ID   Q8N4S3_HUMAN            Unreviewed;       292 AA.
AC   Q8N4S3;
DT   01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 111.
DE   RecName: Full=Tyrosine-protein phosphatase non-receptor type 3 {ECO:0008006|Google:ProtNLM};
DE   Flags: Fragment;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAH33716.1};
RN   [1] {ECO:0000313|EMBL:AAH33716.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Kidney {ECO:0000313|EMBL:AAH33716.1};
RA   Strausberg R.;
RL   Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; BC033716; AAH33716.1; -; mRNA.
DR   RefSeq; NP_001138840.1; NM_001145368.1.
DR   RefSeq; NP_001138843.1; NM_001145371.1.
DR   RefSeq; NP_001138844.1; NM_001145372.1.
DR   RefSeq; NP_002820.3; NM_002829.3.
DR   AlphaFoldDB; Q8N4S3; -.
DR   PeptideAtlas; Q8N4S3; -.
DR   DNASU; 5774; -.
DR   GeneID; 5774; -.
DR   KEGG; hsa:5774; -.
DR   CTD; 5774; -.
DR   PharmGKB; PA33999; -.
DR   OrthoDB; 5345383at2759; -.
DR   BioGRID-ORCS; 5774; 18 hits in 1165 CRISPR screens.
DR   GenomeRNAi; 5774; -.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   CDD; cd14600; PTPc-N3; 1.
DR   Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTP_cat.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   PANTHER; PTHR45706; TYROSINE-PROTEIN PHOSPHATASE; 1.
DR   PANTHER; PTHR45706:SF5; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 3; 1.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00194; PTPc; 1.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
DR   Genevisible; Q8N4S3; HS.
PE   2: Evidence at transcript level;
FT   DOMAIN          25..280
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS50055"
FT   DOMAIN          198..271
FT                   /note="Tyrosine specific protein phosphatases"
FT                   /evidence="ECO:0000259|PROSITE:PS50056"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAH33716.1"
SQ   SEQUENCE   292 AA;  33121 MW;  54B838BDD41D1BD7 CRC64;
     HASEGGDTLE GSMAQLKKGL ESGTVLIQFE QLYRKKPGLA ITFAKLPQNL DKNRYKDVLP
     YDTTRVLLQG NEDYINASYV NMEIPAANLV NKYIATQGPL PHTCAQFWQV VWDQKLSLIV
     MLTTLTERGR TKCHQYWPDP PDVMNHGGFH IQCQSEDCTI AYVSREMLVT NTQTGEEHTV
     THLQYVAWPD HGVPDDSSDF LEFVNYVRSL RVDSEPVLVH CSAGIGRTGV LVTMETAMCL
     TERNLPIYPL DIVRKMRDQR AMMVQTSSQY KFVCEAILRV YEEGLVQMLD PS
//