Q8N4L8 (CCD24_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Coiled-coil domain-containing protein 24

Gene names

Name:

CCDC24

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N4L8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N4L8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     43-78: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 307	307	Coiled-coil domain-containing protein 24		PRO_0000233666
Regions
	Coiled coil	168 – 225	58	Potential
Natural variations
	Alternative sequence	43 – 78	36	Missing in isoform 2.		VSP_018148
Experimental info
	Sequence conflict	27	1	I → V in AAR39430. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 55B2AD791E85B1F4	FASTA	307	34,322
	10 20 30 40 50 60 MLRHSPSLWE LVEEHVPLRE RREVKRILGE AAVDLSLELR AEVAMLRALL QEARSSQAPS 70 80 90 100 110 120 SRPISDPSSL LAPPPLLKDL LRQELRQLLQ GLRHKAICEG RDQAQAWVQY SPRVLHFALE 130 140 150 160 170 180 EPRCDLPEQE IFQMRGGGPS SGHRDLSIIK DQLNVSNIDQ VARHLRGLLE EECHTLEREI 190 200 210 220 230 240 LILQRCLEEE YLRPCHPSEA ALEPTLAELK EQKKAMEQEL QASVGPSCVS PNHRQRPLGS 250 260 270 280 290 300 STQGLRPPLP LCGVAPLQCC LPAPPLEPYL RPRGQSATHR WGRQLQCSPR EGPASTPMSS AAPQAPA
	Isoform 2 [UniParc]. Checksum: 787EBCD8761C8700	FASTA	271	30,542
	10 20 30 40 50 60 MLRHSPSLWE LVEEHVPLRE RREVKRILGE AAVDLSLELR AEDLLRQELR QLLQGLRHKA 70 80 90 100 110 120 ICEGRDQAQA WVQYSPRVLH FALEEPRCDL PEQEIFQMRG GGPSSGHRDL SIIKDQLNVS 130 140 150 160 170 180 NIDQVARHLR GLLEEECHTL EREILILQRC LEEEYLRPCH PSEAALEPTL AELKEQKKAM 190 200 210 220 230 240 EQELQASVGP SCVSPNHRQR PLGSSTQGLR PPLPLCGVAP LQCCLPAPPL EPYLRPRGQS 250 260 270 ATHRWGRQLQ CSPREGPAST PMSSAAPQAP A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Zhou G., Zhong G., Ke R., Li H., Shen C., Lin L., Yang S. Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY487420 mRNA. Translation: AAR39430.1. AL139220 Genomic DNA. Translation: CAI19427.1. BC033868 mRNA. Translation: AAH33868.1.
IPI	IPI00166724. IPI00746143.
RefSeq	NP_689712.1. NM_152499.1.
UniGene	Hs.632394.
3D structure databases
ProteinModelPortal	Q8N4L8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8N4L8. 1 interaction.
STRING	9606.ENSP00000361392.
Polymorphism databases
DMDM	74750991.
Proteomic databases
PaxDb	Q8N4L8.
PRIDE	Q8N4L8.
Protocols and materials databases
DNASU	149473.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000372318; ENSP00000361392; ENSG00000159214.
GeneID	149473.
KEGG	hsa:149473.
UCSC	uc001clj.3. human. uc009vxc.3. human.
Organism-specific databases
CTD	149473.
GeneCards	GC01P044457.
HGNC	HGNC:28688. CCDC24.
neXtProt	NX_Q8N4L8.
PharmGKB	PA142672182.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46835.
HOGENOM	HOG000111406.
HOVERGEN	HBG081038.
InParanoid	Q8N4L8.
OMA	QCCLPAP.
OrthoDB	EOG49W2GJ.
PhylomeDB	Q8N4L8.
Gene expression databases
Bgee	Q8N4L8.
CleanEx	HS_CCDC24.
Genevestigator	Q8N4L8.
GermOnline	ENSG00000159214. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	149473.
NextBio	86172.

Entry information

Entry name

CCD24_HUMAN

Accession

Primary (citable) accession number: Q8N4L8
Secondary accession number(s): Q6RWT2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	October 1, 2002
Last modified:	April 3, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.