Q8N4F7 (RN175_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RING finger protein 175

Gene names

Name:

RNF175

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	328 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Contains 1 RING-type zinc finger.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 328	328	RING finger protein 175		PRO_0000245599
Regions
	Transmembrane	51 – 71	21	Helical; Potential
	Transmembrane	83 – 103	21	Helical; Potential
	Transmembrane	104 – 121	18	Helical; Potential
	Transmembrane	149 – 169	21	Helical; Potential
	Transmembrane	180 – 200	21	Helical; Potential
	Zinc finger	227 – 277	51	RING-type; atypical
Natural variations
	Natural variant	159	1	M → V. Corresponds to variant rs10517577 [ dbSNP | Ensembl ].		VAR_026998
	Natural variant	307	1	L → F. Corresponds to variant rs1337 [ dbSNP | Ensembl ].		VAR_026999
	Natural variant	315	1	I → M. Corresponds to variant rs1339 [ dbSNP | Ensembl ].		VAR_027000
	Natural variant	322	1	I → N. Ref.2 Corresponds to variant rs2405432 [ dbSNP | Ensembl ].		VAR_027001

Sequences

	Sequence		Length	Mass (Da)
	Q8N4F7 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: A9EAAE7B4A75B524	FASTA	328	38,266
	10 20 30 40 50 60 MAAGTAARKA APVLEAPPQQ EQLSHTKLSA EDTWNLQQER MYKMHRGHDS MHVEMILIFL 70 80 90 100 110 120 CVLVIAQIVL VQWRQRHGRS YNLVTLLQMW VVPLYFTIKL YWWRFLSMWG MFSVITSYIL 130 140 150 160 170 180 FRATRKPLSG RTPRLVYKWF LLIYKLSYAF GVVGYLAIMF TMCGFNLFFK IKARDSMDFG 190 200 210 220 230 240 IVSLFYGLYY GVMGRDFAEI CSDYMASTIG FYSVSRLPTR SLSDNICAVC GQKIIVELDE 250 260 270 280 290 300 EGLIENTYQL SCNHVFHEFC IRGWCIVGKK QTCPYCKEKV DLKRMISNPW ERTHFLYGQI 310 320 LDWLRYLVAW QPVVIGIVQG IIYSLGLE

References

[1]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-322. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC020703 Genomic DNA. No translation available. AC106865 Genomic DNA. No translation available. BC034385 mRNA. Translation: AAH34385.1.
IPI	IPI00185911.
RefSeq	NP_775933.1. NM_173662.2.
UniGene	Hs.388364.
3D structure databases
ProteinModelPortal	Q8N4F7.
ModBase	Search...
PTM databases
PhosphoSite	Q8N4F7.
Polymorphism databases
DMDM	296452878.
Proteomic databases
PaxDb	Q8N4F7.
PRIDE	Q8N4F7.
Protocols and materials databases
DNASU	285533.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000347063; ENSP00000340979; ENSG00000145428.
GeneID	285533.
KEGG	hsa:285533.
UCSC	uc003int.3. human.
Organism-specific databases
CTD	285533.
GeneCards	GC04M154631.
HGNC	HGNC:27735. RNF175.
HPA	HPA035837.
neXtProt	NX_Q8N4F7.
PharmGKB	PA134909663.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG327922.
HOGENOM	HOG000021822.
HOVERGEN	HBG061177.
InParanoid	Q8N4F7.
OMA	NPWERTH.
OrthoDB	EOG4P5K9H.
Gene expression databases
ArrayExpress	Q8N4F7.
Bgee	Q8N4F7.
CleanEx	HS_RNF175.
Genevestigator	Q8N4F7.
GermOnline	ENSG00000145428. Homo sapiens.
Family and domain databases
Gene3D	3.30.40.10. 1 hit.
InterPro	IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Pfam	PF13639. zf-RING_2. 1 hit. [Graphical view]
SMART	SM00184. RING. 1 hit. [Graphical view]
PROSITE	PS00518. ZF_RING_1. False negative. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	285533.
NextBio	95591.

Entry information

Entry name

RN175_HUMAN

Accession

Primary (citable) accession number: Q8N4F7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.