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Protein

Cation-transporting ATPase

Gene

ATP13A2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cation-transporting ATPaseUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:ATP13A2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei164 – 184HelicalUniRule annotationAdd BLAST21
Transmembranei336 – 357HelicalUniRule annotationAdd BLAST22
Transmembranei369 – 392HelicalUniRule annotationAdd BLAST24
Transmembranei844 – 863HelicalUniRule annotationAdd BLAST20
Transmembranei907 – 930HelicalUniRule annotationAdd BLAST24
Transmembranei957 – 974HelicalUniRule annotationAdd BLAST18
Transmembranei986 – 1006HelicalUniRule annotationAdd BLAST21
Transmembranei1026 – 1046HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ8N4D4.
PeptideAtlasiQ8N4D4.
PRIDEiQ8N4D4.

Structurei

3D structure databases

ProteinModelPortaliQ8N4D4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG0208. Eukaryota.
ENOG410XRCA. LUCA.
HOVERGENiHBG065757.

Family and domain databases

Gene3Di3.40.1110.10. 1 hit.
InterProiView protein in InterPro
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81653. SSF81653. 1 hit.
SSF81660. SSF81660. 2 hits.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q8N4D4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RDKEDSSWQL FTVQVQTEAI GEGSLEPSPQ SQAEDGRSQA AVGAVPEGAW
60 70 80 90 100
KDTAQLHKSE EAVSVGQKRV LRYYLFQGQR YIWIETQQAF YQVSLLDHGR
110 120 130 140 150
SCDDVHRSRH GLSLQDQMVR KAIYGPNVIS IPVKSYPQLL VDEALNPYYG
160 170 180 190 200
FQAFSIALWL ADHYYWYALC IFLISSISIC LSLYKTRKQS QTLRDMVKLS
210 220 230 240 250
MRVCVCRPGG EEEWVDSSEL VPGDCLVLPQ EGGLMPCDAA LVAGECMVNE
260 270 280 290 300
SSLTGESIPV LKTALPEGLG PYCAETHRRH TLFCGTLILQ ARAYVGPHVL
310 320 330 340 350
AVVTRTGFCT AKGGLVSSIL HPRPINFKFY KHSMKFVAAL SVLALLGTIY
360 370 380 390 400
SIFILYRNRV PLNEIVIRAL DLVTVVVPPA LPAAMTVCTL YAQSRLRRQG
410 420 430 440 450
IFCIHPLRIN LGGKLQLVCF DKTGTLTEDG LDVMGVVPLK GQAFLPLVPE
460 470 480 490 500
PRRLPVGPLL RALATCHALS RLQDTPVGDP MDLKMVESTG WVLEEEPAAD
510 520 530 540 550
SAFGTQVLAV MRPPLWEPQL QAMEEPPVPV SVLHRFPFSS ALQRMSVVVA
560 570 580 590 600
WPGATQPEAY VKGSPELVAG LCNPETVPTD FAQMLQSYTA AGYRVVALAS
610 620 630 640 650
KPLPTVPSLE AAQQLTRDTV EGDLSLLGLL VMRNLLKPQT TPVIQALRRT
660 670 680 690 700
RIRAVMVTGD NLQTAVTVAR GCGMVAPQEH LIIVHATHPE RGQPASLEFL
710 720 730 740 750
PMESPTAVNG VKDPDQAASY TVEPDPRSRH LALSGPTFGI IVKHFPKLLP
760 770 780 790 800
KVLVQGTVFA RMAPEQKTEL VCELQKLQYC VGMCGDGAND CGALKAADVG
810 820 830 840 850
ISLSQAEASV VSPFTSSMAS IECVPMVIRE GRCSLDTSFS VFKYMALYSL
860 870 880 890 900
TQFISVLILY TINTNLGDLQ FLAIDLVITT TVAVLMSRTG PALVLGRVRP
910 920 930 940 950
PGALLSVPVL SSLLLQMVLV TGVQLGGYFL TLAQPWFVPL NRTVAAPDNL
960 970 980 990 1000
PNYENTVVFS LSSFQYLILA AAVSKGAPFR RPLYTNVPFL VALALLSSVL
1010 1020 1030 1040 1050
VGLVLVPGLL QGPLALRNIT DTGFKLLLLG LVTLNFVGAF MLESVLDQCL
1060 1070 1080
PACLRRLRPK RASKKRFKQL ERELAEQPWP PLPAGPLR
Length:1,088
Mass (Da):118,812
Last modified:October 1, 2002 - v1
Checksum:i63D6A9E5EFFB2888
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034575 mRNA. Translation: AAH34575.1.
RefSeqiNP_001135445.1. NM_001141973.2.
NP_001135446.1. NM_001141974.2.
UniGeneiHs.128866.

Genome annotation databases

GeneIDi23400.

Similar proteinsi

Entry informationi

Entry nameiQ8N4D4_HUMAN
AccessioniPrimary (citable) accession number: Q8N4D4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation