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Q8N4L8

- CCD24_HUMAN

UniProt

Q8N4L8 - CCD24_HUMAN

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Protein

Coiled-coil domain-containing protein 24

Gene

CCDC24

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 24
Gene namesi
Name:CCDC24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:28688. CCDC24.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672182.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Coiled-coil domain-containing protein 24PRO_0000233666Add
BLAST

Proteomic databases

MaxQBiQ8N4L8.
PaxDbiQ8N4L8.
PRIDEiQ8N4L8.

Expressioni

Gene expression databases

BgeeiQ8N4L8.
CleanExiHS_CCDC24.
ExpressionAtlasiQ8N4L8. baseline and differential.
GenevestigatoriQ8N4L8.

Organism-specific databases

HPAiHPA035424.

Interactioni

Protein-protein interaction databases

BioGridi127217. 1 interaction.
IntActiQ8N4L8. 3 interactions.
STRINGi9606.ENSP00000361392.

Structurei

3D structure databases

ProteinModelPortaliQ8N4L8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili168 – 22558Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG46835.
GeneTreeiENSGT00390000011926.
HOGENOMiHOG000111406.
HOVERGENiHBG081038.
InParanoidiQ8N4L8.
OMAiQCCLPAP.
OrthoDBiEOG7G1V7K.
PhylomeDBiQ8N4L8.
TreeFamiTF336952.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N4L8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRHSPSLWE LVEEHVPLRE RREVKRILGE AAVDLSLELR AEVAMLRALL
60 70 80 90 100
QEARSSQAPS SRPISDPSSL LAPPPLLKDL LRQELRQLLQ GLRHKAICEG
110 120 130 140 150
RDQAQAWVQY SPRVLHFALE EPRCDLPEQE IFQMRGGGPS SGHRDLSIIK
160 170 180 190 200
DQLNVSNIDQ VARHLRGLLE EECHTLEREI LILQRCLEEE YLRPCHPSEA
210 220 230 240 250
ALEPTLAELK EQKKAMEQEL QASVGPSCVS PNHRQRPLGS STQGLRPPLP
260 270 280 290 300
LCGVAPLQCC LPAPPLEPYL RPRGQSATHR WGRQLQCSPR EGPASTPMSS

AAPQAPA
Length:307
Mass (Da):34,322
Last modified:October 1, 2002 - v1
Checksum:i55B2AD791E85B1F4
GO
Isoform 2 (identifier: Q8N4L8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-78: Missing.

Note: No experimental confirmation available.

Show »
Length:271
Mass (Da):30,542
Checksum:i787EBCD8761C8700
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271I → V in AAR39430. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei43 – 7836Missing in isoform 2. 1 PublicationVSP_018148Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY487420 mRNA. Translation: AAR39430.1.
AL139220 Genomic DNA. Translation: CAI19427.1.
BC033868 mRNA. Translation: AAH33868.1.
CCDSiCCDS507.1. [Q8N4L8-1]
RefSeqiNP_689712.1. NM_152499.1. [Q8N4L8-1]
XP_005270581.1. XM_005270524.1. [Q8N4L8-2]
UniGeneiHs.632394.

Genome annotation databases

EnsembliENST00000372318; ENSP00000361392; ENSG00000159214. [Q8N4L8-1]
GeneIDi149473.
KEGGihsa:149473.
UCSCiuc001clj.3. human. [Q8N4L8-1]
uc009vxc.3. human. [Q8N4L8-2]

Polymorphism databases

DMDMi74750991.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY487420 mRNA. Translation: AAR39430.1 .
AL139220 Genomic DNA. Translation: CAI19427.1 .
BC033868 mRNA. Translation: AAH33868.1 .
CCDSi CCDS507.1. [Q8N4L8-1 ]
RefSeqi NP_689712.1. NM_152499.1. [Q8N4L8-1 ]
XP_005270581.1. XM_005270524.1. [Q8N4L8-2 ]
UniGenei Hs.632394.

3D structure databases

ProteinModelPortali Q8N4L8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127217. 1 interaction.
IntActi Q8N4L8. 3 interactions.
STRINGi 9606.ENSP00000361392.

Polymorphism databases

DMDMi 74750991.

Proteomic databases

MaxQBi Q8N4L8.
PaxDbi Q8N4L8.
PRIDEi Q8N4L8.

Protocols and materials databases

DNASUi 149473.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000372318 ; ENSP00000361392 ; ENSG00000159214 . [Q8N4L8-1 ]
GeneIDi 149473.
KEGGi hsa:149473.
UCSCi uc001clj.3. human. [Q8N4L8-1 ]
uc009vxc.3. human. [Q8N4L8-2 ]

Organism-specific databases

CTDi 149473.
GeneCardsi GC01P044457.
HGNCi HGNC:28688. CCDC24.
HPAi HPA035424.
neXtProti NX_Q8N4L8.
PharmGKBi PA142672182.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46835.
GeneTreei ENSGT00390000011926.
HOGENOMi HOG000111406.
HOVERGENi HBG081038.
InParanoidi Q8N4L8.
OMAi QCCLPAP.
OrthoDBi EOG7G1V7K.
PhylomeDBi Q8N4L8.
TreeFami TF336952.

Miscellaneous databases

GenomeRNAii 149473.
NextBioi 86172.
PROi Q8N4L8.

Gene expression databases

Bgeei Q8N4L8.
CleanExi HS_CCDC24.
ExpressionAtlasi Q8N4L8. baseline and differential.
Genevestigatori Q8N4L8.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Zhou G., Zhong G., Ke R., Li H., Shen C., Lin L., Yang S.
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.

Entry informationi

Entry nameiCCD24_HUMAN
AccessioniPrimary (citable) accession number: Q8N4L8
Secondary accession number(s): Q6RWT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM

External Data

Dasty 3