Q8N4Q0 (ZADH2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc-binding alcohol dehydrogenase domain-containing protein 2
EC=1.-.-.-

Gene names

Name:

ZADH2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Peroxisome By similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Ontologies

Keywords
Cellular component	Peroxisome
Coding sequence diversity	Polymorphism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	peroxisome Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 377

377

Zinc-binding alcohol dehydrogenase domain-containing protein 2

PRO_0000223467

Regions

Nucleotide binding

303 – 305

3

NADP

Sites

Binding site

185

1

NADP; via amide nitrogen

Binding site

205

1

NADP

Binding site

209

1

NADP

Binding site

224

1

NADP

Binding site

247

1

NADP

Binding site

269

1

NADP; via carbonyl oxygen

Binding site

275

1

NADP

Binding site

361

1

NADP

Natural variations

Natural variant

323

1

C → F.
Corresponds to variant rs17056661 [ dbSNP | Ensembl ].

VAR_048202

Secondary structure

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377

Helix Strand Turn

Details...

Beta strand

33 – 38

6

Helix

45 – 48

4

Beta strand

49 – 56

8

Beta strand

64 – 73

10

Helix

78 – 82

5

Turn

83 – 86

4

Beta strand

98 – 107

10

Helix

111 – 113

3

Beta strand

120 – 124

5

Beta strand

129 – 136

8

Helix

137 – 139

3

Beta strand

144 – 146

3

Helix

148 – 151

4

Turn

152 – 155

4

Helix

156 – 167

12

Beta strand

175 – 178

4

Turn

179 – 182

4

Helix

186 – 195

10

Beta strand

199 – 206

8

Helix

207 – 215

9

Beta strand

219 – 223

5

Turn

224 – 226

3

Helix

229 – 236

8

Beta strand

241 – 246

6

Helix

251 – 259

9

Beta strand

260 – 268

9

Helix

272 – 274

3

Beta strand

277 – 279

3

Helix

289 – 296

8

Beta strand

299 – 302

4

Helix

305 – 307

3

Helix

309 – 311

3

Helix

312 – 324

13

Helix

348 – 357

10

Beta strand

362 – 368

7

Sequences

	Sequence		Length	Mass (Da)
	Q8N4Q0 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 9CDC927D815314D1	FASTA	377	40,140
	10 20 30 40 50 60 MLRLVPTGAR AIVDMSYARH FLDFQGSAIP QAMQKLVVTR LSPNFREAVT LSRDCPVPLP 70 80 90 100 110 120 GDGDLLVRNR FVGVNASDIN YSAGRYDPSV KPPFDIGFEG IGEVVALGLS ASARYTVGQA 130 140 150 160 170 180 VAYMAPGSFA EYTVVPASIA TPVPSVKPEY LTLLVSGTTA YISLKELGGL SEGKKVLVTA 190 200 210 220 230 240 AAGGTGQFAM QLSKKAKCHV IGTCSSDEKS AFLKSLGCDR PINYKTEPVG TVLKQEYPEG 250 260 270 280 290 300 VDVVYESVGG AMFDLAVDAL ATKGRLIVIG FISGYQTPTG LSPVKAGTLP AKLLKKSASV 310 320 330 340 350 360 QGFFLNHYLS KYQAAMSHLL EMCVSGDLVC EVDLGDLSPE GRFTGLESIF RAVNYMYMGK 370 NTGKIVVELP HSVNSKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Trachea.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]	"The structure of MGC45594 gene product." Bunkoczi G., Shafqat N., Guo K., Smee C., Arrowsmith C., Edwards A., Weigelt J., Sundstrom M., Gileadi O., Von Delft F., Oppermann U. Submitted (SEP-2005) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 33-371 IN COMPLEX WITH NADP.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK292880 mRNA. Translation: BAF85569.1.
CH471117 Genomic DNA. Translation: EAW66569.1.
BC033780 mRNA. Translation: AAH33780.1.
BC078661 mRNA. Translation: AAH78661.1.

IPI

IPI00166738.

RefSeq

NP_787103.1. NM_175907.4.

UniGene

Hs.465433.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2C0C	X-ray	1.45	A/B	33-371	[»]
2WEK	X-ray	1.90	A/B	33-371	[»]
2X1H	X-ray	1.75	A/B	33-371	[»]
2X7H	X-ray	1.60	A/B	25-371	[»]

ProteinModelPortal

Q8N4Q0.

SMR

Q8N4Q0. Positions 33-371.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q8N4Q0. 1 interaction.

Polymorphism databases

DMDM

74728888.

Proteomic databases

PRIDE

Q8N4Q0.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000322342; ENSP00000323678; ENSG00000180011.

GeneID

284273.

KEGG

hsa:284273.

UCSC

uc002llx.1. human.

Organism-specific databases

CTD

284273.

GeneCards

GC18M072907.

HGNC

HGNC:28697. ZADH2.

HPA

HPA021468.

neXtProt

NX_Q8N4Q0.

GenAtlas

Search...

Phylogenomic databases

GeneTree

ENSGT00550000074483.

HOGENOM

HBG320169.

HOVERGEN

HBG056525.

InParanoid

Q8N4Q0.

OMA

FRAVDYM.

OrthoDB

EOG441QBK.

PhylomeDB

Q8N4Q0.

Gene expression databases

ArrayExpress

Q8N4Q0.

Bgee

Q8N4Q0.

CleanEx

HS_ZADH2.

Genevestigator

Q8N4Q0.

GermOnline

ENSG00000180011. Homo sapiens.

Family and domain databases

InterPro

IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]

Gene3D

G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.

KO

K07119.

PANTHER

PTHR11695. ADH_Sf_Zn. 1 hit.

Pfam

PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]

SUPFAM

SSF50129. GroES_like. 1 hit.

PROSITE

PS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

94683.

Entry information

Entry name

ZADH2_HUMAN

Accession

Primary (citable) accession number: Q8N4Q0
Secondary accession number(s): A8KA15

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2006
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.