Reviewed, UniProtKB/Swiss-Prot Q8N4H5 (TOM5_HUMAN)

Names and origin

Protein names

Recommended name:
    Mitochondrial import receptor subunit TOM5 homolog

Gene names

Name:	TOMM5
Synonyms:	C9orf105, TOM5

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	51 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).
Subcellular location	Mitochondrion outer membrane; Single-pass membrane protein. Ref.1
Sequence similarities	Belongs to the Tom5 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Membrane Mitochondrion Mitochondrion outer membrane
Domain	Transmembrane
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein targeting to mitochondrion Ref.1 Inferred by curator. Source: UniProtKB
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial outer membrane translocase complex Ref.1 Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 51	51	Mitochondrial import receptor subunit TOM5 homolog		PRO_0000230671
Regions
	Transmembrane	27 – 45	19	Potential
Amino acid modifications
	Modified residue	46	1	N6-acetyllysine Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q8N4H5-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 5B5204D78754B0FE	FASTA	51	6,035
	10 20 30 40 50 MFRIEGLAPK LDPEEMKRKM REDVISSIRN FLIYVALLRV TPFILKKLDS I

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane." Kato H., Mihara K. Biochem. Biophys. Res. Commun. 369:958-963(2008) [PubMed: 18331822] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION IN THE TOM COMPLEX, SUBCELLULAR LOCATION.
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
[4]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[5]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-46, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB435233 mRNA. Translation: BAG30953.1. AL513165 Genomic DNA. Translation: CAI16154.1. BC034247 mRNA. Translation: AAH34247.1.
IPI	IPI00166704.
RefSeq	NP_001001790.1.
UniGene	Hs.130774
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q8N4H5.
Genome annotation databases
Ensembl	ENST00000321301; ENSP00000313584; ENSG00000175768; Homo sapiens. [Genome view] ENST00000377773; ENSP00000367004; ENSG00000175768; Homo sapiens. [Genome view] ENST00000401811; ENSP00000384411; ENSG00000175768; Homo sapiens. [Genome view]
GeneID	401505.
KEGG	hsa:401505.
UCSC	uc010mlx.1. human.
Organism-specific databases
CTD	401505.
GeneCards	GC09M037582.
HGNC	HGNC:31369. TOMM5.
PharmGKB	PA134994263.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8N4H5.
Gene expression databases
ArrayExpress	Q8N4H5.
Bgee	Q8N4H5.
CleanEx	HS_TOMM5.
Genevestigator	Q8N4H5.
GermOnline	ENSG00000175768. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	106916.

Entry information

Entry name

TOM5_HUMAN

Accession

Primary (citable) accession number: Q8N4H5
Secondary accession number(s): B2DG07

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	October 1, 2002
Last modified:	October 13, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.