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Q8N4L8 (CCD24_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coiled-coil domain-containing protein 24
Gene names
Name:CCDC24
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N4L8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N4L8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     43-78: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307Coiled-coil domain-containing protein 24
PRO_0000233666

Regions

Coiled coil168 – 22558 Potential

Natural variations

Alternative sequence43 – 7836Missing in isoform 2.
VSP_018148

Experimental info

Sequence conflict271I → V in AAR39430. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 55B2AD791E85B1F4

FASTA30734,322
        10         20         30         40         50         60 
MLRHSPSLWE LVEEHVPLRE RREVKRILGE AAVDLSLELR AEVAMLRALL QEARSSQAPS 

        70         80         90        100        110        120 
SRPISDPSSL LAPPPLLKDL LRQELRQLLQ GLRHKAICEG RDQAQAWVQY SPRVLHFALE 

       130        140        150        160        170        180 
EPRCDLPEQE IFQMRGGGPS SGHRDLSIIK DQLNVSNIDQ VARHLRGLLE EECHTLEREI 

       190        200        210        220        230        240 
LILQRCLEEE YLRPCHPSEA ALEPTLAELK EQKKAMEQEL QASVGPSCVS PNHRQRPLGS 

       250        260        270        280        290        300 
STQGLRPPLP LCGVAPLQCC LPAPPLEPYL RPRGQSATHR WGRQLQCSPR EGPASTPMSS 


AAPQAPA 

« Hide

Isoform 2 [UniParc].

Checksum: 787EBCD8761C8700
Show »

FASTA27130,542

References

« Hide 'large scale' references
[1]Zhou G., Zhong G., Ke R., Li H., Shen C., Lin L., Yang S.
Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lung.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY487420 mRNA. Translation: AAR39430.1.
AL139220 Genomic DNA. Translation: CAI19427.1.
BC033868 mRNA. Translation: AAH33868.1.
RefSeqNP_689712.1. NM_152499.1.
XP_005270581.1. XM_005270524.1.
UniGeneHs.632394.

3D structure databases

ProteinModelPortalQ8N4L8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127217. 1 interaction.
IntActQ8N4L8. 1 interaction.
STRING9606.ENSP00000361392.

Polymorphism databases

DMDM74750991.

Proteomic databases

PaxDbQ8N4L8.
PRIDEQ8N4L8.

Protocols and materials databases

DNASU149473.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000372318; ENSP00000361392; ENSG00000159214. [Q8N4L8-1]
GeneID149473.
KEGGhsa:149473.
UCSCuc001clj.3. human. [Q8N4L8-1]
uc009vxc.3. human. [Q8N4L8-2]

Organism-specific databases

CTD149473.
GeneCardsGC01P044457.
HGNCHGNC:28688. CCDC24.
HPAHPA035424.
neXtProtNX_Q8N4L8.
PharmGKBPA142672182.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46835.
HOGENOMHOG000111406.
HOVERGENHBG081038.
InParanoidQ8N4L8.
OMAQCCLPAP.
OrthoDBEOG7G1V7K.
PhylomeDBQ8N4L8.
TreeFamTF336952.

Gene expression databases

BgeeQ8N4L8.
CleanExHS_CCDC24.
GenevestigatorQ8N4L8.

Family and domain databases

ProtoNetSearch...

Other

GenomeRNAi149473.
NextBio86172.
PROQ8N4L8.

Entry information

Entry nameCCD24_HUMAN
AccessionPrimary (citable) accession number: Q8N4L8
Secondary accession number(s): Q6RWT2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 1, 2002
Last modified: March 19, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM