 1891G → E in BAB70758. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei56 – 13075Missing in isoform 3. 1 PublicationVSP_011482Add
BLAST
Alternative sequencei56 – 9439Missing in isoform 2. 1 PublicationVSP_011481Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424282 mRNA. Translation: AAR08370.1.
AK054564 mRNA. Translation: BAB70758.1.
AK092173 mRNA. Translation: BAC03821.1.
AK291373 mRNA. Translation: BAF84062.1.
CH471112 Genomic DNA. Translation: EAW85441.1.
CH471112 Genomic DNA. Translation: EAW85442.1.
CH471112 Genomic DNA. Translation: EAW85443.1.
CH471112 Genomic DNA. Translation: EAW85444.1.
BC033703 mRNA. Translation: AAH33703.1.
CCDSiCCDS10485.1. [Q8N4S7-1]
CCDS66911.1. [Q8N4S7-2]
RefSeqiNP_001271440.1. NM_001284511.1. [Q8N4S7-2]
NP_001271441.1. NM_001284512.1.
NP_689554.2. NM_152341.4. [Q8N4S7-1]
UniGeneiHs.351474.

Genome annotation databases

EnsembliENST00000293978; ENSP00000293978; ENSG00000162073. [Q8N4S7-2]
ENST00000318782; ENSP00000321804; ENSG00000162073. [Q8N4S7-1]
GeneIDi124222.
KEGGihsa:124222.
UCSCiuc002csj.4. human. [Q8N4S7-1]
uc002csk.4. human. [Q8N4S7-2]

Polymorphism databases

DMDMi146345478.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424282 mRNA. Translation: AAR08370.1.
AK054564 mRNA. Translation: BAB70758.1.
AK092173 mRNA. Translation: BAC03821.1.
AK291373 mRNA. Translation: BAF84062.1.
CH471112 Genomic DNA. Translation: EAW85441.1.
CH471112 Genomic DNA. Translation: EAW85442.1.
CH471112 Genomic DNA. Translation: EAW85443.1.
CH471112 Genomic DNA. Translation: EAW85444.1.
BC033703 mRNA. Translation: AAH33703.1.
CCDSiCCDS10485.1. [Q8N4S7-1]
CCDS66911.1. [Q8N4S7-2]
RefSeqiNP_001271440.1. NM_001284511.1. [Q8N4S7-2]
NP_001271441.1. NM_001284512.1.
NP_689554.2. NM_152341.4. [Q8N4S7-1]
UniGeneiHs.351474.

3D structure databases

ProteinModelPortaliQ8N4S7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125857. 1 interaction.
STRINGi9606.ENSP00000321804.

Polymorphism databases

DMDMi146345478.

Proteomic databases

MaxQBiQ8N4S7.
PaxDbiQ8N4S7.
PRIDEiQ8N4S7.

Protocols and materials databases

DNASUi124222.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293978; ENSP00000293978; ENSG00000162073. [Q8N4S7-2]
ENST00000318782; ENSP00000321804; ENSG00000162073. [Q8N4S7-1]
GeneIDi124222.
KEGGihsa:124222.
UCSCiuc002csj.4. human. [Q8N4S7-1]
uc002csk.4. human. [Q8N4S7-2]

Organism-specific databases

CTDi124222.
GeneCardsiGC16P002992.
HGNCiHGNC:26386. PAQR4.
MIMi614578. gene.
neXtProtiNX_Q8N4S7.
PharmGKBiPA134945614.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1272.
GeneTreeiENSGT00530000062926.
HOGENOMiHOG000006893.
HOVERGENiHBG053505.
InParanoidiQ8N4S7.
OMAiCHQGGSP.
OrthoDBiEOG7PK905.
PhylomeDBiQ8N4S7.
TreeFamiTF323692.

Miscellaneous databases

ChiTaRSiPAQR4. human.
GenomeRNAii124222.
NextBioi81246.
PROiQ8N4S7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N4S7.
CleanExiHS_PAQR4.
ExpressionAtlasiQ8N4S7. baseline and differential.
GenevestigatoriQ8N4S7.

Family and domain databases

InterProiIPR004254. AdipoR/HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
    Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
    J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Brain, Neuroblastoma and Teratocarcinoma.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiPAQR4_HUMAN
AccessioniPrimary (citable) accession number: Q8N4S7
Secondary accession number(s): A8K5Q8
, D3DUA2, D3DUA3, Q8NAS6, Q96NW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: May 1, 2007
Last modified: February 4, 2015
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.