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Q8N4L8

- CCD24_HUMAN

UniProt

Q8N4L8 - CCD24_HUMAN

Protein

Coiled-coil domain-containing protein 24

Gene

CCDC24

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coiled-coil domain-containing protein 24
    Gene namesi
    Name:CCDC24
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:28688. CCDC24.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672182.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 307307Coiled-coil domain-containing protein 24PRO_0000233666Add
    BLAST

    Proteomic databases

    MaxQBiQ8N4L8.
    PaxDbiQ8N4L8.
    PRIDEiQ8N4L8.

    Expressioni

    Gene expression databases

    BgeeiQ8N4L8.
    CleanExiHS_CCDC24.
    GenevestigatoriQ8N4L8.

    Organism-specific databases

    HPAiHPA035424.

    Interactioni

    Protein-protein interaction databases

    BioGridi127217. 1 interaction.
    IntActiQ8N4L8. 1 interaction.
    STRINGi9606.ENSP00000361392.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N4L8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili168 – 22558Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG46835.
    HOGENOMiHOG000111406.
    HOVERGENiHBG081038.
    InParanoidiQ8N4L8.
    OMAiQCCLPAP.
    OrthoDBiEOG7G1V7K.
    PhylomeDBiQ8N4L8.
    TreeFamiTF336952.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N4L8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLRHSPSLWE LVEEHVPLRE RREVKRILGE AAVDLSLELR AEVAMLRALL    50
    QEARSSQAPS SRPISDPSSL LAPPPLLKDL LRQELRQLLQ GLRHKAICEG 100
    RDQAQAWVQY SPRVLHFALE EPRCDLPEQE IFQMRGGGPS SGHRDLSIIK 150
    DQLNVSNIDQ VARHLRGLLE EECHTLEREI LILQRCLEEE YLRPCHPSEA 200
    ALEPTLAELK EQKKAMEQEL QASVGPSCVS PNHRQRPLGS STQGLRPPLP 250
    LCGVAPLQCC LPAPPLEPYL RPRGQSATHR WGRQLQCSPR EGPASTPMSS 300
    AAPQAPA 307
    Length:307
    Mass (Da):34,322
    Last modified:October 1, 2002 - v1
    Checksum:i55B2AD791E85B1F4
    GO
    Isoform 2 (identifier: Q8N4L8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         43-78: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:271
    Mass (Da):30,542
    Checksum:i787EBCD8761C8700
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 271I → V in AAR39430. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei43 – 7836Missing in isoform 2. 1 PublicationVSP_018148Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY487420 mRNA. Translation: AAR39430.1.
    AL139220 Genomic DNA. Translation: CAI19427.1.
    BC033868 mRNA. Translation: AAH33868.1.
    CCDSiCCDS507.1. [Q8N4L8-1]
    RefSeqiNP_689712.1. NM_152499.1. [Q8N4L8-1]
    XP_005270581.1. XM_005270524.1. [Q8N4L8-2]
    UniGeneiHs.632394.

    Genome annotation databases

    EnsembliENST00000372318; ENSP00000361392; ENSG00000159214. [Q8N4L8-1]
    GeneIDi149473.
    KEGGihsa:149473.
    UCSCiuc001clj.3. human. [Q8N4L8-1]
    uc009vxc.3. human. [Q8N4L8-2]

    Polymorphism databases

    DMDMi74750991.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY487420 mRNA. Translation: AAR39430.1 .
    AL139220 Genomic DNA. Translation: CAI19427.1 .
    BC033868 mRNA. Translation: AAH33868.1 .
    CCDSi CCDS507.1. [Q8N4L8-1 ]
    RefSeqi NP_689712.1. NM_152499.1. [Q8N4L8-1 ]
    XP_005270581.1. XM_005270524.1. [Q8N4L8-2 ]
    UniGenei Hs.632394.

    3D structure databases

    ProteinModelPortali Q8N4L8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127217. 1 interaction.
    IntActi Q8N4L8. 1 interaction.
    STRINGi 9606.ENSP00000361392.

    Polymorphism databases

    DMDMi 74750991.

    Proteomic databases

    MaxQBi Q8N4L8.
    PaxDbi Q8N4L8.
    PRIDEi Q8N4L8.

    Protocols and materials databases

    DNASUi 149473.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372318 ; ENSP00000361392 ; ENSG00000159214 . [Q8N4L8-1 ]
    GeneIDi 149473.
    KEGGi hsa:149473.
    UCSCi uc001clj.3. human. [Q8N4L8-1 ]
    uc009vxc.3. human. [Q8N4L8-2 ]

    Organism-specific databases

    CTDi 149473.
    GeneCardsi GC01P044457.
    HGNCi HGNC:28688. CCDC24.
    HPAi HPA035424.
    neXtProti NX_Q8N4L8.
    PharmGKBi PA142672182.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46835.
    HOGENOMi HOG000111406.
    HOVERGENi HBG081038.
    InParanoidi Q8N4L8.
    OMAi QCCLPAP.
    OrthoDBi EOG7G1V7K.
    PhylomeDBi Q8N4L8.
    TreeFami TF336952.

    Miscellaneous databases

    GenomeRNAii 149473.
    NextBioi 86172.
    PROi Q8N4L8.

    Gene expression databases

    Bgeei Q8N4L8.
    CleanExi HS_CCDC24.
    Genevestigatori Q8N4L8.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. Zhou G., Zhong G., Ke R., Li H., Shen C., Lin L., Yang S.
      Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.

    Entry informationi

    Entry nameiCCD24_HUMAN
    AccessioniPrimary (citable) accession number: Q8N4L8
    Secondary accession number(s): Q6RWT2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM

    External Data

    Dasty 3