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Q8N4N3

- KLH36_HUMAN

UniProt

Q8N4N3 - KLH36_HUMAN

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Protein
Kelch-like protein 36
Gene
KLHL36, C16orf44
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.1 Publication

Pathwayi

GO - Biological processi

  1. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 36
Gene namesi
Name:KLHL36
Synonyms:C16orf44
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:17844. KLHL36.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162393612.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 616616Kelch-like protein 36
PRO_0000274691Add
BLAST

Proteomic databases

MaxQBiQ8N4N3.
PaxDbiQ8N4N3.
PRIDEiQ8N4N3.

PTM databases

PhosphoSiteiQ8N4N3.

Expressioni

Gene expression databases

ArrayExpressiQ8N4N3.
BgeeiQ8N4N3.
CleanExiHS_KLHL36.
GenevestigatoriQ8N4N3.

Organism-specific databases

HPAiHPA023423.

Interactioni

Subunit structurei

Interacts with CUL3.1 Publication

Protein-protein interaction databases

BioGridi122886. 4 interactions.
IntActiQ8N4N3. 1 interaction.
STRINGi9606.ENSP00000317442.

Structurei

3D structure databases

ProteinModelPortaliQ8N4N3.
SMRiQ8N4N3. Positions 14-274, 296-576.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 11368BTB
Add
BLAST
Domaini148 – 250103BACK
Add
BLAST
Repeati296 – 34550Kelch 1
Add
BLAST
Repeati346 – 39752Kelch 2
Add
BLAST
Repeati398 – 44447Kelch 3
Add
BLAST
Repeati446 – 49348Kelch 4
Add
BLAST
Repeati494 – 54653Kelch 5
Add
BLAST
Repeati547 – 59549Kelch 6
Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.
Contains 6 Kelch repeats.

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiNOG281791.
HOGENOMiHOG000231583.
HOVERGENiHBG106526.
InParanoidiQ8N4N3.
KOiK13958.
OMAiSMFTIGM.
OrthoDBiEOG73V6JX.
PhylomeDBiQ8N4N3.
TreeFamiTF328485.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015916. Gal_Oxidase_b-propeller.
IPR017096. Kelch-like_gigaxonin-typ.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 4 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N4N3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MMEGSRQTRV SRPYKISESS KVYRWADHSS TVLQRLNEQR LRGLFCDVVL    50
VADEQRVPAH RNLLAVCSDY FNSMFTIGMR EAFQKEVELI GASYIGLKAV 100
VDFLYGGELV LDGGNIDYVL ETAHLLQIWT VVDFCCEYLE QEVSEDNYLY 150
LQELASIYSL KRLDAFIDGF ILNHFGTLSF TPDFLQNVSM QKLCVYLSSS 200
EVQRECEHDL LQAALQWLTQ QPEREAHARQ VLENIHFPLI PKNDLLHRVK 250
PAVCSLLPKE ANCEGFIEEA VRYHNNLAAQ PVMQTKRTAL RTNQERLLFV 300
GGEVSERCLE LSDDTCYLDA KSEQWVKETP LPARRSHHCV AVLGGFIFIA 350
GGSFSRDNGG DAASNLLYRY DPRCKQWIKV ASMNQRRVDF YLASIEDMLV 400
AIGGRNENGA LSSVETYSPK TDSWSYVAGL PRFTYGHAGT IYKDFVYISG 450
GHDYQIGPYR KNLLCYDHRT DVWEERRPMT TARGWHSMCS LGDSIYSIGG 500
SDDNIESMER FDVLGVEAYS PQCNQWTRVA PLLHANSESG VAVWEGRIYI 550
LGGYSWENTA FSKTVQVYDR EADKWSRGVD LPKAIAGGSA CVCALEPRPE 600
DKKKKGKGKR HQDRGQ 616
Length:616
Mass (Da):69,896
Last modified:October 1, 2002 - v1
Checksum:iD2504144EF34C80F
GO
Isoform 2 (identifier: Q8N4N3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     369-431: Missing.

Note: No experimental confirmation available.

Show »
Length:553
Mass (Da):62,772
Checksum:iA1296DFEE22A8E80
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei369 – 43163Missing in isoform 2.
VSP_022867Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti494 – 4941S → G in BAB14124. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK022605 mRNA. Translation: BAB14124.1.
BC032400 mRNA. Translation: AAH32400.1.
BC033821 mRNA. Translation: AAH33821.1.
CCDSiCCDS10948.1. [Q8N4N3-1]
RefSeqiNP_079007.2. NM_024731.2. [Q8N4N3-1]
XP_005256206.1. XM_005256149.1. [Q8N4N3-1]
UniGeneiHs.222731.
Hs.578546.

Genome annotation databases

EnsembliENST00000258157; ENSP00000258157; ENSG00000135686. [Q8N4N3-2]
ENST00000564996; ENSP00000456743; ENSG00000135686. [Q8N4N3-1]
GeneIDi79786.
KEGGihsa:79786.
UCSCiuc002fig.3. human. [Q8N4N3-1]
uc010chl.3. human. [Q8N4N3-2]

Polymorphism databases

DMDMi74728879.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK022605 mRNA. Translation: BAB14124.1 .
BC032400 mRNA. Translation: AAH32400.1 .
BC033821 mRNA. Translation: AAH33821.1 .
CCDSi CCDS10948.1. [Q8N4N3-1 ]
RefSeqi NP_079007.2. NM_024731.2. [Q8N4N3-1 ]
XP_005256206.1. XM_005256149.1. [Q8N4N3-1 ]
UniGenei Hs.222731.
Hs.578546.

3D structure databases

ProteinModelPortali Q8N4N3.
SMRi Q8N4N3. Positions 14-274, 296-576.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122886. 4 interactions.
IntActi Q8N4N3. 1 interaction.
STRINGi 9606.ENSP00000317442.

PTM databases

PhosphoSitei Q8N4N3.

Polymorphism databases

DMDMi 74728879.

Proteomic databases

MaxQBi Q8N4N3.
PaxDbi Q8N4N3.
PRIDEi Q8N4N3.

Protocols and materials databases

DNASUi 79786.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000258157 ; ENSP00000258157 ; ENSG00000135686 . [Q8N4N3-2 ]
ENST00000564996 ; ENSP00000456743 ; ENSG00000135686 . [Q8N4N3-1 ]
GeneIDi 79786.
KEGGi hsa:79786.
UCSCi uc002fig.3. human. [Q8N4N3-1 ]
uc010chl.3. human. [Q8N4N3-2 ]

Organism-specific databases

CTDi 79786.
GeneCardsi GC16P084682.
HGNCi HGNC:17844. KLHL36.
HPAi HPA023423.
neXtProti NX_Q8N4N3.
PharmGKBi PA162393612.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG281791.
HOGENOMi HOG000231583.
HOVERGENi HBG106526.
InParanoidi Q8N4N3.
KOi K13958.
OMAi SMFTIGM.
OrthoDBi EOG73V6JX.
PhylomeDBi Q8N4N3.
TreeFami TF328485.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

GenomeRNAii 79786.
NextBioi 69308.
PROi Q8N4N3.

Gene expression databases

ArrayExpressi Q8N4N3.
Bgeei Q8N4N3.
CleanExi HS_KLHL36.
Genevestigatori Q8N4N3.

Family and domain databases

Gene3Di 2.130.10.80. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015916. Gal_Oxidase_b-propeller.
IPR017096. Kelch-like_gigaxonin-typ.
IPR006652. Kelch_1.
[Graphical view ]
Pfami PF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 4 hits.
[Graphical view ]
PIRSFi PIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTi SM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Blood.
  3. "Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases."
    Furukawa M., He Y.J., Borchers C., Xiong Y.
    Nat. Cell Biol. 5:1001-1007(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL3.

Entry informationi

Entry nameiKLH36_HUMAN
AccessioniPrimary (citable) accession number: Q8N4N3
Secondary accession number(s): Q8N5G6, Q9H9U6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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