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Protein

Phosducin-like protein 2

Gene

PDCL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in germ cell maturation.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Phosducin-like protein 2
Gene namesi
Name:PDCL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:29524. PDCL2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134987062.

Polymorphism and mutation databases

BioMutaiPDCL2.
DMDMi215273865.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Phosducin-like protein 2PRO_0000246157Add
BLAST

Proteomic databases

PaxDbiQ8N4E4.
PRIDEiQ8N4E4.

PTM databases

PhosphoSiteiQ8N4E4.

Expressioni

Gene expression databases

BgeeiQ8N4E4.
CleanExiHS_PDCL2.
ExpressionAtlasiQ8N4E4. baseline and differential.
GenevisibleiQ8N4E4. HS.

Organism-specific databases

HPAiHPA048260.

Interactioni

Subunit structurei

Forms a complex with 14-3-3 protein(s).By similarity

Protein-protein interaction databases

BioGridi126343. 2 interactions.
STRINGi9606.ENSP00000295645.

Structurei

Secondary structure

1
241
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi97 – 993Combined sources
Helixi100 – 1034Combined sources
Turni104 – 1063Combined sources
Beta strandi112 – 1187Combined sources
Helixi123 – 13816Combined sources
Beta strandi142 – 1487Combined sources
Helixi149 – 1513Combined sources
Helixi158 – 1603Combined sources
Beta strandi162 – 1687Combined sources
Beta strandi171 – 1788Combined sources
Turni179 – 1835Combined sources
Helixi189 – 1979Combined sources
Turni198 – 2003Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EVIX-ray2.70A/B88-205[»]
ProteinModelPortaliQ8N4E4.
SMRiQ8N4E4. Positions 19-205.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8N4E4.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni89 – 241153Thioredoxin foldBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the phosducin family.Curated

Phylogenomic databases

eggNOGiKOG3170. Eukaryota.
ENOG4111H24. LUCA.
GeneTreeiENSGT00530000062970.
HOGENOMiHOG000184445.
HOVERGENiHBG108238.
InParanoidiQ8N4E4.
OrthoDBiEOG7DRJ41.
PhylomeDBiQ8N4E4.
TreeFamiTF315179.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR024253. Phosducin_thioredoxin-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02114. Phosducin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8N4E4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDPNEDTEW NDILRDFGIL PPKEESKDEI EEMVLRLQKE AMVKPFEKMT
60 70 80 90 100
LAQLKEAEDE FDEEDMQAVE TYRKKRLQEW KALKKKQKFG ELREISGNQY
110 120 130 140 150
VNEVTNAEED VWVIIHLYRS SIPMCLLVNQ HLSLLARKFP ETKFVKAIVN
160 170 180 190 200
SCIQHYHDNC LPTIFVYKNG QIEAKFIGII ECGGINLKLE ELEWKLAEVG
210 220 230 240
AIQTDLEENP RKDMVDMMVS SIRNTSIHDD SDSSNSDNDT K
Length:241
Mass (Da):28,071
Last modified:November 25, 2008 - v2
Checksum:iF2F21C7252EE45CB
GO

Sequence cautioni

The sequence AAH34431.1 differs from that shown. Reason: Frameshift at position 239. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621D → N in AAH34431 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024243 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05469.1.
BC034431 mRNA. Translation: AAH34431.1. Frameshift.
CCDSiCCDS47059.1.
RefSeqiNP_689614.2. NM_152401.2.
UniGeneiHs.223712.

Genome annotation databases

EnsembliENST00000295645; ENSP00000295645; ENSG00000163440.
GeneIDi132954.
KEGGihsa:132954.
UCSCiuc003hbb.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024243 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05469.1.
BC034431 mRNA. Translation: AAH34431.1. Frameshift.
CCDSiCCDS47059.1.
RefSeqiNP_689614.2. NM_152401.2.
UniGeneiHs.223712.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EVIX-ray2.70A/B88-205[»]
ProteinModelPortaliQ8N4E4.
SMRiQ8N4E4. Positions 19-205.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126343. 2 interactions.
STRINGi9606.ENSP00000295645.

PTM databases

PhosphoSiteiQ8N4E4.

Polymorphism and mutation databases

BioMutaiPDCL2.
DMDMi215273865.

Proteomic databases

PaxDbiQ8N4E4.
PRIDEiQ8N4E4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295645; ENSP00000295645; ENSG00000163440.
GeneIDi132954.
KEGGihsa:132954.
UCSCiuc003hbb.3. human.

Organism-specific databases

CTDi132954.
GeneCardsiPDCL2.
H-InvDBHIX0004227.
HGNCiHGNC:29524. PDCL2.
HPAiHPA048260.
MIMi611676. gene.
neXtProtiNX_Q8N4E4.
PharmGKBiPA134987062.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3170. Eukaryota.
ENOG4111H24. LUCA.
GeneTreeiENSGT00530000062970.
HOGENOMiHOG000184445.
HOVERGENiHBG108238.
InParanoidiQ8N4E4.
OrthoDBiEOG7DRJ41.
PhylomeDBiQ8N4E4.
TreeFamiTF315179.

Miscellaneous databases

EvolutionaryTraceiQ8N4E4.
GenomeRNAii132954.
NextBioi83167.
PROiQ8N4E4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N4E4.
CleanExiHS_PDCL2.
ExpressionAtlasiQ8N4E4. baseline and differential.
GenevisibleiQ8N4E4. HS.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR024253. Phosducin_thioredoxin-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02114. Phosducin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Structure of the thioredoxin-fold domain of human phosducin-like protein 2."
    Lou X., Bao R., Zhou C.Z., Chen Y.
    Acta Crystallogr. F 65:67-70(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 88-205.

Entry informationi

Entry nameiPDCL2_HUMAN
AccessioniPrimary (citable) accession number: Q8N4E4
Secondary accession number(s): A8MWA2, B9ZVQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 25, 2008
Last modified: February 17, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.