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Q8N4F7 (RN175_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RING finger protein 175
Gene names
Name:RNF175
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Contains 1 RING-type zinc finger.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 328328RING finger protein 175
PRO_0000245599

Regions

Transmembrane51 – 7121Helical; Potential
Transmembrane83 – 10321Helical; Potential
Transmembrane104 – 12118Helical; Potential
Transmembrane149 – 16921Helical; Potential
Transmembrane180 – 20021Helical; Potential
Zinc finger227 – 27751RING-type; atypical

Natural variations

Natural variant1591M → V.
Corresponds to variant rs10517577 [ dbSNP | Ensembl ].
VAR_026998
Natural variant3071L → F.
Corresponds to variant rs1337 [ dbSNP | Ensembl ].
VAR_026999
Natural variant3151I → M.
Corresponds to variant rs1339 [ dbSNP | Ensembl ].
VAR_027000
Natural variant3221I → N. Ref.2
Corresponds to variant rs2405432 [ dbSNP | Ensembl ].
VAR_027001

Sequences

Sequence LengthMass (Da)Tools
Q8N4F7 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: A9EAAE7B4A75B524

FASTA32838,266
        10         20         30         40         50         60 
MAAGTAARKA APVLEAPPQQ EQLSHTKLSA EDTWNLQQER MYKMHRGHDS MHVEMILIFL 

        70         80         90        100        110        120 
CVLVIAQIVL VQWRQRHGRS YNLVTLLQMW VVPLYFTIKL YWWRFLSMWG MFSVITSYIL 

       130        140        150        160        170        180 
FRATRKPLSG RTPRLVYKWF LLIYKLSYAF GVVGYLAIMF TMCGFNLFFK IKARDSMDFG 

       190        200        210        220        230        240 
IVSLFYGLYY GVMGRDFAEI CSDYMASTIG FYSVSRLPTR SLSDNICAVC GQKIIVELDE 

       250        260        270        280        290        300 
EGLIENTYQL SCNHVFHEFC IRGWCIVGKK QTCPYCKEKV DLKRMISNPW ERTHFLYGQI 

       310        320 
LDWLRYLVAW QPVVIGIVQG IIYSLGLE 

« Hide

References

[1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-322.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC020703 Genomic DNA. No translation available.
AC106865 Genomic DNA. No translation available.
BC034385 mRNA. Translation: AAH34385.1.
RefSeqNP_775933.1. NM_173662.2.
UniGeneHs.388364.

3D structure databases

ProteinModelPortalQ8N4F7.
SMRQ8N4F7. Positions 223-280.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8N4F7.

Polymorphism databases

DMDM296452878.

Proteomic databases

PaxDbQ8N4F7.
PRIDEQ8N4F7.

Protocols and materials databases

DNASU285533.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000347063; ENSP00000340979; ENSG00000145428.
GeneID285533.
KEGGhsa:285533.
UCSCuc003int.3. human.

Organism-specific databases

CTD285533.
GeneCardsGC04M154631.
HGNCHGNC:27735. RNF175.
HPAHPA028830.
HPA035837.
neXtProtNX_Q8N4F7.
PharmGKBPA134909663.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG327922.
HOGENOMHOG000021822.
HOVERGENHBG061177.
InParanoidQ8N4F7.
OMANPWERTH.
OrthoDBEOG7R831T.
PhylomeDBQ8N4F7.
TreeFamTF314357.

Gene expression databases

ArrayExpressQ8N4F7.
BgeeQ8N4F7.
CleanExHS_RNF175.
GenevestigatorQ8N4F7.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTSM00184. RING. 1 hit.
[Graphical view]
PROSITEPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi285533.
NextBio95591.
PROQ8N4F7.

Entry information

Entry nameRN175_HUMAN
AccessionPrimary (citable) accession number: Q8N4F7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM