Reviewed, UniProtKB/Swiss-Prot Q8N4F0 (BPIL1_HUMAN)

Names and origin

Protein names

Recommended name:
    Bactericidal/permeability-increasing protein-like 1
Alternative name(s):
    Long palate, lung and nasal epithelium carcinoma-associated protein 2
    RYSR

Gene names

Name:	BPIL1
Synonyms:	C20orf184, LPLUNC2
ORF Names:	UNQ2489/PRO5776

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	458 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Secreted By similarity Ref.6.
Tissue specificity	Highly expressed in tonsils, especially in hypertrophic tonsils. Detected at very low levels in fetal liver. Ref.6
Sequence similarities	Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	lipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Ref.5
	Chain	21 – 458	438	Bactericidal/permeability-increasing protein-like 1		PRO_0000017164
Regions
	Compositional bias	268 – 271	4	Poly-Leu
Amino acid modifications
	Glycosylation	96	1	N-linked (GlcNAc...) Ref.7
	Glycosylation	151	1	N-linked (GlcNAc...) Potential
	Glycosylation	293	1	N-linked (GlcNAc...) Ref.7
	Glycosylation	332	1	N-linked (GlcNAc...) Ref.7
Natural variations
	Natural variant	20	1	A → V in a colorectal cancer sample; somatic mutation. Ref.8		VAR_036550
	Natural variant	31	1	K → M: dbSNP rs6088066.		VAR_024515
	Natural variant	63	1	A → V: dbSNP rs34128772.		VAR_049740
Experimental info
	Sequence conflict	231	1	K → N in AAQ89085. Ref.2
	Sequence conflict	257	1	V → G in AAH34415. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q8N4F0-1 [UniParc]. Last modified March 29, 2005. Version 2. Checksum: E2016619A93ABECD	FASTA	458	49,172
	10 20 30 40 50 60 MAWASRLGLL LALLLPVVGA STPGTVVRLN KAALSYVSEI GKAPLQRALQ VTVPHFLDWS 70 80 90 100 110 120 GEALQPTRIR ILNVHVPRLH LKFIAGFGVR LLAAANFTFK VFRAPEPLEL TLPVELLADT 130 140 150 160 170 180 RVTQSSIRTP VVSISACSLF SGHANEFDGS NSTSHALLVL VQKHIKAVLS NKLCLSISNL 190 200 210 220 230 240 VQGVNVHLGT LIGLNPVGPE SQIRYSMVSV PTVTSDYISL EVNAVLFLLG KPIILPTDAT 250 260 270 280 290 300 PFVLPRHVGT EGSMATVGLS QQLFDSALLL LQKAGALNLD ITGQLRSDDN LLNTSALGRL 310 320 330 340 350 360 IPEVARQFPE PMPVVLKVRL GATPVAMLHT NNATLRLQPF VEVLATASNS AFQSLFSLDV 370 380 390 400 410 420 VVNLRLQLSV SKVKLQGTTS VLGDVQLTVA SSNVGFIDTD QVRTLMGTVF EKPLLDHLNA 430 440 450 LLAMGIALPG VVNLHYVAPE IFVYEGYVVI SSGLFYQS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP)." Mulero J.J., Boyle B.J., Bradley S., Bright J.M., Nelken S.T., Ho T.T., Mize N.K., Childs J.D., Ballinger D.G., Ford J.E., Rupp F. Immunogenetics 54:293-300(2002) [PubMed: 12185532] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Trachea.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Lung and Testis.
[5]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 21-35.
[6]	"Expansion of the BPI family by duplication on human chromosome 20: characterization of the RY gene cluster in 20q11.21 encoding olfactory transporters/antimicrobial-like peptides." Andrault J.-B., Gaillard I., Giorgi D., Rouquier S. Genomics 82:172-184(2003) [PubMed: 12837268] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Fetal brain.
[7]	"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry." Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A. J. Proteome Res. 5:1493-1503(2006) [PubMed: 16740002] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-96; ASN-293 AND ASN-332, MASS SPECTROMETRY. Tissue: Saliva.
[8]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-20.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF465765 mRNA. Translation: AAM73983.1. AY358723 mRNA. Translation: AAQ89085.1. AL121756 Genomic DNA. No translation available. BC034415 mRNA. Translation: AAH34415.1.
IPI	IPI00296654.
RefSeq	NP_079503.1.
UniGene	Hs.257045
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8N4F0.
Proteomic databases
PeptideAtlas	Q8N4F0.
PRIDE	Q8N4F0.
Genome annotation databases
Ensembl	ENST00000170150; ENSP00000170150; ENSG00000078898; Homo sapiens. [Genome view]
GeneID	80341.
KEGG	hsa:80341.
UCSC	uc002wyj.1. human.
Organism-specific databases
CTD	80341.
GeneCards	GC20P031059.
H-InvDB	HIX0015732.
HGNC	HGNC:16177. BPIL1.
PharmGKB	PA25404.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG12932.
HOGENOM	HBG126048.
HOVERGEN	Q8N4F0.
InParanoid	Q8N4F0.
OMA	LQPFVEV.
OrthoDB	EOG9NKFFT.
PhylomeDB	Q8N4F0.
Gene expression databases
ArrayExpress	Q8N4F0.
Bgee	Q8N4F0.
CleanEx	HS_BPIL1.
Genevestigator	Q8N4F0.
GermOnline	ENSG00000078898. Homo sapiens.
Family and domain databases
InterPro	IPR017943. Bactericidal_perm-incr_a/b_dom. IPR017942. Lipid-bd_serum_glycop_N. IPR001124. Lipid_bd_serum_glycop_C. [Graphical view]
Pfam	PF01273. LBP_BPI_CETP. 1 hit. PF02886. LBP_BPI_CETP_C. 1 hit. [Graphical view]
SMART	SM00329. BPI2. 1 hit. [Graphical view]
PROSITE	PS00400. LBP_BPI_CETP. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	70914.

Entry information

Entry name

BPIL1_HUMAN

Accession

Primary (citable) accession number: Q8N4F0
Secondary accession number(s): Q6UWN3, Q8NFQ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	March 29, 2005
Last modified:	January 19, 2010
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.