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Q8N4C7 (STX19_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Syntaxin-19
Gene names
Name:STX19
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Peripheral membrane protein Potential.

Sequence similarities

Belongs to the syntaxin family.

Contains 1 t-SNARE coiled-coil homology domain.

Ontologies

Keywords
   Cellular componentMembrane
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processintracellular protein transport

Inferred from electronic annotation. Source: InterPro

vesicle-mediated transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: InterPro

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 23455924. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

KDM1AO603412EBI-8484990,EBI-710124
SUV39H1O434632EBI-8484990,EBI-349968

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 294294Syntaxin-19
PRO_0000263709

Regions

Domain209 – 27163t-SNARE coiled-coil homology
Compositional bias280 – 29112Cys-rich

Sequences

Sequence LengthMass (Da)Tools
Q8N4C7 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 1A7FE896916DCE57

FASTA29434,324
        10         20         30         40         50         60 
MKDRLQELKQ RTKEIELSRD SHVSTTETEE QGVFLQQAVI YEREPVAERH LHEIQKLQES 

        70         80         90        100        110        120 
INNLADNVQK FGQQQKSLVA SMRRFSLLKR ESTITKEIKI QAEYINRSLN DLVKEVKKSE 

       130        140        150        160        170        180 
VENGPSSVVT RILKSQHAAM FRHFQQIMFI YNDTIAAKQE KCKTFILRQL EVAGKEMSEE 

       190        200        210        220        230        240 
DVNDMLHQGK WEVFNESLLT EINITKAQLS EIEQRHKELV NLENQIKDLR DLFIQISLLV 

       250        260        270        280        290 
EEQGESINNI EMTVNSTKEY VNNTKEKFGL AVKYKKRNPC RVLCCWCCPC CSSK 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, expression and characterization of a novel human SNARE protein syntaxin-19 in MDCK cells."
Zhang Z., Low S.H., Li X., Miura M., Kudo N., Hofmann K., Weimbs T.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF461456 mRNA. Translation: AAQ04780.1.
BC034696 mRNA. Translation: AAH34696.1.
CCDSCCDS33793.1.
RefSeqNP_001001850.1. NM_001001850.2.
XP_005247512.1. XM_005247455.2.
XP_005247513.1. XM_005247456.1.
UniGeneHs.679768.

3D structure databases

ProteinModelPortalQ8N4C7.
SMRQ8N4C7. Positions 48-288.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid136105. 2 interactions.
IntActQ8N4C7. 2 interactions.
MINTMINT-6940674.
STRING9606.ENSP00000320679.

PTM databases

PhosphoSiteQ8N4C7.

Polymorphism databases

DMDM74728839.

Proteomic databases

PaxDbQ8N4C7.
PRIDEQ8N4C7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000315099; ENSP00000320679; ENSG00000178750.
GeneID415117.
KEGGhsa:415117.
UCSCuc003drh.1. human.

Organism-specific databases

CTD415117.
GeneCardsGC03M093733.
HGNCHGNC:19300. STX19.
HPAHPA030604.
neXtProtNX_Q8N4C7.
PharmGKBPA142670857.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG270635.
HOGENOMHOG000286023.
HOVERGENHBG099780.
InParanoidQ8N4C7.
KOK08487.
OMAHFQQTMF.
OrthoDBEOG7X9G7R.
PhylomeDBQ8N4C7.
TreeFamTF313763.

Gene expression databases

BgeeQ8N4C7.
CleanExHS_STX19.
GenevestigatorQ8N4C7.

Family and domain databases

InterProIPR015708. STX19.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERPTHR19957:SF29. PTHR19957:SF29. 1 hit.
PfamPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMSSF47661. SSF47661. 1 hit.
PROSITEPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi415117.
NextBio108685.
PROQ8N4C7.

Entry information

Entry nameSTX19_HUMAN
AccessionPrimary (citable) accession number: Q8N4C7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM