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Protein

Coiled-coil domain-containing protein 24

Gene

CCDC24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 24
Gene namesi
Name:CCDC24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000159214.12.
HGNCiHGNC:28688. CCDC24.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000159214.
PharmGKBiPA142672182.

Polymorphism and mutation databases

BioMutaiCCDC24.
DMDMi74750991.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002336661 – 307Coiled-coil domain-containing protein 24Add BLAST307

Proteomic databases

PaxDbiQ8N4L8.
PeptideAtlasiQ8N4L8.
PRIDEiQ8N4L8.

Expressioni

Gene expression databases

BgeeiENSG00000159214.
CleanExiHS_CCDC24.
ExpressionAtlasiQ8N4L8. baseline and differential.
GenevisibleiQ8N4L8. HS.

Organism-specific databases

HPAiHPA035424.
HPA061710.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi127217. 5 interactors.
IntActiQ8N4L8. 29 interactors.
STRINGi9606.ENSP00000361392.

Structurei

3D structure databases

ProteinModelPortaliQ8N4L8.
SMRiQ8N4L8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili168 – 225Sequence analysisAdd BLAST58

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IW4J. Eukaryota.
ENOG41125IY. LUCA.
GeneTreeiENSGT00390000011926.
HOGENOMiHOG000111406.
HOVERGENiHBG081038.
InParanoidiQ8N4L8.
OMAiTCRWGRK.
OrthoDBiEOG091G1373.
PhylomeDBiQ8N4L8.
TreeFamiTF336952.

Family and domain databases

InterProiView protein in InterPro
IPR031367. CCDC24.
PfamiView protein in Pfam
PF15669. CCDC24. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N4L8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRHSPSLWE LVEEHVPLRE RREVKRILGE AAVDLSLELR AEVAMLRALL
60 70 80 90 100
QEARSSQAPS SRPISDPSSL LAPPPLLKDL LRQELRQLLQ GLRHKAICEG
110 120 130 140 150
RDQAQAWVQY SPRVLHFALE EPRCDLPEQE IFQMRGGGPS SGHRDLSIIK
160 170 180 190 200
DQLNVSNIDQ VARHLRGLLE EECHTLEREI LILQRCLEEE YLRPCHPSEA
210 220 230 240 250
ALEPTLAELK EQKKAMEQEL QASVGPSCVS PNHRQRPLGS STQGLRPPLP
260 270 280 290 300
LCGVAPLQCC LPAPPLEPYL RPRGQSATHR WGRQLQCSPR EGPASTPMSS

AAPQAPA
Length:307
Mass (Da):34,322
Last modified:October 1, 2002 - v1
Checksum:i55B2AD791E85B1F4
GO
Isoform 2 (identifier: Q8N4L8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-78: Missing.

Note: No experimental confirmation available.
Show »
Length:271
Mass (Da):30,542
Checksum:i787EBCD8761C8700
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27I → V in AAR39430 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01814843 – 78Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY487420 mRNA. Translation: AAR39430.1.
AL139220 Genomic DNA. Translation: CAI19427.1.
BC033868 mRNA. Translation: AAH33868.1.
CCDSiCCDS507.1. [Q8N4L8-1]
RefSeqiNP_689712.1. NM_152499.2. [Q8N4L8-1]
XP_016855930.1. XM_017000441.1. [Q8N4L8-2]
UniGeneiHs.632394.

Genome annotation databases

EnsembliENST00000372318; ENSP00000361392; ENSG00000159214. [Q8N4L8-1]
GeneIDi149473.
KEGGihsa:149473.
UCSCiuc001clj.4. human. [Q8N4L8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCCD24_HUMAN
AccessioniPrimary (citable) accession number: Q8N4L8
Secondary accession number(s): Q6RWT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM