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Q8N4F0

- BPIB2_HUMAN

UniProt

Q8N4F0 - BPIB2_HUMAN

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Protein

BPI fold-containing family B member 2

Gene

BPIFB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. lipid binding Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family B member 2
Alternative name(s):
Bactericidal/permeability-increasing protein-like 1
Short name:
BPI-like 1
Long palate, lung and nasal epithelium carcinoma-associated protein 2
RYSR
Gene namesi
Name:BPIFB2
Synonyms:BPIL1, C20orf184, LPLUNC2
ORF Names:UNQ2489/PRO5776
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:16177. BPIFB2.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25404.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20201 PublicationAdd
BLAST
Chaini21 – 458438BPI fold-containing family B member 2PRO_0000017164Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi96 – 961N-linked (GlcNAc...)1 Publication
Disulfide bondi137 ↔ 174By similarity
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi293 – 2931N-linked (GlcNAc...)1 Publication
Glycosylationi332 – 3321N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8N4F0.
PeptideAtlasiQ8N4F0.
PRIDEiQ8N4F0.

PTM databases

PhosphoSiteiQ8N4F0.

Expressioni

Tissue specificityi

Highly expressed in tonsils, especially in hypertrophic tonsils. Detected at very low levels in fetal liver.1 Publication

Gene expression databases

BgeeiQ8N4F0.
CleanExiHS_BPIL1.
GenevestigatoriQ8N4F0.

Organism-specific databases

HPAiHPA049491.

Structurei

3D structure databases

ProteinModelPortaliQ8N4F0.
SMRiQ8N4F0. Positions 23-429.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi268 – 2714Poly-Leu

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG285532.
GeneTreeiENSGT00730000110772.
HOGENOMiHOG000095253.
HOVERGENiHBG050717.
InParanoidiQ8N4F0.
OMAiFTFKVFR.
OrthoDBiEOG700881.
PhylomeDBiQ8N4F0.
TreeFamiTF315617.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTiSM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N4F0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAWASRLGLL LALLLPVVGA STPGTVVRLN KAALSYVSEI GKAPLQRALQ
60 70 80 90 100
VTVPHFLDWS GEALQPTRIR ILNVHVPRLH LKFIAGFGVR LLAAANFTFK
110 120 130 140 150
VFRAPEPLEL TLPVELLADT RVTQSSIRTP VVSISACSLF SGHANEFDGS
160 170 180 190 200
NSTSHALLVL VQKHIKAVLS NKLCLSISNL VQGVNVHLGT LIGLNPVGPE
210 220 230 240 250
SQIRYSMVSV PTVTSDYISL EVNAVLFLLG KPIILPTDAT PFVLPRHVGT
260 270 280 290 300
EGSMATVGLS QQLFDSALLL LQKAGALNLD ITGQLRSDDN LLNTSALGRL
310 320 330 340 350
IPEVARQFPE PMPVVLKVRL GATPVAMLHT NNATLRLQPF VEVLATASNS
360 370 380 390 400
AFQSLFSLDV VVNLRLQLSV SKVKLQGTTS VLGDVQLTVA SSNVGFIDTD
410 420 430 440 450
QVRTLMGTVF EKPLLDHLNA LLAMGIALPG VVNLHYVAPE IFVYEGYVVI

SSGLFYQS
Length:458
Mass (Da):49,172
Last modified:March 29, 2005 - v2
Checksum:iE2016619A93ABECD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti231 – 2311K → N in AAQ89085. (PubMed:12975309)Curated
Sequence conflicti257 – 2571V → G in AAH34415. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201A → V in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036550
Natural varianti31 – 311K → M.
Corresponds to variant rs6088066 [ dbSNP | Ensembl ].
VAR_024515
Natural varianti63 – 631A → V.
Corresponds to variant rs34128772 [ dbSNP | Ensembl ].
VAR_049740

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465765 mRNA. Translation: AAM73983.1.
AY358723 mRNA. Translation: AAQ89085.1.
AK172819 mRNA. Translation: BAD18788.1.
AL121756 Genomic DNA. Translation: CAC18884.1.
CH471077 Genomic DNA. Translation: EAW76341.1.
BC034415 mRNA. Translation: AAH34415.1.
CCDSiCCDS13210.1.
RefSeqiNP_079503.1. NM_025227.2.
UniGeneiHs.257045.

Genome annotation databases

EnsembliENST00000170150; ENSP00000170150; ENSG00000078898.
GeneIDi80341.
KEGGihsa:80341.
UCSCiuc002wyj.4. human.

Polymorphism databases

DMDMi62298542.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465765 mRNA. Translation: AAM73983.1 .
AY358723 mRNA. Translation: AAQ89085.1 .
AK172819 mRNA. Translation: BAD18788.1 .
AL121756 Genomic DNA. Translation: CAC18884.1 .
CH471077 Genomic DNA. Translation: EAW76341.1 .
BC034415 mRNA. Translation: AAH34415.1 .
CCDSi CCDS13210.1.
RefSeqi NP_079503.1. NM_025227.2.
UniGenei Hs.257045.

3D structure databases

ProteinModelPortali Q8N4F0.
SMRi Q8N4F0. Positions 23-429.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8N4F0.

Polymorphism databases

DMDMi 62298542.

Proteomic databases

PaxDbi Q8N4F0.
PeptideAtlasi Q8N4F0.
PRIDEi Q8N4F0.

Protocols and materials databases

DNASUi 80341.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000170150 ; ENSP00000170150 ; ENSG00000078898 .
GeneIDi 80341.
KEGGi hsa:80341.
UCSCi uc002wyj.4. human.

Organism-specific databases

CTDi 80341.
GeneCardsi GC20P031596.
HGNCi HGNC:16177. BPIFB2.
HPAi HPA049491.
MIMi 614108. gene.
neXtProti NX_Q8N4F0.
PharmGKBi PA25404.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG285532.
GeneTreei ENSGT00730000110772.
HOGENOMi HOG000095253.
HOVERGENi HBG050717.
InParanoidi Q8N4F0.
OMAi FTFKVFR.
OrthoDBi EOG700881.
PhylomeDBi Q8N4F0.
TreeFami TF315617.

Miscellaneous databases

GeneWikii BPIL1.
GenomeRNAii 80341.
NextBioi 70914.
PROi Q8N4F0.
SOURCEi Search...

Gene expression databases

Bgeei Q8N4F0.
CleanExi HS_BPIL1.
Genevestigatori Q8N4F0.

Family and domain databases

InterProi IPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view ]
Pfami PF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view ]
SMARTi SM00329. BPI2. 1 hit.
[Graphical view ]
SUPFAMi SSF55394. SSF55394. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP)."
    Mulero J.J., Boyle B.J., Bradley S., Bright J.M., Nelken S.T., Ho T.T., Mize N.K., Childs J.D., Ballinger D.G., Ford J.E., Rupp F.
    Immunogenetics 54:293-300(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Trachea.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Lung and Testis.
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-35.
  8. "Expansion of the BPI family by duplication on human chromosome 20: characterization of the RY gene cluster in 20q11.21 encoding olfactory transporters/antimicrobial-like peptides."
    Andrault J.-B., Gaillard I., Giorgi D., Rouquier S.
    Genomics 82:172-184(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Fetal brain.
  9. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
    Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
    J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-96; ASN-293 AND ASN-332.
    Tissue: Saliva.
  10. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-20.

Entry informationi

Entry nameiBPIB2_HUMAN
AccessioniPrimary (citable) accession number: Q8N4F0
Secondary accession number(s): Q6UWN3, Q6ZME0, Q8NFQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: March 29, 2005
Last modified: October 29, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3