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Protein

Solute carrier family 22 member 24

Gene

SLC22A24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 24
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28542. SLC22A24.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence analysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence analysisAdd
BLAST
Transmembranei178 – 20023HelicalSequence analysisAdd
BLAST
Transmembranei204 – 22623HelicalSequence analysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence analysisAdd
BLAST
Transmembranei260 – 28021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi74728846.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Solute carrier family 22 member 24PRO_0000317526Add
BLAST

Proteomic databases

EPDiQ8N4F4.
PaxDbiQ8N4F4.
PRIDEiQ8N4F4.

PTM databases

PhosphoSiteiQ8N4F4.

Expressioni

Gene expression databases

BgeeiQ8N4F4.
CleanExiHS_SLC22A24.
ExpressionAtlasiQ8N4F4. baseline and differential.
GenevisibleiQ8N4F4. HS.

Organism-specific databases

HPAiHPA045015.

Interactioni

Protein-protein interaction databases

BioGridi129508. 1 interaction.
IntActiQ8N4F4. 1 interaction.
MINTiMINT-1451757.
STRINGi9606.ENSP00000396586.

Structurei

3D structure databases

ProteinModelPortaliQ8N4F4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
COG0477. LUCA.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ8N4F4.
KOiK08206.
PhylomeDBiQ8N4F4.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N4F4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFDVLLDQV GGMGRFQICL IAFFCITNIL LFPNIVLENF TAFTPSHRCW
60 70 80 90 100
VPLLDNDSVS DNDTGTLSKD DLLRISIPLD SNLRPQKCQR FIHPQWQLLH
110 120 130 140 150
LNGTFPNTNE PDTEPCVDGW VYDRSSFLST IVTEWDLVCE SQSLKSMVQS
160 170 180 190 200
LFMAGSLLGG LIYGHLSDRV GRKIICKLCF LQLAISNTCA AFAPTFLVYC
210 220 230 240 250
ILRFLAGFST MTILGNTFIL SLEWTLPRSR SMTIMVLLCS YSVGQMLLGG
260 270 280 290 300
LAFAIQDWHI LQLTVSTPII VLFLSSWYEQ SPHSLPVSEA MVDIERKIVT
310 320
PGICSVSGLV LSHDVHSTYC VT
Length:322
Mass (Da):35,933
Last modified:October 1, 2002 - v1
Checksum:i6A4A7C1E2616747D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034394 mRNA. Translation: AAH34394.1.
CCDSiCCDS76422.1.
RefSeqiNP_775857.2. NM_173586.2.
UniGeneiHs.375139.

Genome annotation databases

EnsembliENST00000326192; ENSP00000321549; ENSG00000197658.
GeneIDi283238.
KEGGihsa:283238.
UCSCiuc010rmn.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034394 mRNA. Translation: AAH34394.1.
CCDSiCCDS76422.1.
RefSeqiNP_775857.2. NM_173586.2.
UniGeneiHs.375139.

3D structure databases

ProteinModelPortaliQ8N4F4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129508. 1 interaction.
IntActiQ8N4F4. 1 interaction.
MINTiMINT-1451757.
STRINGi9606.ENSP00000396586.

PTM databases

PhosphoSiteiQ8N4F4.

Polymorphism and mutation databases

DMDMi74728846.

Proteomic databases

EPDiQ8N4F4.
PaxDbiQ8N4F4.
PRIDEiQ8N4F4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326192; ENSP00000321549; ENSG00000197658.
GeneIDi283238.
KEGGihsa:283238.
UCSCiuc010rmn.3. human.

Organism-specific databases

CTDi283238.
GeneCardsiSLC22A24.
H-InvDBHIX0009734.
HGNCiHGNC:28542. SLC22A24.
HPAiHPA045015.
MIMi611698. gene.
neXtProtiNX_Q8N4F4.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
COG0477. LUCA.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ8N4F4.
KOiK08206.
PhylomeDBiQ8N4F4.

Miscellaneous databases

GenomeRNAii283238.
PROiQ8N4F4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N4F4.
CleanExiHS_SLC22A24.
ExpressionAtlasiQ8N4F4. baseline and differential.
GenevisibleiQ8N4F4. HS.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family."
    Jacobsson J.A., Haitina T., Lindblom J., Fredriksson R.
    Genomics 90:595-609(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiS22AO_HUMAN
AccessioniPrimary (citable) accession number: Q8N4F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.