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Q8N4C7

- STX19_HUMAN

UniProt

Q8N4C7 - STX19_HUMAN

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Protein

Syntaxin-19

Gene

STX19

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. intracellular protein transport Source: InterPro
  2. vesicle-mediated transport Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-19
Gene namesi
Name:STX19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:19300. STX19.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670857.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Syntaxin-19PRO_0000263709Add
BLAST

Proteomic databases

PaxDbiQ8N4C7.
PRIDEiQ8N4C7.

PTM databases

PhosphoSiteiQ8N4C7.

Expressioni

Gene expression databases

BgeeiQ8N4C7.
CleanExiHS_STX19.
GenevestigatoriQ8N4C7.

Organism-specific databases

HPAiHPA030604.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KDM1AO603412EBI-8484990,EBI-710124
SUV39H1O434632EBI-8484990,EBI-349968

Protein-protein interaction databases

BioGridi136105. 18 interactions.
IntActiQ8N4C7. 2 interactions.
MINTiMINT-6940674.
STRINGi9606.ENSP00000320679.

Structurei

3D structure databases

ProteinModelPortaliQ8N4C7.
SMRiQ8N4C7. Positions 48-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 27163t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi280 – 29112Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG270635.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG099780.
InParanoidiQ8N4C7.
KOiK08487.
OMAiHFQQTMF.
OrthoDBiEOG7X9G7R.
PhylomeDBiQ8N4C7.
TreeFamiTF313763.

Family and domain databases

InterProiIPR015708. STX19.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF29. PTHR19957:SF29. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N4C7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKDRLQELKQ RTKEIELSRD SHVSTTETEE QGVFLQQAVI YEREPVAERH
60 70 80 90 100
LHEIQKLQES INNLADNVQK FGQQQKSLVA SMRRFSLLKR ESTITKEIKI
110 120 130 140 150
QAEYINRSLN DLVKEVKKSE VENGPSSVVT RILKSQHAAM FRHFQQIMFI
160 170 180 190 200
YNDTIAAKQE KCKTFILRQL EVAGKEMSEE DVNDMLHQGK WEVFNESLLT
210 220 230 240 250
EINITKAQLS EIEQRHKELV NLENQIKDLR DLFIQISLLV EEQGESINNI
260 270 280 290
EMTVNSTKEY VNNTKEKFGL AVKYKKRNPC RVLCCWCCPC CSSK
Length:294
Mass (Da):34,324
Last modified:October 1, 2002 - v1
Checksum:i1A7FE896916DCE57
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF461456 mRNA. Translation: AAQ04780.1.
BC034696 mRNA. Translation: AAH34696.1.
CCDSiCCDS33793.1.
RefSeqiNP_001001850.1. NM_001001850.2.
XP_005247512.1. XM_005247455.2.
XP_005247513.1. XM_005247456.1.
UniGeneiHs.679768.

Genome annotation databases

EnsembliENST00000315099; ENSP00000320679; ENSG00000178750.
GeneIDi415117.
KEGGihsa:415117.
UCSCiuc003drh.1. human.

Polymorphism databases

DMDMi74728839.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF461456 mRNA. Translation: AAQ04780.1 .
BC034696 mRNA. Translation: AAH34696.1 .
CCDSi CCDS33793.1.
RefSeqi NP_001001850.1. NM_001001850.2.
XP_005247512.1. XM_005247455.2.
XP_005247513.1. XM_005247456.1.
UniGenei Hs.679768.

3D structure databases

ProteinModelPortali Q8N4C7.
SMRi Q8N4C7. Positions 48-288.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 136105. 18 interactions.
IntActi Q8N4C7. 2 interactions.
MINTi MINT-6940674.
STRINGi 9606.ENSP00000320679.

PTM databases

PhosphoSitei Q8N4C7.

Polymorphism databases

DMDMi 74728839.

Proteomic databases

PaxDbi Q8N4C7.
PRIDEi Q8N4C7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000315099 ; ENSP00000320679 ; ENSG00000178750 .
GeneIDi 415117.
KEGGi hsa:415117.
UCSCi uc003drh.1. human.

Organism-specific databases

CTDi 415117.
GeneCardsi GC03M093733.
HGNCi HGNC:19300. STX19.
HPAi HPA030604.
neXtProti NX_Q8N4C7.
PharmGKBi PA142670857.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG270635.
GeneTreei ENSGT00760000119200.
HOGENOMi HOG000286023.
HOVERGENi HBG099780.
InParanoidi Q8N4C7.
KOi K08487.
OMAi HFQQTMF.
OrthoDBi EOG7X9G7R.
PhylomeDBi Q8N4C7.
TreeFami TF313763.

Miscellaneous databases

GenomeRNAii 415117.
NextBioi 108685.
PROi Q8N4C7.

Gene expression databases

Bgeei Q8N4C7.
CleanExi HS_STX19.
Genevestigatori Q8N4C7.

Family and domain databases

InterProi IPR015708. STX19.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view ]
PANTHERi PTHR19957:SF29. PTHR19957:SF29. 1 hit.
Pfami PF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view ]
SMARTi SM00397. t_SNARE. 1 hit.
[Graphical view ]
SUPFAMi SSF47661. SSF47661. 1 hit.
PROSITEi PS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression and characterization of a novel human SNARE protein syntaxin-19 in MDCK cells."
    Zhang Z., Low S.H., Li X., Miura M., Kudo N., Hofmann K., Weimbs T.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.

Entry informationi

Entry nameiSTX19_HUMAN
AccessioniPrimary (citable) accession number: Q8N4C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3