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Protein

Phosducin-like protein 2

Gene

PDCL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in germ cell maturation.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163440-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosducin-like protein 2
Gene namesi
Name:PDCL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:29524. PDCL2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi132954.
OpenTargetsiENSG00000163440.
PharmGKBiPA134987062.

Polymorphism and mutation databases

BioMutaiPDCL2.
DMDMi215273865.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002461571 – 241Phosducin-like protein 2Add BLAST241

Proteomic databases

PaxDbiQ8N4E4.
PeptideAtlasiQ8N4E4.
PRIDEiQ8N4E4.

PTM databases

iPTMnetiQ8N4E4.
PhosphoSitePlusiQ8N4E4.

Expressioni

Gene expression databases

BgeeiENSG00000163440.
CleanExiHS_PDCL2.
GenevisibleiQ8N4E4. HS.

Organism-specific databases

HPAiHPA048260.

Interactioni

Subunit structurei

Forms a complex with 14-3-3 protein(s).By similarity

Protein-protein interaction databases

BioGridi126343. 2 interactors.
STRINGi9606.ENSP00000295645.

Structurei

Secondary structure

1241
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi97 – 99Combined sources3
Helixi100 – 103Combined sources4
Turni104 – 106Combined sources3
Beta strandi112 – 118Combined sources7
Helixi123 – 138Combined sources16
Beta strandi142 – 148Combined sources7
Helixi149 – 151Combined sources3
Helixi158 – 160Combined sources3
Beta strandi162 – 168Combined sources7
Beta strandi171 – 178Combined sources8
Turni179 – 183Combined sources5
Helixi189 – 197Combined sources9
Turni198 – 200Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EVIX-ray2.70A/B88-205[»]
ProteinModelPortaliQ8N4E4.
SMRiQ8N4E4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8N4E4.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni89 – 241Thioredoxin foldBy similarityAdd BLAST153

Sequence similaritiesi

Belongs to the phosducin family.Curated

Phylogenomic databases

eggNOGiKOG3170. Eukaryota.
ENOG4111H24. LUCA.
GeneTreeiENSGT00530000062970.
HOGENOMiHOG000184445.
HOVERGENiHBG108238.
InParanoidiQ8N4E4.
PhylomeDBiQ8N4E4.
TreeFamiTF315179.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR024253. Phosducin_thioredoxin-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02114. Phosducin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8N4E4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDPNEDTEW NDILRDFGIL PPKEESKDEI EEMVLRLQKE AMVKPFEKMT
60 70 80 90 100
LAQLKEAEDE FDEEDMQAVE TYRKKRLQEW KALKKKQKFG ELREISGNQY
110 120 130 140 150
VNEVTNAEED VWVIIHLYRS SIPMCLLVNQ HLSLLARKFP ETKFVKAIVN
160 170 180 190 200
SCIQHYHDNC LPTIFVYKNG QIEAKFIGII ECGGINLKLE ELEWKLAEVG
210 220 230 240
AIQTDLEENP RKDMVDMMVS SIRNTSIHDD SDSSNSDNDT K
Length:241
Mass (Da):28,071
Last modified:November 25, 2008 - v2
Checksum:iF2F21C7252EE45CB
GO

Sequence cautioni

The sequence AAH34431 differs from that shown. Reason: Frameshift at position 239.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62D → N in AAH34431 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024243 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05469.1.
BC034431 mRNA. Translation: AAH34431.1. Frameshift.
CCDSiCCDS47059.1.
RefSeqiNP_689614.2. NM_152401.2.
UniGeneiHs.223712.

Genome annotation databases

EnsembliENST00000295645; ENSP00000295645; ENSG00000163440.
GeneIDi132954.
KEGGihsa:132954.
UCSCiuc003hbb.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024243 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05469.1.
BC034431 mRNA. Translation: AAH34431.1. Frameshift.
CCDSiCCDS47059.1.
RefSeqiNP_689614.2. NM_152401.2.
UniGeneiHs.223712.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EVIX-ray2.70A/B88-205[»]
ProteinModelPortaliQ8N4E4.
SMRiQ8N4E4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126343. 2 interactors.
STRINGi9606.ENSP00000295645.

PTM databases

iPTMnetiQ8N4E4.
PhosphoSitePlusiQ8N4E4.

Polymorphism and mutation databases

BioMutaiPDCL2.
DMDMi215273865.

Proteomic databases

PaxDbiQ8N4E4.
PeptideAtlasiQ8N4E4.
PRIDEiQ8N4E4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295645; ENSP00000295645; ENSG00000163440.
GeneIDi132954.
KEGGihsa:132954.
UCSCiuc003hbb.3. human.

Organism-specific databases

CTDi132954.
DisGeNETi132954.
GeneCardsiPDCL2.
H-InvDBHIX0004227.
HGNCiHGNC:29524. PDCL2.
HPAiHPA048260.
MIMi611676. gene.
neXtProtiNX_Q8N4E4.
OpenTargetsiENSG00000163440.
PharmGKBiPA134987062.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3170. Eukaryota.
ENOG4111H24. LUCA.
GeneTreeiENSGT00530000062970.
HOGENOMiHOG000184445.
HOVERGENiHBG108238.
InParanoidiQ8N4E4.
PhylomeDBiQ8N4E4.
TreeFamiTF315179.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163440-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ8N4E4.
GenomeRNAii132954.
PROiQ8N4E4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163440.
CleanExiHS_PDCL2.
GenevisibleiQ8N4E4. HS.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR024253. Phosducin_thioredoxin-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02114. Phosducin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPDCL2_HUMAN
AccessioniPrimary (citable) accession number: Q8N4E4
Secondary accession number(s): A8MWA2, B9ZVQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.