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Protein

Kelch-like protein 36

Gene

KLHL36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.1 Publication

Pathway: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 36
Gene namesi
Name:KLHL36
Synonyms:C16orf44
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:17844. KLHL36.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162393612.

Polymorphism and mutation databases

BioMutaiKLHL36.
DMDMi74728879.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 616616Kelch-like protein 36PRO_0000274691Add
BLAST

Proteomic databases

MaxQBiQ8N4N3.
PaxDbiQ8N4N3.
PRIDEiQ8N4N3.

PTM databases

PhosphoSiteiQ8N4N3.

Expressioni

Gene expression databases

BgeeiQ8N4N3.
CleanExiHS_KLHL36.
ExpressionAtlasiQ8N4N3. baseline and differential.
GenevisibleiQ8N4N3. HS.

Organism-specific databases

HPAiHPA023423.

Interactioni

Subunit structurei

Interacts with CUL3.1 Publication

Protein-protein interaction databases

BioGridi122886. 8 interactions.
IntActiQ8N4N3. 2 interactions.
STRINGi9606.ENSP00000456743.

Structurei

3D structure databases

ProteinModelPortaliQ8N4N3.
SMRiQ8N4N3. Positions 14-274, 296-576.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 11368BTBPROSITE-ProRule annotationAdd
BLAST
Domaini148 – 250103BACKAdd
BLAST
Repeati296 – 34550Kelch 1Add
BLAST
Repeati346 – 39752Kelch 2Add
BLAST
Repeati398 – 44447Kelch 3Add
BLAST
Repeati446 – 49348Kelch 4Add
BLAST
Repeati494 – 54653Kelch 5Add
BLAST
Repeati547 – 59549Kelch 6Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiNOG281791.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000231583.
HOVERGENiHBG106526.
InParanoidiQ8N4N3.
KOiK13958.
OMAiSMFTIGM.
OrthoDBiEOG73V6JX.
PhylomeDBiQ8N4N3.
TreeFamiTF328485.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR030585. KLHL36.
[Graphical view]
PANTHERiPTHR24412:SF161. PTHR24412:SF161. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 4 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N4N3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMEGSRQTRV SRPYKISESS KVYRWADHSS TVLQRLNEQR LRGLFCDVVL
60 70 80 90 100
VADEQRVPAH RNLLAVCSDY FNSMFTIGMR EAFQKEVELI GASYIGLKAV
110 120 130 140 150
VDFLYGGELV LDGGNIDYVL ETAHLLQIWT VVDFCCEYLE QEVSEDNYLY
160 170 180 190 200
LQELASIYSL KRLDAFIDGF ILNHFGTLSF TPDFLQNVSM QKLCVYLSSS
210 220 230 240 250
EVQRECEHDL LQAALQWLTQ QPEREAHARQ VLENIHFPLI PKNDLLHRVK
260 270 280 290 300
PAVCSLLPKE ANCEGFIEEA VRYHNNLAAQ PVMQTKRTAL RTNQERLLFV
310 320 330 340 350
GGEVSERCLE LSDDTCYLDA KSEQWVKETP LPARRSHHCV AVLGGFIFIA
360 370 380 390 400
GGSFSRDNGG DAASNLLYRY DPRCKQWIKV ASMNQRRVDF YLASIEDMLV
410 420 430 440 450
AIGGRNENGA LSSVETYSPK TDSWSYVAGL PRFTYGHAGT IYKDFVYISG
460 470 480 490 500
GHDYQIGPYR KNLLCYDHRT DVWEERRPMT TARGWHSMCS LGDSIYSIGG
510 520 530 540 550
SDDNIESMER FDVLGVEAYS PQCNQWTRVA PLLHANSESG VAVWEGRIYI
560 570 580 590 600
LGGYSWENTA FSKTVQVYDR EADKWSRGVD LPKAIAGGSA CVCALEPRPE
610
DKKKKGKGKR HQDRGQ
Length:616
Mass (Da):69,896
Last modified:October 1, 2002 - v1
Checksum:iD2504144EF34C80F
GO
Isoform 2 (identifier: Q8N4N3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     369-431: Missing.

Note: No experimental confirmation available.
Show »
Length:553
Mass (Da):62,772
Checksum:iA1296DFEE22A8E80
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti494 – 4941S → G in BAB14124 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei369 – 43163Missing in isoform 2. 1 PublicationVSP_022867Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022605 mRNA. Translation: BAB14124.1.
BC032400 mRNA. Translation: AAH32400.1.
BC033821 mRNA. Translation: AAH33821.1.
CCDSiCCDS10948.1. [Q8N4N3-1]
RefSeqiNP_079007.2. NM_024731.3. [Q8N4N3-1]
XP_005256206.1. XM_005256149.1. [Q8N4N3-1]
UniGeneiHs.222731.
Hs.578546.

Genome annotation databases

EnsembliENST00000258157; ENSP00000258157; ENSG00000135686. [Q8N4N3-2]
ENST00000564996; ENSP00000456743; ENSG00000135686. [Q8N4N3-1]
GeneIDi79786.
KEGGihsa:79786.
UCSCiuc002fig.3. human. [Q8N4N3-1]
uc010chl.3. human. [Q8N4N3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022605 mRNA. Translation: BAB14124.1.
BC032400 mRNA. Translation: AAH32400.1.
BC033821 mRNA. Translation: AAH33821.1.
CCDSiCCDS10948.1. [Q8N4N3-1]
RefSeqiNP_079007.2. NM_024731.3. [Q8N4N3-1]
XP_005256206.1. XM_005256149.1. [Q8N4N3-1]
UniGeneiHs.222731.
Hs.578546.

3D structure databases

ProteinModelPortaliQ8N4N3.
SMRiQ8N4N3. Positions 14-274, 296-576.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122886. 8 interactions.
IntActiQ8N4N3. 2 interactions.
STRINGi9606.ENSP00000456743.

PTM databases

PhosphoSiteiQ8N4N3.

Polymorphism and mutation databases

BioMutaiKLHL36.
DMDMi74728879.

Proteomic databases

MaxQBiQ8N4N3.
PaxDbiQ8N4N3.
PRIDEiQ8N4N3.

Protocols and materials databases

DNASUi79786.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258157; ENSP00000258157; ENSG00000135686. [Q8N4N3-2]
ENST00000564996; ENSP00000456743; ENSG00000135686. [Q8N4N3-1]
GeneIDi79786.
KEGGihsa:79786.
UCSCiuc002fig.3. human. [Q8N4N3-1]
uc010chl.3. human. [Q8N4N3-2]

Organism-specific databases

CTDi79786.
GeneCardsiGC16P084682.
HGNCiHGNC:17844. KLHL36.
HPAiHPA023423.
neXtProtiNX_Q8N4N3.
PharmGKBiPA162393612.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG281791.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000231583.
HOVERGENiHBG106526.
InParanoidiQ8N4N3.
KOiK13958.
OMAiSMFTIGM.
OrthoDBiEOG73V6JX.
PhylomeDBiQ8N4N3.
TreeFamiTF328485.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

GenomeRNAii79786.
NextBioi69308.
PROiQ8N4N3.

Gene expression databases

BgeeiQ8N4N3.
CleanExiHS_KLHL36.
ExpressionAtlasiQ8N4N3. baseline and differential.
GenevisibleiQ8N4N3. HS.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR030585. KLHL36.
[Graphical view]
PANTHERiPTHR24412:SF161. PTHR24412:SF161. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 4 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Blood.
  3. "Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases."
    Furukawa M., He Y.J., Borchers C., Xiong Y.
    Nat. Cell Biol. 5:1001-1007(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL3.

Entry informationi

Entry nameiKLH36_HUMAN
AccessioniPrimary (citable) accession number: Q8N4N3
Secondary accession number(s): Q8N5G6, Q9H9U6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2002
Last modified: June 24, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.