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Q8N4S7

- PAQR4_HUMAN

UniProt

Q8N4S7 - PAQR4_HUMAN

Protein

Progestin and adipoQ receptor family member 4

Gene

PAQR4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 3 (01 May 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. receptor activity Source: RefGenome

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Progestin and adipoQ receptor family member 4
    Alternative name(s):
    Progestin and adipoQ receptor family member IV
    Gene namesi
    Name:PAQR4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:26386. PAQR4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134945614.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 273273Progestin and adipoQ receptor family member 4PRO_0000218848Add
    BLAST

    Proteomic databases

    MaxQBiQ8N4S7.
    PaxDbiQ8N4S7.
    PRIDEiQ8N4S7.

    Expressioni

    Tissue specificityi

    Relatively widely expressed in a range of tissues.1 Publication

    Gene expression databases

    ArrayExpressiQ8N4S7.
    BgeeiQ8N4S7.
    CleanExiHS_PAQR4.
    GenevestigatoriQ8N4S7.

    Interactioni

    Protein-protein interaction databases

    BioGridi125857. 1 interaction.
    STRINGi9606.ENSP00000321804.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N4S7.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei52 – 7221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei79 – 9921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei115 – 13521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei147 – 16721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei185 – 20521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei245 – 26521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ADIPOR family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1272.
    HOGENOMiHOG000006893.
    HOVERGENiHBG053505.
    InParanoidiQ8N4S7.
    OMAiCHQGGSP.
    OrthoDBiEOG7PK905.
    PhylomeDBiQ8N4S7.
    TreeFamiTF323692.

    Family and domain databases

    InterProiIPR004254. HlyIII-related.
    [Graphical view]
    PANTHERiPTHR20855. PTHR20855. 1 hit.
    PfamiPF03006. HlyIII. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N4S7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAFLAGPRLL DWASSPPHLQ FNKFVLTGYR PASSGSGCLR SLFYLHNELG    50
    NIYTHGLALL GFLVLVPMTM PWGQLGKDGW LGGTHCVACL APPAGSVLYH 100
    LFMCHQGGSA VYARLLALDM CGVCLVNTLG ALPIIHCTLA CRPWLRPAAL 150
    VGYTVLSGVA GWRALTAPST SARLRAFGWQ AAARLLVFGA RGVGLGSGAP 200
    GSLPCYLRMD ALALLGGLVN VARLPERWGP GRFDYWGNSH QIMHLLSVGS 250
    ILQLHAGVVP DLLWAAHHAC PRD 273
    Length:273
    Mass (Da):29,126
    Last modified:May 1, 2007 - v3
    Checksum:i147C445B5EFAFFFD
    GO
    Isoform 2 (identifier: Q8N4S7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         56-94: Missing.

    Show »
    Length:234
    Mass (Da):25,152
    Checksum:iEB378DE6BE387C0A
    GO
    Isoform 3 (identifier: Q8N4S7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         56-130: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:198
    Mass (Da):21,357
    Checksum:iC2B5709D29EFE9F9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti54 – 541T → A in BAC03821. (PubMed:14702039)Curated
    Sequence conflicti148 – 1481A → T in BAC03821. (PubMed:14702039)Curated
    Sequence conflicti189 – 1891G → E in BAB70758. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei56 – 13075Missing in isoform 3. 1 PublicationVSP_011482Add
    BLAST
    Alternative sequencei56 – 9439Missing in isoform 2. 1 PublicationVSP_011481Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY424282 mRNA. Translation: AAR08370.1.
    AK054564 mRNA. Translation: BAB70758.1.
    AK092173 mRNA. Translation: BAC03821.1.
    AK291373 mRNA. Translation: BAF84062.1.
    CH471112 Genomic DNA. Translation: EAW85441.1.
    CH471112 Genomic DNA. Translation: EAW85442.1.
    CH471112 Genomic DNA. Translation: EAW85443.1.
    CH471112 Genomic DNA. Translation: EAW85444.1.
    BC033703 mRNA. Translation: AAH33703.1.
    CCDSiCCDS10485.1. [Q8N4S7-1]
    CCDS66911.1. [Q8N4S7-2]
    RefSeqiNP_001271440.1. NM_001284511.1. [Q8N4S7-2]
    NP_001271441.1. NM_001284512.1.
    NP_689554.2. NM_152341.4. [Q8N4S7-1]
    UniGeneiHs.351474.

    Genome annotation databases

    EnsembliENST00000293978; ENSP00000293978; ENSG00000162073. [Q8N4S7-2]
    ENST00000318782; ENSP00000321804; ENSG00000162073. [Q8N4S7-1]
    GeneIDi124222.
    KEGGihsa:124222.
    UCSCiuc002csj.4. human. [Q8N4S7-1]
    uc002csk.4. human. [Q8N4S7-2]

    Polymorphism databases

    DMDMi146345478.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY424282 mRNA. Translation: AAR08370.1 .
    AK054564 mRNA. Translation: BAB70758.1 .
    AK092173 mRNA. Translation: BAC03821.1 .
    AK291373 mRNA. Translation: BAF84062.1 .
    CH471112 Genomic DNA. Translation: EAW85441.1 .
    CH471112 Genomic DNA. Translation: EAW85442.1 .
    CH471112 Genomic DNA. Translation: EAW85443.1 .
    CH471112 Genomic DNA. Translation: EAW85444.1 .
    BC033703 mRNA. Translation: AAH33703.1 .
    CCDSi CCDS10485.1. [Q8N4S7-1 ]
    CCDS66911.1. [Q8N4S7-2 ]
    RefSeqi NP_001271440.1. NM_001284511.1. [Q8N4S7-2 ]
    NP_001271441.1. NM_001284512.1.
    NP_689554.2. NM_152341.4. [Q8N4S7-1 ]
    UniGenei Hs.351474.

    3D structure databases

    ProteinModelPortali Q8N4S7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125857. 1 interaction.
    STRINGi 9606.ENSP00000321804.

    Polymorphism databases

    DMDMi 146345478.

    Proteomic databases

    MaxQBi Q8N4S7.
    PaxDbi Q8N4S7.
    PRIDEi Q8N4S7.

    Protocols and materials databases

    DNASUi 124222.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000293978 ; ENSP00000293978 ; ENSG00000162073 . [Q8N4S7-2 ]
    ENST00000318782 ; ENSP00000321804 ; ENSG00000162073 . [Q8N4S7-1 ]
    GeneIDi 124222.
    KEGGi hsa:124222.
    UCSCi uc002csj.4. human. [Q8N4S7-1 ]
    uc002csk.4. human. [Q8N4S7-2 ]

    Organism-specific databases

    CTDi 124222.
    GeneCardsi GC16P002992.
    HGNCi HGNC:26386. PAQR4.
    MIMi 614578. gene.
    neXtProti NX_Q8N4S7.
    PharmGKBi PA134945614.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1272.
    HOGENOMi HOG000006893.
    HOVERGENi HBG053505.
    InParanoidi Q8N4S7.
    OMAi CHQGGSP.
    OrthoDBi EOG7PK905.
    PhylomeDBi Q8N4S7.
    TreeFami TF323692.

    Miscellaneous databases

    GenomeRNAii 124222.
    NextBioi 81246.
    PROi Q8N4S7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N4S7.
    Bgeei Q8N4S7.
    CleanExi HS_PAQR4.
    Genevestigatori Q8N4S7.

    Family and domain databases

    InterProi IPR004254. HlyIII-related.
    [Graphical view ]
    PANTHERi PTHR20855. PTHR20855. 1 hit.
    Pfami PF03006. HlyIII. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
      Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
      J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Brain, Neuroblastoma and Teratocarcinoma.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiPAQR4_HUMAN
    AccessioniPrimary (citable) accession number: Q8N4S7
    Secondary accession number(s): A8K5Q8
    , D3DUA2, D3DUA3, Q8NAS6, Q96NW1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 87 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3