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Q8N4S7 (PAQR4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Progestin and adipoQ receptor family member 4
Alternative name(s):
Progestin and adipoQ receptor family member IV
Gene names
Name:PAQR4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Relatively widely expressed in a range of tissues. Ref.1

Sequence similarities

Belongs to the ADIPOR family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Molecular functionReceptor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionreceptor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N4S7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N4S7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     56-94: Missing.
Isoform 3 (identifier: Q8N4S7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     56-130: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 273273Progestin and adipoQ receptor family member 4
PRO_0000218848

Regions

Transmembrane52 – 7221Helical; Potential
Transmembrane79 – 9921Helical; Potential
Transmembrane115 – 13521Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane185 – 20521Helical; Potential
Transmembrane245 – 26521Helical; Potential

Natural variations

Alternative sequence56 – 13075Missing in isoform 3.
VSP_011482
Alternative sequence56 – 9439Missing in isoform 2.
VSP_011481

Experimental info

Sequence conflict541T → A in BAC03821. Ref.2
Sequence conflict1481A → T in BAC03821. Ref.2
Sequence conflict1891G → E in BAB70758. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 2007. Version 3.
Checksum: 147C445B5EFAFFFD

FASTA27329,126
        10         20         30         40         50         60 
MAFLAGPRLL DWASSPPHLQ FNKFVLTGYR PASSGSGCLR SLFYLHNELG NIYTHGLALL 

        70         80         90        100        110        120 
GFLVLVPMTM PWGQLGKDGW LGGTHCVACL APPAGSVLYH LFMCHQGGSA VYARLLALDM 

       130        140        150        160        170        180 
CGVCLVNTLG ALPIIHCTLA CRPWLRPAAL VGYTVLSGVA GWRALTAPST SARLRAFGWQ 

       190        200        210        220        230        240 
AAARLLVFGA RGVGLGSGAP GSLPCYLRMD ALALLGGLVN VARLPERWGP GRFDYWGNSH 

       250        260        270 
QIMHLLSVGS ILQLHAGVVP DLLWAAHHAC PRD 

« Hide

Isoform 2 [UniParc].

Checksum: EB378DE6BE387C0A
Show »

FASTA23425,152
Isoform 3 [UniParc].

Checksum: C2B5709D29EFE9F9
Show »

FASTA19821,357

References

« Hide 'large scale' references
[1]"PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Brain, Neuroblastoma and Teratocarcinoma.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY424282 mRNA. Translation: AAR08370.1.
AK054564 mRNA. Translation: BAB70758.1.
AK092173 mRNA. Translation: BAC03821.1.
AK291373 mRNA. Translation: BAF84062.1.
CH471112 Genomic DNA. Translation: EAW85441.1.
CH471112 Genomic DNA. Translation: EAW85442.1.
CH471112 Genomic DNA. Translation: EAW85443.1.
CH471112 Genomic DNA. Translation: EAW85444.1.
BC033703 mRNA. Translation: AAH33703.1.
RefSeqNP_001271440.1. NM_001284511.1.
NP_001271441.1. NM_001284512.1.
NP_689554.2. NM_152341.4.
UniGeneHs.351474.

3D structure databases

ProteinModelPortalQ8N4S7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125857. 1 interaction.
STRING9606.ENSP00000321804.

Polymorphism databases

DMDM146345478.

Proteomic databases

PaxDbQ8N4S7.
PRIDEQ8N4S7.

Protocols and materials databases

DNASU124222.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000293978; ENSP00000293978; ENSG00000162073. [Q8N4S7-2]
ENST00000318782; ENSP00000321804; ENSG00000162073. [Q8N4S7-1]
GeneID124222.
KEGGhsa:124222.
UCSCuc002csj.4. human. [Q8N4S7-1]
uc002csk.4. human. [Q8N4S7-2]

Organism-specific databases

CTD124222.
GeneCardsGC16P002992.
HGNCHGNC:26386. PAQR4.
MIM614578. gene.
neXtProtNX_Q8N4S7.
PharmGKBPA134945614.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1272.
HOGENOMHOG000006893.
HOVERGENHBG053505.
InParanoidQ8N4S7.
OMACHQGGSP.
OrthoDBEOG7PK905.
PhylomeDBQ8N4S7.
TreeFamTF323692.

Gene expression databases

ArrayExpressQ8N4S7.
BgeeQ8N4S7.
CleanExHS_PAQR4.
GenevestigatorQ8N4S7.

Family and domain databases

InterProIPR004254. HlyIII-related.
[Graphical view]
PANTHERPTHR20855. PTHR20855. 1 hit.
PfamPF03006. HlyIII. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi124222.
NextBio81246.
PROQ8N4S7.
SOURCESearch...

Entry information

Entry namePAQR4_HUMAN
AccessionPrimary (citable) accession number: Q8N4S7
Secondary accession number(s): A8K5Q8 expand/collapse secondary AC list , D3DUA2, D3DUA3, Q8NAS6, Q96NW1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: May 1, 2007
Last modified: March 19, 2014
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM