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Q8N4D4

- Q8N4D4_HUMAN

UniProt

Q8N4D4 - Q8N4D4_HUMAN

Protein
Submitted name:

ATP13A2 protein

Gene

ATP13A2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cation-transporting ATPase activity Source: InterPro
    3. metal ion binding Source: InterPro

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    ATP13A2 proteinImported
    Gene namesi
    Name:ATP13A2Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. lysosomal membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Proteomic databases

    PRIDEiQ8N4D4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N4D4.
    BgeeiQ8N4D4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N4D4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. [View classification]UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG065757.

    Family and domain databases

    Gene3Di2.70.150.10. 1 hit.
    3.40.1110.10. 2 hits.
    3.40.50.1000. 2 hits.
    InterProiIPR004014. ATPase_P-typ_cation-transptr_N.
    IPR006544. ATPase_P-typ_Cation_typ_V.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00122. E1-E2_ATPase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SMARTiSM00831. Cation_ATPase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 3 hits.
    SSF81660. SSF81660. 2 hits.
    TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
    TIGR01657. P-ATPase-V. 1 hit.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q8N4D4-1 [UniParc]FASTAAdd to Basket

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    RDKEDSSWQL FTVQVQTEAI GEGSLEPSPQ SQAEDGRSQA AVGAVPEGAW     50
    KDTAQLHKSE EAVSVGQKRV LRYYLFQGQR YIWIETQQAF YQVSLLDHGR 100
    SCDDVHRSRH GLSLQDQMVR KAIYGPNVIS IPVKSYPQLL VDEALNPYYG 150
    FQAFSIALWL ADHYYWYALC IFLISSISIC LSLYKTRKQS QTLRDMVKLS 200
    MRVCVCRPGG EEEWVDSSEL VPGDCLVLPQ EGGLMPCDAA LVAGECMVNE 250
    SSLTGESIPV LKTALPEGLG PYCAETHRRH TLFCGTLILQ ARAYVGPHVL 300
    AVVTRTGFCT AKGGLVSSIL HPRPINFKFY KHSMKFVAAL SVLALLGTIY 350
    SIFILYRNRV PLNEIVIRAL DLVTVVVPPA LPAAMTVCTL YAQSRLRRQG 400
    IFCIHPLRIN LGGKLQLVCF DKTGTLTEDG LDVMGVVPLK GQAFLPLVPE 450
    PRRLPVGPLL RALATCHALS RLQDTPVGDP MDLKMVESTG WVLEEEPAAD 500
    SAFGTQVLAV MRPPLWEPQL QAMEEPPVPV SVLHRFPFSS ALQRMSVVVA 550
    WPGATQPEAY VKGSPELVAG LCNPETVPTD FAQMLQSYTA AGYRVVALAS 600
    KPLPTVPSLE AAQQLTRDTV EGDLSLLGLL VMRNLLKPQT TPVIQALRRT 650
    RIRAVMVTGD NLQTAVTVAR GCGMVAPQEH LIIVHATHPE RGQPASLEFL 700
    PMESPTAVNG VKDPDQAASY TVEPDPRSRH LALSGPTFGI IVKHFPKLLP 750
    KVLVQGTVFA RMAPEQKTEL VCELQKLQYC VGMCGDGAND CGALKAADVG 800
    ISLSQAEASV VSPFTSSMAS IECVPMVIRE GRCSLDTSFS VFKYMALYSL 850
    TQFISVLILY TINTNLGDLQ FLAIDLVITT TVAVLMSRTG PALVLGRVRP 900
    PGALLSVPVL SSLLLQMVLV TGVQLGGYFL TLAQPWFVPL NRTVAAPDNL 950
    PNYENTVVFS LSSFQYLILA AAVSKGAPFR RPLYTNVPFL VALALLSSVL 1000
    VGLVLVPGLL QGPLALRNIT DTGFKLLLLG LVTLNFVGAF MLESVLDQCL 1050
    PACLRRLRPK RASKKRFKQL ERELAEQPWP PLPAGPLR 1088
    Length:1,088
    Mass (Da):118,812
    Last modified:October 1, 2002 - v1
    Checksum:i63D6A9E5EFFB2888
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC034575 mRNA. Translation: AAH34575.1.
    UniGeneiHs.128866.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC034575 mRNA. Translation: AAH34575.1 .
    UniGenei Hs.128866.

    3D structure databases

    ProteinModelPortali Q8N4D4.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q8N4D4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG065757.

    Miscellaneous databases

    ChiTaRSi ATP13A2. human.

    Gene expression databases

    ArrayExpressi Q8N4D4.
    Bgeei Q8N4D4.

    Family and domain databases

    Gene3Di 2.70.150.10. 1 hit.
    3.40.1110.10. 2 hits.
    3.40.50.1000. 2 hits.
    InterProi IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR006544. ATPase_P-typ_Cation_typ_V.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00122. E1-E2_ATPase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SMARTi SM00831. Cation_ATPase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 3 hits.
    SSF81660. SSF81660. 2 hits.
    TIGRFAMsi TIGR01494. ATPase_P-type. 2 hits.
    TIGR01657. P-ATPase-V. 1 hit.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: CervixImported.

    Entry informationi

    Entry nameiQ8N4D4_HUMAN
    AccessioniPrimary (citable) accession number: Q8N4D4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.