Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8N4F7

- RN175_HUMAN

UniProt

Q8N4F7 - RN175_HUMAN

Protein

RING finger protein 175

Gene

RNF175

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri227 – 27751RING-type; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RING finger protein 175
    Gene namesi
    Name:RNF175
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:27735. RNF175.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134909663.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 328328RING finger protein 175PRO_0000245599Add
    BLAST

    Proteomic databases

    PaxDbiQ8N4F7.
    PRIDEiQ8N4F7.

    PTM databases

    PhosphoSiteiQ8N4F7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N4F7.
    BgeeiQ8N4F7.
    CleanExiHS_RNF175.
    GenevestigatoriQ8N4F7.

    Organism-specific databases

    HPAiHPA028830.
    HPA035837.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N4F7.
    SMRiQ8N4F7. Positions 226-283.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei51 – 7121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei83 – 10321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei104 – 12118HelicalSequence AnalysisAdd
    BLAST
    Transmembranei149 – 16921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei180 – 20021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri227 – 27751RING-type; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Transmembrane, Transmembrane helix, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG327922.
    HOGENOMiHOG000021822.
    HOVERGENiHBG061177.
    InParanoidiQ8N4F7.
    OMAiNPWERTH.
    OrthoDBiEOG7R831T.
    PhylomeDBiQ8N4F7.
    TreeFamiTF314357.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF13639. zf-RING_2. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    [Graphical view]
    PROSITEiPS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N4F7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAGTAARKA APVLEAPPQQ EQLSHTKLSA EDTWNLQQER MYKMHRGHDS    50
    MHVEMILIFL CVLVIAQIVL VQWRQRHGRS YNLVTLLQMW VVPLYFTIKL 100
    YWWRFLSMWG MFSVITSYIL FRATRKPLSG RTPRLVYKWF LLIYKLSYAF 150
    GVVGYLAIMF TMCGFNLFFK IKARDSMDFG IVSLFYGLYY GVMGRDFAEI 200
    CSDYMASTIG FYSVSRLPTR SLSDNICAVC GQKIIVELDE EGLIENTYQL 250
    SCNHVFHEFC IRGWCIVGKK QTCPYCKEKV DLKRMISNPW ERTHFLYGQI 300
    LDWLRYLVAW QPVVIGIVQG IIYSLGLE 328
    Length:328
    Mass (Da):38,266
    Last modified:May 18, 2010 - v2
    Checksum:iA9EAAE7B4A75B524
    GO
    Isoform 2 (identifier: Q8N4F7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-6: MAAGTA → MADPTI
         7-134: Missing.
         256-309: FHEFCIRGWC...ILDWLRYLVA → YPFQRKLFGL...AQSSLPVCPC
         310-328: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:181
    Mass (Da):20,321
    Checksum:i240860CA5495634D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti159 – 1591M → V.
    Corresponds to variant rs10517577 [ dbSNP | Ensembl ].
    VAR_026998
    Natural varianti307 – 3071L → F.
    Corresponds to variant rs1337 [ dbSNP | Ensembl ].
    VAR_026999
    Natural varianti315 – 3151I → M.
    Corresponds to variant rs1339 [ dbSNP | Ensembl ].
    VAR_027000
    Natural varianti322 – 3221I → N.1 Publication
    Corresponds to variant rs2405432 [ dbSNP | Ensembl ].
    VAR_027001

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 66MAAGTA → MADPTI in isoform 2. 1 PublicationVSP_055433
    Alternative sequencei7 – 134128Missing in isoform 2. 1 PublicationVSP_055434Add
    BLAST
    Alternative sequencei256 – 30954FHEFC…RYLVA → YPFQRKLFGLHQASFFPPSP PPPPVPISSILLTFHAQTPV LYPPAQSSLPVCPC in isoform 2. 1 PublicationVSP_055435Add
    BLAST
    Alternative sequencei310 – 32819Missing in isoform 2. 1 PublicationVSP_055436Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK091509 mRNA. Translation: BAC03680.1.
    AC020703 Genomic DNA. No translation available.
    AC106865 Genomic DNA. No translation available.
    CH471056 Genomic DNA. Translation: EAX04951.1.
    BC034385 mRNA. Translation: AAH34385.1.
    CCDSiCCDS47149.1.
    RefSeqiNP_775933.1. NM_173662.2.
    UniGeneiHs.388364.

    Genome annotation databases

    EnsembliENST00000347063; ENSP00000340979; ENSG00000145428. [Q8N4F7-1]
    GeneIDi285533.
    KEGGihsa:285533.
    UCSCiuc003int.3. human.

    Polymorphism databases

    DMDMi296452878.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK091509 mRNA. Translation: BAC03680.1 .
    AC020703 Genomic DNA. No translation available.
    AC106865 Genomic DNA. No translation available.
    CH471056 Genomic DNA. Translation: EAX04951.1 .
    BC034385 mRNA. Translation: AAH34385.1 .
    CCDSi CCDS47149.1.
    RefSeqi NP_775933.1. NM_173662.2.
    UniGenei Hs.388364.

    3D structure databases

    ProteinModelPortali Q8N4F7.
    SMRi Q8N4F7. Positions 226-283.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8N4F7.

    Polymorphism databases

    DMDMi 296452878.

    Proteomic databases

    PaxDbi Q8N4F7.
    PRIDEi Q8N4F7.

    Protocols and materials databases

    DNASUi 285533.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000347063 ; ENSP00000340979 ; ENSG00000145428 . [Q8N4F7-1 ]
    GeneIDi 285533.
    KEGGi hsa:285533.
    UCSCi uc003int.3. human.

    Organism-specific databases

    CTDi 285533.
    GeneCardsi GC04M154631.
    HGNCi HGNC:27735. RNF175.
    HPAi HPA028830.
    HPA035837.
    neXtProti NX_Q8N4F7.
    PharmGKBi PA134909663.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG327922.
    HOGENOMi HOG000021822.
    HOVERGENi HBG061177.
    InParanoidi Q8N4F7.
    OMAi NPWERTH.
    OrthoDBi EOG7R831T.
    PhylomeDBi Q8N4F7.
    TreeFami TF314357.

    Miscellaneous databases

    GenomeRNAii 285533.
    NextBioi 95591.
    PROi Q8N4F7.

    Gene expression databases

    ArrayExpressi Q8N4F7.
    Bgeei Q8N4F7.
    CleanExi HS_RNF175.
    Genevestigatori Q8N4F7.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF13639. zf-RING_2. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    [Graphical view ]
    PROSITEi PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASN-322.
      Tissue: Brain.

    Entry informationi

    Entry nameiRN175_HUMAN
    AccessioniPrimary (citable) accession number: Q8N4F7
    Secondary accession number(s): C9JL66, Q8NB61
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3