Q8N4N3 (KLH36_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kelch-like protein 36

Gene names

Name:	KLHL36
Synonyms:	C16orf44

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	616 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ref.3
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Interacts with CUL3. Ref.3
Sequence similarities	Contains 1 BACK (BTB/Kelch associated) domain. Contains 1 BTB (POZ) domain. Contains 6 Kelch repeats.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Coding sequence diversity	Alternative splicing
Domain	Kelch repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein ubiquitination Inferred from electronic annotation. Source: UniProtKB-UniPathway
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N4N3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N4N3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     369-431: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 616	616	Kelch-like protein 36		PRO_0000274691
Regions
	Domain	46 – 113	68	BTB
	Domain	148 – 250	103	BACK
	Repeat	296 – 345	50	Kelch 1
	Repeat	346 – 397	52	Kelch 2
	Repeat	398 – 444	47	Kelch 3
	Repeat	446 – 493	48	Kelch 4
	Repeat	494 – 546	53	Kelch 5
	Repeat	547 – 595	49	Kelch 6
Natural variations
	Alternative sequence	369 – 431	63	Missing in isoform 2.		VSP_022867
Experimental info
	Sequence conflict	494	1	S → G in BAB14124. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: D2504144EF34C80F	FASTA	616	69,896
	10 20 30 40 50 60 MMEGSRQTRV SRPYKISESS KVYRWADHSS TVLQRLNEQR LRGLFCDVVL VADEQRVPAH 70 80 90 100 110 120 RNLLAVCSDY FNSMFTIGMR EAFQKEVELI GASYIGLKAV VDFLYGGELV LDGGNIDYVL 130 140 150 160 170 180 ETAHLLQIWT VVDFCCEYLE QEVSEDNYLY LQELASIYSL KRLDAFIDGF ILNHFGTLSF 190 200 210 220 230 240 TPDFLQNVSM QKLCVYLSSS EVQRECEHDL LQAALQWLTQ QPEREAHARQ VLENIHFPLI 250 260 270 280 290 300 PKNDLLHRVK PAVCSLLPKE ANCEGFIEEA VRYHNNLAAQ PVMQTKRTAL RTNQERLLFV 310 320 330 340 350 360 GGEVSERCLE LSDDTCYLDA KSEQWVKETP LPARRSHHCV AVLGGFIFIA GGSFSRDNGG 370 380 390 400 410 420 DAASNLLYRY DPRCKQWIKV ASMNQRRVDF YLASIEDMLV AIGGRNENGA LSSVETYSPK 430 440 450 460 470 480 TDSWSYVAGL PRFTYGHAGT IYKDFVYISG GHDYQIGPYR KNLLCYDHRT DVWEERRPMT 490 500 510 520 530 540 TARGWHSMCS LGDSIYSIGG SDDNIESMER FDVLGVEAYS PQCNQWTRVA PLLHANSESG 550 560 570 580 590 600 VAVWEGRIYI LGGYSWENTA FSKTVQVYDR EADKWSRGVD LPKAIAGGSA CVCALEPRPE 610 DKKKKGKGKR HQDRGQ
	Isoform 2 [UniParc]. Checksum: A1296DFEE22A8E80	FASTA	553	62,772
	10 20 30 40 50 60 MMEGSRQTRV SRPYKISESS KVYRWADHSS TVLQRLNEQR LRGLFCDVVL VADEQRVPAH 70 80 90 100 110 120 RNLLAVCSDY FNSMFTIGMR EAFQKEVELI GASYIGLKAV VDFLYGGELV LDGGNIDYVL 130 140 150 160 170 180 ETAHLLQIWT VVDFCCEYLE QEVSEDNYLY LQELASIYSL KRLDAFIDGF ILNHFGTLSF 190 200 210 220 230 240 TPDFLQNVSM QKLCVYLSSS EVQRECEHDL LQAALQWLTQ QPEREAHARQ VLENIHFPLI 250 260 270 280 290 300 PKNDLLHRVK PAVCSLLPKE ANCEGFIEEA VRYHNNLAAQ PVMQTKRTAL RTNQERLLFV 310 320 330 340 350 360 GGEVSERCLE LSDDTCYLDA KSEQWVKETP LPARRSHHCV AVLGGFIFIA GGSFSRDNGG 370 380 390 400 410 420 DAASNLLYRF TYGHAGTIYK DFVYISGGHD YQIGPYRKNL LCYDHRTDVW EERRPMTTAR 430 440 450 460 470 480 GWHSMCSLGD SIYSIGGSDD NIESMERFDV LGVEAYSPQC NQWTRVAPLL HANSESGVAV 490 500 510 520 530 540 WEGRIYILGG YSWENTAFSK TVQVYDREAD KWSRGVDLPK AIAGGSACVC ALEPRPEDKK 550 KKGKGKRHQD RGQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Blood.
[3]	"Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases." Furukawa M., He Y.J., Borchers C., Xiong Y. Nat. Cell Biol. 5:1001-1007(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK022605 mRNA. Translation: BAB14124.1. BC032400 mRNA. Translation: AAH32400.1. BC033821 mRNA. Translation: AAH33821.1.
IPI	IPI00166852. IPI00296724.
RefSeq	NP_079007.2. NM_024731.2.
UniGene	Hs.578546.
3D structure databases
HSSP	HSSP built from PDB template 1R29 based on UniProtKB P41182.
ProteinModelPortal	Q8N4N3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8N4N3. 1 interaction.
STRING	9606.ENSP00000317442.
PTM databases
PhosphoSite	Q8N4N3.
Polymorphism databases
DMDM	74728879.
Proteomic databases
PaxDb	Q8N4N3.
PRIDE	Q8N4N3.
Protocols and materials databases
DNASU	79786.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000258157; ENSP00000258157; ENSG00000135686. ENST00000564996; ENSP00000456743; ENSG00000135686.
GeneID	79786.
KEGG	hsa:79786.
UCSC	uc002fig.3. human. uc010chl.3. human.
Organism-specific databases
CTD	79786.
GeneCards	GC16P084682.
HGNC	HGNC:17844. KLHL36.
HPA	HPA023423.
neXtProt	NX_Q8N4N3.
PharmGKB	PA162393612.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG281791.
HOGENOM	HOG000231583.
HOVERGEN	HBG106526.
InParanoid	Q8N4N3.
KO	K13958.
OMA	SMFTIGM.
OrthoDB	EOG476K00.
PhylomeDB	Q8N4N3.
Enzyme and pathway databases
UniPathway	UPA00143.
Gene expression databases
ArrayExpress	Q8N4N3.
Bgee	Q8N4N3.
CleanEx	HS_KLHL36.
Genevestigator	Q8N4N3.
Family and domain databases
Gene3D	2.130.10.80. 1 hit. 3.30.710.10. 1 hit.
InterPro	IPR011705. BACK. IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR015916. Gal_Oxidase_b-propeller. IPR017096. Kelch-like_gigaxonin. IPR006652. Kelch_1. [Graphical view]
Pfam	PF07707. BACK. 1 hit. PF00651. BTB. 1 hit. PF01344. Kelch_1. 4 hits. [Graphical view]
PIRSF	PIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMART	SM00875. BACK. 1 hit. SM00225. BTB. 1 hit. SM00612. Kelch. 6 hits. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
PROSITE	PS50097. BTB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	79786.
NextBio	69308.

Entry information

Entry name

KLH36_HUMAN

Accession

Primary (citable) accession number: Q8N4N3
Secondary accession number(s): Q8N5G6, Q9H9U6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.