Reviewed, UniProtKB/Swiss-Prot Q8N4C6 (NIN_HUMAN)

Names and origin

Protein names

Recommended name:
    Ninein
      Short name=hNinein
Alternative name(s):
    Glycogen synthase kinase 3 beta-interacting protein
      Short name=GSK3B-interacting protein

Gene names

Name:	NIN
Synonyms:	KIAA1565

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	2090 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. May also act as a centrosome maturation factor. May play a role in microtubule nucleation. Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules. Ref.3
Subunit structure	Homooligomer. Interacts with GSK3B (GSK3-beta) via its C-terminus domain. Interacts with C14ORF166, such interaction may prevent its phosphorylation by GSK3-beta. Ref.1 Ref.12 Ref.13
Subcellular location	Cytoplasm › cytoskeleton › centrosome. Note: Component of the core centrosome. Arranged in a tubular conformation with an open and a closed end within the centrosome. In the mother centrosome, it localizes at both ends of the centrosome tube, including the site of centrosome duplication, while in the daughter centrosome it is present only at the closed end. Requires PCM1 for centrosome localization. Ref.3 Ref.1 Ref.12 Ref.10 Ref.11
Tissue specificity	Ubiquitous. Highly expressed in heart and skeletal muscle. Isoform 1 is more expressed than isoform 5. Ref.1 Ref.2
Developmental stage	In interphase cells, it is localized in the centrosome. Decreases in metaphase and anaphase and reappears in telophase. Ref.12
Domain	The coiled coil region from Asn-1611 to Pro-1693 is necessary and sufficient for the targeting to centrosome.
Post-translational modification	Phosphorylated by Aurora A (AIK) and PKA kinases but not CK2 or Aurora B (AIM). Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.12 Ref.16 Ref.17 Ref.18
Involvement in disease	Antibodies against NIN are present in sera from patients with autoimmune diseases that developed autoantibodies against centrosomal proteins. Ref.14 Ref.15
Sequence similarities	Contains 5 EF-hand domains.
Sequence caution	The sequence AAH65521.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Microtubule
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat
Ligand	GTP-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	centrosome localization Traceable author statement. Source: HGNC
Cellular component	centrosome Ref.12 Inferred from direct assay. Source: HGNC microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Ref.12 Ref.13 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
C14orf166	Q9Y224	3	EBI-1164022,EBI-1104547
GSK3B	P49841	1	EBI-1164022,EBI-373586

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N4C6-1)

Also known as: Lm;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N4C6-2)

Also known as: Isotype 3;

The sequence of this isoform differs from the canonical sequence as follows:
     492-508: Missing.

Isoform 3 (identifier: Q8N4C6-3)

Also known as: Isotype 2;

The sequence of this isoform differs from the canonical sequence as follows:
     492-508: Missing.
     2065-2090: VSLPGHLCSPTSHSSFNSSFTSLYCH → LCKNTKADAMVKDLYVENAQVC

Isoform 4 (identifier: Q8N4C6-4)

Also known as: Isotype 1;

The sequence of this isoform differs from the canonical sequence as follows:
     492-508: Missing.
     2027-2046: GNQEQLVTVMEERMIEVEQK → ALLPEQRAVHADSYRRIGHL
     2047-2090: Missing.

Isoform 5 (identifier: Q8N4C6-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTD → MAEVTVPRVY...HRKIQHVKNE

Isoform 6 (identifier: Q8N4C6-6)

The sequence of this isoform differs from the canonical sequence as follows:
     800-1512: Missing.
     1555-1555: Missing.
     1960-1988: MQHLRSTATPSPSPHAWDLQLLQQQACPM → NSVVGSSREGCSSLPEIVCEDAAPEVHCDA
     1989-2090: Missing.

Note: No experimental confirmation available.

Isoform 7 (identifier: Q8N4C6-7)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     2065-2090: VSLPGHLCSPTSHSSFNSSFTSLYCH → LCKNTKADAM...PLTSTPPLRS

Isoform 8 (identifier: Q8N4C6-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MDEVEQDQHEARLKELFD → SALGAAVPLPPPSPECASGHGSRGGAGRLSPGTQALEAGCRLCGRSGETDR

Note: Incomplete sequence. No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2090	2090	Ninein		PRO_0000096844
Regions
	Domain	8 – 43	36	EF-hand 1
	Domain	42 – 77	36	EF-hand 2
	Domain	182 – 217	36	EF-hand 3
	Domain	219 – 252	34	EF-hand 4
	Domain	317 – 352	36	EF-hand 5
	Nucleotide binding	245 – 252	8	GTP Potential
	Nucleotide binding	300 – 304	5	GTP Potential
	Nucleotide binding	420 – 423	4	GTP Potential
	Coiled coil	357 – 570	214	Potential
	Coiled coil	625 – 1027	403	Potential
	Coiled coil	1068 – 1099	32	Potential
	Coiled coil	1181 – 1341	161	Potential
	Coiled coil	1441 – 1816	376	Potential
	Coiled coil	1854 – 1885	32	Potential
	Coiled coil	1922 – 2067	146	Potential
Amino acid modifications
	Modified residue	1550	1	Phosphoserine Ref.16 Ref.17 Ref.18
Natural variations
	Alternative sequence	1 – 35	35	MDEVE…EELTD → MAEVTVPRVYVVFGIHCIMA KASSDVQVSGFHRKIQHVKN E in isoform 5.		VSP_010950
	Alternative sequence	1 – 18	18	MDEVE…KELFD → SALGAAVPLPPPSPECASGH GSRGGAGRLSPGTQALEAGC RLCGRSGETDR in isoform 8.		VSP_010951
	Alternative sequence	492 – 508	17	Missing in isoform 2, isoform 3 and isoform 4.		VSP_010952
	Alternative sequence	800 – 1512	713	Missing in isoform 6.		VSP_010953
	Alternative sequence	1555	1	Missing in isoform 6.		VSP_010954
	Alternative sequence	1960 – 1988	29	MQHLR…QACPM → NSVVGSSREGCSSLPEIVCE DAAPEVHCDA in isoform 6.		VSP_010955
	Alternative sequence	1989 – 2090	102	Missing in isoform 6.		VSP_010956
	Alternative sequence	2027 – 2046	20	GNQEQ…EVEQK → ALLPEQRAVHADSYRRIGHL in isoform 4.		VSP_010957
	Alternative sequence	2047 – 2090	44	Missing in isoform 4.		VSP_010958
	Alternative sequence	2065 – 2090	26	VSLPG…SLYCH → LCKNTKADAMVKDLYVENAQ VC in isoform 3.		VSP_010959
	Alternative sequence	2065 – 2090	26	VSLPG…SLYCH → LCKNTKADAMVKDLYVENAQ LLKALEVTEQRQKTAEKKNY LLEEKIASLSNIVRNLTPAP LTSTPPLRS in isoform 7.		VSP_010960
	Natural variant	1111	1	P → A: dbSNP rs2236316.		VAR_019453
	Natural variant	1125	1	P → Q: dbSNP rs12882191.		VAR_051235
	Natural variant	1320	1	E → G: dbSNP rs2073347. Ref.19		VAR_019454
	Natural variant	1837	1	S → T: dbSNP rs12717411.		VAR_019455
	Natural variant	1934	1	Q → E: dbSNP rs2295847.		VAR_051236
Experimental info
	Sequence conflict	4 – 5	2	VE → LD in AAK00628. Ref.3
	Sequence conflict	4 – 5	2	VE → LD in AAK00629. Ref.3
	Sequence conflict	10 – 11	2	EA → G in AAK00628. Ref.3
	Sequence conflict	10 – 11	2	EA → G in AAK00629. Ref.3
	Sequence conflict	15	1	E → D in AAK00628. Ref.3
	Sequence conflict	15	1	E → D in AAK00629. Ref.3
	Sequence conflict	15	1	E → D in AAK00630. Ref.3
	Sequence conflict	135	1	P → A in AAK00628. Ref.3
	Sequence conflict	135	1	P → A in AAK00629. Ref.3
	Sequence conflict	135	1	P → A in AAK00630. Ref.3
	Sequence conflict	137	1	H → Y Ref.1
	Sequence conflict	137	1	H → Y Ref.2
	Sequence conflict	177	1	S → F in AAF23015. Ref.1
	Sequence conflict	203	1	N → D in AAG33512. Ref.2
	Sequence conflict	223	1	M → I in AAG33512. Ref.2
	Sequence conflict	264 – 268	5	LKRHL → TKKAPF in AAK00628. Ref.3
	Sequence conflict	264 – 268	5	LKRHL → TKKAPF in AAK00629. Ref.3
	Sequence conflict	295	1	F → I in AAG33512. Ref.2
	Sequence conflict	348	1	N → Y in AAK00628. Ref.3
	Sequence conflict	348	1	N → Y in AAK00629. Ref.3
	Sequence conflict	348	1	N → Y in AAK00630. Ref.3
	Sequence conflict	357	1	I → T in AAK00628. Ref.3
	Sequence conflict	357	1	I → T in AAK00629. Ref.3
	Sequence conflict	357	1	I → T in AAK00630. Ref.3
	Sequence conflict	369	1	I → V in AAG33512. Ref.2
	Sequence conflict	399	1	L → S in AAG33512. Ref.2
	Sequence conflict	568	1	L → F in AAG33512. Ref.2
	Sequence conflict	809	1	R → I in AAF23015. Ref.1
	Sequence conflict	812	1	S → T in AAG33512. Ref.2
	Sequence conflict	932	1	L → M in AAK00628. Ref.3
	Sequence conflict	932	1	L → M in AAK00629. Ref.3
	Sequence conflict	932	1	L → M in AAK00630. Ref.3
	Sequence conflict	945	1	K → I in AAG33512. Ref.2
	Sequence conflict	977	1	D → A in AAG33512. Ref.2
	Sequence conflict	980	1	R → G in AAF23015. Ref.1
	Sequence conflict	1034	1	S → N in AAK00628. Ref.3
	Sequence conflict	1034	1	S → N in AAK00629. Ref.3
	Sequence conflict	1034	1	S → N in AAK00630. Ref.3
	Sequence conflict	1054	1	Q → H in AAG33512. Ref.2
	Sequence conflict	1067	1	L → F in AAG33512. Ref.2
	Sequence conflict	1070	1	L → Q in AAF23015. Ref.1
	Sequence conflict	1150	1	D → G in AAF23015. Ref.1
	Sequence conflict	1168	1	V → A in AAK00628. Ref.3
	Sequence conflict	1168	1	V → A in AAK00629. Ref.3
	Sequence conflict	1168	1	V → A in AAK00630. Ref.3
	Sequence conflict	1237	1	M → I in AAF23015. Ref.1
	Sequence conflict	1548 – 1555	8	NGSQEEMW → YWNSGRMR in AAK00628. Ref.3
	Sequence conflict	1859	1	L → S in AAK00628. Ref.3
	Sequence conflict	1859	1	L → S in AAK00629. Ref.3
	Sequence conflict	1859	1	L → S in AAK00630. Ref.3
	Sequence conflict	1865 – 1869	5	NTKAE → EHQSR in AAK00630. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Lm) [UniParc]. Last modified July 19, 2004. Version 3. Checksum: F71E610FF9B7792E	FASTA	2,090	243,290
	10 20 30 40 50 60 MDEVEQDQHE ARLKELFDSF DTTGTGSLGQ EELTDLCHML SLEEVAPVLQ QTLLQDNLLG 70 80 90 100 110 120 RVHFDQFKEA LILILSRTLS NEEHFQEPDC SLEAQPKYVR GGKRYGRRSL PEFQESVEEF 130 140 150 160 170 180 PEVTVIEPLD EEARPSHIPA GDCSEHWKTQ RSEEYEAEGQ LRFWNPDDLN ASQSGSSPPQ 190 200 210 220 230 240 DWIEEKLQEV CEDLGITRDG HLNRKKLVSI CEQYGLQNVD GEMLEEVFHN LDPDGTMSVE 250 260 270 280 290 300 DFFYGLFKNG KSLTPSASTP YRQLKRHLSM QSFDESGRRT TTSSAMTSTI GFRVFSCLDD 310 320 330 340 350 360 GMGHASVERI LDTWQEEGIE NSQEILKALD FSLDGNINLT ELTLALENEL LVTKNSIHQA 370 380 390 400 410 420 ALASFKAEIR HLLERVDQVV REKEKLRSDL DKAEKLKSLM ASEVDDHHAA IERRNEYNLR 430 440 450 460 470 480 KLDEEYKERI AALKNELRKE REQILQQAGK QRLELEQEIE KAKTEENYIR DRLALSLKEN 490 500 510 520 530 540 SRLENELLEN AEKLAEYENL TNKLQRNLEN VLAEKFGDLD PSSAEFFLQE ERLTQMRNEY 550 560 570 580 590 600 ERQCRVLQDQ VDELQSELEE YRAQGRVLRL PLKNSPSEEV EANSGGIEPE HGLGSEECNP 610 620 630 640 650 660 LNMSIEAELV IEQMKEQHHR DICCLRLELE DKVRHYEKQL DETVVSCKKA QENMKQRHEN 670 680 690 700 710 720 ETHTLEKQIS DLKNEIAELQ GQAAVLKEAH HEATCRHEEE KKQLQVKLEE EKTHLQEKLR 730 740 750 760 770 780 LQHEMELKAR LTQAQASFER EREGLQSSAW TEEKVRGLTQ ELEQFHQEQL TSLVEKHTLE 790 800 810 820 830 840 KEELRKELLE KHQRELQEGR EKMETECNRR TSQIEAQFQS DCQKVTERCE SALQSLEGRY 850 860 870 880 890 900 RQELKDLQEQ QREEKSQWEF EKDELTQECA EAQELLKETL KREKTTSLVL TQEREMLEKT 910 920 930 940 950 960 YKEHLNSMVV ERQQLLQDLE DLRNVSETQQ SLLSDQILEL KSSHKRELRE REEVLCQAGA 970 980 990 1000 1010 1020 SEQLASQRLE RLEMEHDQER QEMMSKLLAM ENIHKATCET ADRERAEMST EISRLQSKIK 1030 1040 1050 1060 1070 1080 EMQQATSPLS MLQSGCQVIG EEEVEGDGAL SLLQQGEQLL EENGDVLLSL QRAHEQAVKE 1090 1100 1110 1120 1130 1140 NVKMATEISR LQQRLQKLEP GLVMSSCLDE PATEFFGNTA EQTEPFLQQN RTKQVEGVTR 1150 1160 1170 1180 1190 1200 RHVLSDLEDD EVRDLGSTGT SSVQRQEVKI EESEASVEGF SELENSEETR TESWELKNQI 1210 1220 1230 1240 1250 1260 SQLQEQLMML CADCDRASEK KQDLLFDVSV LKKKLKMLER IPEASPKYKL LYEDVSREND 1270 1280 1290 1300 1310 1320 CLQEELRMME TRYDEALENN KELTAEVFRL QDELKKMEEV TETFLSLEKS YDEVKIENEE 1330 1340 1350 1360 1370 1380 LNVLVLRLQG KIEKLQESVV QRCDCCLWEA SLENLEIEPD GNILQLNQTL EECVPRVRSV 1390 1400 1410 1420 1430 1440 HHVIEECKQE NQYLEGNTQL LEKVKAHEIA WLHGTIQTHQ ERPRVQNQVI LEENTTLLGF 1450 1460 1470 1480 1490 1500 QDKHFQHQAT IAELELEKTK LQELTRKLKE RVTILVKQKD VLSHGEKEEE LKAMMHDLQI 1510 1520 1530 1540 1550 1560 TCSEMQQKVE LLRYESEKLQ QENSILRNEI TTLNEEDSIS NLKLGTLNGS QEEMWQKTET 1570 1580 1590 1600 1610 1620 VKQENAAVQK MVENLKKQIS ELKIKNQQLD LENTELSQKN SQNQEKLQEL NQRLTEMLCQ 1630 1640 1650 1660 1670 1680 KEKEPGNSAL EEREQEKFNL KEELERCKVQ SSTLVSSLEA ELSEVKIQTH IVQQENHLLK 1690 1700 1710 1720 1730 1740 DELEKMKQLH RCPDLSDFQQ KISSVLSYNE KLLKEKEALS EELNSCVDKL AKSSLLEHRI 1750 1760 1770 1780 1790 1800 ATMKQEQKSW EHQSASLKSQ LVASQEKVQN LEDTVQNVNL QMSRMKSDLR VTQQEKEALK 1810 1820 1830 1840 1850 1860 QEVMSLHKQL QNAGGKSWAP EIATHPSGLH NQQKRLSWDK LDHLMNEEQQ LLWQENERLQ 1870 1880 1890 1900 1910 1920 TMVQNTKAEL THSREKVRQL ESNLLPKHQK HLNPSGTMNP TEQEKLSLKR ECDQFQKEQS 1930 1940 1950 1960 1970 1980 PANRKVSQMN SLEQELETIH LENEGLKKKQ VKLDEQLMEM QHLRSTATPS PSPHAWDLQL 1990 2000 2010 2020 2030 2040 LQQQACPMVP REQFLQLQRQ LLQAERINQH LQEELENRTS ETNTPQGNQE QLVTVMEERM 2050 2060 2070 2080 2090 IEVEQKLKLV KRLLQEKVNQ LKEQVSLPGH LCSPTSHSSF NSSFTSLYCH
	Isoform 2 (Isotype 3). Checksum: DE8238722E9D83F9	FASTA	2,073	241,232
	10 20 30 40 50 60 MDEVEQDQHE ARLKELFDSF DTTGTGSLGQ EELTDLCHML SLEEVAPVLQ QTLLQDNLLG 70 80 90 100 110 120 RVHFDQFKEA LILILSRTLS NEEHFQEPDC SLEAQPKYVR GGKRYGRRSL PEFQESVEEF 130 140 150 160 170 180 PEVTVIEPLD EEARPSHIPA GDCSEHWKTQ RSEEYEAEGQ LRFWNPDDLN ASQSGSSPPQ 190 200 210 220 230 240 DWIEEKLQEV CEDLGITRDG HLNRKKLVSI CEQYGLQNVD GEMLEEVFHN LDPDGTMSVE 250 260 270 280 290 300 DFFYGLFKNG KSLTPSASTP YRQLKRHLSM QSFDESGRRT TTSSAMTSTI GFRVFSCLDD 310 320 330 340 350 360 GMGHASVERI LDTWQEEGIE NSQEILKALD FSLDGNINLT ELTLALENEL LVTKNSIHQA 370 380 390 400 410 420 ALASFKAEIR HLLERVDQVV REKEKLRSDL DKAEKLKSLM ASEVDDHHAA IERRNEYNLR 430 440 450 460 470 480 KLDEEYKERI AALKNELRKE REQILQQAGK QRLELEQEIE KAKTEENYIR DRLALSLKEN 490 500 510 520 530 540 SRLENELLEN AENVLAEKFG DLDPSSAEFF LQEERLTQMR NEYERQCRVL QDQVDELQSE 550 560 570 580 590 600 LEEYRAQGRV LRLPLKNSPS EEVEANSGGI EPEHGLGSEE CNPLNMSIEA ELVIEQMKEQ 610 620 630 640 650 660 HHRDICCLRL ELEDKVRHYE KQLDETVVSC KKAQENMKQR HENETHTLEK QISDLKNEIA 670 680 690 700 710 720 ELQGQAAVLK EAHHEATCRH EEEKKQLQVK LEEEKTHLQE KLRLQHEMEL KARLTQAQAS 730 740 750 760 770 780 FEREREGLQS SAWTEEKVRG LTQELEQFHQ EQLTSLVEKH TLEKEELRKE LLEKHQRELQ 790 800 810 820 830 840 EGREKMETEC NRRTSQIEAQ FQSDCQKVTE RCESALQSLE GRYRQELKDL QEQQREEKSQ 850 860 870 880 890 900 WEFEKDELTQ ECAEAQELLK ETLKREKTTS LVLTQEREML EKTYKEHLNS MVVERQQLLQ 910 920 930 940 950 960 DLEDLRNVSE TQQSLLSDQI LELKSSHKRE LREREEVLCQ AGASEQLASQ RLERLEMEHD 970 980 990 1000 1010 1020 QERQEMMSKL LAMENIHKAT CETADRERAE MSTEISRLQS KIKEMQQATS PLSMLQSGCQ 1030 1040 1050 1060 1070 1080 VIGEEEVEGD GALSLLQQGE QLLEENGDVL LSLQRAHEQA VKENVKMATE ISRLQQRLQK 1090 1100 1110 1120 1130 1140 LEPGLVMSSC LDEPATEFFG NTAEQTEPFL QQNRTKQVEG VTRRHVLSDL EDDEVRDLGS 1150 1160 1170 1180 1190 1200 TGTSSVQRQE VKIEESEASV EGFSELENSE ETRTESWELK NQISQLQEQL MMLCADCDRA 1210 1220 1230 1240 1250 1260 SEKKQDLLFD VSVLKKKLKM LERIPEASPK YKLLYEDVSR ENDCLQEELR MMETRYDEAL 1270 1280 1290 1300 1310 1320 ENNKELTAEV FRLQDELKKM EEVTETFLSL EKSYDEVKIE NEELNVLVLR LQGKIEKLQE 1330 1340 1350 1360 1370 1380 SVVQRCDCCL WEASLENLEI EPDGNILQLN QTLEECVPRV RSVHHVIEEC KQENQYLEGN 1390 1400 1410 1420 1430 1440 TQLLEKVKAH EIAWLHGTIQ THQERPRVQN QVILEENTTL LGFQDKHFQH QATIAELELE 1450 1460 1470 1480 1490 1500 KTKLQELTRK LKERVTILVK QKDVLSHGEK EEELKAMMHD LQITCSEMQQ KVELLRYESE 1510 1520 1530 1540 1550 1560 KLQQENSILR NEITTLNEED SISNLKLGTL NGSQEEMWQK TETVKQENAA VQKMVENLKK 1570 1580 1590 1600 1610 1620 QISELKIKNQ QLDLENTELS QKNSQNQEKL QELNQRLTEM LCQKEKEPGN SALEEREQEK 1630 1640 1650 1660 1670 1680 FNLKEELERC KVQSSTLVSS LEAELSEVKI QTHIVQQENH LLKDELEKMK QLHRCPDLSD 1690 1700 1710 1720 1730 1740 FQQKISSVLS YNEKLLKEKE ALSEELNSCV DKLAKSSLLE HRIATMKQEQ KSWEHQSASL 1750 1760 1770 1780 1790 1800 KSQLVASQEK VQNLEDTVQN VNLQMSRMKS DLRVTQQEKE ALKQEVMSLH KQLQNAGGKS 1810 1820 1830 1840 1850 1860 WAPEIATHPS GLHNQQKRLS WDKLDHLMNE EQQLLWQENE RLQTMVQNTK AELTHSREKV 1870 1880 1890 1900 1910 1920 RQLESNLLPK HQKHLNPSGT MNPTEQEKLS LKRECDQFQK EQSPANRKVS QMNSLEQELE 1930 1940 1950 1960 1970 1980 TIHLENEGLK KKQVKLDEQL MEMQHLRSTA TPSPSPHAWD LQLLQQQACP MVPREQFLQL 1990 2000 2010 2020 2030 2040 QRQLLQAERI NQHLQEELEN RTSETNTPQG NQEQLVTVME ERMIEVEQKL KLVKRLLQEK 2050 2060 2070 VNQLKEQVSL PGHLCSPTSH SSFNSSFTSL YCH
	Isoform 3 (Isotype 2). Checksum: 607083A99006772F	FASTA	2,069	240,892
	10 20 30 40 50 60 MDEVEQDQHE ARLKELFDSF DTTGTGSLGQ EELTDLCHML SLEEVAPVLQ QTLLQDNLLG 70 80 90 100 110 120 RVHFDQFKEA LILILSRTLS NEEHFQEPDC SLEAQPKYVR GGKRYGRRSL PEFQESVEEF 130 140 150 160 170 180 PEVTVIEPLD EEARPSHIPA GDCSEHWKTQ RSEEYEAEGQ LRFWNPDDLN ASQSGSSPPQ 190 200 210 220 230 240 DWIEEKLQEV CEDLGITRDG HLNRKKLVSI CEQYGLQNVD GEMLEEVFHN LDPDGTMSVE 250 260 270 280 290 300 DFFYGLFKNG KSLTPSASTP YRQLKRHLSM QSFDESGRRT TTSSAMTSTI GFRVFSCLDD 310 320 330 340 350 360 GMGHASVERI LDTWQEEGIE NSQEILKALD FSLDGNINLT ELTLALENEL LVTKNSIHQA 370 380 390 400 410 420 ALASFKAEIR HLLERVDQVV REKEKLRSDL DKAEKLKSLM ASEVDDHHAA IERRNEYNLR 430 440 450 460 470 480 KLDEEYKERI AALKNELRKE REQILQQAGK QRLELEQEIE KAKTEENYIR DRLALSLKEN 490 500 510 520 530 540 SRLENELLEN AENVLAEKFG DLDPSSAEFF LQEERLTQMR NEYERQCRVL QDQVDELQSE 550 560 570 580 590 600 LEEYRAQGRV LRLPLKNSPS EEVEANSGGI EPEHGLGSEE CNPLNMSIEA ELVIEQMKEQ 610 620 630 640 650 660 HHRDICCLRL ELEDKVRHYE KQLDETVVSC KKAQENMKQR HENETHTLEK QISDLKNEIA 670 680 690 700 710 720 ELQGQAAVLK EAHHEATCRH EEEKKQLQVK LEEEKTHLQE KLRLQHEMEL KARLTQAQAS 730 740 750 760 770 780 FEREREGLQS SAWTEEKVRG LTQELEQFHQ EQLTSLVEKH TLEKEELRKE LLEKHQRELQ 790 800 810 820 830 840 EGREKMETEC NRRTSQIEAQ FQSDCQKVTE RCESALQSLE GRYRQELKDL QEQQREEKSQ 850 860 870 880 890 900 WEFEKDELTQ ECAEAQELLK ETLKREKTTS LVLTQEREML EKTYKEHLNS MVVERQQLLQ 910 920 930 940 950 960 DLEDLRNVSE TQQSLLSDQI LELKSSHKRE LREREEVLCQ AGASEQLASQ RLERLEMEHD 970 980 990 1000 1010 1020 QERQEMMSKL LAMENIHKAT CETADRERAE MSTEISRLQS KIKEMQQATS PLSMLQSGCQ 1030 1040 1050 1060 1070 1080 VIGEEEVEGD GALSLLQQGE QLLEENGDVL LSLQRAHEQA VKENVKMATE ISRLQQRLQK 1090 1100 1110 1120 1130 1140 LEPGLVMSSC LDEPATEFFG NTAEQTEPFL QQNRTKQVEG VTRRHVLSDL EDDEVRDLGS 1150 1160 1170 1180 1190 1200 TGTSSVQRQE VKIEESEASV EGFSELENSE ETRTESWELK NQISQLQEQL MMLCADCDRA 1210 1220 1230 1240 1250 1260 SEKKQDLLFD VSVLKKKLKM LERIPEASPK YKLLYEDVSR ENDCLQEELR MMETRYDEAL 1270 1280 1290 1300 1310 1320 ENNKELTAEV FRLQDELKKM EEVTETFLSL EKSYDEVKIE NEELNVLVLR LQGKIEKLQE 1330 1340 1350 1360 1370 1380 SVVQRCDCCL WEASLENLEI EPDGNILQLN QTLEECVPRV RSVHHVIEEC KQENQYLEGN 1390 1400 1410 1420 1430 1440 TQLLEKVKAH EIAWLHGTIQ THQERPRVQN QVILEENTTL LGFQDKHFQH QATIAELELE 1450 1460 1470 1480 1490 1500 KTKLQELTRK LKERVTILVK QKDVLSHGEK EEELKAMMHD LQITCSEMQQ KVELLRYESE 1510 1520 1530 1540 1550 1560 KLQQENSILR NEITTLNEED SISNLKLGTL NGSQEEMWQK TETVKQENAA VQKMVENLKK 1570 1580 1590 1600 1610 1620 QISELKIKNQ QLDLENTELS QKNSQNQEKL QELNQRLTEM LCQKEKEPGN SALEEREQEK 1630 1640 1650 1660 1670 1680 FNLKEELERC KVQSSTLVSS LEAELSEVKI QTHIVQQENH LLKDELEKMK QLHRCPDLSD 1690 1700 1710 1720 1730 1740 FQQKISSVLS YNEKLLKEKE ALSEELNSCV DKLAKSSLLE HRIATMKQEQ KSWEHQSASL 1750 1760 1770 1780 1790 1800 KSQLVASQEK VQNLEDTVQN VNLQMSRMKS DLRVTQQEKE ALKQEVMSLH KQLQNAGGKS 1810 1820 1830 1840 1850 1860 WAPEIATHPS GLHNQQKRLS WDKLDHLMNE EQQLLWQENE RLQTMVQNTK AELTHSREKV 1870 1880 1890 1900 1910 1920 RQLESNLLPK HQKHLNPSGT MNPTEQEKLS LKRECDQFQK EQSPANRKVS QMNSLEQELE 1930 1940 1950 1960 1970 1980 TIHLENEGLK KKQVKLDEQL MEMQHLRSTA TPSPSPHAWD LQLLQQQACP MVPREQFLQL 1990 2000 2010 2020 2030 2040 QRQLLQAERI NQHLQEELEN RTSETNTPQG NQEQLVTVME ERMIEVEQKL KLVKRLLQEK 2050 2060 VNQLKEQLCK NTKADAMVKD LYVENAQVC
	Isoform 4 (Isotype 1). Checksum: A3C86C82FE273FA2	FASTA	2,029	236,176
	10 20 30 40 50 60 MDEVEQDQHE ARLKELFDSF DTTGTGSLGQ EELTDLCHML SLEEVAPVLQ QTLLQDNLLG 70 80 90 100 110 120 RVHFDQFKEA LILILSRTLS NEEHFQEPDC SLEAQPKYVR GGKRYGRRSL PEFQESVEEF 130 140 150 160 170 180 PEVTVIEPLD EEARPSHIPA GDCSEHWKTQ RSEEYEAEGQ LRFWNPDDLN ASQSGSSPPQ 190 200 210 220 230 240 DWIEEKLQEV CEDLGITRDG HLNRKKLVSI CEQYGLQNVD GEMLEEVFHN LDPDGTMSVE 250 260 270 280 290 300 DFFYGLFKNG KSLTPSASTP YRQLKRHLSM QSFDESGRRT TTSSAMTSTI GFRVFSCLDD 310 320 330 340 350 360 GMGHASVERI LDTWQEEGIE NSQEILKALD FSLDGNINLT ELTLALENEL LVTKNSIHQA 370 380 390 400 410 420 ALASFKAEIR HLLERVDQVV REKEKLRSDL DKAEKLKSLM ASEVDDHHAA IERRNEYNLR 430 440 450 460 470 480 KLDEEYKERI AALKNELRKE REQILQQAGK QRLELEQEIE KAKTEENYIR DRLALSLKEN 490 500 510 520 530 540 SRLENELLEN AENVLAEKFG DLDPSSAEFF LQEERLTQMR NEYERQCRVL QDQVDELQSE 550 560 570 580 590 600 LEEYRAQGRV LRLPLKNSPS EEVEANSGGI EPEHGLGSEE CNPLNMSIEA ELVIEQMKEQ 610 620 630 640 650 660 HHRDICCLRL ELEDKVRHYE KQLDETVVSC KKAQENMKQR HENETHTLEK QISDLKNEIA 670 680 690 700 710 720 ELQGQAAVLK EAHHEATCRH EEEKKQLQVK LEEEKTHLQE KLRLQHEMEL KARLTQAQAS 730 740 750 760 770 780 FEREREGLQS SAWTEEKVRG LTQELEQFHQ EQLTSLVEKH TLEKEELRKE LLEKHQRELQ 790 800 810 820 830 840 EGREKMETEC NRRTSQIEAQ FQSDCQKVTE RCESALQSLE GRYRQELKDL QEQQREEKSQ 850 860 870 880 890 900 WEFEKDELTQ ECAEAQELLK ETLKREKTTS LVLTQEREML EKTYKEHLNS MVVERQQLLQ 910 920 930 940 950 960 DLEDLRNVSE TQQSLLSDQI LELKSSHKRE LREREEVLCQ AGASEQLASQ RLERLEMEHD 970 980 990 1000 1010 1020 QERQEMMSKL LAMENIHKAT CETADRERAE MSTEISRLQS KIKEMQQATS PLSMLQSGCQ 1030 1040 1050 1060 1070 1080 VIGEEEVEGD GALSLLQQGE QLLEENGDVL LSLQRAHEQA VKENVKMATE ISRLQQRLQK 1090 1100 1110 1120 1130 1140 LEPGLVMSSC LDEPATEFFG NTAEQTEPFL QQNRTKQVEG VTRRHVLSDL EDDEVRDLGS 1150 1160 1170 1180 1190 1200 TGTSSVQRQE VKIEESEASV EGFSELENSE ETRTESWELK NQISQLQEQL MMLCADCDRA 1210 1220 1230 1240 1250 1260 SEKKQDLLFD VSVLKKKLKM LERIPEASPK YKLLYEDVSR ENDCLQEELR MMETRYDEAL 1270 1280 1290 1300 1310 1320 ENNKELTAEV FRLQDELKKM EEVTETFLSL EKSYDEVKIE NEELNVLVLR LQGKIEKLQE 1330 1340 1350 1360 1370 1380 SVVQRCDCCL WEASLENLEI EPDGNILQLN QTLEECVPRV RSVHHVIEEC KQENQYLEGN 1390 1400 1410 1420 1430 1440 TQLLEKVKAH EIAWLHGTIQ THQERPRVQN QVILEENTTL LGFQDKHFQH QATIAELELE 1450 1460 1470 1480 1490 1500 KTKLQELTRK LKERVTILVK QKDVLSHGEK EEELKAMMHD LQITCSEMQQ KVELLRYESE 1510 1520 1530 1540 1550 1560 KLQQENSILR NEITTLNEED SISNLKLGTL NGSQEEMWQK TETVKQENAA VQKMVENLKK 1570 1580 1590 1600 1610 1620 QISELKIKNQ QLDLENTELS QKNSQNQEKL QELNQRLTEM LCQKEKEPGN SALEEREQEK 1630 1640 1650 1660 1670 1680 FNLKEELERC KVQSSTLVSS LEAELSEVKI QTHIVQQENH LLKDELEKMK QLHRCPDLSD 1690 1700 1710 1720 1730 1740 FQQKISSVLS YNEKLLKEKE ALSEELNSCV DKLAKSSLLE HRIATMKQEQ KSWEHQSASL 1750 1760 1770 1780 1790 1800 KSQLVASQEK VQNLEDTVQN VNLQMSRMKS DLRVTQQEKE ALKQEVMSLH KQLQNAGGKS 1810 1820 1830 1840 1850 1860 WAPEIATHPS GLHNQQKRLS WDKLDHLMNE EQQLLWQENE RLQTMVQNTK AELTHSREKV 1870 1880 1890 1900 1910 1920 RQLESNLLPK HQKHLNPSGT MNPTEQEKLS LKRECDQFQK EQSPANRKVS QMNSLEQELE 1930 1940 1950 1960 1970 1980 TIHLENEGLK KKQVKLDEQL MEMQHLRSTA TPSPSPHAWD LQLLQQQACP MVPREQFLQL 1990 2000 2010 2020 QRQLLQAERI NQHLQEELEN RTSETNTPQA LLPEQRAVHA DSYRRIGHL
	Isoform 5. Checksum: 949937215250D157	FASTA	2,096	243,930
	10 20 30 40 50 60 MAEVTVPRVY VVFGIHCIMA KASSDVQVSG FHRKIQHVKN ELCHMLSLEE VAPVLQQTLL 70 80 90 100 110 120 QDNLLGRVHF DQFKEALILI LSRTLSNEEH FQEPDCSLEA QPKYVRGGKR YGRRSLPEFQ 130 140 150 160 170 180 ESVEEFPEVT VIEPLDEEAR PSHIPAGDCS EHWKTQRSEE YEAEGQLRFW NPDDLNASQS 190 200 210 220 230 240 GSSPPQDWIE EKLQEVCEDL GITRDGHLNR KKLVSICEQY GLQNVDGEML EEVFHNLDPD 250 260 270 280 290 300 GTMSVEDFFY GLFKNGKSLT PSASTPYRQL KRHLSMQSFD ESGRRTTTSS AMTSTIGFRV 310 320 330 340 350 360 FSCLDDGMGH ASVERILDTW QEEGIENSQE ILKALDFSLD GNINLTELTL ALENELLVTK 370 380 390 400 410 420 NSIHQAALAS FKAEIRHLLE RVDQVVREKE KLRSDLDKAE KLKSLMASEV DDHHAAIERR 430 440 450 460 470 480 NEYNLRKLDE EYKERIAALK NELRKEREQI LQQAGKQRLE LEQEIEKAKT EENYIRDRLA 490 500 510 520 530 540 LSLKENSRLE NELLENAEKL AEYENLTNKL QRNLENVLAE KFGDLDPSSA EFFLQEERLT 550 560 570 580 590 600 QMRNEYERQC RVLQDQVDEL QSELEEYRAQ GRVLRLPLKN SPSEEVEANS GGIEPEHGLG 610 620 630 640 650 660 SEECNPLNMS IEAELVIEQM KEQHHRDICC LRLELEDKVR HYEKQLDETV VSCKKAQENM 670 680 690 700 710 720 KQRHENETHT LEKQISDLKN EIAELQGQAA VLKEAHHEAT CRHEEEKKQL QVKLEEEKTH 730 740 750 760 770 780 LQEKLRLQHE MELKARLTQA QASFEREREG LQSSAWTEEK VRGLTQELEQ FHQEQLTSLV 790 800 810 820 830 840 EKHTLEKEEL RKELLEKHQR ELQEGREKME TECNRRTSQI EAQFQSDCQK VTERCESALQ 850 860 870 880 890 900 SLEGRYRQEL KDLQEQQREE KSQWEFEKDE LTQECAEAQE LLKETLKREK TTSLVLTQER 910 920 930 940 950 960 EMLEKTYKEH LNSMVVERQQ LLQDLEDLRN VSETQQSLLS DQILELKSSH KRELREREEV 970 980 990 1000 1010 1020 LCQAGASEQL ASQRLERLEM EHDQERQEMM SKLLAMENIH KATCETADRE RAEMSTEISR 1030 1040 1050 1060 1070 1080 LQSKIKEMQQ ATSPLSMLQS GCQVIGEEEV EGDGALSLLQ QGEQLLEENG DVLLSLQRAH 1090 1100 1110 1120 1130 1140 EQAVKENVKM ATEISRLQQR LQKLEPGLVM SSCLDEPATE FFGNTAEQTE PFLQQNRTKQ 1150 1160 1170 1180 1190 1200 VEGVTRRHVL SDLEDDEVRD LGSTGTSSVQ RQEVKIEESE ASVEGFSELE NSEETRTESW 1210 1220 1230 1240 1250 1260 ELKNQISQLQ EQLMMLCADC DRASEKKQDL LFDVSVLKKK LKMLERIPEA SPKYKLLYED 1270 1280 1290 1300 1310 1320 VSRENDCLQE ELRMMETRYD EALENNKELT AEVFRLQDEL KKMEEVTETF LSLEKSYDEV 1330 1340 1350 1360 1370 1380 KIENEELNVL VLRLQGKIEK LQESVVQRCD CCLWEASLEN LEIEPDGNIL QLNQTLEECV 1390 1400 1410 1420 1430 1440 PRVRSVHHVI EECKQENQYL EGNTQLLEKV KAHEIAWLHG TIQTHQERPR VQNQVILEEN 1450 1460 1470 1480 1490 1500 TTLLGFQDKH FQHQATIAEL ELEKTKLQEL TRKLKERVTI LVKQKDVLSH GEKEEELKAM 1510 1520 1530 1540 1550 1560 MHDLQITCSE MQQKVELLRY ESEKLQQENS ILRNEITTLN EEDSISNLKL GTLNGSQEEM 1570 1580 1590 1600 1610 1620 WQKTETVKQE NAAVQKMVEN LKKQISELKI KNQQLDLENT ELSQKNSQNQ EKLQELNQRL 1630 1640 1650 1660 1670 1680 TEMLCQKEKE PGNSALEERE QEKFNLKEEL ERCKVQSSTL VSSLEAELSE VKIQTHIVQQ 1690 1700 1710 1720 1730 1740 ENHLLKDELE KMKQLHRCPD LSDFQQKISS VLSYNEKLLK EKEALSEELN SCVDKLAKSS 1750 1760 1770 1780 1790 1800 LLEHRIATMK QEQKSWEHQS ASLKSQLVAS QEKVQNLEDT VQNVNLQMSR MKSDLRVTQQ 1810 1820 1830 1840 1850 1860 EKEALKQEVM SLHKQLQNAG GKSWAPEIAT HPSGLHNQQK RLSWDKLDHL MNEEQQLLWQ 1870 1880 1890 1900 1910 1920 ENERLQTMVQ NTKAELTHSR EKVRQLESNL LPKHQKHLNP SGTMNPTEQE KLSLKRECDQ 1930 1940 1950 1960 1970 1980 FQKEQSPANR KVSQMNSLEQ ELETIHLENE GLKKKQVKLD EQLMEMQHLR STATPSPSPH 1990 2000 2010 2020 2030 2040 AWDLQLLQQQ ACPMVPREQF LQLQRQLLQA ERINQHLQEE LENRTSETNT PQGNQEQLVT 2050 2060 2070 2080 2090 VMEERMIEVE QKLKLVKRLL QEKVNQLKEQ VSLPGHLCSP TSHSSFNSSF TSLYCH
	Isoform 6. Checksum: A34D34D74D9B861C	FASTA	1,275	147,799
	10 20 30 40 50 60 MDEVEQDQHE ARLKELFDSF DTTGTGSLGQ EELTDLCHML SLEEVAPVLQ QTLLQDNLLG 70 80 90 100 110 120 RVHFDQFKEA LILILSRTLS NEEHFQEPDC SLEAQPKYVR GGKRYGRRSL PEFQESVEEF 130 140 150 160 170 180 PEVTVIEPLD EEARPSHIPA GDCSEHWKTQ RSEEYEAEGQ LRFWNPDDLN ASQSGSSPPQ 190 200 210 220 230 240 DWIEEKLQEV CEDLGITRDG HLNRKKLVSI CEQYGLQNVD GEMLEEVFHN LDPDGTMSVE 250 260 270 280 290 300 DFFYGLFKNG KSLTPSASTP YRQLKRHLSM QSFDESGRRT TTSSAMTSTI GFRVFSCLDD 310 320 330 340 350 360 GMGHASVERI LDTWQEEGIE NSQEILKALD FSLDGNINLT ELTLALENEL LVTKNSIHQA 370 380 390 400 410 420 ALASFKAEIR HLLERVDQVV REKEKLRSDL DKAEKLKSLM ASEVDDHHAA IERRNEYNLR 430 440 450 460 470 480 KLDEEYKERI AALKNELRKE REQILQQAGK QRLELEQEIE KAKTEENYIR DRLALSLKEN 490 500 510 520 530 540 SRLENELLEN AEKLAEYENL TNKLQRNLEN VLAEKFGDLD PSSAEFFLQE ERLTQMRNEY 550 560 570 580 590 600 ERQCRVLQDQ VDELQSELEE YRAQGRVLRL PLKNSPSEEV EANSGGIEPE HGLGSEECNP 610 620 630 640 650 660 LNMSIEAELV IEQMKEQHHR DICCLRLELE DKVRHYEKQL DETVVSCKKA QENMKQRHEN 670 680 690 700 710 720 ETHTLEKQIS DLKNEIAELQ GQAAVLKEAH HEATCRHEEE KKQLQVKLEE EKTHLQEKLR 730 740 750 760 770 780 LQHEMELKAR LTQAQASFER EREGLQSSAW TEEKVRGLTQ ELEQFHQEQL TSLVEKHTLE 790 800 810 820 830 840 KEELRKELLE KHQRELQEGR YESEKLQQEN SILRNEITTL NEEDSISNLK LGTLNGSQEE 850 860 870 880 890 900 MQKTETVKQE NAAVQKMVEN LKKQISELKI KNQQLDLENT ELSQKNSQNQ EKLQELNQRL 910 920 930 940 950 960 TEMLCQKEKE PGNSALEERE QEKFNLKEEL ERCKVQSSTL VSSLEAELSE VKIQTHIVQQ 970 980 990 1000 1010 1020 ENHLLKDELE KMKQLHRCPD LSDFQQKISS VLSYNEKLLK EKEALSEELN SCVDKLAKSS 1030 1040 1050 1060 1070 1080 LLEHRIATMK QEQKSWEHQS ASLKSQLVAS QEKVQNLEDT VQNVNLQMSR MKSDLRVTQQ 1090 1100 1110 1120 1130 1140 EKEALKQEVM SLHKQLQNAG GKSWAPEIAT HPSGLHNQQK RLSWDKLDHL MNEEQQLLWQ 1150 1160 1170 1180 1190 1200 ENERLQTMVQ NTKAELTHSR EKVRQLESNL LPKHQKHLNP SGTMNPTEQE KLSLKRECDQ 1210 1220 1230 1240 1250 1260 FQKEQSPANR KVSQMNSLEQ ELETIHLENE GLKKKQVKLD EQLMENSVVG SSREGCSSLP 1270 EIVCEDAAPE VHCDA
	Isoform 7 (B). Checksum: 4772D23E47C8EF23	FASTA	2,133	248,235
	10 20 30 40 50 60 MDEVEQDQHE ARLKELFDSF DTTGTGSLGQ EELTDLCHML SLEEVAPVLQ QTLLQDNLLG 70 80 90 100 110 120 RVHFDQFKEA LILILSRTLS NEEHFQEPDC SLEAQPKYVR GGKRYGRRSL PEFQESVEEF 130 140 150 160 170 180 PEVTVIEPLD EEARPSHIPA GDCSEHWKTQ RSEEYEAEGQ LRFWNPDDLN ASQSGSSPPQ 190 200 210 220 230 240 DWIEEKLQEV CEDLGITRDG HLNRKKLVSI CEQYGLQNVD GEMLEEVFHN LDPDGTMSVE 250 260 270 280 290 300 DFFYGLFKNG KSLTPSASTP YRQLKRHLSM QSFDESGRRT TTSSAMTSTI GFRVFSCLDD 310 320 330 340 350 360 GMGHASVERI LDTWQEEGIE NSQEILKALD FSLDGNINLT ELTLALENEL LVTKNSIHQA 370 380 390 400 410 420 ALASFKAEIR HLLERVDQVV REKEKLRSDL DKAEKLKSLM ASEVDDHHAA IERRNEYNLR 430 440 450 460 470 480 KLDEEYKERI AALKNELRKE REQILQQAGK QRLELEQEIE KAKTEENYIR DRLALSLKEN 490 500 510 520 530 540 SRLENELLEN AEKLAEYENL TNKLQRNLEN VLAEKFGDLD PSSAEFFLQE ERLTQMRNEY 550 560 570 580 590 600 ERQCRVLQDQ VDELQSELEE YRAQGRVLRL PLKNSPSEEV EANSGGIEPE HGLGSEECNP 610 620 630 640 650 660 LNMSIEAELV IEQMKEQHHR DICCLRLELE DKVRHYEKQL DETVVSCKKA QENMKQRHEN 670 680 690 700 710 720 ETHTLEKQIS DLKNEIAELQ GQAAVLKEAH HEATCRHEEE KKQLQVKLEE EKTHLQEKLR 730 740 750 760 770 780 LQHEMELKAR LTQAQASFER EREGLQSSAW TEEKVRGLTQ ELEQFHQEQL TSLVEKHTLE 790 800 810 820 830 840 KEELRKELLE KHQRELQEGR EKMETECNRR TSQIEAQFQS DCQKVTERCE SALQSLEGRY 850 860 870 880 890 900 RQELKDLQEQ QREEKSQWEF EKDELTQECA EAQELLKETL KREKTTSLVL TQEREMLEKT 910 920 930 940 950 960 YKEHLNSMVV ERQQLLQDLE DLRNVSETQQ SLLSDQILEL KSSHKRELRE REEVLCQAGA 970 980 990 1000 1010 1020 SEQLASQRLE RLEMEHDQER QEMMSKLLAM ENIHKATCET ADRERAEMST EISRLQSKIK 1030 1040 1050 1060 1070 1080 EMQQATSPLS MLQSGCQVIG EEEVEGDGAL SLLQQGEQLL EENGDVLLSL QRAHEQAVKE 1090 1100 1110 1120 1130 1140 NVKMATEISR LQQRLQKLEP GLVMSSCLDE PATEFFGNTA EQTEPFLQQN RTKQVEGVTR 1150 1160 1170 1180 1190 1200 RHVLSDLEDD EVRDLGSTGT SSVQRQEVKI EESEASVEGF SELENSEETR TESWELKNQI 1210 1220 1230 1240 1250 1260 SQLQEQLMML CADCDRASEK KQDLLFDVSV LKKKLKMLER IPEASPKYKL LYEDVSREND 1270 1280 1290 1300 1310 1320 CLQEELRMME TRYDEALENN KELTAEVFRL QDELKKMEEV TETFLSLEKS YDEVKIENEE 1330 1340 1350 1360 1370 1380 LNVLVLRLQG KIEKLQESVV QRCDCCLWEA SLENLEIEPD GNILQLNQTL EECVPRVRSV 1390 1400 1410 1420 1430 1440 HHVIEECKQE NQYLEGNTQL LEKVKAHEIA WLHGTIQTHQ ERPRVQNQVI LEENTTLLGF 1450 1460 1470 1480 1490 1500 QDKHFQHQAT IAELELEKTK LQELTRKLKE RVTILVKQKD VLSHGEKEEE LKAMMHDLQI 1510 1520 1530 1540 1550 1560 TCSEMQQKVE LLRYESEKLQ QENSILRNEI TTLNEEDSIS NLKLGTLNGS QEEMWQKTET 1570 1580 1590 1600 1610 1620 VKQENAAVQK MVENLKKQIS ELKIKNQQLD LENTELSQKN SQNQEKLQEL NQRLTEMLCQ 1630 1640 1650 1660 1670 1680 KEKEPGNSAL EEREQEKFNL KEELERCKVQ SSTLVSSLEA ELSEVKIQTH IVQQENHLLK 1690 1700 1710 1720 1730 1740 DELEKMKQLH RCPDLSDFQQ KISSVLSYNE KLLKEKEALS EELNSCVDKL AKSSLLEHRI 1750 1760 1770 1780 1790 1800 ATMKQEQKSW EHQSASLKSQ LVASQEKVQN LEDTVQNVNL QMSRMKSDLR VTQQEKEALK 1810 1820 1830 1840 1850 1860 QEVMSLHKQL QNAGGKSWAP EIATHPSGLH NQQKRLSWDK LDHLMNEEQQ LLWQENERLQ 1870 1880 1890 1900 1910 1920 TMVQNTKAEL THSREKVRQL ESNLLPKHQK HLNPSGTMNP TEQEKLSLKR ECDQFQKEQS 1930 1940 1950 1960 1970 1980 PANRKVSQMN SLEQELETIH LENEGLKKKQ VKLDEQLMEM QHLRSTATPS PSPHAWDLQL 1990 2000 2010 2020 2030 2040 LQQQACPMVP REQFLQLQRQ LLQAERINQH LQEELENRTS ETNTPQGNQE QLVTVMEERM 2050 2060 2070 2080 2090 2100 IEVEQKLKLV KRLLQEKVNQ LKEQLCKNTK ADAMVKDLYV ENAQLLKALE VTEQRQKTAE 2110 2120 2130 KKNYLLEEKI ASLSNIVRNL TPAPLTSTPP LRS
	Isoform 8. Checksum: DB76830A02798077	FASTA	2,123	245,974
	10 20 30 40 50 60 SALGAAVPLP PPSPECASGH GSRGGAGRLS PGTQALEAGC RLCGRSGETD RSFDTTGTGS 70 80 90 100 110 120 LGQEELTDLC HMLSLEEVAP VLQQTLLQDN LLGRVHFDQF KEALILILSR TLSNEEHFQE 130 140 150 160 170 180 PDCSLEAQPK YVRGGKRYGR RSLPEFQESV EEFPEVTVIE PLDEEARPSH IPAGDCSEHW 190 200 210 220 230 240 KTQRSEEYEA EGQLRFWNPD DLNASQSGSS PPQDWIEEKL QEVCEDLGIT RDGHLNRKKL 250 260 270 280 290 300 VSICEQYGLQ NVDGEMLEEV FHNLDPDGTM SVEDFFYGLF KNGKSLTPSA STPYRQLKRH 310 320 330 340 350 360 LSMQSFDESG RRTTTSSAMT STIGFRVFSC LDDGMGHASV ERILDTWQEE GIENSQEILK 370 380 390 400 410 420 ALDFSLDGNI NLTELTLALE NELLVTKNSI HQAALASFKA EIRHLLERVD QVVREKEKLR 430 440 450 460 470 480 SDLDKAEKLK SLMASEVDDH HAAIERRNEY NLRKLDEEYK ERIAALKNEL RKEREQILQQ 490 500 510 520 530 540 AGKQRLELEQ EIEKAKTEEN YIRDRLALSL KENSRLENEL LENAEKLAEY ENLTNKLQRN 550 560 570 580 590 600 LENVLAEKFG DLDPSSAEFF LQEERLTQMR NEYERQCRVL QDQVDELQSE LEEYRAQGRV 610 620 630 640 650 660 LRLPLKNSPS EEVEANSGGI EPEHGLGSEE CNPLNMSIEA ELVIEQMKEQ HHRDICCLRL 670 680 690 700 710 720 ELEDKVRHYE KQLDETVVSC KKAQENMKQR HENETHTLEK QISDLKNEIA ELQGQAAVLK 730 740 750 760 770 780 EAHHEATCRH EEEKKQLQVK LEEEKTHLQE KLRLQHEMEL KARLTQAQAS FEREREGLQS 790 800 810 820 830 840 SAWTEEKVRG LTQELEQFHQ EQLTSLVEKH TLEKEELRKE LLEKHQRELQ EGREKMETEC 850 860 870 880 890 900 NRRTSQIEAQ FQSDCQKVTE RCESALQSLE GRYRQELKDL QEQQREEKSQ WEFEKDELTQ 910 920 930 940 950 960 ECAEAQELLK ETLKREKTTS LVLTQEREML EKTYKEHLNS MVVERQQLLQ DLEDLRNVSE 970 980 990 1000 1010 1020 TQQSLLSDQI LELKSSHKRE LREREEVLCQ AGASEQLASQ RLERLEMEHD QERQEMMSKL 1030 1040 1050 1060 1070 1080 LAMENIHKAT CETADRERAE MSTEISRLQS KIKEMQQATS PLSMLQSGCQ VIGEEEVEGD 1090 1100 1110 1120 1130 1140 GALSLLQQGE QLLEENGDVL LSLQRAHEQA VKENVKMATE ISRLQQRLQK LEPGLVMSSC 1150 1160 1170 1180 1190 1200 LDEPATEFFG NTAEQTEPFL QQNRTKQVEG VTRRHVLSDL EDDEVRDLGS TGTSSVQRQE 1210 1220 1230 1240 1250 1260 VKIEESEASV EGFSELENSE ETRTESWELK NQISQLQEQL MMLCADCDRA SEKKQDLLFD 1270 1280 1290 1300 1310 1320 VSVLKKKLKM LERIPEASPK YKLLYEDVSR ENDCLQEELR MMETRYDEAL ENNKELTAEV 1330 1340 1350 1360 1370 1380 FRLQDELKKM EEVTETFLSL EKSYDEVKIE NEELNVLVLR LQGKIEKLQE SVVQRCDCCL 1390 1400 1410 1420 1430 1440 WEASLENLEI EPDGNILQLN QTLEECVPRV RSVHHVIEEC KQENQYLEGN TQLLEKVKAH 1450 1460 1470 1480 1490 1500 EIAWLHGTIQ THQERPRVQN QVILEENTTL LGFQDKHFQH QATIAELELE KTKLQELTRK 1510 1520 1530 1540 1550 1560 LKERVTILVK QKDVLSHGEK EEELKAMMHD LQITCSEMQQ KVELLRYESE KLQQENSILR 1570 1580 1590 1600 1610 1620 NEITTLNEED SISNLKLGTL NGSQEEMWQK TETVKQENAA VQKMVENLKK QISELKIKNQ 1630 1640 1650 1660 1670 1680 QLDLENTELS QKNSQNQEKL QELNQRLTEM LCQKEKEPGN SALEEREQEK FNLKEELERC 1690 1700 1710 1720 1730 1740 KVQSSTLVSS LEAELSEVKI QTHIVQQENH LLKDELEKMK QLHRCPDLSD FQQKISSVLS 1750 1760 1770 1780 1790 1800 YNEKLLKEKE ALSEELNSCV DKLAKSSLLE HRIATMKQEQ KSWEHQSASL KSQLVASQEK 1810 1820 1830 1840 1850 1860 VQNLEDTVQN VNLQMSRMKS DLRVTQQEKE ALKQEVMSLH KQLQNAGGKS WAPEIATHPS 1870 1880 1890 1900 1910 1920 GLHNQQKRLS WDKLDHLMNE EQQLLWQENE RLQTMVQNTK AELTHSREKV RQLESNLLPK 1930 1940 1950 1960 1970 1980 HQKHLNPSGT MNPTEQEKLS LKRECDQFQK EQSPANRKVS QMNSLEQELE TIHLENEGLK 1990 2000 2010 2020 2030 2040 KKQVKLDEQL MEMQHLRSTA TPSPSPHAWD LQLLQQQACP MVPREQFLQL QRQLLQAERI 2050 2060 2070 2080 2090 2100 NQHLQEELEN RTSETNTPQG NQEQLVTVME ERMIEVEQKL KLVKRLLQEK VNQLKEQVSL 2110 2120 PGHLCSPTSH SSFNSSFTSL YCH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta." Hong Y.-R., Chen C.-H., Chang J.-H., Wang S.-K., Sy W.-D., Chou C.-K., Howng S.-L. Biochim. Biophys. Acta 1492:513-516(2000) [PubMed: 11004522] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH GSK3B. Tissue: Fetal liver.
[2]	"Genomic organization and molecular characterization of the human ninein gene." Hong Y.-R., Chen C.-H., Chuo M.-H., Liou S.-Y., Howng S.-L. Biochem. Biophys. Res. Commun. 279:989-995(2000) [PubMed: 11162463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[3]	"Human ninein is a centrosomal autoantigen recognized by CREST patient sera and plays a regulatory role in microtubule nucleation." Stillwell E.E., Zhou J., Joshi H.C. Cell Cycle 3:923-930(2004) [PubMed: 15190203] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4), FUNCTION, ALTERNATIVE SPLICING, SUBCELLULAR LOCATION. Tissue: Thymus.
[4]	"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O. DNA Res. 7:273-281(2000) [PubMed: 10997877] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6). Tissue: Brain.
[5]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[6]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-434 (ISOFORM 8), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1877-2090 (ISOFORM 4). Tissue: Lymph.
[8]	"3' isoforms of human ninein." Choquette M.C., de Medicis E. Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1561-2090 (ISOFORM 7). Tissue: Bone marrow.
[9]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1928-2090 (ISOFORM 7). Tissue: Hepatoma.
[10]	"CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation." Ou Y.Y., Mack G.J., Zhang M., Rattner J.B. J. Cell Sci. 115:1825-1835(2002) [PubMed: 11956314] [Abstract] Cited for: SUBCELLULAR LOCATION.
[11]	"Assembly of centrosomal proteins and microtubule organization depends on PCM-1." Dammermann A., Merdes A. J. Cell Biol. 159:255-266(2002) [PubMed: 12403812] [Abstract] Cited for: SUBCELLULAR LOCATION.
[12]	"Molecular characterization of human ninein protein: two distinct subdomains required for centrosomal targeting and regulating signals in cell cycle." Chen C.-H., Howng S.-L., Cheng T.-S., Chou M.-H., Huang C.-Y., Hong Y.-R. Biochem. Biophys. Res. Commun. 308:975-983(2003) [PubMed: 12927815] [Abstract] Cited for: HOMOOLIGOMERIZATION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, PHOSPHORYLATION.
[13]	"A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors." Howng S.-L., Hsu H.-C., Cheng T.-S., Lee Y.-L., Chang L.-K., Lu P.-J., Hong Y.-R. FEBS Lett. 566:162-168(2004) [PubMed: 15147888] [Abstract] Cited for: INTERACTION WITH C14ORF166.
[14]	"Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome." Mack G.J., Rees J., Sandblom O., Balczon R., Fritzler M.J., Rattner J.B. Arthritis Rheum. 41:551-558(1998) [PubMed: 9506584] [Abstract] Cited for: DISEASE.
[15]	"Spectrum of centrosome autoantibodies in childhood varicella and post-varicella acute cerebellar ataxia." Fritzler M.J., Zhang M., Stinton L.M., Rattner J.B. BMC Pediatr. 3:11-11(2003) [PubMed: 14503922] [Abstract] Cited for: DISEASE.
[16]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1550, MASS SPECTROMETRY.
[17]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1550, MASS SPECTROMETRY.
[18]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1550, MASS SPECTROMETRY. Tissue: T-cell.
[19]	"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome." Ley T.J., Mardis E.R., Ding L., Fulton B., McLellan M.D., Chen K., Dooling D., Dunford-Shore B.H., McGrath S., Hickenbotham M., Cook L., Abbott R., Larson D.E., Koboldt D.C., Pohl C., Smith S., Hawkins A., Abbott S. , Locke D., Hillier L.W., Miner T., Fulton L., Magrini V., Wylie T., Glasscock J., Conyers J., Sander N., Shi X., Osborne J.R., Minx P., Gordon D., Chinwalla A., Zhao Y., Ries R.E., Payton J.E., Westervelt P., Tomasson M.H., Watson M., Baty J., Ivanovich J., Heath S., Shannon W.D., Nagarajan R., Walter M.J., Link D.C., Graubert T.A., DiPersio J.F., Wilson R.K. Nature 456:66-72(2008) [PubMed: 18987736] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-1320.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF212162 mRNA. Translation: AAF23015.2. AF302773 mRNA. Translation: AAG33512.2. AF223937 mRNA. Translation: AAK00628.1. AF223938 mRNA. Translation: AAK00629.1. AF223939 mRNA. Translation: AAK00630.1. AB046785 mRNA. Translation: BAB13391.2. Different initiation. AL133485 Genomic DNA. No translation available. AL606834 Genomic DNA. No translation available. BC034708 mRNA. Translation: AAH34708.2. BC065521 mRNA. Translation: AAH65521.1. Sequence problems. AY027794 mRNA. Translation: AAK27375.1. AY027795 mRNA. Translation: AAK27376.1. AY027796 mRNA. Translation: AAK27377.1. AF186776 mRNA. Translation: AAG17027.1. AK027054 mRNA. Translation: BAB15640.1. Different initiation.
IPI	IPI00171791. IPI00329695. IPI00441952. IPI00441955. IPI00441959. IPI00441960. IPI00883941. IPI00921003.
RefSeq	NP_057434.3. NP_065972.3. NP_891989.2. NP_891991.1.
UniGene	Hs.310429
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8N4C6. 2 interactions.
STRING	Q8N4C6.
PTM databases
PhosphoSite	Q8N4C6.
Proteomic databases
PRIDE	Q8N4C6.
Genome annotation databases
Ensembl	ENST00000382041; ENSP00000371472; ENSG00000100503; Homo sapiens. [Genome view]
GeneID	51199.
KEGG	hsa:51199.
UCSC	uc001wyi.1. human. uc001wym.1. human. uc010anx.1. human.
Organism-specific databases
CTD	51199.
GeneCards	GC14M050256.
H-InvDB	HIX0011645.
HGNC	HGNC:14906. NIN.
MIM	608684. gene.
PharmGKB	PA31630.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8N4C6.
Gene expression databases
ArrayExpress	Q8N4C6.
Bgee	Q8N4C6.
Genevestigator	Q8N4C6.
GermOnline	ENSG00000100503. Homo sapiens.
Family and domain databases
InterPro	IPR018249. EF_HAND_2. [Graphical view]
PROSITE	PS50222. EF_HAND_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	54220.
SOURCE	Search...

Entry information

Entry name

NIN_HUMAN

Accession

Primary (citable) accession number: Q8N4C6
Secondary accession number(s): Q6P0P6 , Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	February 9, 2010
This is version 69 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.