Q8N4M1 (CTL3_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 83.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Choline transporter-like protein 3 Alternative name(s): Solute carrier family 44 member 3 | ||||||
| Gene names |
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| Organism | Homo sapiens (Human) [Reference proteome] | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 653 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Subcellular location | Membrane; Multi-pass membrane protein By similarity. |
| Sequence similarities | Belongs to the CTL (choline transporter-like) family. |
| Sequence caution | The sequence AAH33858.2 differs from that shown. Reason: Erroneous initiation. The sequence AAQ89022.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Transmembrane Transmembrane helix |
| PTM | Glycoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | phosphatidylcholine biosynthetic process Traceable author statement. Source: Reactome transmembrane transportTraceable author statement. Source: Reactome |
| Cellular_component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneTraceable author statement. Source: Reactome |
| Complete GO annotation... | |
Alternative products
| This entry describes 5 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q8N4M1-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q8N4M1-2) The sequence of this isoform differs from the canonical sequence as follows: 1-48: Missing. | ||||||
| Isoform 3 (identifier: Q8N4M1-3) The sequence of this isoform differs from the canonical sequence as follows: 11-46: Missing. | ||||||
| Isoform 4 (identifier: Q8N4M1-4) The sequence of this isoform differs from the canonical sequence as follows: 11-46: Missing. 107-138: Missing. | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform 5 (identifier: Q8N4M1-5) The sequence of this isoform differs from the canonical sequence as follows: 1-48: Missing. 107-138: Missing. 465-465: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 653 | 653 | Choline transporter-like protein 3 | PRO_0000191720 | |||||
Regions | |||||||||
| Transmembrane | 34 – 54 | 21 | Helical; Potential | ||||||
| Transmembrane | 213 – 233 | 21 | Helical; Potential | ||||||
| Transmembrane | 243 – 263 | 21 | Helical; Potential | ||||||
| Transmembrane | 284 – 304 | 21 | Helical; Potential | ||||||
| Transmembrane | 334 – 354 | 21 | Helical; Potential | ||||||
| Transmembrane | 384 – 404 | 21 | Helical; Potential | ||||||
| Transmembrane | 534 – 554 | 21 | Helical; Potential | ||||||
| Transmembrane | 563 – 583 | 21 | Helical; Potential | ||||||
| Compositional bias | 477 – 484 | 8 | Cys-rich | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 136 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 151 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 412 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 503 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 521 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 48 | 48 | Missing in isoform 2 and isoform 5. | VSP_036151 | |||||
| Alternative sequence | 11 – 46 | 36 | Missing in isoform 3 and isoform 4. | VSP_036152 | |||||
| Alternative sequence | 107 – 138 | 32 | Missing in isoform 4 and isoform 5. | VSP_044713 | |||||
| Alternative sequence | 465 | 1 | Missing in isoform 5. | VSP_045974 | |||||
| Natural variant | 438 | 1 | V → I. Ref.1 Ref.3 Corresponds to variant rs859098 [ dbSNP | Ensembl ]. | VAR_023405 | |||||
| Natural variant | 441 | 1 | G → W Found in a renal cell carcinoma sample; somatic mutation. Ref.6 | VAR_064752 | |||||
Experimental info | |||||||||
| Sequence conflict | 3 | 1 | C → R in BAG62846. Ref.1 | ||||||
| Sequence conflict | 316 | 1 | F → L in BAG62846. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5), VARIANT ILE-438. Tissue: Colon, Stomach and Trachea. |
| [2] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ILE-438. Tissue: Brain and Colon. |
| [4] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 147-653. |
| [5] | "An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins." O'Regan S., Traiffort E., Ruat M., Cha N., Compaore D., Meunier F.-M. Proc. Natl. Acad. Sci. U.S.A. 97:1835-1840(2000) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, NOMENCLATURE. |
| [6] | "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma." Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H., Jones D., Lin M.L., Teague J., Bignell G., Butler A., Cho J., Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C., Jia M. Futreal P.A.Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT TRP-441. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AK303906 mRNA. Translation: BAG64836.1. AK301288 mRNA. Translation: BAG62846.1. AK316123 mRNA. Translation: BAH14494.1. AC093429 Genomic DNA. No translation available. AL359554 Genomic DNA. Translation: CAC36091.1. BC033858 mRNA. Translation: AAH33858.2. Different initiation. BC053877 mRNA. Translation: AAH53877.1. AY358659 mRNA. Translation: AAQ89022.1. Different initiation. |
| IPI | IPI00296714. IPI00396115. IPI00917110. IPI00983999. IPI00984686. |
| RefSeq | NP_001107578.1. NM_001114106.2. NP_001245269.1. NM_001258340.1. NP_001245270.1. NM_001258341.1. NP_001245271.1. NM_001258342.1. NP_001245272.1. NM_001258343.1. NP_689582.2. NM_152369.4. |
| UniGene | Hs.483423. |
3D structure databases | |
| ProteinModelPortal | Q8N4M1. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 9606.ENSP00000271227. |
PTM databases | |
| PhosphoSite | Q8N4M1. |
Polymorphism databases | |
| DMDM | 259016387. |
Proteomic databases | |
| PaxDb | Q8N4M1. |
| PRIDE | Q8N4M1. |
Protocols and materials databases | |
| DNASU | 126969. |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000271227; ENSP00000271227; ENSG00000143036. ENST00000446120; ENSP00000389143; ENSG00000143036. ENST00000467909; ENSP00000432789; ENSG00000143036. ENST00000527077; ENSP00000433641; ENSG00000143036. |
| GeneID | 126969. |
| KEGG | hsa:126969. |
| UCSC | uc001dqv.4. human. uc010otr.2. human. |
Organism-specific databases | |
| CTD | 126969. |
| GeneCards | GC01P095286. |
| H-InvDB | HIX0023639. |
| HGNC | HGNC:28689. SLC44A3. |
| HPA | HPA047433. |
| neXtProt | NX_Q8N4M1. |
| PharmGKB | PA142670900. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | NOG310633. |
| HOGENOM | HOG000231655. |
| HOVERGEN | HBG080361. |
| InParanoid | Q8N4M1. |
| KO | K15282. |
| OMA | CTDTAWL. |
| OrthoDB | EOG412M50. |
Enzyme and pathway databases | |
| Reactome | REACT_111217. Metabolism. REACT_15518. Transmembrane transport of small molecules. REACT_20679. Amine compound SLC transporters. |
Gene expression databases | |
| ArrayExpress | Q8N4M1. |
| Bgee | Q8N4M1. |
| CleanEx | HS_SLC44A3. |
| Genevestigator | Q8N4M1. |
| GermOnline | ENSG00000143036. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR007603. Choline_transptr-like. [Graphical view] |
| PANTHER | PTHR12385. PTHR12385. 1 hit. |
| Pfam | PF04515. Choline_transpo. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| ChiTaRS | SLC44A3. human. |
| DrugBank | DB00122. Choline. |
| GenomeRNAi | 126969. |
| NextBio | 81968. |
Entry information
| Entry name | CTL3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8N4M1 Secondary accession number(s): B4DVY4 Q9BWY7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

Clusters with
