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Protein

Spermatid maturation protein 1

Gene

SPEM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Required for proper cytoplasm removal during spermatogenesis.By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatid maturation protein 1
Gene namesi
Name:SPEM1
Synonyms:C17orf83
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000181323.7.
HGNCiHGNC:32429. SPEM1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000181323.
PharmGKBiPA162404476.

Polymorphism and mutation databases

BioMutaiSPEM1.
DMDMi74728870.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003078061 – 309Spermatid maturation protein 1Add BLAST309

Proteomic databases

PaxDbiQ8N4L4.
PeptideAtlasiQ8N4L4.
PRIDEiQ8N4L4.

PTM databases

iPTMnetiQ8N4L4.
PhosphoSitePlusiQ8N4L4.

Expressioni

Gene expression databases

BgeeiENSG00000181323.
CleanExiHS_SPEM1.
GenevisibleiQ8N4L4. HS.

Interactioni

Protein-protein interaction databases

BioGridi131920. 2 interactors.
IntActiQ8N4L4. 1 interactor.
STRINGi9606.ENSP00000315554.

Structurei

3D structure databases

ProteinModelPortaliQ8N4L4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili259 – 285Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi209 – 214Poly-Pro6

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2CE. Eukaryota.
ENOG41118KW. LUCA.
GeneTreeiENSGT00510000049389.
HOGENOMiHOG000154380.
HOVERGENiHBG108506.
InParanoidiQ8N4L4.
OMAiAWAPDTD.
OrthoDBiEOG091G0L7A.
PhylomeDBiQ8N4L4.
TreeFamiTF338031.

Family and domain databases

InterProiView protein in InterPro
IPR031368. SPEM1_N.
PfamiView protein in Pfam
PF15670. Spem1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8N4L4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMVERPRPE WASYHNCNSN SCQDLGNSVL LLLGLIICIN ISINIVTLLW
60 70 80 90 100
SRFRGVLYQV FHDTICEKEA PKSSLLRKQT QPPKKQSSPA VHLRCTMDPV
110 120 130 140 150
MMTVSPPPAH RHRRRGSPTR CAHCPVAWAP DTDDEKPHQY PAICSYHWDV
160 170 180 190 200
PEDWEGFQHT QGTWVPWSQD APESPPQTIR FQPTVEERPL KTGIWSELGL
210 220 230 240 250
RAYVYPVNPP PPSPEAPSHK NGGEGAVPEA EAAQYQPVPA PTLGPAVIPE
260 270 280 290 300
FSRHRSSGRI VYDARDMRRR LRELTREVEA LSGCYPLASG SSTAEETSKN

WVYRSLTGR
Length:309
Mass (Da):34,773
Last modified:October 1, 2002 - v1
Checksum:i55C2CAD33C8670E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC033882 mRNA. Translation: AAH33882.1.
CCDSiCCDS42254.1.
RefSeqiNP_955371.2. NM_199339.2.
UniGeneiHs.710599.

Genome annotation databases

EnsembliENST00000323675; ENSP00000315554; ENSG00000181323.
ENST00000640564; ENSP00000492561; ENSG00000284598.
GeneIDi374768.
KEGGihsa:374768.
UCSCiuc002ggv.3. human.

Similar proteinsi

Entry informationi

Entry nameiSPEM1_HUMAN
AccessioniPrimary (citable) accession number: Q8N4L4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot