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Q8N4E7

- FTMT_HUMAN

UniProt

Q8N4E7 - FTMT_HUMAN

Protein

Ferritin, mitochondrial

Gene

FTMT

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.2 Publications

    Catalytic activityi

    4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi87 – 871Iron 1
    Metal bindingi122 – 1221Iron 1
    Metal bindingi122 – 1221Iron 2
    Metal bindingi125 – 1251Iron 1
    Metal bindingi167 – 1671Iron 2
    Metal bindingi201 – 2011Iron 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric iron binding Source: InterPro
    2. ferroxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular iron ion homeostasis Source: BHF-UCL
    2. iron ion transport Source: InterPro
    3. positive regulation of cell proliferation Source: BHF-UCL
    4. positive regulation of lyase activity Source: BHF-UCL
    5. positive regulation of oxidoreductase activity Source: BHF-UCL
    6. positive regulation of transferase activity Source: BHF-UCL

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Iron storage

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ferritin, mitochondrial (EC:1.16.3.1)
    Gene namesi
    Name:FTMT
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:17345. FTMT.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    2. nucleus Source: UniProt

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi204 – 2041S → A: Increases ferroxidase activity and iron binding. 1 Publication

    Organism-specific databases

    PharmGKBiPA134941146.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4949MitochondrionSequence AnalysisAdd
    BLAST
    Chaini50 – 242193Ferritin, mitochondrialPRO_0000008850Add
    BLAST

    Proteomic databases

    PaxDbiQ8N4E7.
    PRIDEiQ8N4E7.

    Expressioni

    Tissue specificityi

    Detected in testis and erythroleukemia. Expression is very low or not detectable in brain, colon, heart, kidney, liver, lung, muscle, placental, spleen and small intestine.1 Publication

    Gene expression databases

    BgeeiQ8N4E7.
    CleanExiHS_FTMT.
    GenevestigatoriQ8N4E7.

    Interactioni

    Subunit structurei

    Homooligomer of 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited.

    Protein-protein interaction databases

    STRINGi9606.ENSP00000313691.

    Structurei

    Secondary structure

    1
    242
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi74 – 10027
    Turni104 – 1063
    Helixi109 – 13628
    Helixi156 – 18328
    Helixi187 – 19610
    Helixi198 – 21821
    Turni219 – 2224
    Helixi226 – 2338

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1R03X-ray1.70A61-242[»]
    ProteinModelPortaliQ8N4E7.
    SMRiQ8N4E7. Positions 66-235.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8N4E7.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini70 – 219150Ferritin-like diironPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ferritin family.Curated
    Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1528.
    HOGENOMiHOG000223383.
    HOVERGENiHBG000410.
    InParanoidiQ8N4E7.
    KOiK00522.
    OMAiFLETYYL.
    OrthoDBiEOG7DRJ49.
    PhylomeDBiQ8N4E7.
    TreeFamiTF313885.

    Family and domain databases

    Gene3Di1.20.1260.10. 1 hit.
    InterProiIPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view]
    PANTHERiPTHR11431. PTHR11431. 1 hit.
    PfamiPF00210. Ferritin. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00204. FERRITIN_2. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8N4E7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSCFRLLSR HISPSLASLR PVRCCFALPL RWAPGRPLDP RQIAPRRPLA    50
    AAASSRDPTG PAAGPSRVRQ NFHPDSEAAI NRQINLELYA SYVYLSMAYY 100
    FSRDDVALNN FSRYFLHQSR EETEHAEKLM RLQNQRGGRI RLQDIKKPEQ 150
    DDWESGLHAM ECALLLEKNV NQSLLELHAL ASDKGDPHLC DFLETYYLNE 200
    QVKSIKELGD HVHNLVKMGA PDAGLAEYLF DTHTLGNENK QN 242
    Length:242
    Mass (Da):27,538
    Last modified:October 1, 2002 - v1
    Checksum:i29E4B41616A74A3F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC034419 mRNA. Translation: AAH34419.1.
    CCDSiCCDS4128.1.
    RefSeqiNP_803431.1. NM_177478.1.
    UniGeneiHs.105324.

    Genome annotation databases

    EnsembliENST00000321339; ENSP00000313691; ENSG00000181867.
    GeneIDi94033.
    KEGGihsa:94033.
    UCSCiuc003kss.3. human.

    Polymorphism databases

    DMDMi62900307.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Ferritin entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC034419 mRNA. Translation: AAH34419.1 .
    CCDSi CCDS4128.1.
    RefSeqi NP_803431.1. NM_177478.1.
    UniGenei Hs.105324.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1R03 X-ray 1.70 A 61-242 [» ]
    ProteinModelPortali Q8N4E7.
    SMRi Q8N4E7. Positions 66-235.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000313691.

    Polymorphism databases

    DMDMi 62900307.

    Proteomic databases

    PaxDbi Q8N4E7.
    PRIDEi Q8N4E7.

    Protocols and materials databases

    DNASUi 94033.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000321339 ; ENSP00000313691 ; ENSG00000181867 .
    GeneIDi 94033.
    KEGGi hsa:94033.
    UCSCi uc003kss.3. human.

    Organism-specific databases

    CTDi 94033.
    GeneCardsi GC05P121215.
    HGNCi HGNC:17345. FTMT.
    MIMi 608847. gene.
    neXtProti NX_Q8N4E7.
    PharmGKBi PA134941146.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1528.
    HOGENOMi HOG000223383.
    HOVERGENi HBG000410.
    InParanoidi Q8N4E7.
    KOi K00522.
    OMAi FLETYYL.
    OrthoDBi EOG7DRJ49.
    PhylomeDBi Q8N4E7.
    TreeFami TF313885.

    Miscellaneous databases

    EvolutionaryTracei Q8N4E7.
    GeneWikii Mitochondrial_ferritin.
    GenomeRNAii 94033.
    NextBioi 78343.
    PROi Q8N4E7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8N4E7.
    CleanExi HS_FTMT.
    Genevestigatori Q8N4E7.

    Family and domain databases

    Gene3Di 1.20.1260.10. 1 hit.
    InterProi IPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view ]
    PANTHERi PTHR11431. PTHR11431. 1 hit.
    Pfami PF00210. Ferritin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00204. FERRITIN_2. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    3. "Crystal structure and biochemical properties of the human mitochondrial ferritin and its mutant Ser144Ala."
      Langlois d'Estaintot B., Santambrogio P., Granier T., Gallois B., Chevalier J.M., Precigoux G., Levi S., Arosio P.
      J. Mol. Biol. 340:277-293(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.38 ANGSTROMS) OF 61-242, FUNCTION, MUTAGENESIS OF SER-204.

    Entry informationi

    Entry nameiFTMT_HUMAN
    AccessioniPrimary (citable) accession number: Q8N4E7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3