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Protein

Choline transporter-like protein 3

Gene

SLC44A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143036-MONOMER.
ReactomeiR-HSA-1483191. Synthesis of PC.
R-HSA-425366. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Protein family/group databases

TCDBi2.A.92.1.3. the choline transporter-like (ctl) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Choline transporter-like protein 3
Alternative name(s):
Solute carrier family 44 member 3
Gene namesi
Name:SLC44A3
Synonyms:CTL3
ORF Names:UNQ558/PRO1115
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28689. SLC44A3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Transmembranei284 – 304HelicalSequence analysisAdd BLAST21
Transmembranei334 – 354HelicalSequence analysisAdd BLAST21
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Transmembranei534 – 554HelicalSequence analysisAdd BLAST21
Transmembranei563 – 583HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi126969.
OpenTargetsiENSG00000143036.
PharmGKBiPA142670900.

Chemistry databases

DrugBankiDB00122. Choline.

Polymorphism and mutation databases

BioMutaiSLC44A3.
DMDMi259016387.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001917201 – 653Choline transporter-like protein 3Add BLAST653

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi136N-linked (GlcNAc...)Sequence analysis1
Glycosylationi151N-linked (GlcNAc...)Sequence analysis1
Glycosylationi412N-linked (GlcNAc...)Sequence analysis1
Glycosylationi503N-linked (GlcNAc...)Sequence analysis1
Glycosylationi521N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8N4M1.
PaxDbiQ8N4M1.
PeptideAtlasiQ8N4M1.
PRIDEiQ8N4M1.

PTM databases

iPTMnetiQ8N4M1.
PhosphoSitePlusiQ8N4M1.

Expressioni

Gene expression databases

BgeeiENSG00000143036.
CleanExiHS_SLC44A3.
ExpressionAtlasiQ8N4M1. baseline and differential.
GenevisibleiQ8N4M1. HS.

Organism-specific databases

HPAiHPA047433.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FHL3Q136433EBI-10265585,EBI-741101

Protein-protein interaction databases

BioGridi126026. 1 interactor.
IntActiQ8N4M1. 2 interactors.
STRINGi9606.ENSP00000271227.

Structurei

3D structure databases

ProteinModelPortaliQ8N4M1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi477 – 484Cys-rich8

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1362. Eukaryota.
ENOG410XS0P. LUCA.
GeneTreeiENSGT00550000074521.
HOGENOMiHOG000231655.
HOVERGENiHBG080361.
InParanoidiQ8N4M1.
KOiK15282.
OMAiKCTDTAW.
OrthoDBiEOG091G0CMQ.
PhylomeDBiQ8N4M1.
TreeFamiTF313325.

Family and domain databases

InterProiIPR007603. Choline_transptr-like.
[Graphical view]
PANTHERiPTHR12385. PTHR12385. 1 hit.
PfamiPF04515. Choline_transpo. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N4M1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHCLGAEYLV SAEGAPRQRE WRPQIYRKCT DTAWLFLFFL FWTGLVFIMG
60 70 80 90 100
YSVVAGAAGR LLFGYDSFGN MCGKKNSPVE GAPLSGQDMT LKKHVFFMNS
110 120 130 140 150
CNLEVKGTQL NRMALCVSNC PEEQLDSLEE VQFFANTSGS FLCVYSLNSF
160 170 180 190 200
NYTHSPKADS LCPRLPVPPS KSFPLFNRCV PQTPECYSLF ASVLINDVDT
210 220 230 240 250
LHRILSGIMS GRDTILGLCI LALALSLAMM FTFRFITTLL VHIFISLVIL
260 270 280 290 300
GLLFVCGVLW WLYYDYTNDL SIELDTEREN MKCVLGFAIV STGITAVLLV
310 320 330 340 350
LIFVLRKRIK LTVELFQITN KAISSAPFLL FQPLWTFAIL IFFWVLWVAV
360 370 380 390 400
LLSLGTAGAA QVMEGGQVEY KPLSGIRYMW SYHLIGLIWT SEFILACQQM
410 420 430 440 450
TIAGAVVTCY FNRSKNDPPD HPILSSLSIL FFYHQGTVVK GSFLISVVRI
460 470 480 490 500
PRIIVMYMQN ALKEQQHGAL SRYLFRCCYC CFWCLDKYLL HLNQNAYTTT
510 520 530 540 550
AINGTDFCTS AKDAFKILSK NSSHFTSINC FGDFIIFLGK VLVVCFTVFG
560 570 580 590 600
GLMAFNYNRA FQVWAVPLLL VAFFAYLVAH SFLSVFETVL DALFLCFAVD
610 620 630 640 650
LETNDGSSEK PYFMDQEFLS FVKRSNKLNN ARAQQDKHSL RNEEGTELQA

IVR
Length:653
Mass (Da):73,783
Last modified:September 22, 2009 - v4
Checksum:i083859F3FC332382
GO
Isoform 2 (identifier: Q8N4M1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.

Show »
Length:605
Mass (Da):68,033
Checksum:i4D3A762E69E3BB24
GO
Isoform 3 (identifier: Q8N4M1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-46: Missing.

Show »
Length:617
Mass (Da):69,410
Checksum:i2E5CE3201DEB5EE2
GO
Isoform 4 (identifier: Q8N4M1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-46: Missing.
     107-138: Missing.

Note: No experimental confirmation available.
Show »
Length:585
Mass (Da):65,853
Checksum:iEB0DF13AC1E723B7
GO
Isoform 5 (identifier: Q8N4M1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     107-138: Missing.
     465-465: Missing.

Note: No experimental confirmation available.
Show »
Length:572
Mass (Da):64,348
Checksum:i4DDA14D76622D2A2
GO
Isoform 6 (identifier: Q8N4M1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-138: Missing.
     465-465: Missing.

Note: No experimental confirmation available.
Show »
Length:620
Mass (Da):70,098
Checksum:iD18ABAFA2ECD4B5C
GO

Sequence cautioni

The sequence AAH33858 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ89022 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3C → R in BAG62846 (PubMed:14702039).Curated1
Sequence conflicti316F → L in BAG62846 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023405438V → I.2 PublicationsCorresponds to variant rs859098dbSNPEnsembl.1
Natural variantiVAR_064752441G → W Found in a renal cell carcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0361511 – 48Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST48
Alternative sequenceiVSP_03615211 – 46Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_044713107 – 138Missing in isoform 4, isoform 5 and isoform 6. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_045974465Missing in isoform 5 and isoform 6. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303906 mRNA. Translation: BAG64836.1.
AK301288 mRNA. Translation: BAG62846.1.
AK316123 mRNA. Translation: BAH14494.1.
AC093429 Genomic DNA. No translation available.
AL359554 Genomic DNA. Translation: CAC36091.1.
BC033858 mRNA. Translation: AAH33858.2. Different initiation.
BC053877 mRNA. Translation: AAH53877.1.
AY358659 mRNA. Translation: AAQ89022.1. Different initiation.
CCDSiCCDS44176.1. [Q8N4M1-1]
CCDS58011.1. [Q8N4M1-6]
CCDS58012.1. [Q8N4M1-4]
CCDS58013.1. [Q8N4M1-3]
CCDS751.1. [Q8N4M1-2]
RefSeqiNP_001107578.1. NM_001114106.2. [Q8N4M1-1]
NP_001245269.1. NM_001258340.1.
NP_001245270.1. NM_001258341.1. [Q8N4M1-6]
NP_001245271.1. NM_001258342.1. [Q8N4M1-3]
NP_001245272.1. NM_001258343.1. [Q8N4M1-4]
NP_001288008.1. NM_001301079.1.
NP_689582.2. NM_152369.4. [Q8N4M1-2]
XP_005270498.1. XM_005270441.2. [Q8N4M1-2]
UniGeneiHs.483423.

Genome annotation databases

EnsembliENST00000271227; ENSP00000271227; ENSG00000143036. [Q8N4M1-1]
ENST00000446120; ENSP00000389143; ENSG00000143036. [Q8N4M1-3]
ENST00000467909; ENSP00000432789; ENSG00000143036. [Q8N4M1-2]
ENST00000527077; ENSP00000433641; ENSG00000143036. [Q8N4M1-4]
ENST00000529450; ENSP00000431836; ENSG00000143036. [Q8N4M1-6]
GeneIDi126969.
KEGGihsa:126969.
UCSCiuc001dqv.6. human. [Q8N4M1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303906 mRNA. Translation: BAG64836.1.
AK301288 mRNA. Translation: BAG62846.1.
AK316123 mRNA. Translation: BAH14494.1.
AC093429 Genomic DNA. No translation available.
AL359554 Genomic DNA. Translation: CAC36091.1.
BC033858 mRNA. Translation: AAH33858.2. Different initiation.
BC053877 mRNA. Translation: AAH53877.1.
AY358659 mRNA. Translation: AAQ89022.1. Different initiation.
CCDSiCCDS44176.1. [Q8N4M1-1]
CCDS58011.1. [Q8N4M1-6]
CCDS58012.1. [Q8N4M1-4]
CCDS58013.1. [Q8N4M1-3]
CCDS751.1. [Q8N4M1-2]
RefSeqiNP_001107578.1. NM_001114106.2. [Q8N4M1-1]
NP_001245269.1. NM_001258340.1.
NP_001245270.1. NM_001258341.1. [Q8N4M1-6]
NP_001245271.1. NM_001258342.1. [Q8N4M1-3]
NP_001245272.1. NM_001258343.1. [Q8N4M1-4]
NP_001288008.1. NM_001301079.1.
NP_689582.2. NM_152369.4. [Q8N4M1-2]
XP_005270498.1. XM_005270441.2. [Q8N4M1-2]
UniGeneiHs.483423.

3D structure databases

ProteinModelPortaliQ8N4M1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126026. 1 interactor.
IntActiQ8N4M1. 2 interactors.
STRINGi9606.ENSP00000271227.

Chemistry databases

DrugBankiDB00122. Choline.

Protein family/group databases

TCDBi2.A.92.1.3. the choline transporter-like (ctl) family.

PTM databases

iPTMnetiQ8N4M1.
PhosphoSitePlusiQ8N4M1.

Polymorphism and mutation databases

BioMutaiSLC44A3.
DMDMi259016387.

Proteomic databases

MaxQBiQ8N4M1.
PaxDbiQ8N4M1.
PeptideAtlasiQ8N4M1.
PRIDEiQ8N4M1.

Protocols and materials databases

DNASUi126969.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271227; ENSP00000271227; ENSG00000143036. [Q8N4M1-1]
ENST00000446120; ENSP00000389143; ENSG00000143036. [Q8N4M1-3]
ENST00000467909; ENSP00000432789; ENSG00000143036. [Q8N4M1-2]
ENST00000527077; ENSP00000433641; ENSG00000143036. [Q8N4M1-4]
ENST00000529450; ENSP00000431836; ENSG00000143036. [Q8N4M1-6]
GeneIDi126969.
KEGGihsa:126969.
UCSCiuc001dqv.6. human. [Q8N4M1-1]

Organism-specific databases

CTDi126969.
DisGeNETi126969.
GeneCardsiSLC44A3.
H-InvDBHIX0023639.
HGNCiHGNC:28689. SLC44A3.
HPAiHPA047433.
neXtProtiNX_Q8N4M1.
OpenTargetsiENSG00000143036.
PharmGKBiPA142670900.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1362. Eukaryota.
ENOG410XS0P. LUCA.
GeneTreeiENSGT00550000074521.
HOGENOMiHOG000231655.
HOVERGENiHBG080361.
InParanoidiQ8N4M1.
KOiK15282.
OMAiKCTDTAW.
OrthoDBiEOG091G0CMQ.
PhylomeDBiQ8N4M1.
TreeFamiTF313325.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143036-MONOMER.
ReactomeiR-HSA-1483191. Synthesis of PC.
R-HSA-425366. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Miscellaneous databases

ChiTaRSiSLC44A3. human.
GenomeRNAii126969.
PROiQ8N4M1.

Gene expression databases

BgeeiENSG00000143036.
CleanExiHS_SLC44A3.
ExpressionAtlasiQ8N4M1. baseline and differential.
GenevisibleiQ8N4M1. HS.

Family and domain databases

InterProiIPR007603. Choline_transptr-like.
[Graphical view]
PANTHERiPTHR12385. PTHR12385. 1 hit.
PfamiPF04515. Choline_transpo. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTL3_HUMAN
AccessioniPrimary (citable) accession number: Q8N4M1
Secondary accession number(s): B4DVY4
, B4E1M4, B7ZA08, E9PJH2, E9PJY8, Q6UWT1, Q7Z6C5, Q9BWY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: September 22, 2009
Last modified: November 30, 2016
This is version 116 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.