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Protein

Zinc-binding alcohol dehydrogenase domain-containing protein 2

Gene

ZADH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei185 – 1851NADP; via amide nitrogen1 Publication
Binding sitei205 – 2051NADP1 Publication
Binding sitei209 – 2091NADP1 Publication
Binding sitei224 – 2241NADP1 Publication
Binding sitei247 – 2471NADP1 Publication
Binding sitei269 – 2691NADP; via carbonyl oxygen1 Publication
Binding sitei275 – 2751NADP1 Publication
Binding sitei361 – 3611NADP1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi303 – 3053NADP1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-binding alcohol dehydrogenase domain-containing protein 2 (EC:1.-.-.-)
Gene namesi
Name:ZADH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:28697. ZADH2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134951623.

Polymorphism and mutation databases

BioMutaiZADH2.
DMDMi74728888.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Zinc-binding alcohol dehydrogenase domain-containing protein 2PRO_0000223467Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351N6-acetyllysineBy similarity
Modified residuei299 – 2991PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8N4Q0.
MaxQBiQ8N4Q0.
PaxDbiQ8N4Q0.
PeptideAtlasiQ8N4Q0.
PRIDEiQ8N4Q0.

PTM databases

iPTMnetiQ8N4Q0.
PhosphoSiteiQ8N4Q0.

Expressioni

Gene expression databases

BgeeiENSG00000180011.
CleanExiHS_ZADH2.
ExpressionAtlasiQ8N4Q0. baseline and differential.
GenevisibleiQ8N4Q0. HS.

Organism-specific databases

HPAiHPA021468.
HPA053646.

Interactioni

Protein-protein interaction databases

BioGridi129813. 15 interactions.
IntActiQ8N4Q0. 1 interaction.
STRINGi9606.ENSP00000323678.

Structurei

Secondary structure

1
377
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi33 – 386Combined sources
Helixi45 – 484Combined sources
Beta strandi49 – 568Combined sources
Beta strandi64 – 7310Combined sources
Helixi78 – 825Combined sources
Turni83 – 864Combined sources
Beta strandi98 – 10710Combined sources
Helixi111 – 1133Combined sources
Beta strandi120 – 1245Combined sources
Beta strandi129 – 1368Combined sources
Helixi137 – 1393Combined sources
Beta strandi144 – 1463Combined sources
Helixi148 – 1514Combined sources
Turni152 – 1554Combined sources
Helixi156 – 16712Combined sources
Beta strandi175 – 1784Combined sources
Turni179 – 1824Combined sources
Helixi186 – 19510Combined sources
Beta strandi199 – 2068Combined sources
Helixi207 – 2159Combined sources
Beta strandi219 – 2235Combined sources
Turni224 – 2263Combined sources
Helixi229 – 2368Combined sources
Beta strandi241 – 2466Combined sources
Helixi251 – 2599Combined sources
Beta strandi260 – 2689Combined sources
Helixi272 – 2743Combined sources
Beta strandi277 – 2793Combined sources
Helixi289 – 2968Combined sources
Beta strandi299 – 3024Combined sources
Helixi305 – 3073Combined sources
Helixi309 – 3113Combined sources
Helixi312 – 32413Combined sources
Beta strandi338 – 3403Combined sources
Helixi348 – 35710Combined sources
Beta strandi362 – 3687Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2C0CX-ray1.45A/B33-371[»]
2WEKX-ray1.90A/B33-371[»]
2X1HX-ray1.75A/B33-371[»]
2X7HX-ray1.60A/B25-371[»]
ProteinModelPortaliQ8N4Q0.
SMRiQ8N4Q0. Positions 33-371.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8N4Q0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IQ9R. Eukaryota.
COG2130. LUCA.
GeneTreeiENSGT00550000074483.
HOGENOMiHOG000294682.
HOVERGENiHBG056525.
InParanoidiQ8N4Q0.
KOiK07119.
OMAiYMAPGSF.
OrthoDBiEOG091G0CTI.
PhylomeDBiQ8N4Q0.
TreeFamiTF328691.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N4Q0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRLVPTGAR AIVDMSYARH FLDFQGSAIP QAMQKLVVTR LSPNFREAVT
60 70 80 90 100
LSRDCPVPLP GDGDLLVRNR FVGVNASDIN YSAGRYDPSV KPPFDIGFEG
110 120 130 140 150
IGEVVALGLS ASARYTVGQA VAYMAPGSFA EYTVVPASIA TPVPSVKPEY
160 170 180 190 200
LTLLVSGTTA YISLKELGGL SEGKKVLVTA AAGGTGQFAM QLSKKAKCHV
210 220 230 240 250
IGTCSSDEKS AFLKSLGCDR PINYKTEPVG TVLKQEYPEG VDVVYESVGG
260 270 280 290 300
AMFDLAVDAL ATKGRLIVIG FISGYQTPTG LSPVKAGTLP AKLLKKSASV
310 320 330 340 350
QGFFLNHYLS KYQAAMSHLL EMCVSGDLVC EVDLGDLSPE GRFTGLESIF
360 370
RAVNYMYMGK NTGKIVVELP HSVNSKL
Length:377
Mass (Da):40,140
Last modified:October 1, 2002 - v1
Checksum:i9CDC927D815314D1
GO
Isoform 2 (identifier: Q8N4Q0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Note: No experimental confirmation available.
Show »
Length:254
Mass (Da):26,900
Checksum:i1335CE641CBEE387
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti323 – 3231C → F.
Corresponds to variant rs17056661 [ dbSNP | Ensembl ].
VAR_048202

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 123123Missing in isoform 2. 1 PublicationVSP_055796Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292880 mRNA. Translation: BAF85569.1.
AK302801 mRNA. Translation: BAG64003.1.
AC025105 Genomic DNA. No translation available.
CH471117 Genomic DNA. Translation: EAW66569.1.
BC033780 mRNA. Translation: AAH33780.1.
BC078661 mRNA. Translation: AAH78661.1.
CCDSiCCDS12008.1. [Q8N4Q0-1]
CCDS77198.1. [Q8N4Q0-2]
RefSeqiNP_001293022.1. NM_001306093.1. [Q8N4Q0-2]
NP_787103.1. NM_175907.5. [Q8N4Q0-1]
UniGeneiHs.465433.
Hs.719383.

Genome annotation databases

EnsembliENST00000322342; ENSP00000323678; ENSG00000180011. [Q8N4Q0-1]
ENST00000537114; ENSP00000440111; ENSG00000180011. [Q8N4Q0-2]
GeneIDi284273.
KEGGihsa:284273.
UCSCiuc002llx.4. human. [Q8N4Q0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292880 mRNA. Translation: BAF85569.1.
AK302801 mRNA. Translation: BAG64003.1.
AC025105 Genomic DNA. No translation available.
CH471117 Genomic DNA. Translation: EAW66569.1.
BC033780 mRNA. Translation: AAH33780.1.
BC078661 mRNA. Translation: AAH78661.1.
CCDSiCCDS12008.1. [Q8N4Q0-1]
CCDS77198.1. [Q8N4Q0-2]
RefSeqiNP_001293022.1. NM_001306093.1. [Q8N4Q0-2]
NP_787103.1. NM_175907.5. [Q8N4Q0-1]
UniGeneiHs.465433.
Hs.719383.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2C0CX-ray1.45A/B33-371[»]
2WEKX-ray1.90A/B33-371[»]
2X1HX-ray1.75A/B33-371[»]
2X7HX-ray1.60A/B25-371[»]
ProteinModelPortaliQ8N4Q0.
SMRiQ8N4Q0. Positions 33-371.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129813. 15 interactions.
IntActiQ8N4Q0. 1 interaction.
STRINGi9606.ENSP00000323678.

PTM databases

iPTMnetiQ8N4Q0.
PhosphoSiteiQ8N4Q0.

Polymorphism and mutation databases

BioMutaiZADH2.
DMDMi74728888.

Proteomic databases

EPDiQ8N4Q0.
MaxQBiQ8N4Q0.
PaxDbiQ8N4Q0.
PeptideAtlasiQ8N4Q0.
PRIDEiQ8N4Q0.

Protocols and materials databases

DNASUi284273.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322342; ENSP00000323678; ENSG00000180011. [Q8N4Q0-1]
ENST00000537114; ENSP00000440111; ENSG00000180011. [Q8N4Q0-2]
GeneIDi284273.
KEGGihsa:284273.
UCSCiuc002llx.4. human. [Q8N4Q0-1]

Organism-specific databases

CTDi284273.
GeneCardsiZADH2.
HGNCiHGNC:28697. ZADH2.
HPAiHPA021468.
HPA053646.
neXtProtiNX_Q8N4Q0.
PharmGKBiPA134951623.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQ9R. Eukaryota.
COG2130. LUCA.
GeneTreeiENSGT00550000074483.
HOGENOMiHOG000294682.
HOVERGENiHBG056525.
InParanoidiQ8N4Q0.
KOiK07119.
OMAiYMAPGSF.
OrthoDBiEOG091G0CTI.
PhylomeDBiQ8N4Q0.
TreeFamiTF328691.

Miscellaneous databases

ChiTaRSiZADH2. human.
EvolutionaryTraceiQ8N4Q0.
GenomeRNAii284273.
PROiQ8N4Q0.

Gene expression databases

BgeeiENSG00000180011.
CleanExiHS_ZADH2.
ExpressionAtlasiQ8N4Q0. baseline and differential.
GenevisibleiQ8N4Q0. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZADH2_HUMAN
AccessioniPrimary (citable) accession number: Q8N4Q0
Secondary accession number(s): A8KA15, B4DZ91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.