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Protein

Spermatid maturation protein 1

Gene

SPEM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Required for proper cytoplasm removal during spermatogenesis.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatid maturation protein 1
Gene namesi
Name:SPEM1
Synonyms:C17orf83
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:32429. SPEM1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 4921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162404476.

Polymorphism and mutation databases

BioMutaiSPEM1.
DMDMi74728870.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Spermatid maturation protein 1PRO_0000307806Add
BLAST

Proteomic databases

PaxDbiQ8N4L4.
PRIDEiQ8N4L4.

PTM databases

PhosphoSiteiQ8N4L4.

Expressioni

Gene expression databases

BgeeiQ8N4L4.
CleanExiHS_SPEM1.
GenevisibleiQ8N4L4. HS.

Interactioni

Protein-protein interaction databases

BioGridi131920. 2 interactions.
STRINGi9606.ENSP00000315554.

Structurei

3D structure databases

ProteinModelPortaliQ8N4L4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili259 – 28527Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi209 – 2146Poly-Pro

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2CE. Eukaryota.
ENOG41118KW. LUCA.
GeneTreeiENSGT00510000049389.
HOGENOMiHOG000154380.
HOVERGENiHBG108506.
InParanoidiQ8N4L4.
OMAiAWAPDTD.
OrthoDBiEOG7CG713.
PhylomeDBiQ8N4L4.
TreeFamiTF338031.

Family and domain databases

InterProiIPR031368. SPEM1_N.
[Graphical view]
PfamiPF15670. Spem1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N4L4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMVERPRPE WASYHNCNSN SCQDLGNSVL LLLGLIICIN ISINIVTLLW
60 70 80 90 100
SRFRGVLYQV FHDTICEKEA PKSSLLRKQT QPPKKQSSPA VHLRCTMDPV
110 120 130 140 150
MMTVSPPPAH RHRRRGSPTR CAHCPVAWAP DTDDEKPHQY PAICSYHWDV
160 170 180 190 200
PEDWEGFQHT QGTWVPWSQD APESPPQTIR FQPTVEERPL KTGIWSELGL
210 220 230 240 250
RAYVYPVNPP PPSPEAPSHK NGGEGAVPEA EAAQYQPVPA PTLGPAVIPE
260 270 280 290 300
FSRHRSSGRI VYDARDMRRR LRELTREVEA LSGCYPLASG SSTAEETSKN

WVYRSLTGR
Length:309
Mass (Da):34,773
Last modified:October 1, 2002 - v1
Checksum:i55C2CAD33C8670E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC033882 mRNA. Translation: AAH33882.1.
CCDSiCCDS42254.1.
RefSeqiNP_955371.2. NM_199339.2.
UniGeneiHs.710599.

Genome annotation databases

EnsembliENST00000323675; ENSP00000315554; ENSG00000181323.
GeneIDi374768.
KEGGihsa:374768.
UCSCiuc002ggv.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC033882 mRNA. Translation: AAH33882.1.
CCDSiCCDS42254.1.
RefSeqiNP_955371.2. NM_199339.2.
UniGeneiHs.710599.

3D structure databases

ProteinModelPortaliQ8N4L4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131920. 2 interactions.
STRINGi9606.ENSP00000315554.

PTM databases

PhosphoSiteiQ8N4L4.

Polymorphism and mutation databases

BioMutaiSPEM1.
DMDMi74728870.

Proteomic databases

PaxDbiQ8N4L4.
PRIDEiQ8N4L4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323675; ENSP00000315554; ENSG00000181323.
GeneIDi374768.
KEGGihsa:374768.
UCSCiuc002ggv.3. human.

Organism-specific databases

CTDi374768.
GeneCardsiSPEM1.
HGNCiHGNC:32429. SPEM1.
MIMi615116. gene.
neXtProtiNX_Q8N4L4.
PharmGKBiPA162404476.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2CE. Eukaryota.
ENOG41118KW. LUCA.
GeneTreeiENSGT00510000049389.
HOGENOMiHOG000154380.
HOVERGENiHBG108506.
InParanoidiQ8N4L4.
OMAiAWAPDTD.
OrthoDBiEOG7CG713.
PhylomeDBiQ8N4L4.
TreeFamiTF338031.

Miscellaneous databases

GenomeRNAii374768.
NextBioi100255.
PROiQ8N4L4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N4L4.
CleanExiHS_SPEM1.
GenevisibleiQ8N4L4. HS.

Family and domain databases

InterProiIPR031368. SPEM1_N.
[Graphical view]
PfamiPF15670. Spem1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiSPEM1_HUMAN
AccessioniPrimary (citable) accession number: Q8N4L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2002
Last modified: November 11, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.