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Q8N4C7

- STX19_HUMAN

UniProt

Q8N4C7 - STX19_HUMAN

Protein

Syntaxin-19

Gene

STX19

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. intracellular protein transport Source: InterPro
    2. vesicle-mediated transport Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Syntaxin-19
    Gene namesi
    Name:STX19
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:19300. STX19.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: InterPro

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670857.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 294294Syntaxin-19PRO_0000263709Add
    BLAST

    Proteomic databases

    PaxDbiQ8N4C7.
    PRIDEiQ8N4C7.

    PTM databases

    PhosphoSiteiQ8N4C7.

    Expressioni

    Gene expression databases

    BgeeiQ8N4C7.
    CleanExiHS_STX19.
    GenevestigatoriQ8N4C7.

    Organism-specific databases

    HPAiHPA030604.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    KDM1AO603412EBI-8484990,EBI-710124
    SUV39H1O434632EBI-8484990,EBI-349968

    Protein-protein interaction databases

    BioGridi136105. 2 interactions.
    IntActiQ8N4C7. 2 interactions.
    MINTiMINT-6940674.
    STRINGi9606.ENSP00000320679.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N4C7.
    SMRiQ8N4C7. Positions 48-288.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini209 – 27163t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi280 – 29112Cys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the syntaxin family.Curated
    Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG270635.
    HOGENOMiHOG000286023.
    HOVERGENiHBG099780.
    InParanoidiQ8N4C7.
    KOiK08487.
    OMAiHFQQTMF.
    OrthoDBiEOG7X9G7R.
    PhylomeDBiQ8N4C7.
    TreeFamiTF313763.

    Family and domain databases

    InterProiIPR015708. STX19.
    IPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view]
    PANTHERiPTHR19957:SF29. PTHR19957:SF29. 1 hit.
    PfamiPF05739. SNARE. 1 hit.
    PF00804. Syntaxin. 1 hit.
    [Graphical view]
    SMARTiSM00397. t_SNARE. 1 hit.
    [Graphical view]
    SUPFAMiSSF47661. SSF47661. 1 hit.
    PROSITEiPS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N4C7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKDRLQELKQ RTKEIELSRD SHVSTTETEE QGVFLQQAVI YEREPVAERH    50
    LHEIQKLQES INNLADNVQK FGQQQKSLVA SMRRFSLLKR ESTITKEIKI 100
    QAEYINRSLN DLVKEVKKSE VENGPSSVVT RILKSQHAAM FRHFQQIMFI 150
    YNDTIAAKQE KCKTFILRQL EVAGKEMSEE DVNDMLHQGK WEVFNESLLT 200
    EINITKAQLS EIEQRHKELV NLENQIKDLR DLFIQISLLV EEQGESINNI 250
    EMTVNSTKEY VNNTKEKFGL AVKYKKRNPC RVLCCWCCPC CSSK 294
    Length:294
    Mass (Da):34,324
    Last modified:October 1, 2002 - v1
    Checksum:i1A7FE896916DCE57
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF461456 mRNA. Translation: AAQ04780.1.
    BC034696 mRNA. Translation: AAH34696.1.
    CCDSiCCDS33793.1.
    RefSeqiNP_001001850.1. NM_001001850.2.
    XP_005247512.1. XM_005247455.2.
    XP_005247513.1. XM_005247456.1.
    UniGeneiHs.679768.

    Genome annotation databases

    EnsembliENST00000315099; ENSP00000320679; ENSG00000178750.
    GeneIDi415117.
    KEGGihsa:415117.
    UCSCiuc003drh.1. human.

    Polymorphism databases

    DMDMi74728839.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF461456 mRNA. Translation: AAQ04780.1 .
    BC034696 mRNA. Translation: AAH34696.1 .
    CCDSi CCDS33793.1.
    RefSeqi NP_001001850.1. NM_001001850.2.
    XP_005247512.1. XM_005247455.2.
    XP_005247513.1. XM_005247456.1.
    UniGenei Hs.679768.

    3D structure databases

    ProteinModelPortali Q8N4C7.
    SMRi Q8N4C7. Positions 48-288.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 136105. 2 interactions.
    IntActi Q8N4C7. 2 interactions.
    MINTi MINT-6940674.
    STRINGi 9606.ENSP00000320679.

    PTM databases

    PhosphoSitei Q8N4C7.

    Polymorphism databases

    DMDMi 74728839.

    Proteomic databases

    PaxDbi Q8N4C7.
    PRIDEi Q8N4C7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000315099 ; ENSP00000320679 ; ENSG00000178750 .
    GeneIDi 415117.
    KEGGi hsa:415117.
    UCSCi uc003drh.1. human.

    Organism-specific databases

    CTDi 415117.
    GeneCardsi GC03M093733.
    HGNCi HGNC:19300. STX19.
    HPAi HPA030604.
    neXtProti NX_Q8N4C7.
    PharmGKBi PA142670857.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG270635.
    HOGENOMi HOG000286023.
    HOVERGENi HBG099780.
    InParanoidi Q8N4C7.
    KOi K08487.
    OMAi HFQQTMF.
    OrthoDBi EOG7X9G7R.
    PhylomeDBi Q8N4C7.
    TreeFami TF313763.

    Miscellaneous databases

    GenomeRNAii 415117.
    NextBioi 108685.
    PROi Q8N4C7.

    Gene expression databases

    Bgeei Q8N4C7.
    CleanExi HS_STX19.
    Genevestigatori Q8N4C7.

    Family and domain databases

    InterProi IPR015708. STX19.
    IPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view ]
    PANTHERi PTHR19957:SF29. PTHR19957:SF29. 1 hit.
    Pfami PF05739. SNARE. 1 hit.
    PF00804. Syntaxin. 1 hit.
    [Graphical view ]
    SMARTi SM00397. t_SNARE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47661. SSF47661. 1 hit.
    PROSITEi PS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression and characterization of a novel human SNARE protein syntaxin-19 in MDCK cells."
      Zhang Z., Low S.H., Li X., Miura M., Kudo N., Hofmann K., Weimbs T.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.

    Entry informationi

    Entry nameiSTX19_HUMAN
    AccessioniPrimary (citable) accession number: Q8N4C7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3