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Q8N4C8

- MINK1_HUMAN

UniProt

Q8N4C8 - MINK1_HUMAN

Protein

Misshapen-like kinase 1

Gene

MINK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.
    Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.By similarity

    Cofactori

    Magnesium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei54 – 541ATPPROSITE-ProRule annotation
    Active sitei153 – 1531Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi31 – 399ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. protein kinase activity Source: ProtInc
    4. protein serine/threonine kinase activity Source: UniProtKB
    5. small GTPase regulator activity Source: InterPro

    GO - Biological processi

    1. actin cytoskeleton reorganization Source: UniProtKB
    2. dendrite morphogenesis Source: UniProtKB
    3. intracellular signal transduction Source: UniProtKB
    4. JNK cascade Source: ProtInc
    5. multicellular organismal development Source: UniProtKB
    6. negative thymic T cell selection Source: Ensembl
    7. positive regulation of JNK cascade Source: UniProtKB
    8. protein autophosphorylation Source: UniProtKB
    9. protein phosphorylation Source: UniProtKB
    10. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: UniProtKB
    11. regulation of cell-cell adhesion Source: UniProtKB
    12. regulation of cell-matrix adhesion Source: UniProtKB
    13. regulation of cell migration Source: UniProtKB
    14. response to stress Source: UniProtKB
    15. synaptic transmission Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_169436. Oxidative Stress Induced Senescence.
    SignaLinkiQ8N4C8.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Misshapen-like kinase 1 (EC:2.7.11.1)
    Alternative name(s):
    GCK family kinase MiNK
    MAPK/ERK kinase kinase kinase 6
    Short name:
    MEK kinase kinase 6
    Short name:
    MEKKK 6
    Misshapen/NIK-related kinase
    Mitogen-activated protein kinase kinase kinase kinase 6
    Gene namesi
    Name:MINK1Imported
    Synonyms:B55, MAP4K6By similarity, MINKImported, YSK2, ZC3
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:17565. MINK1.

    Subcellular locationi

    Cytoplasm 2 Publications. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Cell projectionaxon By similarity. Cell projectiondendrite By similarity

    GO - Cellular componenti

    1. axon Source: UniProtKB-SubCell
    2. cell junction Source: UniProtKB-KW
    3. cytoplasm Source: UniProtKB
    4. cytosol Source: Reactome
    5. dendrite Source: UniProtKB-SubCell
    6. extracellular vesicular exosome Source: UniProt
    7. Golgi apparatus Source: UniProtKB
    8. postsynaptic density Source: UniProtKB-SubCell
    9. postsynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Cytoplasm, Golgi apparatus, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134910641.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13321332Misshapen-like kinase 1PRO_0000086329Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei641 – 6411Phosphoserine1 Publication
    Modified residuei763 – 7631Phosphoserine8 Publications
    Modified residuei777 – 7771Phosphoserine1 Publication
    Modified residuei778 – 7781Phosphoserine2 Publications
    Modified residuei782 – 7821Phosphoserine2 Publications

    Post-translational modificationi

    Autophosphorylated.9 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8N4C8.
    PaxDbiQ8N4C8.
    PRIDEiQ8N4C8.

    PTM databases

    PhosphoSiteiQ8N4C8.

    Expressioni

    Tissue specificityi

    Expressed in the brain, isoform 2 is more abundant than isoform 1. Isoform 3 is ubiquitously expressed. Isoform 1 is most abundant in the skeletal muscle. Isoform 4 is ubiquitously expressed with relative high levels in brain, skeletal muscle, pancreas and testis.1 Publication

    Inductioni

    Activated after Ras induction via a mechanism involving reactive oxygen species.1 Publication

    Gene expression databases

    ArrayExpressiQ8N4C8.
    BgeeiQ8N4C8.
    CleanExiHS_MINK1.
    GenevestigatoriQ8N4C8.

    Organism-specific databases

    HPAiHPA056296.

    Interactioni

    Subunit structurei

    Interacts with TANC1 By similarity. Interacts with RAP2A. Isoform 4 interacts with NCK1.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi119075. 5 interactions.
    IntActiQ8N4C8. 2 interactions.
    STRINGi9606.ENSP00000347427.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N4C8.
    SMRiQ8N4C8. Positions 13-313.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 289265Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini1019 – 1306288CNHPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni866 – 1332467Mediates interaction with RAP2AAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi359 – 495137Gln-richAdd
    BLAST
    Compositional biasi542 – 729188Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CNH domain.CuratedPROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000290708.
    HOVERGENiHBG036506.
    InParanoidiQ8N4C8.
    KOiK04413.
    OMAiGTQTPYG.
    OrthoDBiEOG73803V.
    PhylomeDBiQ8N4C8.
    TreeFamiTF105138.

    Family and domain databases

    InterProiIPR001180. Citron.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00780. CNH. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00036. CNH. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50219. CNH. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 31 Publication (identifier: Q8N4C8-1) [UniParc]FASTAAdd to Basket

    Also known as: MINK-alpha

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGDPAPARSL DDIDLSALRD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL     50
    AAIKVMDVTE DEEEEIKQEI NMLKKYSHHR NIATYYGAFI KKSPPGNDDQ 100
    LWLVMEFCGA GSVTDLVKNT KGNALKEDCI AYICREILRG LAHLHAHKVI 150
    HRDIKGQNVL LTENAEVKLV DFGVSAQLDR TVGRRNTFIG TPYWMAPEVI 200
    ACDENPDATY DYRSDIWSLG ITAIEMAEGA PPLCDMHPMR ALFLIPRNPP 250
    PRLKSKKWSK KFIDFIDTCL IKTYLSRPPT EQLLKFPFIR DQPTERQVRI 300
    QLKDHIDRSR KKRGEKEETE YEYSGSEEED DSHGEEGEPS SIMNVPGEST 350
    LRREFLRLQQ ENKSNSEALK QQQQLQQQQQ RDPEAHIKHL LHQRQRRIEE 400
    QKEERRRVEE QQRREREQRK LQEKEQQRRL EDMQALRREE ERRQAEREQE 450
    YKRKQLEEQR QSERLQRQLQ QEHAYLKSLQ QQQQQQQLQK QQQQQLLPGD 500
    RKPLYHYGRG MNPADKPAWA REVEERTRMN KQQNSPLAKS KPGSTGPEPP 550
    IPQASPGPPG PLSQTPPMQR PVEPQEGPHK SLVAHRVPLK PYAAPVPRSQ 600
    SLQDQPTRNL AAFPASHDPD PAIPAPTATP SARGAVIRQN SDPTSEGPGP 650
    SPNPPAWVRP DNEAPPKVPQ RTSSIATALN TSGAGGSRPA QAVRARPRSN 700
    SAWQIYLQRR AERGTPKPPG PPAQPPGPPN ASSNPDLRRS DPGWERSDSV 750
    LPASHGHLPQ AGSLERNRVG VSSKPDSSPV LSPGNKAKPD DHRSRPGRPA 800
    DFVLLKERTL DEAPRPPKKA MDYSSSSEEV ESSEDDEEEG EGGPAEGSRD 850
    TPGGRSDGDT DSVSTMVVHD VEEITGTQPP YGGGTMVVQR TPEEERNLLH 900
    ADSNGYTNLP DVVQPSHSPT ENSKGQSPPS KDGSGDYQSR GLVKAPGKSS 950
    FTMFVDLGIY QPGGSGDSIP ITALVGGEGT RLDQLQYDVR KGSVVNVNPT 1000
    NTRAHSETPE IRKYKKRFNS EILCAALWGV NLLVGTENGL MLLDRSGQGK 1050
    VYGLIGRRRF QQMDVLEGLN LLITISGKRN KLRVYYLSWL RNKILHNDPE 1100
    VEKKQGWTTV GDMEGCGHYR VVKYERIKFL VIALKSSVEV YAWAPKPYHK 1150
    FMAFKSFADL PHRPLLVDLT VEEGQRLKVI YGSSAGFHAV DVDSGNSYDI 1200
    YIPVHIQSQI TPHAIIFLPN TDGMEMLLCY EDEGVYVNTY GRIIKDVVLQ 1250
    WGEMPTSVAY ICSNQIMGWG EKAIEIRSVE TGHLDGVFMH KRAQRLKFLC 1300
    ERNDKVFFAS VRSGGSSQVY FMTLNRNCIM NW 1332
    Length:1,332
    Mass (Da):149,822
    Last modified:May 18, 2010 - v2
    Checksum:i3E3B182CDDB3659C
    GO
    Isoform 11 Publication (identifier: Q8N4C8-2) [UniParc]FASTAAdd to Basket

    Also known as: MiNK-1, MINK-delta

    The sequence of this isoform differs from the canonical sequence as follows:
         696-732: Missing.

    Show »
    Length:1,295
    Mass (Da):145,806
    Checksum:i029AD8C2806C90EE
    GO
    Isoform 21 Publication (identifier: Q8N4C8-3) [UniParc]FASTAAdd to Basket

    Also known as: MiNK-2, MINK-gamma

    The sequence of this isoform differs from the canonical sequence as follows:
         696-732: Missing.
         800-800: A → ASYKRAIGE

    Show »
    Length:1,303
    Mass (Da):146,711
    Checksum:iFD65470BFC6981B2
    GO
    Isoform 4 (identifier: Q8N4C8-4) [UniParc]FASTAAdd to Basket

    Also known as: MINK-beta

    The sequence of this isoform differs from the canonical sequence as follows:
         581-600: Missing.

    Show »
    Length:1,312
    Mass (Da):147,653
    Checksum:iB8D157A582DA5D18
    GO
    Isoform 5 (identifier: Q8N4C8-5) [UniParc]FASTAAdd to Basket

    Also known as: MINK-eta

    The sequence of this isoform differs from the canonical sequence as follows:
         581-600: Missing.
         696-732: Missing.

    Show »
    Length:1,275
    Mass (Da):143,637
    Checksum:i4E992F63A486A95A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti514 – 5141A → T.1 Publication
    Corresponds to variant rs56131206 [ dbSNP | Ensembl ].
    VAR_040799
    Natural varianti771 – 7711V → A.2 Publications
    Corresponds to variant rs11556634 [ dbSNP | Ensembl ].
    VAR_046058
    Natural varianti775 – 7751P → L.7 Publications
    Corresponds to variant rs11556635 [ dbSNP | Ensembl ].
    VAR_046059
    Natural varianti863 – 8631V → I.1 Publication
    Corresponds to variant rs2302319 [ dbSNP | Ensembl ].
    VAR_046060
    Natural varianti1010 – 10101E → V in a gastric adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_046061
    Natural varianti1200 – 12001I → V.1 Publication
    VAR_040800

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei581 – 60020Missing in isoform 4 and isoform 5. 1 PublicationVSP_041871Add
    BLAST
    Alternative sequencei696 – 73237Missing in isoform 1, isoform 2 and isoform 5. 1 PublicationVSP_007059Add
    BLAST
    Alternative sequencei800 – 8001A → ASYKRAIGE in isoform 2. 1 PublicationVSP_007060

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB041926 mRNA. Translation: BAA94838.1.
    AB035698 mRNA. Translation: BAA90753.1.
    AY775058 mRNA. Translation: AAV41830.1.
    AC233723 Genomic DNA. No translation available.
    CH471108 Genomic DNA. Translation: EAW90401.1.
    CH471108 Genomic DNA. Translation: EAW90403.1.
    CH471108 Genomic DNA. Translation: EAW90399.1.
    CH471108 Genomic DNA. Translation: EAW90400.1.
    CH471108 Genomic DNA. Translation: EAW90402.1.
    BC034673 mRNA. Translation: AAH34673.1.
    CCDSiCCDS45588.1. [Q8N4C8-1]
    CCDS45589.1. [Q8N4C8-3]
    CCDS45590.1. [Q8N4C8-4]
    RefSeqiNP_001020108.1. NM_001024937.3. [Q8N4C8-4]
    NP_056531.1. NM_015716.4. [Q8N4C8-2]
    NP_722549.2. NM_153827.4. [Q8N4C8-1]
    NP_733763.1. NM_170663.4. [Q8N4C8-3]
    UniGeneiHs.443417.

    Genome annotation databases

    EnsembliENST00000347992; ENSP00000269296; ENSG00000141503. [Q8N4C8-3]
    ENST00000355280; ENSP00000347427; ENSG00000141503. [Q8N4C8-1]
    ENST00000453408; ENSP00000406487; ENSG00000141503. [Q8N4C8-4]
    GeneIDi50488.
    KEGGihsa:50488.
    UCSCiuc010vsk.2. human. [Q8N4C8-3]
    uc010vsl.2. human. [Q8N4C8-1]
    uc010vsm.2. human. [Q8N4C8-4]
    uc010vsn.2. human. [Q8N4C8-2]

    Polymorphism databases

    DMDMi296437370.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB041926 mRNA. Translation: BAA94838.1 .
    AB035698 mRNA. Translation: BAA90753.1 .
    AY775058 mRNA. Translation: AAV41830.1 .
    AC233723 Genomic DNA. No translation available.
    CH471108 Genomic DNA. Translation: EAW90401.1 .
    CH471108 Genomic DNA. Translation: EAW90403.1 .
    CH471108 Genomic DNA. Translation: EAW90399.1 .
    CH471108 Genomic DNA. Translation: EAW90400.1 .
    CH471108 Genomic DNA. Translation: EAW90402.1 .
    BC034673 mRNA. Translation: AAH34673.1 .
    CCDSi CCDS45588.1. [Q8N4C8-1 ]
    CCDS45589.1. [Q8N4C8-3 ]
    CCDS45590.1. [Q8N4C8-4 ]
    RefSeqi NP_001020108.1. NM_001024937.3. [Q8N4C8-4 ]
    NP_056531.1. NM_015716.4. [Q8N4C8-2 ]
    NP_722549.2. NM_153827.4. [Q8N4C8-1 ]
    NP_733763.1. NM_170663.4. [Q8N4C8-3 ]
    UniGenei Hs.443417.

    3D structure databases

    ProteinModelPortali Q8N4C8.
    SMRi Q8N4C8. Positions 13-313.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119075. 5 interactions.
    IntActi Q8N4C8. 2 interactions.
    STRINGi 9606.ENSP00000347427.

    Chemistry

    ChEMBLi CHEMBL5518.
    GuidetoPHARMACOLOGYi 2103.

    PTM databases

    PhosphoSitei Q8N4C8.

    Polymorphism databases

    DMDMi 296437370.

    Proteomic databases

    MaxQBi Q8N4C8.
    PaxDbi Q8N4C8.
    PRIDEi Q8N4C8.

    Protocols and materials databases

    DNASUi 50488.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000347992 ; ENSP00000269296 ; ENSG00000141503 . [Q8N4C8-3 ]
    ENST00000355280 ; ENSP00000347427 ; ENSG00000141503 . [Q8N4C8-1 ]
    ENST00000453408 ; ENSP00000406487 ; ENSG00000141503 . [Q8N4C8-4 ]
    GeneIDi 50488.
    KEGGi hsa:50488.
    UCSCi uc010vsk.2. human. [Q8N4C8-3 ]
    uc010vsl.2. human. [Q8N4C8-1 ]
    uc010vsm.2. human. [Q8N4C8-4 ]
    uc010vsn.2. human. [Q8N4C8-2 ]

    Organism-specific databases

    CTDi 50488.
    GeneCardsi GC17P004736.
    H-InvDB HIX0013452.
    HGNCi HGNC:17565. MINK1.
    HPAi HPA056296.
    MIMi 609426. gene.
    neXtProti NX_Q8N4C8.
    PharmGKBi PA134910641.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000290708.
    HOVERGENi HBG036506.
    InParanoidi Q8N4C8.
    KOi K04413.
    OMAi GTQTPYG.
    OrthoDBi EOG73803V.
    PhylomeDBi Q8N4C8.
    TreeFami TF105138.

    Enzyme and pathway databases

    Reactomei REACT_169436. Oxidative Stress Induced Senescence.
    SignaLinki Q8N4C8.

    Miscellaneous databases

    ChiTaRSi MINK1. human.
    GeneWikii MINK1.
    GenomeRNAii 50488.
    NextBioi 53052.
    PROi Q8N4C8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N4C8.
    Bgeei Q8N4C8.
    CleanExi HS_MINK1.
    Genevestigatori Q8N4C8.

    Family and domain databases

    InterProi IPR001180. Citron.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00780. CNH. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00036. CNH. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50219. CNH. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development."
      Dan I., Watanabe N.M., Kobayashi T., Yamashita-Suzuki K., Fukagaya Y., Kajikawa E., Kimura W.K., Nakashima T.M., Matsumoto K., Ninomiya-Tsuji J., Kusumi A.
      FEBS Lett. 469:19-23(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.
    2. "Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta."
      Hu Y., Leo C., Yu S., Huang B.C., Wang H., Shen M., Luo Y., Daniel-Issakani S., Payan D.G., Xu X.
      J. Biol. Chem. 279:54387-54397(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH NCK1, TISSUE SPECIFICITY, ALTERNATIVE SPLICING, AUTOPHOSPHORYLATION, VARIANTS ALA-771 AND LEU-775.
    3. Erratum
      Hu Y., Leo C., Yu S., Huang B.C., Wang H., Shen M., Luo Y., Daniel-Issakani S., Payan D.G., Xu X.
      J. Biol. Chem. 280:5128-5128(2005)
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS ALA-771 AND LEU-775.
      Tissue: Lymph.
    7. "Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells."
      Nicke B., Bastien J., Khanna S.J., Warne P.H., Cowling V., Cook S.J., Peters G., Delpuech O., Schulze A., Berns K., Mullenders J., Beijersbergen R.L., Bernards R., Ganesan T.S., Downward J., Hancock D.C.
      Mol. Cell 20:673-685(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-763, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: FUNCTION, INTERACTION WITH RAP2A, SUBCELLULAR LOCATION.
    10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-763, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-763, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-641; SER-763 AND SER-782, VARIANT [LARGE SCALE ANALYSIS] LEU-775, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-763; SER-777; SER-778 AND SER-782, VARIANT [LARGE SCALE ANALYSIS] LEU-775, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-763, VARIANT [LARGE SCALE ANALYSIS] LEU-775, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-778, VARIANT [LARGE SCALE ANALYSIS] LEU-775, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-763, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. Cited for: FUNCTION.
    19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-763, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    20. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-514; ILE-863; VAL-1010 AND VAL-1200.
    21. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-775, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMINK1_HUMAN
    AccessioniPrimary (citable) accession number: Q8N4C8
    Secondary accession number(s): D3DTK3
    , D3DTK4, Q5U8Z0, Q9P1X1, Q9P2R8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 28, 2003
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3