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Protein

Misshapen-like kinase 1

Gene

MINK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.
Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei54ATPPROSITE-ProRule annotation1
Active sitei153Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi31 – 39ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • protein kinase activity Source: ProtInc
  • protein serine/threonine kinase activity Source: UniProtKB
  • receptor signaling protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • actin cytoskeleton reorganization Source: UniProtKB
  • chemical synaptic transmission Source: UniProtKB
  • dendrite morphogenesis Source: UniProtKB
  • intracellular signal transduction Source: UniProtKB
  • JNK cascade Source: ProtInc
  • multicellular organism development Source: UniProtKB
  • positive regulation of JNK cascade Source: UniProtKB
  • protein autophosphorylation Source: UniProtKB
  • protein phosphorylation Source: UniProtKB
  • regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: UniProtKB
  • regulation of cell-cell adhesion Source: UniProtKB
  • regulation of cell-matrix adhesion Source: UniProtKB
  • regulation of cell migration Source: UniProtKB
  • response to stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS06836-MONOMER.
ReactomeiR-HSA-2559580. Oxidative Stress Induced Senescence.
SignaLinkiQ8N4C8.
SIGNORiQ8N4C8.

Names & Taxonomyi

Protein namesi
Recommended name:
Misshapen-like kinase 1 (EC:2.7.11.1)
Alternative name(s):
GCK family kinase MiNK
MAPK/ERK kinase kinase kinase 6
Short name:
MEK kinase kinase 6
Short name:
MEKKK 6
Misshapen/NIK-related kinase
Mitogen-activated protein kinase kinase kinase kinase 6
Gene namesi
Name:MINK1Imported
Synonyms:B55, MAP4K6By similarity, MINKImported, YSK2, ZC3
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:17565. MINK1.

Subcellular locationi

GO - Cellular componenti

  • axon Source: UniProtKB-SubCell
  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • dendrite Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • postsynaptic density Source: UniProtKB-SubCell
  • postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Golgi apparatus, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi50488.
OpenTargetsiENSG00000141503.
PharmGKBiPA134910641.

Chemistry databases

ChEMBLiCHEMBL5518.
GuidetoPHARMACOLOGYi2103.

Polymorphism and mutation databases

BioMutaiMINK1.
DMDMi296437370.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000863291 – 1332Misshapen-like kinase 1Add BLAST1332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei324PhosphoserineBy similarity1
Modified residuei326PhosphoserineBy similarity1
Modified residuei501Omega-N-methylarginineBy similarity1
Modified residuei509Omega-N-methylarginineCombined sources1
Modified residuei641PhosphoserineCombined sources1
Modified residuei701PhosphoserineCombined sources1
Modified residuei754PhosphoserineCombined sources1
Modified residuei763PhosphoserineCombined sources1
Modified residuei777PhosphoserineCombined sources1
Modified residuei778PhosphoserineCombined sources1
Modified residuei782PhosphoserineCombined sources1
Modified residuei891PhosphothreonineBy similarity1

Post-translational modificationi

Autophosphorylated.

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ8N4C8.
MaxQBiQ8N4C8.
PaxDbiQ8N4C8.
PeptideAtlasiQ8N4C8.
PRIDEiQ8N4C8.

PTM databases

iPTMnetiQ8N4C8.
PhosphoSitePlusiQ8N4C8.

Expressioni

Tissue specificityi

Expressed in the brain, isoform 2 is more abundant than isoform 1. Isoform 3 is ubiquitously expressed. Isoform 1 is most abundant in the skeletal muscle. Isoform 4 is ubiquitously expressed with relative high levels in brain, skeletal muscle, pancreas and testis.1 Publication

Inductioni

Activated after Ras induction via a mechanism involving reactive oxygen species.1 Publication

Gene expression databases

BgeeiENSG00000141503.
CleanExiHS_MINK1.
ExpressionAtlasiQ8N4C8. baseline and differential.
GenevisibleiQ8N4C8. HS.

Organism-specific databases

HPAiHPA056296.

Interactioni

Subunit structurei

Interacts with TANC1 (By similarity). Interacts with RAP2A. Isoform 4 interacts with NCK1.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HSF1Q006132EBI-2133481,EBI-719620
IER5Q5VY092EBI-11475194,EBI-1774000

Protein-protein interaction databases

BioGridi119075. 11 interactors.
IntActiQ8N4C8. 6 interactors.
STRINGi9606.ENSP00000347427.

Chemistry databases

BindingDBiQ8N4C8.

Structurei

3D structure databases

ProteinModelPortaliQ8N4C8.
SMRiQ8N4C8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 289Protein kinasePROSITE-ProRule annotationAdd BLAST265
Domaini1019 – 1306CNHPROSITE-ProRule annotationAdd BLAST288

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni866 – 1332Mediates interaction with RAP2A1 PublicationAdd BLAST467

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi359 – 495Gln-richAdd BLAST137
Compositional biasi542 – 729Pro-richAdd BLAST188

Sequence similaritiesi

Contains 1 CNH domain.PROSITE-ProRule annotationCurated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0587. Eukaryota.
ENOG410XPHR. LUCA.
GeneTreeiENSGT00810000125351.
HOGENOMiHOG000290708.
HOVERGENiHBG036506.
InParanoidiQ8N4C8.
KOiK04413.
OMAiWAQEYKR.
OrthoDBiEOG091G018A.
PhylomeDBiQ8N4C8.
TreeFamiTF105138.

Family and domain databases

InterProiIPR001180. CNH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00036. CNH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50219. CNH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 31 Publication (identifier: Q8N4C8-1) [UniParc]FASTAAdd to basket
Also known as: MINK-alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDPAPARSL DDIDLSALRD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL
60 70 80 90 100
AAIKVMDVTE DEEEEIKQEI NMLKKYSHHR NIATYYGAFI KKSPPGNDDQ
110 120 130 140 150
LWLVMEFCGA GSVTDLVKNT KGNALKEDCI AYICREILRG LAHLHAHKVI
160 170 180 190 200
HRDIKGQNVL LTENAEVKLV DFGVSAQLDR TVGRRNTFIG TPYWMAPEVI
210 220 230 240 250
ACDENPDATY DYRSDIWSLG ITAIEMAEGA PPLCDMHPMR ALFLIPRNPP
260 270 280 290 300
PRLKSKKWSK KFIDFIDTCL IKTYLSRPPT EQLLKFPFIR DQPTERQVRI
310 320 330 340 350
QLKDHIDRSR KKRGEKEETE YEYSGSEEED DSHGEEGEPS SIMNVPGEST
360 370 380 390 400
LRREFLRLQQ ENKSNSEALK QQQQLQQQQQ RDPEAHIKHL LHQRQRRIEE
410 420 430 440 450
QKEERRRVEE QQRREREQRK LQEKEQQRRL EDMQALRREE ERRQAEREQE
460 470 480 490 500
YKRKQLEEQR QSERLQRQLQ QEHAYLKSLQ QQQQQQQLQK QQQQQLLPGD
510 520 530 540 550
RKPLYHYGRG MNPADKPAWA REVEERTRMN KQQNSPLAKS KPGSTGPEPP
560 570 580 590 600
IPQASPGPPG PLSQTPPMQR PVEPQEGPHK SLVAHRVPLK PYAAPVPRSQ
610 620 630 640 650
SLQDQPTRNL AAFPASHDPD PAIPAPTATP SARGAVIRQN SDPTSEGPGP
660 670 680 690 700
SPNPPAWVRP DNEAPPKVPQ RTSSIATALN TSGAGGSRPA QAVRARPRSN
710 720 730 740 750
SAWQIYLQRR AERGTPKPPG PPAQPPGPPN ASSNPDLRRS DPGWERSDSV
760 770 780 790 800
LPASHGHLPQ AGSLERNRVG VSSKPDSSPV LSPGNKAKPD DHRSRPGRPA
810 820 830 840 850
DFVLLKERTL DEAPRPPKKA MDYSSSSEEV ESSEDDEEEG EGGPAEGSRD
860 870 880 890 900
TPGGRSDGDT DSVSTMVVHD VEEITGTQPP YGGGTMVVQR TPEEERNLLH
910 920 930 940 950
ADSNGYTNLP DVVQPSHSPT ENSKGQSPPS KDGSGDYQSR GLVKAPGKSS
960 970 980 990 1000
FTMFVDLGIY QPGGSGDSIP ITALVGGEGT RLDQLQYDVR KGSVVNVNPT
1010 1020 1030 1040 1050
NTRAHSETPE IRKYKKRFNS EILCAALWGV NLLVGTENGL MLLDRSGQGK
1060 1070 1080 1090 1100
VYGLIGRRRF QQMDVLEGLN LLITISGKRN KLRVYYLSWL RNKILHNDPE
1110 1120 1130 1140 1150
VEKKQGWTTV GDMEGCGHYR VVKYERIKFL VIALKSSVEV YAWAPKPYHK
1160 1170 1180 1190 1200
FMAFKSFADL PHRPLLVDLT VEEGQRLKVI YGSSAGFHAV DVDSGNSYDI
1210 1220 1230 1240 1250
YIPVHIQSQI TPHAIIFLPN TDGMEMLLCY EDEGVYVNTY GRIIKDVVLQ
1260 1270 1280 1290 1300
WGEMPTSVAY ICSNQIMGWG EKAIEIRSVE TGHLDGVFMH KRAQRLKFLC
1310 1320 1330
ERNDKVFFAS VRSGGSSQVY FMTLNRNCIM NW
Length:1,332
Mass (Da):149,822
Last modified:May 18, 2010 - v2
Checksum:i3E3B182CDDB3659C
GO
Isoform 11 Publication (identifier: Q8N4C8-2) [UniParc]FASTAAdd to basket
Also known as: MiNK-1, MINK-delta

The sequence of this isoform differs from the canonical sequence as follows:
     696-732: Missing.

Show »
Length:1,295
Mass (Da):145,806
Checksum:i029AD8C2806C90EE
GO
Isoform 21 Publication (identifier: Q8N4C8-3) [UniParc]FASTAAdd to basket
Also known as: MiNK-2, MINK-gamma

The sequence of this isoform differs from the canonical sequence as follows:
     696-732: Missing.
     800-800: A → ASYKRAIGE

Show »
Length:1,303
Mass (Da):146,711
Checksum:iFD65470BFC6981B2
GO
Isoform 4 (identifier: Q8N4C8-4) [UniParc]FASTAAdd to basket
Also known as: MINK-beta

The sequence of this isoform differs from the canonical sequence as follows:
     581-600: Missing.

Show »
Length:1,312
Mass (Da):147,653
Checksum:iB8D157A582DA5D18
GO
Isoform 5 (identifier: Q8N4C8-5) [UniParc]FASTAAdd to basket
Also known as: MINK-eta

The sequence of this isoform differs from the canonical sequence as follows:
     581-600: Missing.
     696-732: Missing.

Show »
Length:1,275
Mass (Da):143,637
Checksum:i4E992F63A486A95A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_040799514A → T.1 PublicationCorresponds to variant rs56131206dbSNPEnsembl.1
Natural variantiVAR_046058771V → A.2 PublicationsCorresponds to variant rs11556634dbSNPEnsembl.1
Natural variantiVAR_046059775P → L.Combined sources2 PublicationsCorresponds to variant rs11556635dbSNPEnsembl.1
Natural variantiVAR_046060863V → I.1 PublicationCorresponds to variant rs2302319dbSNPEnsembl.1
Natural variantiVAR_0460611010E → V in a gastric adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0408001200I → V.1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041871581 – 600Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_007059696 – 732Missing in isoform 1, isoform 2 and isoform 5. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_007060800A → ASYKRAIGE in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041926 mRNA. Translation: BAA94838.1.
AB035698 mRNA. Translation: BAA90753.1.
AY775058 mRNA. Translation: AAV41830.1.
AC233723 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90401.1.
CH471108 Genomic DNA. Translation: EAW90403.1.
CH471108 Genomic DNA. Translation: EAW90399.1.
CH471108 Genomic DNA. Translation: EAW90400.1.
CH471108 Genomic DNA. Translation: EAW90402.1.
BC034673 mRNA. Translation: AAH34673.1.
CCDSiCCDS45588.1. [Q8N4C8-1]
CCDS45589.1. [Q8N4C8-3]
CCDS45590.1. [Q8N4C8-4]
RefSeqiNP_001020108.1. NM_001024937.3. [Q8N4C8-4]
NP_001308165.1. NM_001321236.1.
NP_056531.1. NM_015716.4. [Q8N4C8-2]
NP_722549.2. NM_153827.4. [Q8N4C8-1]
NP_733763.1. NM_170663.4. [Q8N4C8-3]
UniGeneiHs.443417.

Genome annotation databases

EnsembliENST00000347992; ENSP00000269296; ENSG00000141503. [Q8N4C8-3]
ENST00000355280; ENSP00000347427; ENSG00000141503. [Q8N4C8-1]
ENST00000453408; ENSP00000406487; ENSG00000141503. [Q8N4C8-4]
GeneIDi50488.
KEGGihsa:50488.
UCSCiuc010vsl.3. human. [Q8N4C8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041926 mRNA. Translation: BAA94838.1.
AB035698 mRNA. Translation: BAA90753.1.
AY775058 mRNA. Translation: AAV41830.1.
AC233723 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90401.1.
CH471108 Genomic DNA. Translation: EAW90403.1.
CH471108 Genomic DNA. Translation: EAW90399.1.
CH471108 Genomic DNA. Translation: EAW90400.1.
CH471108 Genomic DNA. Translation: EAW90402.1.
BC034673 mRNA. Translation: AAH34673.1.
CCDSiCCDS45588.1. [Q8N4C8-1]
CCDS45589.1. [Q8N4C8-3]
CCDS45590.1. [Q8N4C8-4]
RefSeqiNP_001020108.1. NM_001024937.3. [Q8N4C8-4]
NP_001308165.1. NM_001321236.1.
NP_056531.1. NM_015716.4. [Q8N4C8-2]
NP_722549.2. NM_153827.4. [Q8N4C8-1]
NP_733763.1. NM_170663.4. [Q8N4C8-3]
UniGeneiHs.443417.

3D structure databases

ProteinModelPortaliQ8N4C8.
SMRiQ8N4C8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119075. 11 interactors.
IntActiQ8N4C8. 6 interactors.
STRINGi9606.ENSP00000347427.

Chemistry databases

BindingDBiQ8N4C8.
ChEMBLiCHEMBL5518.
GuidetoPHARMACOLOGYi2103.

PTM databases

iPTMnetiQ8N4C8.
PhosphoSitePlusiQ8N4C8.

Polymorphism and mutation databases

BioMutaiMINK1.
DMDMi296437370.

Proteomic databases

EPDiQ8N4C8.
MaxQBiQ8N4C8.
PaxDbiQ8N4C8.
PeptideAtlasiQ8N4C8.
PRIDEiQ8N4C8.

Protocols and materials databases

DNASUi50488.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000347992; ENSP00000269296; ENSG00000141503. [Q8N4C8-3]
ENST00000355280; ENSP00000347427; ENSG00000141503. [Q8N4C8-1]
ENST00000453408; ENSP00000406487; ENSG00000141503. [Q8N4C8-4]
GeneIDi50488.
KEGGihsa:50488.
UCSCiuc010vsl.3. human. [Q8N4C8-1]

Organism-specific databases

CTDi50488.
DisGeNETi50488.
GeneCardsiMINK1.
H-InvDBHIX0013452.
HGNCiHGNC:17565. MINK1.
HPAiHPA056296.
MIMi609426. gene.
neXtProtiNX_Q8N4C8.
OpenTargetsiENSG00000141503.
PharmGKBiPA134910641.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0587. Eukaryota.
ENOG410XPHR. LUCA.
GeneTreeiENSGT00810000125351.
HOGENOMiHOG000290708.
HOVERGENiHBG036506.
InParanoidiQ8N4C8.
KOiK04413.
OMAiWAQEYKR.
OrthoDBiEOG091G018A.
PhylomeDBiQ8N4C8.
TreeFamiTF105138.

Enzyme and pathway databases

BioCyciZFISH:HS06836-MONOMER.
ReactomeiR-HSA-2559580. Oxidative Stress Induced Senescence.
SignaLinkiQ8N4C8.
SIGNORiQ8N4C8.

Miscellaneous databases

ChiTaRSiMINK1. human.
GeneWikiiMINK1.
GenomeRNAii50488.
PROiQ8N4C8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141503.
CleanExiHS_MINK1.
ExpressionAtlasiQ8N4C8. baseline and differential.
GenevisibleiQ8N4C8. HS.

Family and domain databases

InterProiIPR001180. CNH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00036. CNH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50219. CNH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMINK1_HUMAN
AccessioniPrimary (citable) accession number: Q8N4C8
Secondary accession number(s): D3DTK3
, D3DTK4, Q5U8Z0, Q9P1X1, Q9P2R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.