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Protein

Syntaxin-19

Gene

STX19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-19
Gene namesi
Name:STX19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:19300. STX19.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670857.

Polymorphism and mutation databases

BioMutaiSTX19.
DMDMi74728839.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Syntaxin-19PRO_0000263709Add
BLAST

Proteomic databases

PaxDbiQ8N4C7.
PRIDEiQ8N4C7.

PTM databases

PhosphoSiteiQ8N4C7.

Expressioni

Gene expression databases

BgeeiQ8N4C7.
CleanExiHS_STX19.
GenevisibleiQ8N4C7. HS.

Organism-specific databases

HPAiHPA030604.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KDM1AO603412EBI-8484990,EBI-710124
PRKAB2O437413EBI-8484990,EBI-1053424
STXBP1P617643EBI-8484990,EBI-960169
SUV39H1O434632EBI-8484990,EBI-349968
SYCE1Q8N0S23EBI-8484990,EBI-6872807

Protein-protein interaction databases

BioGridi136105. 19 interactions.
IntActiQ8N4C7. 5 interactions.
MINTiMINT-6940674.
STRINGi9606.ENSP00000320679.

Structurei

3D structure databases

ProteinModelPortaliQ8N4C7.
SMRiQ8N4C7. Positions 48-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 27163t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi280 – 29112Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG270635.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG099780.
InParanoidiQ8N4C7.
KOiK08487.
OMAiHFQQTMF.
OrthoDBiEOG7X9G7R.
PhylomeDBiQ8N4C7.
TreeFamiTF313763.

Family and domain databases

InterProiIPR015708. STX19.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF29. PTHR19957:SF29. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N4C7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDRLQELKQ RTKEIELSRD SHVSTTETEE QGVFLQQAVI YEREPVAERH
60 70 80 90 100
LHEIQKLQES INNLADNVQK FGQQQKSLVA SMRRFSLLKR ESTITKEIKI
110 120 130 140 150
QAEYINRSLN DLVKEVKKSE VENGPSSVVT RILKSQHAAM FRHFQQIMFI
160 170 180 190 200
YNDTIAAKQE KCKTFILRQL EVAGKEMSEE DVNDMLHQGK WEVFNESLLT
210 220 230 240 250
EINITKAQLS EIEQRHKELV NLENQIKDLR DLFIQISLLV EEQGESINNI
260 270 280 290
EMTVNSTKEY VNNTKEKFGL AVKYKKRNPC RVLCCWCCPC CSSK
Length:294
Mass (Da):34,324
Last modified:October 1, 2002 - v1
Checksum:i1A7FE896916DCE57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461456 mRNA. Translation: AAQ04780.1.
BC034696 mRNA. Translation: AAH34696.1.
CCDSiCCDS33793.1.
RefSeqiNP_001001850.1. NM_001001850.2.
UniGeneiHs.679768.

Genome annotation databases

EnsembliENST00000315099; ENSP00000320679; ENSG00000178750.
GeneIDi415117.
KEGGihsa:415117.
UCSCiuc003drh.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461456 mRNA. Translation: AAQ04780.1.
BC034696 mRNA. Translation: AAH34696.1.
CCDSiCCDS33793.1.
RefSeqiNP_001001850.1. NM_001001850.2.
UniGeneiHs.679768.

3D structure databases

ProteinModelPortaliQ8N4C7.
SMRiQ8N4C7. Positions 48-288.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136105. 19 interactions.
IntActiQ8N4C7. 5 interactions.
MINTiMINT-6940674.
STRINGi9606.ENSP00000320679.

PTM databases

PhosphoSiteiQ8N4C7.

Polymorphism and mutation databases

BioMutaiSTX19.
DMDMi74728839.

Proteomic databases

PaxDbiQ8N4C7.
PRIDEiQ8N4C7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315099; ENSP00000320679; ENSG00000178750.
GeneIDi415117.
KEGGihsa:415117.
UCSCiuc003drh.1. human.

Organism-specific databases

CTDi415117.
GeneCardsiGC03M093733.
HGNCiHGNC:19300. STX19.
HPAiHPA030604.
neXtProtiNX_Q8N4C7.
PharmGKBiPA142670857.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG270635.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG099780.
InParanoidiQ8N4C7.
KOiK08487.
OMAiHFQQTMF.
OrthoDBiEOG7X9G7R.
PhylomeDBiQ8N4C7.
TreeFamiTF313763.

Miscellaneous databases

GenomeRNAii415117.
NextBioi108685.
PROiQ8N4C7.

Gene expression databases

BgeeiQ8N4C7.
CleanExiHS_STX19.
GenevisibleiQ8N4C7. HS.

Family and domain databases

InterProiIPR015708. STX19.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF29. PTHR19957:SF29. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression and characterization of a novel human SNARE protein syntaxin-19 in MDCK cells."
    Zhang Z., Low S.H., Li X., Miura M., Kudo N., Hofmann K., Weimbs T.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.

Entry informationi

Entry nameiSTX19_HUMAN
AccessioniPrimary (citable) accession number: Q8N4C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: June 24, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.