ID   KLH36_HUMAN             Reviewed;         616 AA.
AC   Q8N4N3; Q8N5G6; Q9H9U6;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 159.
DE   RecName: Full=Kelch-like protein 36;
GN   Name=KLHL36; Synonyms=C16orf44;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Blood;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, AND INTERACTION WITH CUL3.
RX   PubMed=14528312; DOI=10.1038/ncb1056;
RA   Furukawa M., He Y.J., Borchers C., Xiong Y.;
RT   "Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin
RT   ligases.";
RL   Nat. Cell Biol. 5:1001-1007(2003).
CC   -!- FUNCTION: Probable substrate-specific adapter of an E3 ubiquitin-
CC       protein ligase complex which mediates the ubiquitination and subsequent
CC       proteasomal degradation of target proteins.
CC       {ECO:0000269|PubMed:14528312}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Interacts with CUL3. {ECO:0000269|PubMed:14528312}.
CC   -!- INTERACTION:
CC       Q8N4N3; P07686: HEXB; NbExp=3; IntAct=EBI-6426427, EBI-7133736;
CC       Q8N4N3-2; P54253: ATXN1; NbExp=6; IntAct=EBI-10973851, EBI-930964;
CC       Q8N4N3-2; P55212: CASP6; NbExp=3; IntAct=EBI-10973851, EBI-718729;
CC       Q8N4N3-2; P55210: CASP7; NbExp=3; IntAct=EBI-10973851, EBI-523958;
CC       Q8N4N3-2; O00291: HIP1; NbExp=3; IntAct=EBI-10973851, EBI-473886;
CC       Q8N4N3-2; P13473-2: LAMP2; NbExp=3; IntAct=EBI-10973851, EBI-21591415;
CC       Q8N4N3-2; P07237: P4HB; NbExp=3; IntAct=EBI-10973851, EBI-395883;
CC       Q8N4N3-2; P60201-2: PLP1; NbExp=3; IntAct=EBI-10973851, EBI-12188331;
CC       Q8N4N3-2; O75400-2: PRPF40A; NbExp=3; IntAct=EBI-10973851, EBI-5280197;
CC       Q8N4N3-2; P00441: SOD1; NbExp=3; IntAct=EBI-10973851, EBI-990792;
CC       Q8N4N3-2; Q9P1I4: ST13; NbExp=3; IntAct=EBI-10973851, EBI-25892254;
CC       Q8N4N3-2; Q13148: TARDBP; NbExp=6; IntAct=EBI-10973851, EBI-372899;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8N4N3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8N4N3-2; Sequence=VSP_022867;
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DR   EMBL; AK022605; BAB14124.1; -; mRNA.
DR   EMBL; BC032400; AAH32400.1; -; mRNA.
DR   EMBL; BC033821; AAH33821.1; -; mRNA.
DR   CCDS; CCDS10948.1; -. [Q8N4N3-1]
DR   CCDS; CCDS76909.1; -. [Q8N4N3-2]
DR   RefSeq; NP_001290380.1; NM_001303451.1. [Q8N4N3-2]
DR   RefSeq; NP_079007.2; NM_024731.3. [Q8N4N3-1]
DR   RefSeq; XP_005256206.1; XM_005256149.2. [Q8N4N3-1]
DR   RefSeq; XP_016879163.1; XM_017023674.1.
DR   RefSeq; XP_016879164.1; XM_017023675.1.
DR   AlphaFoldDB; Q8N4N3; -.
DR   SMR; Q8N4N3; -.
DR   BioGRID; 122886; 69.
DR   ComplexPortal; CPX-8222; CRL3 E3 ubiquitin ligase complex, KLHL36 variant.
DR   IntAct; Q8N4N3; 34.
DR   MINT; Q8N4N3; -.
DR   STRING; 9606.ENSP00000456743; -.
DR   GlyGen; Q8N4N3; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q8N4N3; -.
DR   PhosphoSitePlus; Q8N4N3; -.
DR   BioMuta; KLHL36; -.
DR   DMDM; 74728879; -.
DR   EPD; Q8N4N3; -.
DR   jPOST; Q8N4N3; -.
DR   MassIVE; Q8N4N3; -.
DR   MaxQB; Q8N4N3; -.
DR   PaxDb; 9606-ENSP00000456743; -.
DR   PeptideAtlas; Q8N4N3; -.
DR   ProteomicsDB; 71948; -. [Q8N4N3-1]
DR   ProteomicsDB; 71949; -. [Q8N4N3-2]
DR   Pumba; Q8N4N3; -.
DR   Antibodypedia; 17099; 104 antibodies from 23 providers.
DR   DNASU; 79786; -.
DR   Ensembl; ENST00000258157.9; ENSP00000258157.5; ENSG00000135686.13. [Q8N4N3-2]
DR   Ensembl; ENST00000564996.6; ENSP00000456743.1; ENSG00000135686.13. [Q8N4N3-1]
DR   GeneID; 79786; -.
DR   KEGG; hsa:79786; -.
DR   MANE-Select; ENST00000564996.6; ENSP00000456743.1; NM_024731.4; NP_079007.2.
DR   UCSC; uc002fig.4; human. [Q8N4N3-1]
DR   AGR; HGNC:17844; -.
DR   CTD; 79786; -.
DR   GeneCards; KLHL36; -.
DR   HGNC; HGNC:17844; KLHL36.
DR   HPA; ENSG00000135686; Low tissue specificity.
DR   neXtProt; NX_Q8N4N3; -.
DR   OpenTargets; ENSG00000135686; -.
DR   PharmGKB; PA162393612; -.
DR   VEuPathDB; HostDB:ENSG00000135686; -.
DR   eggNOG; KOG4441; Eukaryota.
DR   GeneTree; ENSGT00940000157543; -.
DR   HOGENOM; CLU_004253_14_3_1; -.
DR   InParanoid; Q8N4N3; -.
DR   OMA; GQVQHES; -.
DR   OrthoDB; 5472491at2759; -.
DR   PhylomeDB; Q8N4N3; -.
DR   TreeFam; TF328485; -.
DR   PathwayCommons; Q8N4N3; -.
DR   SignaLink; Q8N4N3; -.
DR   UniPathway; UPA00143; -.
DR   BioGRID-ORCS; 79786; 16 hits in 1195 CRISPR screens.
DR   ChiTaRS; KLHL36; human.
DR   GenomeRNAi; 79786; -.
DR   Pharos; Q8N4N3; Tdark.
DR   PRO; PR:Q8N4N3; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   RNAct; Q8N4N3; Protein.
DR   Bgee; ENSG00000135686; Expressed in seminal vesicle and 186 other cell types or tissues.
DR   ExpressionAtlas; Q8N4N3; baseline and differential.
DR   GO; GO:0097602; F:cullin family protein binding; IPI:UniProtKB.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd18475; BACK_KLHL36; 1.
DR   CDD; cd18266; BTB_POZ_KLHL36; 1.
DR   Gene3D; 1.25.40.420; -; 1.
DR   Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR45632:SF4; KELCH-LIKE PROTEIN 36; 1.
DR   PANTHER; PTHR45632; LD33804P; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 4.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 6.
DR   SUPFAM; SSF117281; Kelch motif; 1.
DR   SUPFAM; SSF54695; POZ domain; 1.
DR   PROSITE; PS50097; BTB; 1.
DR   Genevisible; Q8N4N3; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Kelch repeat; Reference proteome; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..616
FT                   /note="Kelch-like protein 36"
FT                   /id="PRO_0000274691"
FT   DOMAIN          46..113
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          148..250
FT                   /note="BACK"
FT   REPEAT          296..345
FT                   /note="Kelch 1"
FT   REPEAT          346..397
FT                   /note="Kelch 2"
FT   REPEAT          398..444
FT                   /note="Kelch 3"
FT   REPEAT          446..493
FT                   /note="Kelch 4"
FT   REPEAT          494..546
FT                   /note="Kelch 5"
FT   REPEAT          547..595
FT                   /note="Kelch 6"
FT   REGION          597..616
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         369..431
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_022867"
FT   CONFLICT        494
FT                   /note="S -> G (in Ref. 1; BAB14124)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   616 AA;  69896 MW;  D2504144EF34C80F CRC64;
     MMEGSRQTRV SRPYKISESS KVYRWADHSS TVLQRLNEQR LRGLFCDVVL VADEQRVPAH
     RNLLAVCSDY FNSMFTIGMR EAFQKEVELI GASYIGLKAV VDFLYGGELV LDGGNIDYVL
     ETAHLLQIWT VVDFCCEYLE QEVSEDNYLY LQELASIYSL KRLDAFIDGF ILNHFGTLSF
     TPDFLQNVSM QKLCVYLSSS EVQRECEHDL LQAALQWLTQ QPEREAHARQ VLENIHFPLI
     PKNDLLHRVK PAVCSLLPKE ANCEGFIEEA VRYHNNLAAQ PVMQTKRTAL RTNQERLLFV
     GGEVSERCLE LSDDTCYLDA KSEQWVKETP LPARRSHHCV AVLGGFIFIA GGSFSRDNGG
     DAASNLLYRY DPRCKQWIKV ASMNQRRVDF YLASIEDMLV AIGGRNENGA LSSVETYSPK
     TDSWSYVAGL PRFTYGHAGT IYKDFVYISG GHDYQIGPYR KNLLCYDHRT DVWEERRPMT
     TARGWHSMCS LGDSIYSIGG SDDNIESMER FDVLGVEAYS PQCNQWTRVA PLLHANSESG
     VAVWEGRIYI LGGYSWENTA FSKTVQVYDR EADKWSRGVD LPKAIAGGSA CVCALEPRPE
     DKKKKGKGKR HQDRGQ
//