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Q8N4N3 (KLH36_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kelch-like protein 36
Gene names
Name:KLHL36
Synonyms:C16orf44
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length616 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ref.3

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Interacts with CUL3. Ref.3

Sequence similarities

Contains 1 BACK (BTB/Kelch associated) domain.

Contains 1 BTB (POZ) domain.

Contains 6 Kelch repeats.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Coding sequence diversityAlternative splicing
   DomainKelch repeat
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein ubiquitination

Inferred from electronic annotation. Source: UniProtKB-UniPathway

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N4N3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N4N3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     369-431: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 616616Kelch-like protein 36
PRO_0000274691

Regions

Domain46 – 11368BTB
Domain148 – 250103BACK
Repeat296 – 34550Kelch 1
Repeat346 – 39752Kelch 2
Repeat398 – 44447Kelch 3
Repeat446 – 49348Kelch 4
Repeat494 – 54653Kelch 5
Repeat547 – 59549Kelch 6

Natural variations

Alternative sequence369 – 43163Missing in isoform 2.
VSP_022867

Experimental info

Sequence conflict4941S → G in BAB14124. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: D2504144EF34C80F

FASTA61669,896
        10         20         30         40         50         60 
MMEGSRQTRV SRPYKISESS KVYRWADHSS TVLQRLNEQR LRGLFCDVVL VADEQRVPAH 

        70         80         90        100        110        120 
RNLLAVCSDY FNSMFTIGMR EAFQKEVELI GASYIGLKAV VDFLYGGELV LDGGNIDYVL 

       130        140        150        160        170        180 
ETAHLLQIWT VVDFCCEYLE QEVSEDNYLY LQELASIYSL KRLDAFIDGF ILNHFGTLSF 

       190        200        210        220        230        240 
TPDFLQNVSM QKLCVYLSSS EVQRECEHDL LQAALQWLTQ QPEREAHARQ VLENIHFPLI 

       250        260        270        280        290        300 
PKNDLLHRVK PAVCSLLPKE ANCEGFIEEA VRYHNNLAAQ PVMQTKRTAL RTNQERLLFV 

       310        320        330        340        350        360 
GGEVSERCLE LSDDTCYLDA KSEQWVKETP LPARRSHHCV AVLGGFIFIA GGSFSRDNGG 

       370        380        390        400        410        420 
DAASNLLYRY DPRCKQWIKV ASMNQRRVDF YLASIEDMLV AIGGRNENGA LSSVETYSPK 

       430        440        450        460        470        480 
TDSWSYVAGL PRFTYGHAGT IYKDFVYISG GHDYQIGPYR KNLLCYDHRT DVWEERRPMT 

       490        500        510        520        530        540 
TARGWHSMCS LGDSIYSIGG SDDNIESMER FDVLGVEAYS PQCNQWTRVA PLLHANSESG 

       550        560        570        580        590        600 
VAVWEGRIYI LGGYSWENTA FSKTVQVYDR EADKWSRGVD LPKAIAGGSA CVCALEPRPE 

       610 
DKKKKGKGKR HQDRGQ 

« Hide

Isoform 2 [UniParc].

Checksum: A1296DFEE22A8E80
Show »

FASTA55362,772

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Blood.
[3]"Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases."
Furukawa M., He Y.J., Borchers C., Xiong Y.
Nat. Cell Biol. 5:1001-1007(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK022605 mRNA. Translation: BAB14124.1.
BC032400 mRNA. Translation: AAH32400.1.
BC033821 mRNA. Translation: AAH33821.1.
RefSeqNP_079007.2. NM_024731.2.
XP_005256206.1. XM_005256149.1.
UniGeneHs.222731.
Hs.578546.

3D structure databases

ProteinModelPortalQ8N4N3.
SMRQ8N4N3. Positions 14-274, 283-597.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122886. 4 interactions.
IntActQ8N4N3. 1 interaction.
STRING9606.ENSP00000317442.

PTM databases

PhosphoSiteQ8N4N3.

Polymorphism databases

DMDM74728879.

Proteomic databases

PaxDbQ8N4N3.
PRIDEQ8N4N3.

Protocols and materials databases

DNASU79786.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000258157; ENSP00000258157; ENSG00000135686. [Q8N4N3-2]
ENST00000564996; ENSP00000456743; ENSG00000135686. [Q8N4N3-1]
GeneID79786.
KEGGhsa:79786.
UCSCuc002fig.3. human. [Q8N4N3-1]
uc010chl.3. human. [Q8N4N3-2]

Organism-specific databases

CTD79786.
GeneCardsGC16P084682.
HGNCHGNC:17844. KLHL36.
HPAHPA023423.
neXtProtNX_Q8N4N3.
PharmGKBPA162393612.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG281791.
HOGENOMHOG000231583.
HOVERGENHBG106526.
InParanoidQ8N4N3.
KOK13958.
OMASMFTIGM.
OrthoDBEOG73V6JX.
PhylomeDBQ8N4N3.
TreeFamTF328485.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

ArrayExpressQ8N4N3.
BgeeQ8N4N3.
CleanExHS_KLHL36.
GenevestigatorQ8N4N3.

Family and domain databases

Gene3D2.130.10.80. 1 hit.
3.30.710.10. 1 hit.
InterProIPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015916. Gal_Oxidase_b-propeller.
IPR017096. Kelch-like_gigaxonin-typ.
IPR006652. Kelch_1.
[Graphical view]
PfamPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 4 hits.
[Graphical view]
PIRSFPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
PROSITEPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi79786.
NextBio69308.
PROQ8N4N3.

Entry information

Entry nameKLH36_HUMAN
AccessionPrimary (citable) accession number: Q8N4N3
Secondary accession number(s): Q8N5G6, Q9H9U6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM