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Q8N4N3

- KLH36_HUMAN

UniProt

Q8N4N3 - KLH36_HUMAN

Protein

Kelch-like protein 36

Gene

KLHL36

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.1 Publication

    Pathwayi

    GO - Biological processi

    1. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kelch-like protein 36
    Gene namesi
    Name:KLHL36
    Synonyms:C16orf44
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:17844. KLHL36.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162393612.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 616616Kelch-like protein 36PRO_0000274691Add
    BLAST

    Proteomic databases

    MaxQBiQ8N4N3.
    PaxDbiQ8N4N3.
    PRIDEiQ8N4N3.

    PTM databases

    PhosphoSiteiQ8N4N3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N4N3.
    BgeeiQ8N4N3.
    CleanExiHS_KLHL36.
    GenevestigatoriQ8N4N3.

    Organism-specific databases

    HPAiHPA023423.

    Interactioni

    Subunit structurei

    Interacts with CUL3.1 Publication

    Protein-protein interaction databases

    BioGridi122886. 4 interactions.
    IntActiQ8N4N3. 2 interactions.
    STRINGi9606.ENSP00000317442.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N4N3.
    SMRiQ8N4N3. Positions 14-274, 296-576.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 11368BTBPROSITE-ProRule annotationAdd
    BLAST
    Domaini148 – 250103BACKAdd
    BLAST
    Repeati296 – 34550Kelch 1Add
    BLAST
    Repeati346 – 39752Kelch 2Add
    BLAST
    Repeati398 – 44447Kelch 3Add
    BLAST
    Repeati446 – 49348Kelch 4Add
    BLAST
    Repeati494 – 54653Kelch 5Add
    BLAST
    Repeati547 – 59549Kelch 6Add
    BLAST

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 6 Kelch repeats.Curated

    Keywords - Domaini

    Kelch repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG281791.
    HOGENOMiHOG000231583.
    HOVERGENiHBG106526.
    InParanoidiQ8N4N3.
    KOiK13958.
    OMAiSMFTIGM.
    OrthoDBiEOG73V6JX.
    PhylomeDBiQ8N4N3.
    TreeFamiTF328485.

    Family and domain databases

    Gene3Di2.130.10.80. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR011705. BACK.
    IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR015916. Gal_Oxidase_b-propeller.
    IPR017096. Kelch-like_gigaxonin-typ.
    IPR006652. Kelch_1.
    [Graphical view]
    PfamiPF07707. BACK. 1 hit.
    PF00651. BTB. 1 hit.
    PF01344. Kelch_1. 4 hits.
    [Graphical view]
    PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
    SMARTiSM00875. BACK. 1 hit.
    SM00225. BTB. 1 hit.
    SM00612. Kelch. 6 hits.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N4N3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMEGSRQTRV SRPYKISESS KVYRWADHSS TVLQRLNEQR LRGLFCDVVL    50
    VADEQRVPAH RNLLAVCSDY FNSMFTIGMR EAFQKEVELI GASYIGLKAV 100
    VDFLYGGELV LDGGNIDYVL ETAHLLQIWT VVDFCCEYLE QEVSEDNYLY 150
    LQELASIYSL KRLDAFIDGF ILNHFGTLSF TPDFLQNVSM QKLCVYLSSS 200
    EVQRECEHDL LQAALQWLTQ QPEREAHARQ VLENIHFPLI PKNDLLHRVK 250
    PAVCSLLPKE ANCEGFIEEA VRYHNNLAAQ PVMQTKRTAL RTNQERLLFV 300
    GGEVSERCLE LSDDTCYLDA KSEQWVKETP LPARRSHHCV AVLGGFIFIA 350
    GGSFSRDNGG DAASNLLYRY DPRCKQWIKV ASMNQRRVDF YLASIEDMLV 400
    AIGGRNENGA LSSVETYSPK TDSWSYVAGL PRFTYGHAGT IYKDFVYISG 450
    GHDYQIGPYR KNLLCYDHRT DVWEERRPMT TARGWHSMCS LGDSIYSIGG 500
    SDDNIESMER FDVLGVEAYS PQCNQWTRVA PLLHANSESG VAVWEGRIYI 550
    LGGYSWENTA FSKTVQVYDR EADKWSRGVD LPKAIAGGSA CVCALEPRPE 600
    DKKKKGKGKR HQDRGQ 616
    Length:616
    Mass (Da):69,896
    Last modified:October 1, 2002 - v1
    Checksum:iD2504144EF34C80F
    GO
    Isoform 2 (identifier: Q8N4N3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         369-431: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:553
    Mass (Da):62,772
    Checksum:iA1296DFEE22A8E80
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti494 – 4941S → G in BAB14124. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei369 – 43163Missing in isoform 2. 1 PublicationVSP_022867Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022605 mRNA. Translation: BAB14124.1.
    BC032400 mRNA. Translation: AAH32400.1.
    BC033821 mRNA. Translation: AAH33821.1.
    CCDSiCCDS10948.1. [Q8N4N3-1]
    RefSeqiNP_079007.2. NM_024731.2. [Q8N4N3-1]
    XP_005256206.1. XM_005256149.1. [Q8N4N3-1]
    UniGeneiHs.222731.
    Hs.578546.

    Genome annotation databases

    EnsembliENST00000258157; ENSP00000258157; ENSG00000135686. [Q8N4N3-2]
    ENST00000564996; ENSP00000456743; ENSG00000135686. [Q8N4N3-1]
    GeneIDi79786.
    KEGGihsa:79786.
    UCSCiuc002fig.3. human. [Q8N4N3-1]
    uc010chl.3. human. [Q8N4N3-2]

    Polymorphism databases

    DMDMi74728879.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022605 mRNA. Translation: BAB14124.1 .
    BC032400 mRNA. Translation: AAH32400.1 .
    BC033821 mRNA. Translation: AAH33821.1 .
    CCDSi CCDS10948.1. [Q8N4N3-1 ]
    RefSeqi NP_079007.2. NM_024731.2. [Q8N4N3-1 ]
    XP_005256206.1. XM_005256149.1. [Q8N4N3-1 ]
    UniGenei Hs.222731.
    Hs.578546.

    3D structure databases

    ProteinModelPortali Q8N4N3.
    SMRi Q8N4N3. Positions 14-274, 296-576.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122886. 4 interactions.
    IntActi Q8N4N3. 2 interactions.
    STRINGi 9606.ENSP00000317442.

    PTM databases

    PhosphoSitei Q8N4N3.

    Polymorphism databases

    DMDMi 74728879.

    Proteomic databases

    MaxQBi Q8N4N3.
    PaxDbi Q8N4N3.
    PRIDEi Q8N4N3.

    Protocols and materials databases

    DNASUi 79786.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000258157 ; ENSP00000258157 ; ENSG00000135686 . [Q8N4N3-2 ]
    ENST00000564996 ; ENSP00000456743 ; ENSG00000135686 . [Q8N4N3-1 ]
    GeneIDi 79786.
    KEGGi hsa:79786.
    UCSCi uc002fig.3. human. [Q8N4N3-1 ]
    uc010chl.3. human. [Q8N4N3-2 ]

    Organism-specific databases

    CTDi 79786.
    GeneCardsi GC16P084682.
    HGNCi HGNC:17844. KLHL36.
    HPAi HPA023423.
    neXtProti NX_Q8N4N3.
    PharmGKBi PA162393612.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG281791.
    HOGENOMi HOG000231583.
    HOVERGENi HBG106526.
    InParanoidi Q8N4N3.
    KOi K13958.
    OMAi SMFTIGM.
    OrthoDBi EOG73V6JX.
    PhylomeDBi Q8N4N3.
    TreeFami TF328485.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    GenomeRNAii 79786.
    NextBioi 69308.
    PROi Q8N4N3.

    Gene expression databases

    ArrayExpressi Q8N4N3.
    Bgeei Q8N4N3.
    CleanExi HS_KLHL36.
    Genevestigatori Q8N4N3.

    Family and domain databases

    Gene3Di 2.130.10.80. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR011705. BACK.
    IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR015916. Gal_Oxidase_b-propeller.
    IPR017096. Kelch-like_gigaxonin-typ.
    IPR006652. Kelch_1.
    [Graphical view ]
    Pfami PF07707. BACK. 1 hit.
    PF00651. BTB. 1 hit.
    PF01344. Kelch_1. 4 hits.
    [Graphical view ]
    PIRSFi PIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
    SMARTi SM00875. BACK. 1 hit.
    SM00225. BTB. 1 hit.
    SM00612. Kelch. 6 hits.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Blood.
    3. "Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases."
      Furukawa M., He Y.J., Borchers C., Xiong Y.
      Nat. Cell Biol. 5:1001-1007(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL3.

    Entry informationi

    Entry nameiKLH36_HUMAN
    AccessioniPrimary (citable) accession number: Q8N4N3
    Secondary accession number(s): Q8N5G6, Q9H9U6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3