Q8N4C7 (STX19_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Syntaxin-19

Gene names

Name:

STX19

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Peripheral membrane protein Potential.
Sequence similarities	Belongs to the syntaxin family. Contains 1 t-SNARE coiled-coil homology domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular protein transport Inferred from electronic annotation. Source: InterPro vesicle-mediated transport Inferred from electronic annotation. Source: InterPro
Cellular_component	membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	Syntaxin-19		PRO_0000263709
Regions
	Domain	209 – 271	63	t-SNARE coiled-coil homology
	Compositional bias	280 – 291	12	Cys-rich

Sequences

	Sequence		Length	Mass (Da)
	Q8N4C7 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 1A7FE896916DCE57	FASTA	294	34,324
	10 20 30 40 50 60 MKDRLQELKQ RTKEIELSRD SHVSTTETEE QGVFLQQAVI YEREPVAERH LHEIQKLQES 70 80 90 100 110 120 INNLADNVQK FGQQQKSLVA SMRRFSLLKR ESTITKEIKI QAEYINRSLN DLVKEVKKSE 130 140 150 160 170 180 VENGPSSVVT RILKSQHAAM FRHFQQIMFI YNDTIAAKQE KCKTFILRQL EVAGKEMSEE 190 200 210 220 230 240 DVNDMLHQGK WEVFNESLLT EINITKAQLS EIEQRHKELV NLENQIKDLR DLFIQISLLV 250 260 270 280 290 EEQGESINNI EMTVNSTKEY VNNTKEKFGL AVKYKKRNPC RVLCCWCCPC CSSK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, expression and characterization of a novel human SNARE protein syntaxin-19 in MDCK cells." Zhang Z., Low S.H., Li X., Miura M., Kudo N., Hofmann K., Weimbs T. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF461456 mRNA. Translation: AAQ04780.1. BC034696 mRNA. Translation: AAH34696.1.
IPI	IPI00166679.
RefSeq	NP_001001850.1. NM_001001850.2.
UniGene	Hs.679768. Hs.741069.
3D structure databases
HSSP	HSSP built from PDB template 1JTH based on UniProtKB P32851.
ProteinModelPortal	Q8N4C7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000320679.
PTM databases
PhosphoSite	Q8N4C7.
Polymorphism databases
DMDM	74728839.
Proteomic databases
PaxDb	Q8N4C7.
PRIDE	Q8N4C7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000315099; ENSP00000320679; ENSG00000178750.
GeneID	415117.
KEGG	hsa:415117.
UCSC	uc003drh.1. human.
Organism-specific databases
CTD	415117.
GeneCards	GC03M093733.
HGNC	HGNC:19300. STX19.
HPA	HPA030604.
neXtProt	NX_Q8N4C7.
PharmGKB	PA142670857.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG270635.
HOGENOM	HOG000286023.
HOVERGEN	HBG099780.
InParanoid	Q8N4C7.
KO	K08487.
OMA	HFQQTMF.
OrthoDB	EOG405S1S.
PhylomeDB	Q8N4C7.
Gene expression databases
Bgee	Q8N4C7.
CleanEx	HS_STX19.
Genevestigator	Q8N4C7.
GermOnline	ENSG00000178750. Homo sapiens.
Family and domain databases
InterPro	IPR006012. Syntaxin/epimorphin_CS. IPR006011. Syntaxin_N. IPR010989. t-SNARE. IPR000727. T_SNARE_dom. [Graphical view]
Pfam	PF05739. SNARE. 1 hit. PF00804. Syntaxin. 1 hit. [Graphical view]
SMART	SM00397. t_SNARE. 1 hit. [Graphical view]
SUPFAM	SSF47661. t-snare. 1 hit.
PROSITE	PS00914. SYNTAXIN. 1 hit. PS50192. T_SNARE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	415117.
NextBio	108685.

Entry information

Entry name

STX19_HUMAN

Accession

Primary (citable) accession number: Q8N4C7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.