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Protein

Tetratricopeptide repeat protein 30B

Gene

TTC30B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.By similarity

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-HSA-5620924 Intraflagellar transport

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 30B
Short name:
TPR repeat protein 30B
Gene namesi
Name:TTC30B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000196659.9
HGNCiHGNC:26425 TTC30B
neXtProtiNX_Q8N4P2

Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196659
PharmGKBiPA145147835

Polymorphism and mutation databases

BioMutaiTTC30B
DMDMi313104039

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003332011 – 665Tetratricopeptide repeat protein 30BAdd BLAST665

Proteomic databases

EPDiQ8N4P2
MaxQBiQ8N4P2
PaxDbiQ8N4P2
PeptideAtlasiQ8N4P2
PRIDEiQ8N4P2

PTM databases

iPTMnetiQ8N4P2
PhosphoSitePlusiQ8N4P2

Expressioni

Gene expression databases

BgeeiENSG00000196659
CleanExiHS_TTC30B
GenevisibleiQ8N4P2 HS

Organism-specific databases

HPAiHPA051714
HPA052100
HPA052487

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi127321, 47 interactors
CORUMiQ8N4P2
IntActiQ8N4P2, 42 interactors
MINTiQ8N4P2
STRINGi9606.ENSP00000386181

Structurei

3D structure databases

ProteinModelPortaliQ8N4P2
SMRiQ8N4P2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 44TPR 1Add BLAST34
Repeati45 – 78TPR 2Add BLAST34
Repeati154 – 187TPR 3Add BLAST34
Repeati189 – 221TPR 4Add BLAST33
Repeati393 – 424TPR 5Add BLAST32
Repeati425 – 457TPR 6Add BLAST33
Repeati459 – 492TPR 7Add BLAST34
Repeati544 – 577TPR 8Add BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili508 – 535Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi326 – 329Poly-Leu4

Sequence similaritiesi

Belongs to the TTC30/dfy-1/fleer family.Curated

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG4340 Eukaryota
ENOG410XNQ1 LUCA
GeneTreeiENSGT00390000010116
HOGENOMiHOG000258608
HOVERGENiHBG061770
InParanoidiQ8N4P2
KOiK19683
OMAiMRNHPEL
OrthoDBiEOG091G03OT
PhylomeDBiQ8N4P2
TreeFamiTF314592

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
SMARTiView protein in SMART
SM00028 TPR, 4 hits
SUPFAMiSSF48452 SSF48452, 6 hits
PROSITEiView protein in PROSITE
PS50293 TPR_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

Q8N4P2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLSGAQIP DGEFTAVVYR LIRNARYAEA VQLLGGELQR SPRSRAGLSL
60 70 80 90 100
LGYCYYRLQE FALAAECYEQ LGQLHPELEQ YRLYQAQALY KACLYAEATR
110 120 130 140 150
VAFLLLDNPA YHSRVLRLQA AIKYSEGDLP GSRSLVEQLP SREGGEESGG
160 170 180 190 200
ENETDGQINL GCLLYKEGQY EAACSKFFAA LQASGYQPDL SYNLALAYYS
210 220 230 240 250
SRQYASALKH IAEIIERGIR QHPELGVGMT TEGIDVRSVG NTLVLHQTAL
260 270 280 290 300
VEAFNLKAAI EYQLRNYEAA QEALTDMPPR AEEELDPVTL HNQALMNMDA
310 320 330 340 350
RPTEGFEKLQ FLLQQNPFPP ETFGNLLLLY CKYEYFDLAA DVLAENAHLI
360 370 380 390 400
YKFLTPYLYD FLDAVITCQT APEEAFIKLD GLAGMLTEVL RKLTIQVQEA
410 420 430 440 450
RHNRDDEAIK KAVNEYDETM EKYIPVLMAQ AKIYWNLENY PMVEKIFRKS
460 470 480 490 500
VEFCNDHDVW KLNVAHVLFM QENKYKEAIG FYEPIVKKHY DNILNVSAIV
510 520 530 540 550
LANLCVSYIM TSQNEEAEEL MRKIEKEEEQ LSYDDPDKKM YHLCIVNLVI
560 570 580 590 600
GTLYCAKGNY DFGISRVIKS LEPYNKKLGT DTWYYAKRCF LSLLENMSKH
610 620 630 640 650
TIMLRDSVIQ ECVQFLEHCE LHGRNIPAVI EQPLEEERMH VGKNTVTYES
660
RQLKALIYEI IGWNI
Length:665
Mass (Da):76,099
Last modified:November 30, 2010 - v2
Checksum:iEE0C5DE820CFB84D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94L → F in BAB70953 (PubMed:14702039).Curated1
Sequence conflicti165 – 191Missing in BAB70953 (PubMed:14702039).CuratedAdd BLAST27
Sequence conflicti366I → T in BAB70953 (PubMed:14702039).Curated1
Sequence conflicti459V → L in CAH56200 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043124117R → H3 PublicationsCorresponds to variant dbSNP:rs11694988Ensembl.1
Natural variantiVAR_043125446I → V. Corresponds to variant dbSNP:rs2695315Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055552 mRNA Translation: BAB70953.1
AC073834 Genomic DNA No translation available.
CH471058 mRNA Translation: EAX11054.1
BC033795 mRNA Translation: AAH33795.1
BX647620 mRNA Translation: CAH56200.1
CCDSiCCDS42784.1
RefSeqiNP_689730.2, NM_152517.2
UniGeneiHs.128384
Hs.447659

Genome annotation databases

EnsembliENST00000408939; ENSP00000386181; ENSG00000196659
GeneIDi150737
KEGGihsa:150737
UCSCiuc002uln.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTT30B_HUMAN
AccessioniPrimary (citable) accession number: Q8N4P2
Secondary accession number(s): Q63HQ1, Q96NE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 30, 2010
Last modified: March 28, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health