Q8N4S7 (PAQR4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Progestin and adipoQ receptor family member 4

Alternative name(s):
Progestin and adipoQ receptor family member IV

Gene names

Name:

PAQR4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Relatively widely expressed in a range of tissues. Ref.1
Sequence similarities	Belongs to the ADIPOR family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Molecular function	Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N4S7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N4S7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     56-94: Missing.

Isoform 3 (identifier: Q8N4S7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     56-130: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 273	273	Progestin and adipoQ receptor family member 4		PRO_0000218848
Regions
	Transmembrane	52 – 72	21	Helical; Potential
	Transmembrane	79 – 99	21	Helical; Potential
	Transmembrane	115 – 135	21	Helical; Potential
	Transmembrane	147 – 167	21	Helical; Potential
	Transmembrane	185 – 205	21	Helical; Potential
	Transmembrane	245 – 265	21	Helical; Potential
Natural variations
	Alternative sequence	56 – 130	75	Missing in isoform 3.		VSP_011482
	Alternative sequence	56 – 94	39	Missing in isoform 2.		VSP_011481
Experimental info
	Sequence conflict	54	1	T → A in BAC03821. Ref.2
	Sequence conflict	148	1	A → T in BAC03821. Ref.2
	Sequence conflict	189	1	G → E in BAB70758. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2007. Version 3. Checksum: 147C445B5EFAFFFD	FASTA	273	29,126
	10 20 30 40 50 60 MAFLAGPRLL DWASSPPHLQ FNKFVLTGYR PASSGSGCLR SLFYLHNELG NIYTHGLALL 70 80 90 100 110 120 GFLVLVPMTM PWGQLGKDGW LGGTHCVACL APPAGSVLYH LFMCHQGGSA VYARLLALDM 130 140 150 160 170 180 CGVCLVNTLG ALPIIHCTLA CRPWLRPAAL VGYTVLSGVA GWRALTAPST SARLRAFGWQ 190 200 210 220 230 240 AAARLLVFGA RGVGLGSGAP GSLPCYLRMD ALALLGGLVN VARLPERWGP GRFDYWGNSH 250 260 270 QIMHLLSVGS ILQLHAGVVP DLLWAAHHAC PRD
	Isoform 2 [UniParc]. Checksum: EB378DE6BE387C0A	FASTA	234	25,152
	10 20 30 40 50 60 MAFLAGPRLL DWASSPPHLQ FNKFVLTGYR PASSGSGCLR SLFYLHNELG NIYTHGSVLY 70 80 90 100 110 120 HLFMCHQGGS AVYARLLALD MCGVCLVNTL GALPIIHCTL ACRPWLRPAA LVGYTVLSGV 130 140 150 160 170 180 AGWRALTAPS TSARLRAFGW QAAARLLVFG ARGVGLGSGA PGSLPCYLRM DALALLGGLV 190 200 210 220 230 NVARLPERWG PGRFDYWGNS HQIMHLLSVG SILQLHAGVV PDLLWAAHHA CPRD
	Isoform 3 [UniParc]. Checksum: C2B5709D29EFE9F9	FASTA	198	21,357
	10 20 30 40 50 60 MAFLAGPRLL DWASSPPHLQ FNKFVLTGYR PASSGSGCLR SLFYLHNELG NIYTHALPII 70 80 90 100 110 120 HCTLACRPWL RPAALVGYTV LSGVAGWRAL TAPSTSARLR AFGWQAAARL LVFGARGVGL 130 140 150 160 170 180 GSGAPGSLPC YLRMDALALL GGLVNVARLP ERWGPGRFDY WGNSHQIMHL LSVGSILQLH 190 AGVVPDLLWA AHHACPRD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif." Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D. J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Brain, Neuroblastoma and Teratocarcinoma.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY424282 mRNA. Translation: AAR08370.1. AK054564 mRNA. Translation: BAB70758.1. AK092173 mRNA. Translation: BAC03821.1. AK291373 mRNA. Translation: BAF84062.1. CH471112 Genomic DNA. Translation: EAW85441.1. CH471112 Genomic DNA. Translation: EAW85442.1. CH471112 Genomic DNA. Translation: EAW85443.1. CH471112 Genomic DNA. Translation: EAW85444.1. BC033703 mRNA. Translation: AAH33703.1.
IPI	IPI00185329. IPI00455669. IPI00455670.
RefSeq	NP_689554.2. NM_152341.3.
UniGene	Hs.351474.
3D structure databases
ProteinModelPortal	Q8N4S7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000321804.
Polymorphism databases
DMDM	146345478.
Proteomic databases
PaxDb	Q8N4S7.
PRIDE	Q8N4S7.
Protocols and materials databases
DNASU	124222.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000293978; ENSP00000293978; ENSG00000162073. ENST00000318782; ENSP00000321804; ENSG00000162073.
GeneID	124222.
KEGG	hsa:124222.
UCSC	uc002csj.4. human. uc002csk.4. human.
Organism-specific databases
CTD	124222.
GeneCards	GC16P002992.
HGNC	HGNC:26386. PAQR4.
MIM	614578. gene.
neXtProt	NX_Q8N4S7.
PharmGKB	PA134945614.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1272.
HOGENOM	HOG000006893.
HOVERGEN	HBG053505.
InParanoid	Q8N4S7.
OMA	CHQGGSP.
OrthoDB	EOG4M91S0.
PhylomeDB	Q8N4S7.
Gene expression databases
ArrayExpress	Q8N4S7.
Bgee	Q8N4S7.
CleanEx	HS_PAQR4.
Genevestigator	Q8N4S7.
GermOnline	ENSG00000162073. Homo sapiens.
Family and domain databases
InterPro	IPR004254. HlyIII-related. [Graphical view]
PANTHER	PTHR20855. PTHR20855. 1 hit.
Pfam	PF03006. HlyIII. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	124222.
NextBio	81246.
SOURCE	Search...

Entry information

Entry name

PAQR4_HUMAN

Accession

Primary (citable) accession number: Q8N4S7
Secondary accession number(s): A8K5Q8 , D3DUA2, D3DUA3, Q8NAS6, Q96NW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	May 1, 2007
Last modified:	April 3, 2013
This is version 77 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.