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Protein

Syntaxin-19

Gene

STX19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-19
Gene namesi
Name:STX19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000178750.2.
HGNCiHGNC:19300. STX19.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178750.
PharmGKBiPA142670857.

Polymorphism and mutation databases

BioMutaiSTX19.
DMDMi74728839.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002637091 – 294Syntaxin-19Add BLAST294

Proteomic databases

PaxDbiQ8N4C7.
PeptideAtlasiQ8N4C7.
PRIDEiQ8N4C7.

PTM databases

iPTMnetiQ8N4C7.
PhosphoSitePlusiQ8N4C7.

Expressioni

Gene expression databases

BgeeiENSG00000178750.
CleanExiHS_STX19.
GenevisibleiQ8N4C7. HS.

Organism-specific databases

HPAiHPA030604.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi136105. 20 interactors.
IntActiQ8N4C7. 10 interactors.
MINTiMINT-6940674.
STRINGi9606.ENSP00000320679.

Structurei

3D structure databases

ProteinModelPortaliQ8N4C7.
SMRiQ8N4C7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 271t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi280 – 291Cys-richAdd BLAST12

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0810. Eukaryota.
COG5074. LUCA.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG099780.
InParanoidiQ8N4C7.
KOiK08487.
OMAiEYVNTTK.
OrthoDBiEOG091G0GIT.
PhylomeDBiQ8N4C7.
TreeFamiTF313763.

Family and domain databases

InterProiView protein in InterPro
IPR010989. SNARE.
IPR015708. STX19.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR000727. T_SNARE_dom.
PANTHERiPTHR19957:SF29. PTHR19957:SF29. 1 hit.
PfamiView protein in Pfam
PF00804. Syntaxin. 1 hit.
SMARTiView protein in SMART
SM00397. t_SNARE. 1 hit.
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiView protein in PROSITE
PS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8N4C7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDRLQELKQ RTKEIELSRD SHVSTTETEE QGVFLQQAVI YEREPVAERH
60 70 80 90 100
LHEIQKLQES INNLADNVQK FGQQQKSLVA SMRRFSLLKR ESTITKEIKI
110 120 130 140 150
QAEYINRSLN DLVKEVKKSE VENGPSSVVT RILKSQHAAM FRHFQQIMFI
160 170 180 190 200
YNDTIAAKQE KCKTFILRQL EVAGKEMSEE DVNDMLHQGK WEVFNESLLT
210 220 230 240 250
EINITKAQLS EIEQRHKELV NLENQIKDLR DLFIQISLLV EEQGESINNI
260 270 280 290
EMTVNSTKEY VNNTKEKFGL AVKYKKRNPC RVLCCWCCPC CSSK
Length:294
Mass (Da):34,324
Last modified:October 1, 2002 - v1
Checksum:i1A7FE896916DCE57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461456 mRNA. Translation: AAQ04780.1.
BC034696 mRNA. Translation: AAH34696.1.
CCDSiCCDS33793.1.
RefSeqiNP_001001850.1. NM_001001850.2.
XP_011511144.1. XM_011512842.2.
UniGeneiHs.679768.

Genome annotation databases

EnsembliENST00000315099; ENSP00000320679; ENSG00000178750.
GeneIDi415117.
KEGGihsa:415117.
UCSCiuc003drh.2. human.

Similar proteinsi

Entry informationi

Entry nameiSTX19_HUMAN
AccessioniPrimary (citable) accession number: Q8N4C7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: October 25, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families