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Q8N4F7

- RN175_HUMAN

UniProt

Q8N4F7 - RN175_HUMAN

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Protein

RING finger protein 175

Gene

RNF175

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri227 – 27751RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 175
Gene namesi
Name:RNF175
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:27735. RNF175.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei51 – 7121HelicalSequence AnalysisAdd
BLAST
Transmembranei83 – 10321HelicalSequence AnalysisAdd
BLAST
Transmembranei104 – 12118HelicalSequence AnalysisAdd
BLAST
Transmembranei149 – 16921HelicalSequence AnalysisAdd
BLAST
Transmembranei180 – 20021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134909663.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328RING finger protein 175PRO_0000245599Add
BLAST

Proteomic databases

PaxDbiQ8N4F7.
PRIDEiQ8N4F7.

PTM databases

PhosphoSiteiQ8N4F7.

Expressioni

Gene expression databases

BgeeiQ8N4F7.
CleanExiHS_RNF175.
ExpressionAtlasiQ8N4F7. baseline and differential.
GenevestigatoriQ8N4F7.

Organism-specific databases

HPAiHPA028830.
HPA035837.

Structurei

3D structure databases

ProteinModelPortaliQ8N4F7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri227 – 27751RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiNOG327922.
GeneTreeiENSGT00390000013075.
HOGENOMiHOG000021822.
HOVERGENiHBG061177.
InParanoidiQ8N4F7.
OMAiNPWERTH.
OrthoDBiEOG7R831T.
PhylomeDBiQ8N4F7.
TreeFamiTF314357.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N4F7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGTAARKA APVLEAPPQQ EQLSHTKLSA EDTWNLQQER MYKMHRGHDS
60 70 80 90 100
MHVEMILIFL CVLVIAQIVL VQWRQRHGRS YNLVTLLQMW VVPLYFTIKL
110 120 130 140 150
YWWRFLSMWG MFSVITSYIL FRATRKPLSG RTPRLVYKWF LLIYKLSYAF
160 170 180 190 200
GVVGYLAIMF TMCGFNLFFK IKARDSMDFG IVSLFYGLYY GVMGRDFAEI
210 220 230 240 250
CSDYMASTIG FYSVSRLPTR SLSDNICAVC GQKIIVELDE EGLIENTYQL
260 270 280 290 300
SCNHVFHEFC IRGWCIVGKK QTCPYCKEKV DLKRMISNPW ERTHFLYGQI
310 320
LDWLRYLVAW QPVVIGIVQG IIYSLGLE
Length:328
Mass (Da):38,266
Last modified:May 18, 2010 - v2
Checksum:iA9EAAE7B4A75B524
GO
Isoform 2 (identifier: Q8N4F7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MAAGTA → MADPTI
     7-134: Missing.
     256-309: FHEFCIRGWC...ILDWLRYLVA → YPFQRKLFGL...AQSSLPVCPC
     310-328: Missing.

Note: No experimental confirmation available.

Show »
Length:181
Mass (Da):20,321
Checksum:i240860CA5495634D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti159 – 1591M → V.
Corresponds to variant rs10517577 [ dbSNP | Ensembl ].
VAR_026998
Natural varianti307 – 3071L → F.
Corresponds to variant rs1337 [ dbSNP | Ensembl ].
VAR_026999
Natural varianti315 – 3151I → M.
Corresponds to variant rs1339 [ dbSNP | Ensembl ].
VAR_027000
Natural varianti322 – 3221I → N.1 Publication
Corresponds to variant rs2405432 [ dbSNP | Ensembl ].
VAR_027001

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 66MAAGTA → MADPTI in isoform 2. 1 PublicationVSP_055433
Alternative sequencei7 – 134128Missing in isoform 2. 1 PublicationVSP_055434Add
BLAST
Alternative sequencei256 – 30954FHEFC…RYLVA → YPFQRKLFGLHQASFFPPSP PPPPVPISSILLTFHAQTPV LYPPAQSSLPVCPC in isoform 2. 1 PublicationVSP_055435Add
BLAST
Alternative sequencei310 – 32819Missing in isoform 2. 1 PublicationVSP_055436Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091509 mRNA. Translation: BAC03680.1.
AC020703 Genomic DNA. No translation available.
AC106865 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04951.1.
BC034385 mRNA. Translation: AAH34385.1.
CCDSiCCDS47149.1. [Q8N4F7-1]
RefSeqiNP_775933.1. NM_173662.2.
UniGeneiHs.388364.

Genome annotation databases

EnsembliENST00000347063; ENSP00000340979; ENSG00000145428. [Q8N4F7-1]
GeneIDi285533.
KEGGihsa:285533.
UCSCiuc003int.3. human. [Q8N4F7-1]

Polymorphism databases

DMDMi296452878.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091509 mRNA. Translation: BAC03680.1 .
AC020703 Genomic DNA. No translation available.
AC106865 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04951.1 .
BC034385 mRNA. Translation: AAH34385.1 .
CCDSi CCDS47149.1. [Q8N4F7-1 ]
RefSeqi NP_775933.1. NM_173662.2.
UniGenei Hs.388364.

3D structure databases

ProteinModelPortali Q8N4F7.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8N4F7.

Polymorphism databases

DMDMi 296452878.

Proteomic databases

PaxDbi Q8N4F7.
PRIDEi Q8N4F7.

Protocols and materials databases

DNASUi 285533.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000347063 ; ENSP00000340979 ; ENSG00000145428 . [Q8N4F7-1 ]
GeneIDi 285533.
KEGGi hsa:285533.
UCSCi uc003int.3. human. [Q8N4F7-1 ]

Organism-specific databases

CTDi 285533.
GeneCardsi GC04M154631.
HGNCi HGNC:27735. RNF175.
HPAi HPA028830.
HPA035837.
neXtProti NX_Q8N4F7.
PharmGKBi PA134909663.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG327922.
GeneTreei ENSGT00390000013075.
HOGENOMi HOG000021822.
HOVERGENi HBG061177.
InParanoidi Q8N4F7.
OMAi NPWERTH.
OrthoDBi EOG7R831T.
PhylomeDBi Q8N4F7.
TreeFami TF314357.

Miscellaneous databases

GenomeRNAii 285533.
NextBioi 95591.
PROi Q8N4F7.

Gene expression databases

Bgeei Q8N4F7.
CleanExi HS_RNF175.
ExpressionAtlasi Q8N4F7. baseline and differential.
Genevestigatori Q8N4F7.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF13639. zf-RING_2. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
[Graphical view ]
PROSITEi PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASN-322.
    Tissue: Brain.

Entry informationi

Entry nameiRN175_HUMAN
AccessioniPrimary (citable) accession number: Q8N4F7
Secondary accession number(s): C9JL66, Q8NB61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3