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Protein

Mitochondrial import receptor subunit TOM5 homolog

Gene

TOMM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • cellular protein metabolic process Source: Reactome
  • macroautophagy Source: Reactome
  • macromitophagy Source: Reactome
  • protein targeting to mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1268020. Mitochondrial protein import.
R-HSA-5205685. Pink/Parkin Mediated Mitophagy.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM5 homolog
Gene namesi
Name:TOMM5
Synonyms:C9orf105, TOM5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:31369. TOMM5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4519HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164726670.

Polymorphism and mutation databases

BioMutaiTOMM5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5151Mitochondrial import receptor subunit TOM5 homologPRO_0000230671Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8N4H5.
MaxQBiQ8N4H5.
PRIDEiQ8N4H5.
TopDownProteomicsiQ8N4H5-1. [Q8N4H5-1]

PTM databases

iPTMnetiQ8N4H5.
PhosphoSiteiQ8N4H5.

Expressioni

Gene expression databases

BgeeiQ8N4H5.
CleanExiHS_TOMM5.
ExpressionAtlasiQ8N4H5. baseline and differential.
GenevisibleiQ8N4H5. HS.

Organism-specific databases

HPAiHPA048712.

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).1 Publication

Protein-protein interaction databases

BioGridi135117. 2 interactions.
IntActiQ8N4H5. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8N4H5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Tom5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000009431.
HOGENOMiHOG000138179.
HOVERGENiHBG056232.
InParanoidiQ8N4H5.
KOiK17773.
OMAiKATGICA.
PhylomeDBiQ8N4H5.
TreeFamiTF333449.

Family and domain databases

InterProiIPR029179. TOMM5.
[Graphical view]
PfamiPF15178. TOM_sub5. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N4H5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFRIEGLAPK LDPEEMKRKM REDVISSIRN FLIYVALLRV TPFILKKLDS

I
Length:51
Mass (Da):6,035
Last modified:October 1, 2002 - v1
Checksum:i5B5204D78754B0FE
GO
Isoform 2 (identifier: Q8N4H5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-51: TPFILKKLDSI → SECLPGCDCETSGELTDGHPLTLRGHRGLRTELNGSGEQGGCALKATGICAV

Note: No experimental confirmation available.
Show »
Length:92
Mass (Da):10,033
Checksum:i61F347FC28616523
GO
Isoform 3 (identifier: Q8N4H5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-41: T → SECLPGCDCETSGELTDGHPLTLRGHRGLRTELNA

Note: No experimental confirmation available.
Show »
Length:85
Mass (Da):9,655
Checksum:iBD2A49CC8E4B5167
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei41 – 5111TPFILKKLDSI → SECLPGCDCETSGELTDGHP LTLRGHRGLRTELNGSGEQG GCALKATGICAV in isoform 2. CuratedVSP_046982Add
BLAST
Alternative sequencei41 – 411T → SECLPGCDCETSGELTDGHP LTLRGHRGLRTELNA in isoform 3. CuratedVSP_046983

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB435233 mRNA. Translation: BAG30953.1.
AL513165 Genomic DNA. Translation: CAI16154.1.
BC034247 mRNA. Translation: AAH34247.1.
CCDSiCCDS43803.1. [Q8N4H5-1]
CCDS47967.1. [Q8N4H5-3]
CCDS47968.1. [Q8N4H5-2]
RefSeqiNP_001001790.1. NM_001001790.2. [Q8N4H5-1]
NP_001127956.1. NM_001134484.1. [Q8N4H5-2]
NP_001127957.1. NM_001134485.1. [Q8N4H5-3]
UniGeneiHs.130774.

Genome annotation databases

EnsembliENST00000321301; ENSP00000313584; ENSG00000175768. [Q8N4H5-1]
ENST00000377773; ENSP00000367004; ENSG00000175768. [Q8N4H5-3]
ENST00000544379; ENSP00000438204; ENSG00000175768. [Q8N4H5-2]
GeneIDi401505.
KEGGihsa:401505.
UCSCiuc004aaf.4. human. [Q8N4H5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB435233 mRNA. Translation: BAG30953.1.
AL513165 Genomic DNA. Translation: CAI16154.1.
BC034247 mRNA. Translation: AAH34247.1.
CCDSiCCDS43803.1. [Q8N4H5-1]
CCDS47967.1. [Q8N4H5-3]
CCDS47968.1. [Q8N4H5-2]
RefSeqiNP_001001790.1. NM_001001790.2. [Q8N4H5-1]
NP_001127956.1. NM_001134484.1. [Q8N4H5-2]
NP_001127957.1. NM_001134485.1. [Q8N4H5-3]
UniGeneiHs.130774.

3D structure databases

ProteinModelPortaliQ8N4H5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi135117. 2 interactions.
IntActiQ8N4H5. 1 interaction.

PTM databases

iPTMnetiQ8N4H5.
PhosphoSiteiQ8N4H5.

Polymorphism and mutation databases

BioMutaiTOMM5.

Proteomic databases

EPDiQ8N4H5.
MaxQBiQ8N4H5.
PRIDEiQ8N4H5.
TopDownProteomicsiQ8N4H5-1. [Q8N4H5-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321301; ENSP00000313584; ENSG00000175768. [Q8N4H5-1]
ENST00000377773; ENSP00000367004; ENSG00000175768. [Q8N4H5-3]
ENST00000544379; ENSP00000438204; ENSG00000175768. [Q8N4H5-2]
GeneIDi401505.
KEGGihsa:401505.
UCSCiuc004aaf.4. human. [Q8N4H5-1]

Organism-specific databases

CTDi401505.
GeneCardsiTOMM5.
HGNCiHGNC:31369. TOMM5.
HPAiHPA048712.
MIMi616169. gene.
neXtProtiNX_Q8N4H5.
PharmGKBiPA164726670.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000009431.
HOGENOMiHOG000138179.
HOVERGENiHBG056232.
InParanoidiQ8N4H5.
KOiK17773.
OMAiKATGICA.
PhylomeDBiQ8N4H5.
TreeFamiTF333449.

Enzyme and pathway databases

ReactomeiR-HSA-1268020. Mitochondrial protein import.
R-HSA-5205685. Pink/Parkin Mediated Mitophagy.

Miscellaneous databases

GenomeRNAii401505.
NextBioi106916.
PROiQ8N4H5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N4H5.
CleanExiHS_TOMM5.
ExpressionAtlasiQ8N4H5. baseline and differential.
GenevisibleiQ8N4H5. HS.

Family and domain databases

InterProiIPR029179. TOMM5.
[Graphical view]
PfamiPF15178. TOM_sub5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane."
    Kato H., Mihara K.
    Biochem. Biophys. Res. Commun. 369:958-963(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION IN THE TOM COMPLEX, SUBCELLULAR LOCATION.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTOM5_HUMAN
AccessioniPrimary (citable) accession number: Q8N4H5
Secondary accession number(s): B2DG07, F6S928, Q5JRT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 1, 2002
Last modified: April 13, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.