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Q8N4F0

- BPIB2_HUMAN

UniProt

Q8N4F0 - BPIB2_HUMAN

Protein

BPI fold-containing family B member 2

Gene

BPIFB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (29 Mar 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. lipid binding Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BPI fold-containing family B member 2
    Alternative name(s):
    Bactericidal/permeability-increasing protein-like 1
    Short name:
    BPI-like 1
    Long palate, lung and nasal epithelium carcinoma-associated protein 2
    RYSR
    Gene namesi
    Name:BPIFB2
    Synonyms:BPIL1, C20orf184, LPLUNC2
    ORF Names:UNQ2489/PRO5776
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:16177. BPIFB2.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25404.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 20201 PublicationAdd
    BLAST
    Chaini21 – 458438BPI fold-containing family B member 2PRO_0000017164Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi96 – 961N-linked (GlcNAc...)1 Publication
    Disulfide bondi137 ↔ 174By similarity
    Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi293 – 2931N-linked (GlcNAc...)1 Publication
    Glycosylationi332 – 3321N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8N4F0.
    PeptideAtlasiQ8N4F0.
    PRIDEiQ8N4F0.

    PTM databases

    PhosphoSiteiQ8N4F0.

    Expressioni

    Tissue specificityi

    Highly expressed in tonsils, especially in hypertrophic tonsils. Detected at very low levels in fetal liver.1 Publication

    Gene expression databases

    BgeeiQ8N4F0.
    CleanExiHS_BPIL1.
    GenevestigatoriQ8N4F0.

    Organism-specific databases

    HPAiHPA049491.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N4F0.
    SMRiQ8N4F0. Positions 23-429.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi268 – 2714Poly-Leu

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG285532.
    HOGENOMiHOG000095253.
    HOVERGENiHBG050717.
    InParanoidiQ8N4F0.
    OMAiFTFKVFR.
    OrthoDBiEOG700881.
    PhylomeDBiQ8N4F0.
    TreeFamiTF315617.

    Family and domain databases

    InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
    IPR001124. Lipid-bd_serum_glycop_C.
    IPR017942. Lipid-bd_serum_glycop_N.
    [Graphical view]
    PfamiPF01273. LBP_BPI_CETP. 1 hit.
    PF02886. LBP_BPI_CETP_C. 1 hit.
    [Graphical view]
    SMARTiSM00329. BPI2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55394. SSF55394. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8N4F0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAWASRLGLL LALLLPVVGA STPGTVVRLN KAALSYVSEI GKAPLQRALQ    50
    VTVPHFLDWS GEALQPTRIR ILNVHVPRLH LKFIAGFGVR LLAAANFTFK 100
    VFRAPEPLEL TLPVELLADT RVTQSSIRTP VVSISACSLF SGHANEFDGS 150
    NSTSHALLVL VQKHIKAVLS NKLCLSISNL VQGVNVHLGT LIGLNPVGPE 200
    SQIRYSMVSV PTVTSDYISL EVNAVLFLLG KPIILPTDAT PFVLPRHVGT 250
    EGSMATVGLS QQLFDSALLL LQKAGALNLD ITGQLRSDDN LLNTSALGRL 300
    IPEVARQFPE PMPVVLKVRL GATPVAMLHT NNATLRLQPF VEVLATASNS 350
    AFQSLFSLDV VVNLRLQLSV SKVKLQGTTS VLGDVQLTVA SSNVGFIDTD 400
    QVRTLMGTVF EKPLLDHLNA LLAMGIALPG VVNLHYVAPE IFVYEGYVVI 450
    SSGLFYQS 458
    Length:458
    Mass (Da):49,172
    Last modified:March 29, 2005 - v2
    Checksum:iE2016619A93ABECD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti231 – 2311K → N in AAQ89085. (PubMed:12975309)Curated
    Sequence conflicti257 – 2571V → G in AAH34415. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti20 – 201A → V in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036550
    Natural varianti31 – 311K → M.
    Corresponds to variant rs6088066 [ dbSNP | Ensembl ].
    VAR_024515
    Natural varianti63 – 631A → V.
    Corresponds to variant rs34128772 [ dbSNP | Ensembl ].
    VAR_049740

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF465765 mRNA. Translation: AAM73983.1.
    AY358723 mRNA. Translation: AAQ89085.1.
    AK172819 mRNA. Translation: BAD18788.1.
    AL121756 Genomic DNA. Translation: CAC18884.1.
    CH471077 Genomic DNA. Translation: EAW76341.1.
    BC034415 mRNA. Translation: AAH34415.1.
    CCDSiCCDS13210.1.
    RefSeqiNP_079503.1. NM_025227.2.
    UniGeneiHs.257045.

    Genome annotation databases

    EnsembliENST00000170150; ENSP00000170150; ENSG00000078898.
    GeneIDi80341.
    KEGGihsa:80341.
    UCSCiuc002wyj.4. human.

    Polymorphism databases

    DMDMi62298542.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF465765 mRNA. Translation: AAM73983.1 .
    AY358723 mRNA. Translation: AAQ89085.1 .
    AK172819 mRNA. Translation: BAD18788.1 .
    AL121756 Genomic DNA. Translation: CAC18884.1 .
    CH471077 Genomic DNA. Translation: EAW76341.1 .
    BC034415 mRNA. Translation: AAH34415.1 .
    CCDSi CCDS13210.1.
    RefSeqi NP_079503.1. NM_025227.2.
    UniGenei Hs.257045.

    3D structure databases

    ProteinModelPortali Q8N4F0.
    SMRi Q8N4F0. Positions 23-429.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8N4F0.

    Polymorphism databases

    DMDMi 62298542.

    Proteomic databases

    PaxDbi Q8N4F0.
    PeptideAtlasi Q8N4F0.
    PRIDEi Q8N4F0.

    Protocols and materials databases

    DNASUi 80341.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000170150 ; ENSP00000170150 ; ENSG00000078898 .
    GeneIDi 80341.
    KEGGi hsa:80341.
    UCSCi uc002wyj.4. human.

    Organism-specific databases

    CTDi 80341.
    GeneCardsi GC20P031596.
    HGNCi HGNC:16177. BPIFB2.
    HPAi HPA049491.
    MIMi 614108. gene.
    neXtProti NX_Q8N4F0.
    PharmGKBi PA25404.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG285532.
    HOGENOMi HOG000095253.
    HOVERGENi HBG050717.
    InParanoidi Q8N4F0.
    OMAi FTFKVFR.
    OrthoDBi EOG700881.
    PhylomeDBi Q8N4F0.
    TreeFami TF315617.

    Miscellaneous databases

    GeneWikii BPIL1.
    GenomeRNAii 80341.
    NextBioi 70914.
    PROi Q8N4F0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8N4F0.
    CleanExi HS_BPIL1.
    Genevestigatori Q8N4F0.

    Family and domain databases

    InterProi IPR017943. Bactericidal_perm-incr_a/b_dom.
    IPR001124. Lipid-bd_serum_glycop_C.
    IPR017942. Lipid-bd_serum_glycop_N.
    [Graphical view ]
    Pfami PF01273. LBP_BPI_CETP. 1 hit.
    PF02886. LBP_BPI_CETP_C. 1 hit.
    [Graphical view ]
    SMARTi SM00329. BPI2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55394. SSF55394. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP)."
      Mulero J.J., Boyle B.J., Bradley S., Bright J.M., Nelken S.T., Ho T.T., Mize N.K., Childs J.D., Ballinger D.G., Ford J.E., Rupp F.
      Immunogenetics 54:293-300(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Trachea.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Lung and Testis.
    7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 21-35.
    8. "Expansion of the BPI family by duplication on human chromosome 20: characterization of the RY gene cluster in 20q11.21 encoding olfactory transporters/antimicrobial-like peptides."
      Andrault J.-B., Gaillard I., Giorgi D., Rouquier S.
      Genomics 82:172-184(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Fetal brain.
    9. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
      Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
      J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-96; ASN-293 AND ASN-332.
      Tissue: Saliva.
    10. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-20.

    Entry informationi

    Entry nameiBPIB2_HUMAN
    AccessioniPrimary (citable) accession number: Q8N4F0
    Secondary accession number(s): Q6UWN3, Q6ZME0, Q8NFQ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: March 29, 2005
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3