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Q8N4C8

- MINK1_HUMAN

UniProt

Q8N4C8 - MINK1_HUMAN

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Protein

Misshapen-like kinase 1

Gene
MINK1, B55, MAP4K6, MINK, YSK2, ZC3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.4 Publications
Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.4 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Magnesium By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 541ATP By similarityBy similarity
Active sitei153 – 1531Proton acceptor By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 399ATP By similarityBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. protein binding Source: UniProtKB
  3. protein kinase activity Source: ProtInc
  4. protein serine/threonine kinase activity Source: UniProtKB
  5. receptor signaling protein serine/threonine kinase activity Source: RefGenome
  6. small GTPase regulator activity Source: InterPro

GO - Biological processi

  1. actin cytoskeleton reorganization Source: UniProtKB
  2. dendrite morphogenesis Source: UniProtKB
  3. intracellular signal transduction Source: UniProtKB
  4. JNK cascade Source: ProtInc
  5. multicellular organismal development Source: UniProtKB
  6. negative thymic T cell selection Source: Ensembl
  7. positive regulation of JNK cascade Source: UniProtKB
  8. protein autophosphorylation Source: UniProtKB
  9. protein phosphorylation Source: UniProtKB
  10. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: UniProtKB
  11. regulation of cell-cell adhesion Source: UniProtKB
  12. regulation of cell-matrix adhesion Source: UniProtKB
  13. regulation of cell migration Source: UniProtKB
  14. response to stress Source: UniProtKB
  15. synaptic transmission Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_169436. Oxidative Stress Induced Senescence.
SignaLinkiQ8N4C8.

Names & Taxonomyi

Protein namesi
Recommended name:
Misshapen-like kinase 1 (EC:2.7.11.1)
Alternative name(s):
GCK family kinase MiNK
MAPK/ERK kinase kinase kinase 6
Short name:
MEK kinase kinase 6
Short name:
MEKKK 6
Misshapen/NIK-related kinase
Mitogen-activated protein kinase kinase kinase kinase 6
Gene namesi
Name:MINK1
Synonyms:B55, MAP4K6, MINK, YSK2, ZC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:17565. MINK1.

Subcellular locationi

Cytoplasm. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Cell projectionaxon By similarity. Cell projectiondendrite By similarity 2 Publications
Isoform 4 : Golgi apparatus 2 Publications

GO - Cellular componenti

  1. axon Source: UniProtKB-SubCell
  2. cell junction Source: UniProtKB-KW
  3. cytoplasm Source: UniProtKB
  4. cytosol Source: Reactome
  5. dendrite Source: UniProtKB-SubCell
  6. extracellular vesicular exosome Source: UniProt
  7. Golgi apparatus Source: UniProtKB
  8. postsynaptic density Source: UniProtKB-SubCell
  9. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Golgi apparatus, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134910641.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13321332Misshapen-like kinase 1PRO_0000086329Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei641 – 6411Phosphoserine1 Publication
Modified residuei763 – 7631Phosphoserine8 Publications
Modified residuei777 – 7771Phosphoserine1 Publication
Modified residuei778 – 7781Phosphoserine2 Publications
Modified residuei782 – 7821Phosphoserine2 Publications

Post-translational modificationi

Autophosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8N4C8.
PaxDbiQ8N4C8.
PRIDEiQ8N4C8.

PTM databases

PhosphoSiteiQ8N4C8.

Expressioni

Tissue specificityi

Expressed in the brain, isoform 2 is more abundant than isoform 1. Isoform 3 is ubiquitously expressed. Isoform 1 is most abundant in the skeletal muscle. Isoform 4 is ubiquitously expressed with relative high levels in brain, skeletal muscle, pancreas and testis.2 Publications

Inductioni

Activated after Ras induction via a mechanism involving reactive oxygen species.1 Publication

Gene expression databases

ArrayExpressiQ8N4C8.
BgeeiQ8N4C8.
CleanExiHS_MINK1.
GenevestigatoriQ8N4C8.

Organism-specific databases

HPAiHPA056296.

Interactioni

Subunit structurei

Interacts with TANC1 By similarity. Interacts with RAP2A. Isoform 4 interacts with NCK1.2 Publications

Protein-protein interaction databases

BioGridi119075. 5 interactions.
IntActiQ8N4C8. 2 interactions.
STRINGi9606.ENSP00000347427.

Structurei

3D structure databases

ProteinModelPortaliQ8N4C8.
SMRiQ8N4C8. Positions 13-313.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 289265Protein kinaseAdd
BLAST
Domaini1019 – 1306288CNHAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni866 – 1332467Mediates interaction with RAP2AAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi359 – 495137Gln-richAdd
BLAST
Compositional biasi542 – 729188Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 CNH domain.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000290708.
HOVERGENiHBG036506.
InParanoidiQ8N4C8.
KOiK04413.
OMAiGTQTPYG.
OrthoDBiEOG73803V.
PhylomeDBiQ8N4C8.
TreeFamiTF105138.

Family and domain databases

InterProiIPR001180. Citron.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00036. CNH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50219. CNH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 31 Publication (identifier: Q8N4C8-1) [UniParc]FASTAAdd to Basket

Also known as: MINK-alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGDPAPARSL DDIDLSALRD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL     50
AAIKVMDVTE DEEEEIKQEI NMLKKYSHHR NIATYYGAFI KKSPPGNDDQ 100
LWLVMEFCGA GSVTDLVKNT KGNALKEDCI AYICREILRG LAHLHAHKVI 150
HRDIKGQNVL LTENAEVKLV DFGVSAQLDR TVGRRNTFIG TPYWMAPEVI 200
ACDENPDATY DYRSDIWSLG ITAIEMAEGA PPLCDMHPMR ALFLIPRNPP 250
PRLKSKKWSK KFIDFIDTCL IKTYLSRPPT EQLLKFPFIR DQPTERQVRI 300
QLKDHIDRSR KKRGEKEETE YEYSGSEEED DSHGEEGEPS SIMNVPGEST 350
LRREFLRLQQ ENKSNSEALK QQQQLQQQQQ RDPEAHIKHL LHQRQRRIEE 400
QKEERRRVEE QQRREREQRK LQEKEQQRRL EDMQALRREE ERRQAEREQE 450
YKRKQLEEQR QSERLQRQLQ QEHAYLKSLQ QQQQQQQLQK QQQQQLLPGD 500
RKPLYHYGRG MNPADKPAWA REVEERTRMN KQQNSPLAKS KPGSTGPEPP 550
IPQASPGPPG PLSQTPPMQR PVEPQEGPHK SLVAHRVPLK PYAAPVPRSQ 600
SLQDQPTRNL AAFPASHDPD PAIPAPTATP SARGAVIRQN SDPTSEGPGP 650
SPNPPAWVRP DNEAPPKVPQ RTSSIATALN TSGAGGSRPA QAVRARPRSN 700
SAWQIYLQRR AERGTPKPPG PPAQPPGPPN ASSNPDLRRS DPGWERSDSV 750
LPASHGHLPQ AGSLERNRVG VSSKPDSSPV LSPGNKAKPD DHRSRPGRPA 800
DFVLLKERTL DEAPRPPKKA MDYSSSSEEV ESSEDDEEEG EGGPAEGSRD 850
TPGGRSDGDT DSVSTMVVHD VEEITGTQPP YGGGTMVVQR TPEEERNLLH 900
ADSNGYTNLP DVVQPSHSPT ENSKGQSPPS KDGSGDYQSR GLVKAPGKSS 950
FTMFVDLGIY QPGGSGDSIP ITALVGGEGT RLDQLQYDVR KGSVVNVNPT 1000
NTRAHSETPE IRKYKKRFNS EILCAALWGV NLLVGTENGL MLLDRSGQGK 1050
VYGLIGRRRF QQMDVLEGLN LLITISGKRN KLRVYYLSWL RNKILHNDPE 1100
VEKKQGWTTV GDMEGCGHYR VVKYERIKFL VIALKSSVEV YAWAPKPYHK 1150
FMAFKSFADL PHRPLLVDLT VEEGQRLKVI YGSSAGFHAV DVDSGNSYDI 1200
YIPVHIQSQI TPHAIIFLPN TDGMEMLLCY EDEGVYVNTY GRIIKDVVLQ 1250
WGEMPTSVAY ICSNQIMGWG EKAIEIRSVE TGHLDGVFMH KRAQRLKFLC 1300
ERNDKVFFAS VRSGGSSQVY FMTLNRNCIM NW 1332
Length:1,332
Mass (Da):149,822
Last modified:May 18, 2010 - v2
Checksum:i3E3B182CDDB3659C
GO
Isoform 11 Publication (identifier: Q8N4C8-2) [UniParc]FASTAAdd to Basket

Also known as: MiNK-1, MINK-delta

The sequence of this isoform differs from the canonical sequence as follows:
     696-732: Missing.

Show »
Length:1,295
Mass (Da):145,806
Checksum:i029AD8C2806C90EE
GO
Isoform 21 Publication (identifier: Q8N4C8-3) [UniParc]FASTAAdd to Basket

Also known as: MiNK-2, MINK-gamma

The sequence of this isoform differs from the canonical sequence as follows:
     696-732: Missing.
     800-800: A → ASYKRAIGE

Show »
Length:1,303
Mass (Da):146,711
Checksum:iFD65470BFC6981B2
GO
Isoform 4 (identifier: Q8N4C8-4) [UniParc]FASTAAdd to Basket

Also known as: MINK-beta

The sequence of this isoform differs from the canonical sequence as follows:
     581-600: Missing.

Show »
Length:1,312
Mass (Da):147,653
Checksum:iB8D157A582DA5D18
GO
Isoform 5 (identifier: Q8N4C8-5) [UniParc]FASTAAdd to Basket

Also known as: MINK-eta

The sequence of this isoform differs from the canonical sequence as follows:
     581-600: Missing.
     696-732: Missing.

Show »
Length:1,275
Mass (Da):143,637
Checksum:i4E992F63A486A95A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti514 – 5141A → T.1 Publication
Corresponds to variant rs56131206 [ dbSNP | Ensembl ].
VAR_040799
Natural varianti771 – 7711V → A.2 Publications
Corresponds to variant rs11556634 [ dbSNP | Ensembl ].
VAR_046058
Natural varianti775 – 7751P → L.7 Publications
Corresponds to variant rs11556635 [ dbSNP | Ensembl ].
VAR_046059
Natural varianti863 – 8631V → I.1 Publication
Corresponds to variant rs2302319 [ dbSNP | Ensembl ].
VAR_046060
Natural varianti1010 – 10101E → V in a gastric adenocarcinoma sample; somatic mutation. 1 Publication
VAR_046061
Natural varianti1200 – 12001I → V.1 Publication
VAR_040800

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei581 – 60020Missing in isoform 4 and isoform 5. VSP_041871Add
BLAST
Alternative sequencei696 – 73237Missing in isoform 1, isoform 2 and isoform 5. 1 PublicationVSP_007059Add
BLAST
Alternative sequencei800 – 8001A → ASYKRAIGE in isoform 2. 1 PublicationVSP_007060

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB041926 mRNA. Translation: BAA94838.1.
AB035698 mRNA. Translation: BAA90753.1.
AY775058 mRNA. Translation: AAV41830.1.
AC233723 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90401.1.
CH471108 Genomic DNA. Translation: EAW90403.1.
CH471108 Genomic DNA. Translation: EAW90399.1.
CH471108 Genomic DNA. Translation: EAW90400.1.
CH471108 Genomic DNA. Translation: EAW90402.1.
BC034673 mRNA. Translation: AAH34673.1.
CCDSiCCDS45588.1. [Q8N4C8-1]
CCDS45589.1. [Q8N4C8-3]
CCDS45590.1. [Q8N4C8-4]
RefSeqiNP_001020108.1. NM_001024937.3. [Q8N4C8-4]
NP_056531.1. NM_015716.4. [Q8N4C8-2]
NP_722549.2. NM_153827.4. [Q8N4C8-1]
NP_733763.1. NM_170663.4. [Q8N4C8-3]
UniGeneiHs.443417.

Genome annotation databases

EnsembliENST00000347992; ENSP00000269296; ENSG00000141503. [Q8N4C8-3]
ENST00000355280; ENSP00000347427; ENSG00000141503. [Q8N4C8-1]
ENST00000453408; ENSP00000406487; ENSG00000141503. [Q8N4C8-4]
GeneIDi50488.
KEGGihsa:50488.
UCSCiuc010vsk.2. human. [Q8N4C8-3]
uc010vsl.2. human. [Q8N4C8-1]
uc010vsm.2. human. [Q8N4C8-4]
uc010vsn.2. human. [Q8N4C8-2]

Polymorphism databases

DMDMi296437370.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB041926 mRNA. Translation: BAA94838.1 .
AB035698 mRNA. Translation: BAA90753.1 .
AY775058 mRNA. Translation: AAV41830.1 .
AC233723 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90401.1 .
CH471108 Genomic DNA. Translation: EAW90403.1 .
CH471108 Genomic DNA. Translation: EAW90399.1 .
CH471108 Genomic DNA. Translation: EAW90400.1 .
CH471108 Genomic DNA. Translation: EAW90402.1 .
BC034673 mRNA. Translation: AAH34673.1 .
CCDSi CCDS45588.1. [Q8N4C8-1 ]
CCDS45589.1. [Q8N4C8-3 ]
CCDS45590.1. [Q8N4C8-4 ]
RefSeqi NP_001020108.1. NM_001024937.3. [Q8N4C8-4 ]
NP_056531.1. NM_015716.4. [Q8N4C8-2 ]
NP_722549.2. NM_153827.4. [Q8N4C8-1 ]
NP_733763.1. NM_170663.4. [Q8N4C8-3 ]
UniGenei Hs.443417.

3D structure databases

ProteinModelPortali Q8N4C8.
SMRi Q8N4C8. Positions 13-313.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119075. 5 interactions.
IntActi Q8N4C8. 2 interactions.
STRINGi 9606.ENSP00000347427.

Chemistry

ChEMBLi CHEMBL5518.
GuidetoPHARMACOLOGYi 2103.

PTM databases

PhosphoSitei Q8N4C8.

Polymorphism databases

DMDMi 296437370.

Proteomic databases

MaxQBi Q8N4C8.
PaxDbi Q8N4C8.
PRIDEi Q8N4C8.

Protocols and materials databases

DNASUi 50488.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000347992 ; ENSP00000269296 ; ENSG00000141503 . [Q8N4C8-3 ]
ENST00000355280 ; ENSP00000347427 ; ENSG00000141503 . [Q8N4C8-1 ]
ENST00000453408 ; ENSP00000406487 ; ENSG00000141503 . [Q8N4C8-4 ]
GeneIDi 50488.
KEGGi hsa:50488.
UCSCi uc010vsk.2. human. [Q8N4C8-3 ]
uc010vsl.2. human. [Q8N4C8-1 ]
uc010vsm.2. human. [Q8N4C8-4 ]
uc010vsn.2. human. [Q8N4C8-2 ]

Organism-specific databases

CTDi 50488.
GeneCardsi GC17P004736.
H-InvDB HIX0013452.
HGNCi HGNC:17565. MINK1.
HPAi HPA056296.
MIMi 609426. gene.
neXtProti NX_Q8N4C8.
PharmGKBi PA134910641.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000290708.
HOVERGENi HBG036506.
InParanoidi Q8N4C8.
KOi K04413.
OMAi GTQTPYG.
OrthoDBi EOG73803V.
PhylomeDBi Q8N4C8.
TreeFami TF105138.

Enzyme and pathway databases

Reactomei REACT_169436. Oxidative Stress Induced Senescence.
SignaLinki Q8N4C8.

Miscellaneous databases

ChiTaRSi MINK1. human.
GeneWikii MINK1.
GenomeRNAii 50488.
NextBioi 53052.
PROi Q8N4C8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8N4C8.
Bgeei Q8N4C8.
CleanExi HS_MINK1.
Genevestigatori Q8N4C8.

Family and domain databases

InterProi IPR001180. Citron.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00036. CNH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50219. CNH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development."
    Dan I., Watanabe N.M., Kobayashi T., Yamashita-Suzuki K., Fukagaya Y., Kajikawa E., Kimura W.K., Nakashima T.M., Matsumoto K., Ninomiya-Tsuji J., Kusumi A.
    FEBS Lett. 469:19-23(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  2. "Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta."
    Hu Y., Leo C., Yu S., Huang B.C., Wang H., Shen M., Luo Y., Daniel-Issakani S., Payan D.G., Xu X.
    J. Biol. Chem. 279:54387-54397(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH NCK1, TISSUE SPECIFICITY, ALTERNATIVE SPLICING, AUTOPHOSPHORYLATION, VARIANTS ALA-771 AND LEU-775.
  3. Erratum
    Hu Y., Leo C., Yu S., Huang B.C., Wang H., Shen M., Luo Y., Daniel-Issakani S., Payan D.G., Xu X.
    J. Biol. Chem. 280:5128-5128(2005)
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS ALA-771 AND LEU-775.
    Tissue: Lymph.
  7. "Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells."
    Nicke B., Bastien J., Khanna S.J., Warne P.H., Cowling V., Cook S.J., Peters G., Delpuech O., Schulze A., Berns K., Mullenders J., Beijersbergen R.L., Bernards R., Ganesan T.S., Downward J., Hancock D.C.
    Mol. Cell 20:673-685(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-763, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: FUNCTION, INTERACTION WITH RAP2A, SUBCELLULAR LOCATION.
  10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-763, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-763, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-641; SER-763 AND SER-782, VARIANT [LARGE SCALE ANALYSIS] LEU-775, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-763; SER-777; SER-778 AND SER-782, VARIANT [LARGE SCALE ANALYSIS] LEU-775, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-763, VARIANT [LARGE SCALE ANALYSIS] LEU-775, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-778, VARIANT [LARGE SCALE ANALYSIS] LEU-775, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-763, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. Cited for: FUNCTION.
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-763, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  20. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-514; ILE-863; VAL-1010 AND VAL-1200.
  21. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-775, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMINK1_HUMAN
AccessioniPrimary (citable) accession number: Q8N4C8
Secondary accession number(s): D3DTK3
, D3DTK4, Q5U8Z0, Q9P1X1, Q9P2R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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