Q8N4E7 (FTMT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ferritin, mitochondrial
EC=1.16.3.1

Gene names

Name:

FTMT

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Ref.2 Ref.3
Catalytic activity	4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.
Subunit structure	Homooligomer of 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited.
Subcellular location	Mitochondrion Ref.2.
Tissue specificity	Detected in testis and erythroleukemia. Expression is very low or not detectable in brain, colon, heart, kidney, liver, lung, muscle, placental, spleen and small intestine. Ref.2
Sequence similarities	Belongs to the ferritin family. Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
Biological process	Iron storage
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular iron ion homeostasis Inferred from direct assay PubMed 18160053. Source: BHF-UCL iron ion transport Inferred from electronic annotation. Source: InterPro positive regulation of cell proliferation Inferred from direct assay PubMed 18160053. Source: BHF-UCL positive regulation of lyase activity Inferred from direct assay PubMed 18160053. Source: BHF-UCL positive regulation of oxidoreductase activity Inferred from direct assay PubMed 18160053. Source: BHF-UCL positive regulation of transferase activity Inferred from direct assay PubMed 18160053. Source: BHF-UCL
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ferric iron binding Inferred from electronic annotation. Source: InterPro ferroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 49

49

Mitochondrion Potential

Chain

50 – 242

193

Ferritin, mitochondrial

PRO_0000008850

Regions

Domain

70 – 219

150

Ferritin-like diiron

Sites

Metal binding

87

1

Iron 1

Metal binding

122

1

Iron 1

Metal binding

122

1

Iron 2

Metal binding

125

1

Iron 1

Metal binding

167

1

Iron 2

Metal binding

201

1

Iron 2 By similarity

Experimental info

Mutagenesis

204

1

S → A: Increases ferroxidase activity and iron binding. Ref.3

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

242

Helix Strand Turn

Details...

Helix

74 – 100

27

Turn

104 – 106

3

Helix

109 – 136

28

Helix

156 – 183

28

Helix

187 – 196

10

Helix

198 – 218

21

Turn

219 – 222

4

Helix

226 – 233

8

Sequences

	Sequence		Length	Mass (Da)
	Q8N4E7 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 29E4B41616A74A3F	FASTA	242	27,538
	10 20 30 40 50 60 MLSCFRLLSR HISPSLASLR PVRCCFALPL RWAPGRPLDP RQIAPRRPLA AAASSRDPTG 70 80 90 100 110 120 PAAGPSRVRQ NFHPDSEAAI NRQINLELYA SYVYLSMAYY FSRDDVALNN FSRYFLHQSR 130 140 150 160 170 180 EETEHAEKLM RLQNQRGGRI RLQDIKKPEQ DDWESGLHAM ECALLLEKNV NQSLLELHAL 190 200 210 220 230 240 ASDKGDPHLC DFLETYYLNE QVKSIKELGD HVHNLVKMGA PDAGLAEYLF DTHTLGNENK QN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"A human mitochondrial ferritin encoded by an intronless gene." Levi S., Corsi B., Bosisio M., Invernizzi R., Volz A., Sanford D., Arosio P., Drysdale J. J. Biol. Chem. 276:24437-24440(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[3]	"Crystal structure and biochemical properties of the human mitochondrial ferritin and its mutant Ser144Ala." Langlois d'Estaintot B., Santambrogio P., Granier T., Gallois B., Chevalier J.M., Precigoux G., Levi S., Arosio P. J. Mol. Biol. 340:277-293(2004) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.38 ANGSTROMS) OF 61-242, FUNCTION, MUTAGENESIS OF SER-204.
+	Additional computationally mapped references.

Web resources

Wikipedia

Ferritin entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

BC034419 mRNA. Translation: AAH34419.1.

IPI

IPI00166689.

RefSeq

NP_803431.1. NM_177478.1.

UniGene

Hs.105324.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1R03	X-ray	1.70	A	61-242	[»]

ProteinModelPortal

Q8N4E7.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000313691.

Polymorphism databases

DMDM

62900307.

Proteomic databases

PaxDb

Q8N4E7.

PRIDE

Q8N4E7.

Protocols and materials databases

DNASU

94033.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000321339; ENSP00000313691; ENSG00000181867.

GeneID

94033.

KEGG

hsa:94033.

UCSC

uc003kss.3. human.

Organism-specific databases

CTD

94033.

GeneCards

GC05P121215.

HGNC

HGNC:17345. FTMT.

MIM

608847. gene.

neXtProt

NX_Q8N4E7.

PharmGKB

PA134941146.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG1528.

HOGENOM

HOG000223383.

HOVERGEN

HBG000410.

InParanoid

Q8N4E7.

KO

K00522.

OMA

GNENKQN.

OrthoDB

EOG47PX78.

PhylomeDB

Q8N4E7.

Gene expression databases

Bgee

Q8N4E7.

CleanEx

HS_FTMT.

Genevestigator

Q8N4E7.

Family and domain databases

Gene3D

1.20.1260.10. 1 hit.

InterPro

IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]

PANTHER

PTHR11431. PTHR11431. 1 hit.

Pfam

PF00210. Ferritin. 1 hit.
[Graphical view]

SUPFAM

SSF47240. Ferritin/RR_like. 1 hit.

PROSITE

PS00540. FERRITIN_1. False negative.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q8N4E7.

GenomeRNAi

94033.

NextBio

78343.

SOURCE

Search...

Entry information

Entry name

FTMT_HUMAN

Accession

Primary (citable) accession number: Q8N4E7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.