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Protein

Choline transporter-like protein 3

Gene

SLC44A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. glycerophospholipid biosynthetic process Source: Reactome
  2. phosphatidylcholine biosynthetic process Source: Reactome
  3. phospholipid metabolic process Source: Reactome
  4. small molecule metabolic process Source: Reactome
  5. transmembrane transport Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_121238. Synthesis of PC.
REACT_19305. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Protein family/group databases

TCDBi2.A.92.1.3. the choline transporter-like (ctl) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Choline transporter-like protein 3
Alternative name(s):
Solute carrier family 44 member 3
Gene namesi
Name:SLC44A3
Synonyms:CTL3
ORF Names:UNQ558/PRO1115
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28689. SLC44A3.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei34 – 5421HelicalSequence AnalysisAdd
BLAST
Transmembranei213 – 23321HelicalSequence AnalysisAdd
BLAST
Transmembranei243 – 26321HelicalSequence AnalysisAdd
BLAST
Transmembranei284 – 30421HelicalSequence AnalysisAdd
BLAST
Transmembranei334 – 35421HelicalSequence AnalysisAdd
BLAST
Transmembranei384 – 40421HelicalSequence AnalysisAdd
BLAST
Transmembranei534 – 55421HelicalSequence AnalysisAdd
BLAST
Transmembranei563 – 58321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670900.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 653653Choline transporter-like protein 3PRO_0000191720Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi136 – 1361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi412 – 4121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi503 – 5031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi521 – 5211N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8N4M1.
PaxDbiQ8N4M1.
PRIDEiQ8N4M1.

PTM databases

PhosphoSiteiQ8N4M1.

Expressioni

Gene expression databases

BgeeiQ8N4M1.
CleanExiHS_SLC44A3.
ExpressionAtlasiQ8N4M1. baseline and differential.
GenevestigatoriQ8N4M1.

Organism-specific databases

HPAiHPA047433.

Interactioni

Protein-protein interaction databases

BioGridi126026. 2 interactions.
STRINGi9606.ENSP00000271227.

Structurei

3D structure databases

ProteinModelPortaliQ8N4M1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi477 – 4848Cys-rich

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG310633.
GeneTreeiENSGT00550000074521.
HOGENOMiHOG000231655.
HOVERGENiHBG080361.
InParanoidiQ8N4M1.
KOiK15282.
OMAiCTDTAWL.
OrthoDBiEOG72JWFP.
PhylomeDBiQ8N4M1.
TreeFamiTF313325.

Family and domain databases

InterProiIPR007603. Choline_transptr-like.
[Graphical view]
PANTHERiPTHR12385. PTHR12385. 1 hit.
PfamiPF04515. Choline_transpo. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N4M1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHCLGAEYLV SAEGAPRQRE WRPQIYRKCT DTAWLFLFFL FWTGLVFIMG
60 70 80 90 100
YSVVAGAAGR LLFGYDSFGN MCGKKNSPVE GAPLSGQDMT LKKHVFFMNS
110 120 130 140 150
CNLEVKGTQL NRMALCVSNC PEEQLDSLEE VQFFANTSGS FLCVYSLNSF
160 170 180 190 200
NYTHSPKADS LCPRLPVPPS KSFPLFNRCV PQTPECYSLF ASVLINDVDT
210 220 230 240 250
LHRILSGIMS GRDTILGLCI LALALSLAMM FTFRFITTLL VHIFISLVIL
260 270 280 290 300
GLLFVCGVLW WLYYDYTNDL SIELDTEREN MKCVLGFAIV STGITAVLLV
310 320 330 340 350
LIFVLRKRIK LTVELFQITN KAISSAPFLL FQPLWTFAIL IFFWVLWVAV
360 370 380 390 400
LLSLGTAGAA QVMEGGQVEY KPLSGIRYMW SYHLIGLIWT SEFILACQQM
410 420 430 440 450
TIAGAVVTCY FNRSKNDPPD HPILSSLSIL FFYHQGTVVK GSFLISVVRI
460 470 480 490 500
PRIIVMYMQN ALKEQQHGAL SRYLFRCCYC CFWCLDKYLL HLNQNAYTTT
510 520 530 540 550
AINGTDFCTS AKDAFKILSK NSSHFTSINC FGDFIIFLGK VLVVCFTVFG
560 570 580 590 600
GLMAFNYNRA FQVWAVPLLL VAFFAYLVAH SFLSVFETVL DALFLCFAVD
610 620 630 640 650
LETNDGSSEK PYFMDQEFLS FVKRSNKLNN ARAQQDKHSL RNEEGTELQA

IVR
Length:653
Mass (Da):73,783
Last modified:September 22, 2009 - v4
Checksum:i083859F3FC332382
GO
Isoform 2 (identifier: Q8N4M1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.

Show »
Length:605
Mass (Da):68,033
Checksum:i4D3A762E69E3BB24
GO
Isoform 3 (identifier: Q8N4M1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-46: Missing.

Show »
Length:617
Mass (Da):69,410
Checksum:i2E5CE3201DEB5EE2
GO
Isoform 4 (identifier: Q8N4M1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-46: Missing.
     107-138: Missing.

Note: No experimental confirmation available.

Show »
Length:585
Mass (Da):65,853
Checksum:iEB0DF13AC1E723B7
GO
Isoform 5 (identifier: Q8N4M1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     107-138: Missing.
     465-465: Missing.

Note: No experimental confirmation available.

Show »
Length:572
Mass (Da):64,348
Checksum:i4DDA14D76622D2A2
GO
Isoform 6 (identifier: Q8N4M1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-138: Missing.
     465-465: Missing.

Note: No experimental confirmation available.

Show »
Length:620
Mass (Da):70,098
Checksum:iD18ABAFA2ECD4B5C
GO

Sequence cautioni

The sequence AAH33858.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAQ89022.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31C → R in BAG62846 (PubMed:14702039).Curated
Sequence conflicti316 – 3161F → L in BAG62846 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti438 – 4381V → I.2 Publications
Corresponds to variant rs859098 [ dbSNP | Ensembl ].
VAR_023405
Natural varianti441 – 4411G → W Found in a renal cell carcinoma sample; somatic mutation. 1 Publication
VAR_064752

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4848Missing in isoform 2 and isoform 5. 2 PublicationsVSP_036151Add
BLAST
Alternative sequencei11 – 4636Missing in isoform 3 and isoform 4. 1 PublicationVSP_036152Add
BLAST
Alternative sequencei107 – 13832Missing in isoform 4, isoform 5 and isoform 6. 1 PublicationVSP_044713Add
BLAST
Alternative sequencei465 – 4651Missing in isoform 5 and isoform 6. 1 PublicationVSP_045974

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303906 mRNA. Translation: BAG64836.1.
AK301288 mRNA. Translation: BAG62846.1.
AK316123 mRNA. Translation: BAH14494.1.
AC093429 Genomic DNA. No translation available.
AL359554 Genomic DNA. Translation: CAC36091.1.
BC033858 mRNA. Translation: AAH33858.2. Different initiation.
BC053877 mRNA. Translation: AAH53877.1.
AY358659 mRNA. Translation: AAQ89022.1. Different initiation.
CCDSiCCDS44176.1. [Q8N4M1-1]
CCDS58011.1. [Q8N4M1-6]
CCDS58012.1. [Q8N4M1-4]
CCDS58013.1. [Q8N4M1-3]
CCDS751.1. [Q8N4M1-2]
RefSeqiNP_001107578.1. NM_001114106.2. [Q8N4M1-1]
NP_001245269.1. NM_001258340.1.
NP_001245270.1. NM_001258341.1. [Q8N4M1-6]
NP_001245271.1. NM_001258342.1. [Q8N4M1-3]
NP_001245272.1. NM_001258343.1. [Q8N4M1-4]
NP_001288008.1. NM_001301079.1.
NP_689582.2. NM_152369.4. [Q8N4M1-2]
XP_005270498.1. XM_005270441.1. [Q8N4M1-2]
UniGeneiHs.483423.

Genome annotation databases

EnsembliENST00000271227; ENSP00000271227; ENSG00000143036. [Q8N4M1-1]
ENST00000446120; ENSP00000389143; ENSG00000143036. [Q8N4M1-3]
ENST00000467909; ENSP00000432789; ENSG00000143036. [Q8N4M1-2]
ENST00000527077; ENSP00000433641; ENSG00000143036. [Q8N4M1-4]
ENST00000529450; ENSP00000431836; ENSG00000143036. [Q8N4M1-6]
GeneIDi126969.
KEGGihsa:126969.
UCSCiuc001dqv.5. human. [Q8N4M1-1]
uc010otr.3. human. [Q8N4M1-3]

Polymorphism databases

DMDMi259016387.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303906 mRNA. Translation: BAG64836.1.
AK301288 mRNA. Translation: BAG62846.1.
AK316123 mRNA. Translation: BAH14494.1.
AC093429 Genomic DNA. No translation available.
AL359554 Genomic DNA. Translation: CAC36091.1.
BC033858 mRNA. Translation: AAH33858.2. Different initiation.
BC053877 mRNA. Translation: AAH53877.1.
AY358659 mRNA. Translation: AAQ89022.1. Different initiation.
CCDSiCCDS44176.1. [Q8N4M1-1]
CCDS58011.1. [Q8N4M1-6]
CCDS58012.1. [Q8N4M1-4]
CCDS58013.1. [Q8N4M1-3]
CCDS751.1. [Q8N4M1-2]
RefSeqiNP_001107578.1. NM_001114106.2. [Q8N4M1-1]
NP_001245269.1. NM_001258340.1.
NP_001245270.1. NM_001258341.1. [Q8N4M1-6]
NP_001245271.1. NM_001258342.1. [Q8N4M1-3]
NP_001245272.1. NM_001258343.1. [Q8N4M1-4]
NP_001288008.1. NM_001301079.1.
NP_689582.2. NM_152369.4. [Q8N4M1-2]
XP_005270498.1. XM_005270441.1. [Q8N4M1-2]
UniGeneiHs.483423.

3D structure databases

ProteinModelPortaliQ8N4M1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126026. 2 interactions.
STRINGi9606.ENSP00000271227.

Chemistry

DrugBankiDB00122. Choline.

Protein family/group databases

TCDBi2.A.92.1.3. the choline transporter-like (ctl) family.

PTM databases

PhosphoSiteiQ8N4M1.

Polymorphism databases

DMDMi259016387.

Proteomic databases

MaxQBiQ8N4M1.
PaxDbiQ8N4M1.
PRIDEiQ8N4M1.

Protocols and materials databases

DNASUi126969.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271227; ENSP00000271227; ENSG00000143036. [Q8N4M1-1]
ENST00000446120; ENSP00000389143; ENSG00000143036. [Q8N4M1-3]
ENST00000467909; ENSP00000432789; ENSG00000143036. [Q8N4M1-2]
ENST00000527077; ENSP00000433641; ENSG00000143036. [Q8N4M1-4]
ENST00000529450; ENSP00000431836; ENSG00000143036. [Q8N4M1-6]
GeneIDi126969.
KEGGihsa:126969.
UCSCiuc001dqv.5. human. [Q8N4M1-1]
uc010otr.3. human. [Q8N4M1-3]

Organism-specific databases

CTDi126969.
GeneCardsiGC01P095286.
H-InvDBHIX0023639.
HGNCiHGNC:28689. SLC44A3.
HPAiHPA047433.
neXtProtiNX_Q8N4M1.
PharmGKBiPA142670900.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG310633.
GeneTreeiENSGT00550000074521.
HOGENOMiHOG000231655.
HOVERGENiHBG080361.
InParanoidiQ8N4M1.
KOiK15282.
OMAiCTDTAWL.
OrthoDBiEOG72JWFP.
PhylomeDBiQ8N4M1.
TreeFamiTF313325.

Enzyme and pathway databases

ReactomeiREACT_121238. Synthesis of PC.
REACT_19305. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Miscellaneous databases

ChiTaRSiSLC44A3. human.
GenomeRNAii126969.
NextBioi81968.
PROiQ8N4M1.

Gene expression databases

BgeeiQ8N4M1.
CleanExiHS_SLC44A3.
ExpressionAtlasiQ8N4M1. baseline and differential.
GenevestigatoriQ8N4M1.

Family and domain databases

InterProiIPR007603. Choline_transptr-like.
[Graphical view]
PANTHERiPTHR12385. PTHR12385. 1 hit.
PfamiPF04515. Choline_transpo. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5), VARIANT ILE-438.
    Tissue: Colon, Stomach and Trachea.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ILE-438.
    Tissue: Brain and Colon.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 147-653.
  5. "An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins."
    O'Regan S., Traiffort E., Ruat M., Cha N., Compaore D., Meunier F.-M.
    Proc. Natl. Acad. Sci. U.S.A. 97:1835-1840(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, NOMENCLATURE.
  6. Cited for: VARIANT TRP-441.

Entry informationi

Entry nameiCTL3_HUMAN
AccessioniPrimary (citable) accession number: Q8N4M1
Secondary accession number(s): B4DVY4
, B4E1M4, B7ZA08, E9PJH2, E9PJY8, Q6UWT1, Q7Z6C5, Q9BWY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: September 22, 2009
Last modified: February 4, 2015
This is version 102 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.