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Q8N4M1 (CTL3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Choline transporter-like protein 3
Alternative name(s):
Solute carrier family 44 member 3
Gene names
Name:SLC44A3
Synonyms:CTL3
ORF Names:UNQ558/PRO1115
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length653 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the CTL (choline transporter-like) family.

Sequence caution

The sequence AAH33858.2 differs from that shown. Reason: Erroneous initiation.

The sequence AAQ89022.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N4M1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N4M1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
Isoform 3 (identifier: Q8N4M1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     11-46: Missing.
Isoform 4 (identifier: Q8N4M1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     11-46: Missing.
     107-138: Missing.
Note: No experimental confirmation available.
Isoform 5 (identifier: Q8N4M1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     107-138: Missing.
     465-465: Missing.
Note: No experimental confirmation available.
Isoform 6 (identifier: Q8N4M1-6)

The sequence of this isoform differs from the canonical sequence as follows:
     107-138: Missing.
     465-465: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 653653Choline transporter-like protein 3
PRO_0000191720

Regions

Transmembrane34 – 5421Helical; Potential
Transmembrane213 – 23321Helical; Potential
Transmembrane243 – 26321Helical; Potential
Transmembrane284 – 30421Helical; Potential
Transmembrane334 – 35421Helical; Potential
Transmembrane384 – 40421Helical; Potential
Transmembrane534 – 55421Helical; Potential
Transmembrane563 – 58321Helical; Potential
Compositional bias477 – 4848Cys-rich

Amino acid modifications

Glycosylation1361N-linked (GlcNAc...) Potential
Glycosylation1511N-linked (GlcNAc...) Potential
Glycosylation4121N-linked (GlcNAc...) Potential
Glycosylation5031N-linked (GlcNAc...) Potential
Glycosylation5211N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 4848Missing in isoform 2 and isoform 5.
VSP_036151
Alternative sequence11 – 4636Missing in isoform 3 and isoform 4.
VSP_036152
Alternative sequence107 – 13832Missing in isoform 4, isoform 5 and isoform 6.
VSP_044713
Alternative sequence4651Missing in isoform 5 and isoform 6.
VSP_045974
Natural variant4381V → I. Ref.1 Ref.3
Corresponds to variant rs859098 [ dbSNP | Ensembl ].
VAR_023405
Natural variant4411G → W Found in a renal cell carcinoma sample; somatic mutation. Ref.6
VAR_064752

Experimental info

Sequence conflict31C → R in BAG62846. Ref.1
Sequence conflict3161F → L in BAG62846. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 22, 2009. Version 4.
Checksum: 083859F3FC332382

FASTA65373,783
        10         20         30         40         50         60 
MHCLGAEYLV SAEGAPRQRE WRPQIYRKCT DTAWLFLFFL FWTGLVFIMG YSVVAGAAGR 

        70         80         90        100        110        120 
LLFGYDSFGN MCGKKNSPVE GAPLSGQDMT LKKHVFFMNS CNLEVKGTQL NRMALCVSNC 

       130        140        150        160        170        180 
PEEQLDSLEE VQFFANTSGS FLCVYSLNSF NYTHSPKADS LCPRLPVPPS KSFPLFNRCV 

       190        200        210        220        230        240 
PQTPECYSLF ASVLINDVDT LHRILSGIMS GRDTILGLCI LALALSLAMM FTFRFITTLL 

       250        260        270        280        290        300 
VHIFISLVIL GLLFVCGVLW WLYYDYTNDL SIELDTEREN MKCVLGFAIV STGITAVLLV 

       310        320        330        340        350        360 
LIFVLRKRIK LTVELFQITN KAISSAPFLL FQPLWTFAIL IFFWVLWVAV LLSLGTAGAA 

       370        380        390        400        410        420 
QVMEGGQVEY KPLSGIRYMW SYHLIGLIWT SEFILACQQM TIAGAVVTCY FNRSKNDPPD 

       430        440        450        460        470        480 
HPILSSLSIL FFYHQGTVVK GSFLISVVRI PRIIVMYMQN ALKEQQHGAL SRYLFRCCYC 

       490        500        510        520        530        540 
CFWCLDKYLL HLNQNAYTTT AINGTDFCTS AKDAFKILSK NSSHFTSINC FGDFIIFLGK 

       550        560        570        580        590        600 
VLVVCFTVFG GLMAFNYNRA FQVWAVPLLL VAFFAYLVAH SFLSVFETVL DALFLCFAVD 

       610        620        630        640        650 
LETNDGSSEK PYFMDQEFLS FVKRSNKLNN ARAQQDKHSL RNEEGTELQA IVR 

« Hide

Isoform 2 [UniParc].

Checksum: 4D3A762E69E3BB24
Show »

FASTA60568,033
Isoform 3 [UniParc].

Checksum: 2E5CE3201DEB5EE2
Show »

FASTA61769,410
Isoform 4 [UniParc].

Checksum: EB0DF13AC1E723B7
Show »

FASTA58565,853
Isoform 5 [UniParc].

Checksum: 4DDA14D76622D2A2
Show »

FASTA57264,348
Isoform 6 [UniParc].

Checksum: D18ABAFA2ECD4B5C
Show »

FASTA62070,098

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5), VARIANT ILE-438.
Tissue: Colon, Stomach and Trachea.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ILE-438.
Tissue: Brain and Colon.
[4]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 147-653.
[5]"An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins."
O'Regan S., Traiffort E., Ruat M., Cha N., Compaore D., Meunier F.-M.
Proc. Natl. Acad. Sci. U.S.A. 97:1835-1840(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, NOMENCLATURE.
[6]"Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma."
Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H., Jones D., Lin M.L., Teague J., Bignell G., Butler A., Cho J., Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C., Jia M. expand/collapse author list , Latimer C., Lau K.W., Marshall J., McLaren S., Menzies A., Mudie L., Stebbings L., Largaespada D.A., Wessels L.F.A., Richard S., Kahnoski R.J., Anema J., Tuveson D.A., Perez-Mancera P.A., Mustonen V., Fischer A., Adams D.J., Rust A., Chan-On W., Subimerb C., Dykema K., Furge K., Campbell P.J., Teh B.T., Stratton M.R., Futreal P.A.
Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT TRP-441.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK303906 mRNA. Translation: BAG64836.1.
AK301288 mRNA. Translation: BAG62846.1.
AK316123 mRNA. Translation: BAH14494.1.
AC093429 Genomic DNA. No translation available.
AL359554 Genomic DNA. Translation: CAC36091.1.
BC033858 mRNA. Translation: AAH33858.2. Different initiation.
BC053877 mRNA. Translation: AAH53877.1.
AY358659 mRNA. Translation: AAQ89022.1. Different initiation.
CCDSCCDS44176.1. [Q8N4M1-1]
CCDS58011.1. [Q8N4M1-6]
CCDS58012.1. [Q8N4M1-4]
CCDS58013.1. [Q8N4M1-3]
CCDS751.1. [Q8N4M1-2]
RefSeqNP_001107578.1. NM_001114106.2. [Q8N4M1-1]
NP_001245269.1. NM_001258340.1.
NP_001245270.1. NM_001258341.1. [Q8N4M1-6]
NP_001245271.1. NM_001258342.1. [Q8N4M1-3]
NP_001245272.1. NM_001258343.1. [Q8N4M1-4]
NP_689582.2. NM_152369.4. [Q8N4M1-2]
XP_005270498.1. XM_005270441.1. [Q8N4M1-2]
UniGeneHs.483423.

3D structure databases

ProteinModelPortalQ8N4M1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126026. 1 interaction.
STRING9606.ENSP00000271227.

Chemistry

DrugBankDB00122. Choline.

Protein family/group databases

TCDB2.A.92.1.3. the choline transporter-like (ctl) family.

PTM databases

PhosphoSiteQ8N4M1.

Polymorphism databases

DMDM259016387.

Proteomic databases

MaxQBQ8N4M1.
PaxDbQ8N4M1.
PRIDEQ8N4M1.

Protocols and materials databases

DNASU126969.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000271227; ENSP00000271227; ENSG00000143036. [Q8N4M1-1]
ENST00000446120; ENSP00000389143; ENSG00000143036. [Q8N4M1-3]
ENST00000467909; ENSP00000432789; ENSG00000143036. [Q8N4M1-2]
ENST00000527077; ENSP00000433641; ENSG00000143036. [Q8N4M1-4]
ENST00000529450; ENSP00000431836; ENSG00000143036. [Q8N4M1-6]
GeneID126969.
KEGGhsa:126969.
UCSCuc001dqv.5. human. [Q8N4M1-1]
uc010otr.3. human. [Q8N4M1-3]

Organism-specific databases

CTD126969.
GeneCardsGC01P095286.
H-InvDBHIX0023639.
HGNCHGNC:28689. SLC44A3.
HPAHPA047433.
neXtProtNX_Q8N4M1.
PharmGKBPA142670900.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG310633.
HOGENOMHOG000231655.
HOVERGENHBG080361.
InParanoidQ8N4M1.
KOK15282.
OMACTDTAWL.
OrthoDBEOG72JWFP.
PhylomeDBQ8N4M1.
TreeFamTF313325.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_15518. Transmembrane transport of small molecules.
REACT_20679. Amine compound SLC transporters.

Gene expression databases

ArrayExpressQ8N4M1.
BgeeQ8N4M1.
CleanExHS_SLC44A3.
GenevestigatorQ8N4M1.

Family and domain databases

InterProIPR007603. Choline_transptr-like.
[Graphical view]
PANTHERPTHR12385. PTHR12385. 1 hit.
PfamPF04515. Choline_transpo. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC44A3. human.
GenomeRNAi126969.
NextBio81968.
PROQ8N4M1.

Entry information

Entry nameCTL3_HUMAN
AccessionPrimary (citable) accession number: Q8N4M1
Secondary accession number(s): B4DVY4 expand/collapse secondary AC list , B4E1M4, B7ZA08, E9PJH2, E9PJY8, Q6UWT1, Q7Z6C5, Q9BWY7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: September 22, 2009
Last modified: July 9, 2014
This is version 96 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM