Q8N4C6 (NIN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ninein
Short name=hNinein

Alternative name(s):
Glycogen synthase kinase 3 beta-interacting protein
Short name=GSK3B-interacting protein

Gene names

Name:	NIN
Synonyms:	KIAA1565

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2090 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. May also act as a centrosome maturation factor. May play a role in microtubule nucleation. Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules. Ref.3
Subunit structure	Homooligomer. Interacts with GSK3B/GSK3-beta via its C-terminus domain. Interacts with C14ORF166, such interaction may prevent its phosphorylation by GSK3B. Interacts with AUNIP (via N-terminus). Identified in a complex with AUNIP and AURKA. Ref.1 Ref.12 Ref.13 Ref.18
Subcellular location	Cytoplasm › cytoskeleton › centrosome. Note: Component of the core centrosome. Arranged in a tubular conformation with an open and a closed end within the centrosome. In the mother centrosome, it localizes at both ends of the centrosome tube, including the site of centrosome duplication, while in the daughter centrosome it is present only at the closed end. Requires PCM1 for centrosome localization. Ref.1 Ref.3 Ref.10 Ref.11 Ref.12
Tissue specificity	Ubiquitous. Highly expressed in heart and skeletal muscle. Isoform 1 is more expressed than isoform 5. Ref.1 Ref.2
Developmental stage	In interphase cells, it is localized in the centrosome. Decreases in metaphase and anaphase and reappears in telophase. Ref.12
Domain	The coiled coil region from Asn-1611 to Pro-1693 is necessary and sufficient for the targeting to centrosome.
Post-translational modification	Phosphorylated by AURKA/Aurora kinase A and PKA kinases but not CK2 or AURKB/ Aurora kinase B. Ref.12
Involvement in disease	Seckel syndrome 7 (SCKL7) [MIM:614851]: A rare autosomal recessive disorder characterized by proportionate dwarfism of prenatal onset associated with low birth weight, growth retardation, severe microcephaly with a bird-headed like appearance, and mental retardation. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.20
Miscellaneous	Antibodies against NIN are present in sera from patients with autoimmune diseases that developed autoantibodies against centrosomal proteins.
Sequence similarities	Contains 5 EF-hand domains.
Sequence caution	The sequence AAH65521.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence AAH65521.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence AAK00628.1 differs from that shown. Reason: Several sequencing errors. The sequence AAK00629.1 differs from that shown. Reason: Several sequencing errors and frameshifts. The sequence AAK00630.1 differs from that shown. Reason: Several sequencing errors. The sequence BAB13391.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAB15640.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Microtubule
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation Dwarfism Mental retardation
Domain	Coiled coil Repeat
Ligand	GTP-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	centrosome localization Traceable author statement PubMed 16154161. Source: HGNC centrosome-templated microtubule nucleation Inferred from electronic annotation. Source: Compara microtubule anchoring at centrosome Inferred from electronic annotation. Source: Compara
Cellular_component	centriole Inferred from electronic annotation. Source: Compara centrosome Inferred from direct assay PubMed 21399614. Source: UniProtKB microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
C14orf166	Q9Y224	4	EBI-1164022,EBI-1104547
GSK3B	P49841	2	EBI-1164022,EBI-373586

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N4C6-1)

Also known as: Lm;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N4C6-2)

Also known as: Isotype 3;

The sequence of this isoform differs from the canonical sequence as follows:
     492-508: Missing.

Note: Dubious isoform produced through aberrant splice sites.

Isoform 3 (identifier: Q8N4C6-10)

Also known as: Isotype 2;

The sequence of this isoform differs from the canonical sequence as follows:
     492-508: Missing.
     2065-2090: VSLPGHLCSPTSHSSFNSSFTSLYCH → LCKNTKADAM...PLTSTPPLRS

Note: Dubious isoform produced through aberrant splice sites.

Isoform 4 (identifier: Q8N4C6-4)

Also known as: Isotype 1;

The sequence of this isoform differs from the canonical sequence as follows:
     492-508: Missing.
     2027-2046: GNQEQLVTVMEERMIEVEQK → ALLPEQRAVHADSYRRIGHL
     2047-2090: Missing.

Note: Dubious isoform produced through aberrant splice sites.

Isoform 5 (identifier: Q8N4C6-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTD → MAEVTVPRVY...HRKIQHVKNE

Isoform 6 (identifier: Q8N4C6-6)

The sequence of this isoform differs from the canonical sequence as follows:
     800-1512: Missing.
     1555-1555: Missing.
     1960-1988: MQHLRSTATPSPSPHAWDLQLLQQQACPM → NSVVGSSREGCSSLPEIVCEDAAPEVHCDA
     1989-2090: Missing.

Note: No experimental confirmation available.

Isoform 7 (identifier: Q8N4C6-7)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     2065-2090: VSLPGHLCSPTSHSSFNSSFTSLYCH → LCKNTKADAM...PLTSTPPLRS

Note: No experimental confirmation available.

Isoform 8 (identifier: Q8N4C6-9)

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.

Note: No experimental confirmation available.

Isoform 9 (identifier: Q8N4C6-11)

The sequence of this isoform differs from the canonical sequence as follows:
     800-1512: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2090	2090	Ninein		PRO_0000096844
Regions
	Domain	8 – 43	36	EF-hand 1
	Domain	42 – 77	36	EF-hand 2
	Domain	182 – 217	36	EF-hand 3
	Domain	219 – 252	34	EF-hand 4
	Domain	317 – 352	36	EF-hand 5
	Nucleotide binding	245 – 252	8	GTP Potential
	Nucleotide binding	300 – 304	5	GTP Potential
	Nucleotide binding	420 – 423	4	GTP Potential
	Coiled coil	357 – 570	214	Potential
	Coiled coil	625 – 1027	403	Potential
	Coiled coil	1068 – 1099	32	Potential
	Coiled coil	1181 – 1341	161	Potential
	Coiled coil	1441 – 1816	376	Potential
	Coiled coil	1854 – 1885	32	Potential
	Coiled coil	1922 – 2067	146	Potential
Amino acid modifications
	Modified residue	1550	1	Phosphoserine Ref.16 Ref.17
Natural variations
	Alternative sequence	1 – 38	38	Missing in isoform 8.		VSP_040039
	Alternative sequence	1 – 35	35	MDEVE…EELTD → MAEVTVPRVYVVFGIHCIMA KASSDVQVSGFHRKIQHVKN E in isoform 5.		VSP_010950
	Alternative sequence	492 – 508	17	Missing in isoform 2, isoform 3 and isoform 4.		VSP_010952
	Alternative sequence	800 – 1512	713	Missing in isoform 6 and isoform 9.		VSP_010953
	Alternative sequence	1555	1	Missing in isoform 6.		VSP_010954
	Alternative sequence	1960 – 1988	29	MQHLR…QACPM → NSVVGSSREGCSSLPEIVCE DAAPEVHCDA in isoform 6.		VSP_010955
	Alternative sequence	1989 – 2090	102	Missing in isoform 6.		VSP_010956
	Alternative sequence	2027 – 2046	20	GNQEQ…EVEQK → ALLPEQRAVHADSYRRIGHL in isoform 4.		VSP_010957
	Alternative sequence	2047 – 2090	44	Missing in isoform 4.		VSP_010958
	Alternative sequence	2065 – 2090	26	VSLPG…SLYCH → LCKNTKADAMVKDLYVENAQ LLKALEVTEQRQKTAEKKNY LLEEKIASLSNIVRNLTPAP LTSTPPLRS in isoform 3 and isoform 7.		VSP_010960
	Natural variant	1111	1	P → A. Corresponds to variant rs2236316 [ dbSNP | Ensembl ].		VAR_019453
	Natural variant	1125	1	Q → P. Ref.1 Ref.2 Ref.3 Corresponds to variant rs12882191 [ dbSNP | Ensembl ].		VAR_051235
	Natural variant	1222	1	Q → R in SCKL7; does not disrupt protein expression or localization or affect mitotic functions in an obvious way. Ref.20		VAR_069083
	Natural variant	1320	1	G → E. Ref.1 Ref.2 Ref.3 Ref.19 Corresponds to variant rs2073347 [ dbSNP | Ensembl ].		VAR_019454
	Natural variant	1709	1	N → S in SCKL7; does not disrupt protein expression or localization or affect mitotic functions in an obvious way. Ref.20		VAR_069084
	Natural variant	1837	1	S → T. Corresponds to variant rs12717411 [ dbSNP | Ensembl ].		VAR_019455
	Natural variant	1934	1	Q → E. Corresponds to variant rs2295847 [ dbSNP | Ensembl ].		VAR_051236
Experimental info
	Sequence conflict	137	1	H → Y in AAF23015. Ref.1
	Sequence conflict	137	1	H → Y in AAG33512. Ref.2
	Sequence conflict	177	1	S → F in AAF23015. Ref.1
	Sequence conflict	203	1	N → D in AAG33512. Ref.2
	Sequence conflict	223	1	M → I in AAG33512. Ref.2
	Sequence conflict	295	1	F → I in AAG33512. Ref.2
	Sequence conflict	369	1	I → V in AAG33512. Ref.2
	Sequence conflict	399	1	L → S in AAG33512. Ref.2
	Sequence conflict	568	1	L → F in AAG33512. Ref.2
	Sequence conflict	809	1	R → I in AAF23015. Ref.1
	Sequence conflict	812	1	S → T in AAG33512. Ref.2
	Sequence conflict	945	1	K → I in AAG33512. Ref.2
	Sequence conflict	977	1	D → A in AAG33512. Ref.2
	Sequence conflict	980	1	R → G in AAF23015. Ref.1
	Sequence conflict	1054	1	Q → H in AAG33512. Ref.2
	Sequence conflict	1067	1	L → F in AAG33512. Ref.2
	Sequence conflict	1070	1	L → Q in AAF23015. Ref.1
	Sequence conflict	1150	1	D → G in AAF23015. Ref.1
	Sequence conflict	1237	1	M → I in AAF23015. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Lm) [UniParc]. Last modified November 2, 2010. Version 4. Checksum: 51D27CD38A369209	FASTA	2,090	243,249
	10 20 30 40 50 60 MDEVEQDQHE ARLKELFDSF DTTGTGSLGQ EELTDLCHML SLEEVAPVLQ QTLLQDNLLG 70 80 90 100 110 120 RVHFDQFKEA LILILSRTLS NEEHFQEPDC SLEAQPKYVR GGKRYGRRSL PEFQESVEEF 130 140 150 160 170 180 PEVTVIEPLD EEARPSHIPA GDCSEHWKTQ RSEEYEAEGQ LRFWNPDDLN ASQSGSSPPQ 190 200 210 220 230 240 DWIEEKLQEV CEDLGITRDG HLNRKKLVSI CEQYGLQNVD GEMLEEVFHN LDPDGTMSVE 250 260 270 280 290 300 DFFYGLFKNG KSLTPSASTP YRQLKRHLSM QSFDESGRRT TTSSAMTSTI GFRVFSCLDD 310 320 330 340 350 360 GMGHASVERI LDTWQEEGIE NSQEILKALD FSLDGNINLT ELTLALENEL LVTKNSIHQA 370 380 390 400 410 420 ALASFKAEIR HLLERVDQVV REKEKLRSDL DKAEKLKSLM ASEVDDHHAA IERRNEYNLR 430 440 450 460 470 480 KLDEEYKERI AALKNELRKE REQILQQAGK QRLELEQEIE KAKTEENYIR DRLALSLKEN 490 500 510 520 530 540 SRLENELLEN AEKLAEYENL TNKLQRNLEN VLAEKFGDLD PSSAEFFLQE ERLTQMRNEY 550 560 570 580 590 600 ERQCRVLQDQ VDELQSELEE YRAQGRVLRL PLKNSPSEEV EANSGGIEPE HGLGSEECNP 610 620 630 640 650 660 LNMSIEAELV IEQMKEQHHR DICCLRLELE DKVRHYEKQL DETVVSCKKA QENMKQRHEN 670 680 690 700 710 720 ETHTLEKQIS DLKNEIAELQ GQAAVLKEAH HEATCRHEEE KKQLQVKLEE EKTHLQEKLR 730 740 750 760 770 780 LQHEMELKAR LTQAQASFER EREGLQSSAW TEEKVRGLTQ ELEQFHQEQL TSLVEKHTLE 790 800 810 820 830 840 KEELRKELLE KHQRELQEGR EKMETECNRR TSQIEAQFQS DCQKVTERCE SALQSLEGRY 850 860 870 880 890 900 RQELKDLQEQ QREEKSQWEF EKDELTQECA EAQELLKETL KREKTTSLVL TQEREMLEKT 910 920 930 940 950 960 YKEHLNSMVV ERQQLLQDLE DLRNVSETQQ SLLSDQILEL KSSHKRELRE REEVLCQAGA 970 980 990 1000 1010 1020 SEQLASQRLE RLEMEHDQER QEMMSKLLAM ENIHKATCET ADRERAEMST EISRLQSKIK 1030 1040 1050 1060 1070 1080 EMQQATSPLS MLQSGCQVIG EEEVEGDGAL SLLQQGEQLL EENGDVLLSL QRAHEQAVKE 1090 1100 1110 1120 1130 1140 NVKMATEISR LQQRLQKLEP GLVMSSCLDE PATEFFGNTA EQTEQFLQQN RTKQVEGVTR 1150 1160 1170 1180 1190 1200 RHVLSDLEDD EVRDLGSTGT SSVQRQEVKI EESEASVEGF SELENSEETR TESWELKNQI 1210 1220 1230 1240 1250 1260 SQLQEQLMML CADCDRASEK KQDLLFDVSV LKKKLKMLER IPEASPKYKL LYEDVSREND 1270 1280 1290 1300 1310 1320 CLQEELRMME TRYDEALENN KELTAEVFRL QDELKKMEEV TETFLSLEKS YDEVKIENEG 1330 1340 1350 1360 1370 1380 LNVLVLRLQG KIEKLQESVV QRCDCCLWEA SLENLEIEPD GNILQLNQTL EECVPRVRSV 1390 1400 1410 1420 1430 1440 HHVIEECKQE NQYLEGNTQL LEKVKAHEIA WLHGTIQTHQ ERPRVQNQVI LEENTTLLGF 1450 1460 1470 1480 1490 1500 QDKHFQHQAT IAELELEKTK LQELTRKLKE RVTILVKQKD VLSHGEKEEE LKAMMHDLQI 1510 1520 1530 1540 1550 1560 TCSEMQQKVE LLRYESEKLQ QENSILRNEI TTLNEEDSIS NLKLGTLNGS QEEMWQKTET 1570 1580 1590 1600 1610 1620 VKQENAAVQK MVENLKKQIS ELKIKNQQLD LENTELSQKN SQNQEKLQEL NQRLTEMLCQ 1630 1640 1650 1660 1670 1680 KEKEPGNSAL EEREQEKFNL KEELERCKVQ SSTLVSSLEA ELSEVKIQTH IVQQENHLLK 1690 1700 1710 1720 1730 1740 DELEKMKQLH RCPDLSDFQQ KISSVLSYNE KLLKEKEALS EELNSCVDKL AKSSLLEHRI 1750 1760 1770 1780 1790 1800 ATMKQEQKSW EHQSASLKSQ LVASQEKVQN LEDTVQNVNL QMSRMKSDLR VTQQEKEALK 1810 1820 1830 1840 1850 1860 QEVMSLHKQL QNAGGKSWAP EIATHPSGLH NQQKRLSWDK LDHLMNEEQQ LLWQENERLQ 1870 1880 1890 1900 1910 1920 TMVQNTKAEL THSREKVRQL ESNLLPKHQK HLNPSGTMNP TEQEKLSLKR ECDQFQKEQS 1930 1940 1950 1960 1970 1980 PANRKVSQMN SLEQELETIH LENEGLKKKQ VKLDEQLMEM QHLRSTATPS PSPHAWDLQL 1990 2000 2010 2020 2030 2040 LQQQACPMVP REQFLQLQRQ LLQAERINQH LQEELENRTS ETNTPQGNQE QLVTVMEERM 2050 2060 2070 2080 2090 IEVEQKLKLV KRLLQEKVNQ LKEQVSLPGH LCSPTSHSSF NSSFTSLYCH
	Isoform 2 (Isotype 3) [UniParc]. Checksum: 784E25AE5D1C68DE	FASTA	2,073	241,191
	10 20 30 40 50 60 MDEVEQDQHE ARLKELFDSF DTTGTGSLGQ EELTDLCHML SLEEVAPVLQ QTLLQDNLLG 70 80 90 100 110 120 RVHFDQFKEA LILILSRTLS NEEHFQEPDC SLEAQPKYVR GGKRYGRRSL PEFQESVEEF 130 140 150 160 170 180 PEVTVIEPLD EEARPSHIPA GDCSEHWKTQ RSEEYEAEGQ LRFWNPDDLN ASQSGSSPPQ 190 200 210 220 230 240 DWIEEKLQEV CEDLGITRDG HLNRKKLVSI CEQYGLQNVD GEMLEEVFHN LDPDGTMSVE 250 260 270 280 290 300 DFFYGLFKNG KSLTPSASTP YRQLKRHLSM QSFDESGRRT TTSSAMTSTI GFRVFSCLDD 310 320 330 340 350 360 GMGHASVERI LDTWQEEGIE NSQEILKALD FSLDGNINLT ELTLALENEL LVTKNSIHQA 370 380 390 400 410 420 ALASFKAEIR HLLERVDQVV REKEKLRSDL DKAEKLKSLM ASEVDDHHAA IERRNEYNLR 430 440 450 460 470 480 KLDEEYKERI AALKNELRKE REQILQQAGK QRLELEQEIE KAKTEENYIR DRLALSLKEN 490 500 510 520 530 540 SRLENELLEN AENVLAEKFG DLDPSSAEFF LQEERLTQMR NEYERQCRVL QDQVDELQSE 550 560 570 580 590 600 LEEYRAQGRV LRLPLKNSPS EEVEANSGGI EPEHGLGSEE CNPLNMSIEA ELVIEQMKEQ 610 620 630 640 650 660 HHRDICCLRL ELEDKVRHYE KQLDETVVSC KKAQENMKQR HENETHTLEK QISDLKNEIA 670 680 690 700 710 720 ELQGQAAVLK EAHHEATCRH EEEKKQLQVK LEEEKTHLQE KLRLQHEMEL KARLTQAQAS 730 740 750 760 770 780 FEREREGLQS SAWTEEKVRG LTQELEQFHQ EQLTSLVEKH TLEKEELRKE LLEKHQRELQ 790 800 810 820 830 840 EGREKMETEC NRRTSQIEAQ FQSDCQKVTE RCESALQSLE GRYRQELKDL QEQQREEKSQ 850 860 870 880 890 900 WEFEKDELTQ ECAEAQELLK ETLKREKTTS LVLTQEREML EKTYKEHLNS MVVERQQLLQ 910 920 930 940 950 960 DLEDLRNVSE TQQSLLSDQI LELKSSHKRE LREREEVLCQ AGASEQLASQ RLERLEMEHD 970 980 990 1000 1010 1020 QERQEMMSKL LAMENIHKAT CETADRERAE MSTEISRLQS KIKEMQQATS PLSMLQSGCQ 1030 1040 1050 1060 1070 1080 VIGEEEVEGD GALSLLQQGE QLLEENGDVL LSLQRAHEQA VKENVKMATE ISRLQQRLQK 1090 1100 1110 1120 1130 1140 LEPGLVMSSC LDEPATEFFG NTAEQTEQFL QQNRTKQVEG VTRRHVLSDL EDDEVRDLGS 1150 1160 1170 1180 1190 1200 TGTSSVQRQE VKIEESEASV EGFSELENSE ETRTESWELK NQISQLQEQL MMLCADCDRA 1210 1220 1230 1240 1250 1260 SEKKQDLLFD VSVLKKKLKM LERIPEASPK YKLLYEDVSR ENDCLQEELR MMETRYDEAL 1270 1280 1290 1300 1310 1320 ENNKELTAEV FRLQDELKKM EEVTETFLSL EKSYDEVKIE NEGLNVLVLR LQGKIEKLQE 1330 1340 1350 1360 1370 1380 SVVQRCDCCL WEASLENLEI EPDGNILQLN QTLEECVPRV RSVHHVIEEC KQENQYLEGN 1390 1400 1410 1420 1430 1440 TQLLEKVKAH EIAWLHGTIQ THQERPRVQN QVILEENTTL LGFQDKHFQH QATIAELELE 1450 1460 1470 1480 1490 1500 KTKLQELTRK LKERVTILVK QKDVLSHGEK EEELKAMMHD LQITCSEMQQ KVELLRYESE 1510 1520 1530 1540 1550 1560 KLQQENSILR NEITTLNEED SISNLKLGTL NGSQEEMWQK TETVKQENAA VQKMVENLKK 1570 1580 1590 1600 1610 1620 QISELKIKNQ QLDLENTELS QKNSQNQEKL QELNQRLTEM LCQKEKEPGN SALEEREQEK 1630 1640 1650 1660 1670 1680 FNLKEELERC KVQSSTLVSS LEAELSEVKI QTHIVQQENH LLKDELEKMK QLHRCPDLSD 1690 1700 1710 1720 1730 1740 FQQKISSVLS YNEKLLKEKE ALSEELNSCV DKLAKSSLLE HRIATMKQEQ KSWEHQSASL 1750 1760 1770 1780 1790 1800 KSQLVASQEK VQNLEDTVQN VNLQMSRMKS DLRVTQQEKE ALKQEVMSLH KQLQNAGGKS 1810 1820 1830 1840 1850 1860 WAPEIATHPS GLHNQQKRLS WDKLDHLMNE EQQLLWQENE RLQTMVQNTK AELTHSREKV 1870 1880 1890 1900 1910 1920 RQLESNLLPK HQKHLNPSGT MNPTEQEKLS LKRECDQFQK EQSPANRKVS QMNSLEQELE 1930 1940 1950 1960 1970 1980 TIHLENEGLK KKQVKLDEQL MEMQHLRSTA TPSPSPHAWD LQLLQQQACP MVPREQFLQL 1990 2000 2010 2020 2030 2040 QRQLLQAERI NQHLQEELEN RTSETNTPQG NQEQLVTVME ERMIEVEQKL KLVKRLLQEK 2050 2060 2070 VNQLKEQVSL PGHLCSPTSH SSFNSSFTSL YCH
	Isoform 3 (Isotype 2) [UniParc]. Checksum: 0A9CEF8ECA2BF346	FASTA	2,116	246,135
	10 20 30 40 50 60 MDEVEQDQHE ARLKELFDSF DTTGTGSLGQ EELTDLCHML SLEEVAPVLQ QTLLQDNLLG 70 80 90 100 110 120 RVHFDQFKEA LILILSRTLS NEEHFQEPDC SLEAQPKYVR GGKRYGRRSL PEFQESVEEF 130 140 150 160 170 180 PEVTVIEPLD EEARPSHIPA GDCSEHWKTQ RSEEYEAEGQ LRFWNPDDLN ASQSGSSPPQ 190 200 210 220 230 240 DWIEEKLQEV CEDLGITRDG HLNRKKLVSI CEQYGLQNVD GEMLEEVFHN LDPDGTMSVE 250 260 270 280 290 300 DFFYGLFKNG KSLTPSASTP YRQLKRHLSM QSFDESGRRT TTSSAMTSTI GFRVFSCLDD 310 320 330 340 350 360 GMGHASVERI LDTWQEEGIE NSQEILKALD FSLDGNINLT ELTLALENEL LVTKNSIHQA 370 380 390 400 410 420 ALASFKAEIR HLLERVDQVV REKEKLRSDL DKAEKLKSLM ASEVDDHHAA IERRNEYNLR 430 440 450 460 470 480 KLDEEYKERI AALKNELRKE REQILQQAGK QRLELEQEIE KAKTEENYIR DRLALSLKEN 490 500 510 520 530 540 SRLENELLEN AENVLAEKFG DLDPSSAEFF LQEERLTQMR NEYERQCRVL QDQVDELQSE 550 560 570 580 590 600 LEEYRAQGRV LRLPLKNSPS EEVEANSGGI EPEHGLGSEE CNPLNMSIEA ELVIEQMKEQ 610 620 630 640 650 660 HHRDICCLRL ELEDKVRHYE KQLDETVVSC KKAQENMKQR HENETHTLEK QISDLKNEIA 670 680 690 700 710 720 ELQGQAAVLK EAHHEATCRH EEEKKQLQVK LEEEKTHLQE KLRLQHEMEL KARLTQAQAS 730 740 750 760 770 780 FEREREGLQS SAWTEEKVRG LTQELEQFHQ EQLTSLVEKH TLEKEELRKE LLEKHQRELQ 790 800 810 820 830 840 EGREKMETEC NRRTSQIEAQ FQSDCQKVTE RCESALQSLE GRYRQELKDL QEQQREEKSQ 850 860 870 880 890 900 WEFEKDELTQ ECAEAQELLK ETLKREKTTS LVLTQEREML EKTYKEHLNS MVVERQQLLQ 910 920 930 940 950 960 DLEDLRNVSE TQQSLLSDQI LELKSSHKRE LREREEVLCQ AGASEQLASQ RLERLEMEHD 970 980 990 1000 1010 1020 QERQEMMSKL LAMENIHKAT CETADRERAE MSTEISRLQS KIKEMQQATS PLSMLQSGCQ 1030 1040 1050 1060 1070 1080 VIGEEEVEGD GALSLLQQGE QLLEENGDVL LSLQRAHEQA VKENVKMATE ISRLQQRLQK 1090 1100 1110 1120 1130 1140 LEPGLVMSSC LDEPATEFFG NTAEQTEQFL QQNRTKQVEG VTRRHVLSDL EDDEVRDLGS 1150 1160 1170 1180 1190 1200 TGTSSVQRQE VKIEESEASV EGFSELENSE ETRTESWELK NQISQLQEQL MMLCADCDRA 1210 1220 1230 1240 1250 1260 SEKKQDLLFD VSVLKKKLKM LERIPEASPK YKLLYEDVSR ENDCLQEELR MMETRYDEAL 1270 1280 1290 1300 1310 1320 ENNKELTAEV FRLQDELKKM EEVTETFLSL EKSYDEVKIE NEGLNVLVLR LQGKIEKLQE 1330 1340 1350 1360 1370 1380 SVVQRCDCCL WEASLENLEI EPDGNILQLN QTLEECVPRV RSVHHVIEEC KQENQYLEGN 1390 1400 1410 1420 1430 1440 TQLLEKVKAH EIAWLHGTIQ THQERPRVQN QVILEENTTL LGFQDKHFQH QATIAELELE 1450 1460 1470 1480 1490 1500 KTKLQELTRK LKERVTILVK QKDVLSHGEK EEELKAMMHD LQITCSEMQQ KVELLRYESE 1510 1520 1530 1540 1550 1560 KLQQENSILR NEITTLNEED SISNLKLGTL NGSQEEMWQK TETVKQENAA VQKMVENLKK 1570 1580 1590 1600 1610 1620 QISELKIKNQ QLDLENTELS QKNSQNQEKL QELNQRLTEM LCQKEKEPGN SALEEREQEK 1630 1640 1650 1660 1670 1680 FNLKEELERC KVQSSTLVSS LEAELSEVKI QTHIVQQENH LLKDELEKMK QLHRCPDLSD 1690 1700 1710 1720 1730 1740 FQQKISSVLS YNEKLLKEKE ALSEELNSCV DKLAKSSLLE HRIATMKQEQ KSWEHQSASL 1750 1760 1770 1780 1790 1800 KSQLVASQEK VQNLEDTVQN VNLQMSRMKS DLRVTQQEKE ALKQEVMSLH KQLQNAGGKS 1810 1820 1830 1840 1850 1860 WAPEIATHPS GLHNQQKRLS WDKLDHLMNE EQQLLWQENE RLQTMVQNTK AELTHSREKV 1870 1880 1890 1900 1910 1920 RQLESNLLPK HQKHLNPSGT MNPTEQEKLS LKRECDQFQK EQSPANRKVS QMNSLEQELE 1930 1940 1950 1960 1970 1980 TIHLENEGLK KKQVKLDEQL MEMQHLRSTA TPSPSPHAWD LQLLQQQACP MVPREQFLQL 1990 2000 2010 2020 2030 2040 QRQLLQAERI NQHLQEELEN RTSETNTPQG NQEQLVTVME ERMIEVEQKL KLVKRLLQEK 2050 2060 2070 2080 2090 2100 VNQLKEQLCK NTKADAMVKD LYVENAQLLK ALEVTEQRQK TAEKKNYLLE EKIASLSNIV 2110 RNLTPAPLTS TPPLRS
	Isoform 4 (Isotype 1) [UniParc]. Checksum: F994E939809252CB	FASTA	2,029	236,135
	10 20 30 40 50 60 MDEVEQDQHE ARLKELFDSF DTTGTGSLGQ EELTDLCHML SLEEVAPVLQ QTLLQDNLLG 70 80 90 100 110 120 RVHFDQFKEA LILILSRTLS NEEHFQEPDC SLEAQPKYVR GGKRYGRRSL PEFQESVEEF 130 140 150 160 170 180 PEVTVIEPLD EEARPSHIPA GDCSEHWKTQ RSEEYEAEGQ LRFWNPDDLN ASQSGSSPPQ 190 200 210 220 230 240 DWIEEKLQEV CEDLGITRDG HLNRKKLVSI CEQYGLQNVD GEMLEEVFHN LDPDGTMSVE 250 260 270 280 290 300 DFFYGLFKNG KSLTPSASTP YRQLKRHLSM QSFDESGRRT TTSSAMTSTI GFRVFSCLDD 310 320 330 340 350 360 GMGHASVERI LDTWQEEGIE NSQEILKALD FSLDGNINLT ELTLALENEL LVTKNSIHQA 370 380 390 400 410 420 ALASFKAEIR HLLERVDQVV REKEKLRSDL DKAEKLKSLM ASEVDDHHAA IERRNEYNLR 430 440 450 460 470 480 KLDEEYKERI AALKNELRKE REQILQQAGK QRLELEQEIE KAKTEENYIR DRLALSLKEN 490 500 510 520 530 540 SRLENELLEN AENVLAEKFG DLDPSSAEFF LQEERLTQMR NEYERQCRVL QDQVDELQSE 550 560 570 580 590 600 LEEYRAQGRV LRLPLKNSPS EEVEANSGGI EPEHGLGSEE CNPLNMSIEA ELVIEQMKEQ 610 620 630 640 650 660 HHRDICCLRL ELEDKVRHYE KQLDETVVSC KKAQENMKQR HENETHTLEK QISDLKNEIA 670 680 690 700 710 720 ELQGQAAVLK EAHHEATCRH EEEKKQLQVK LEEEKTHLQE KLRLQHEMEL KARLTQAQAS 730 740 750 760 770 780 FEREREGLQS SAWTEEKVRG LTQELEQFHQ EQLTSLVEKH TLEKEELRKE LLEKHQRELQ 790 800 810 820 830 840 EGREKMETEC NRRTSQIEAQ FQSDCQKVTE RCESALQSLE GRYRQELKDL QEQQREEKSQ 850 860 870 880 890 900 WEFEKDELTQ ECAEAQELLK ETLKREKTTS LVLTQEREML EKTYKEHLNS MVVERQQLLQ 910 920 930 940 950 960 DLEDLRNVSE TQQSLLSDQI LELKSSHKRE LREREEVLCQ AGASEQLASQ RLERLEMEHD 970 980 990 1000 1010 1020 QERQEMMSKL LAMENIHKAT CETADRERAE MSTEISRLQS KIKEMQQATS PLSMLQSGCQ 1030 1040 1050 1060 1070 1080 VIGEEEVEGD GALSLLQQGE QLLEENGDVL LSLQRAHEQA VKENVKMATE ISRLQQRLQK 1090 1100 1110 1120 1130 1140 LEPGLVMSSC LDEPATEFFG NTAEQTEQFL QQNRTKQVEG VTRRHVLSDL EDDEVRDLGS 1150 1160 1170 1180 1190 1200 TGTSSVQRQE VKIEESEASV EGFSELENSE ETRTESWELK NQISQLQEQL MMLCADCDRA 1210 1220 1230 1240 1250 1260 SEKKQDLLFD VSVLKKKLKM LERIPEASPK YKLLYEDVSR ENDCLQEELR MMETRYDEAL 1270 1280 1290 1300 1310 1320 ENNKELTAEV FRLQDELKKM EEVTETFLSL EKSYDEVKIE NEGLNVLVLR LQGKIEKLQE 1330 1340 1350 1360 1370 1380 SVVQRCDCCL WEASLENLEI EPDGNILQLN QTLEECVPRV RSVHHVIEEC KQENQYLEGN 1390 1400 1410 1420 1430 1440 TQLLEKVKAH EIAWLHGTIQ THQERPRVQN QVILEENTTL LGFQDKHFQH QATIAELELE 1450 1460 1470 1480 1490 1500 KTKLQELTRK LKERVTILVK QKDVLSHGEK EEELKAMMHD LQITCSEMQQ KVELLRYESE 1510 1520 1530 1540 1550 1560 KLQQENSILR NEITTLNEED SISNLKLGTL NGSQEEMWQK TETVKQENAA VQKMVENLKK 1570 1580 1590 1600 1610 1620 QISELKIKNQ QLDLENTELS QKNSQNQEKL QELNQRLTEM LCQKEKEPGN SALEEREQEK 1630 1640 1650 1660 1670 1680 FNLKEELERC KVQSSTLVSS LEAELSEVKI QTHIVQQENH LLKDELEKMK QLHRCPDLSD 1690 1700 1710 1720 1730 1740 FQQKISSVLS YNEKLLKEKE ALSEELNSCV DKLAKSSLLE HRIATMKQEQ KSWEHQSASL 1750 1760 1770 1780 1790 1800 KSQLVASQEK VQNLEDTVQN VNLQMSRMKS DLRVTQQEKE ALKQEVMSLH KQLQNAGGKS 1810 1820 1830 1840 1850 1860 WAPEIATHPS GLHNQQKRLS WDKLDHLMNE EQQLLWQENE RLQTMVQNTK AELTHSREKV 1870 1880 1890 1900 1910 1920 RQLESNLLPK HQKHLNPSGT MNPTEQEKLS LKRECDQFQK EQSPANRKVS QMNSLEQELE 1930 1940 1950 1960 1970 1980 TIHLENEGLK KKQVKLDEQL MEMQHLRSTA TPSPSPHAWD LQLLQQQACP MVPREQFLQL 1990 2000 2010 2020 QRQLLQAERI NQHLQEELEN RTSETNTPQA LLPEQRAVHA DSYRRIGHL
	Isoform 5 [UniParc]. Checksum: 32552AFD21D13A70	FASTA	2,096	243,889
	10 20 30 40 50 60 MAEVTVPRVY VVFGIHCIMA KASSDVQVSG FHRKIQHVKN ELCHMLSLEE VAPVLQQTLL 70 80 90 100 110 120 QDNLLGRVHF DQFKEALILI LSRTLSNEEH FQEPDCSLEA QPKYVRGGKR YGRRSLPEFQ 130 140 150 160 170 180 ESVEEFPEVT VIEPLDEEAR PSHIPAGDCS EHWKTQRSEE YEAEGQLRFW NPDDLNASQS 190 200 210 220 230 240 GSSPPQDWIE EKLQEVCEDL GITRDGHLNR KKLVSICEQY GLQNVDGEML EEVFHNLDPD 250 260 270 280 290 300 GTMSVEDFFY GLFKNGKSLT PSASTPYRQL KRHLSMQSFD ESGRRTTTSS AMTSTIGFRV 310 320 330 340 350 360 FSCLDDGMGH ASVERILDTW QEEGIENSQE ILKALDFSLD GNINLTELTL ALENELLVTK 370 380 390 400 410 420 NSIHQAALAS FKAEIRHLLE RVDQVVREKE KLRSDLDKAE KLKSLMASEV DDHHAAIERR 430 440 450 460 470 480 NEYNLRKLDE EYKERIAALK NELRKEREQI LQQAGKQRLE LEQEIEKAKT EENYIRDRLA 490 500 510 520 530 540 LSLKENSRLE NELLENAEKL AEYENLTNKL QRNLENVLAE KFGDLDPSSA EFFLQEERLT 550 560 570 580 590 600 QMRNEYERQC RVLQDQVDEL QSELEEYRAQ GRVLRLPLKN SPSEEVEANS GGIEPEHGLG 610 620 630 640 650 660 SEECNPLNMS IEAELVIEQM KEQHHRDICC LRLELEDKVR HYEKQLDETV VSCKKAQENM 670 680 690 700 710 720 KQRHENETHT LEKQISDLKN EIAELQGQAA VLKEAHHEAT CRHEEEKKQL QVKLEEEKTH 730 740 750 760 770 780 LQEKLRLQHE MELKARLTQA QASFEREREG LQSSAWTEEK VRGLTQELEQ FHQEQLTSLV 790 800 810 820 830 840 EKHTLEKEEL RKELLEKHQR ELQEGREKME TECNRRTSQI EAQFQSDCQK VTERCESALQ 850 860 870 880 890 900 SLEGRYRQEL KDLQEQQREE KSQWEFEKDE LTQECAEAQE LLKETLKREK TTSLVLTQER 910 920 930 940 950 960 EMLEKTYKEH LNSMVVERQQ LLQDLEDLRN VSETQQSLLS DQILELKSSH KRELREREEV 970 980 990 1000 1010 1020 LCQAGASEQL ASQRLERLEM EHDQERQEMM SKLLAMENIH KATCETADRE RAEMSTEISR 1030 1040 1050 1060 1070 1080 LQSKIKEMQQ ATSPLSMLQS GCQVIGEEEV EGDGALSLLQ QGEQLLEENG DVLLSLQRAH 1090 1100 1110 1120 1130 1140 EQAVKENVKM ATEISRLQQR LQKLEPGLVM SSCLDEPATE FFGNTAEQTE QFLQQNRTKQ 1150 1160 1170 1180 1190 1200 VEGVTRRHVL SDLEDDEVRD LGSTGTSSVQ RQEVKIEESE ASVEGFSELE NSEETRTESW 1210 1220 1230 1240 1250 1260 ELKNQISQLQ EQLMMLCADC DRASEKKQDL LFDVSVLKKK LKMLERIPEA SPKYKLLYED 1270 1280 1290 1300 1310 1320 VSRENDCLQE ELRMMETRYD EALENNKELT AEVFRLQDEL KKMEEVTETF LSLEKSYDEV 1330 1340 1350 1360 1370 1380 KIENEGLNVL VLRLQGKIEK LQESVVQRCD CCLWEASLEN LEIEPDGNIL QLNQTLEECV 1390 1400 1410 1420 1430 1440 PRVRSVHHVI EECKQENQYL EGNTQLLEKV KAHEIAWLHG TIQTHQERPR VQNQVILEEN 1450 1460 1470 1480 1490 1500 TTLLGFQDKH FQHQATIAEL ELEKTKLQEL TRKLKERVTI LVKQKDVLSH GEKEEELKAM 1510 1520 1530 1540 1550 1560 MHDLQITCSE MQQKVELLRY ESEKLQQENS ILRNEITTLN EEDSISNLKL GTLNGSQEEM 1570 1580 1590 1600 1610 1620 WQKTETVKQE NAAVQKMVEN LKKQISELKI KNQQLDLENT ELSQKNSQNQ EKLQELNQRL 1630 1640 1650 1660 1670 1680 TEMLCQKEKE PGNSALEERE QEKFNLKEEL ERCKVQSSTL VSSLEAELSE VKIQTHIVQQ 1690 1700 1710 1720 1730 1740 ENHLLKDELE KMKQLHRCPD LSDFQQKISS VLSYNEKLLK EKEALSEELN SCVDKLAKSS 1750 1760 1770 1780 1790 1800 LLEHRIATMK QEQKSWEHQS ASLKSQLVAS QEKVQNLEDT VQNVNLQMSR MKSDLRVTQQ 1810 1820 1830 1840 1850 1860 EKEALKQEVM SLHKQLQNAG GKSWAPEIAT HPSGLHNQQK RLSWDKLDHL MNEEQQLLWQ 1870 1880 1890 1900 1910 1920 ENERLQTMVQ NTKAELTHSR EKVRQLESNL LPKHQKHLNP SGTMNPTEQE KLSLKRECDQ 1930 1940 1950 1960 1970 1980 FQKEQSPANR KVSQMNSLEQ ELETIHLENE GLKKKQVKLD EQLMEMQHLR STATPSPSPH 1990 2000 2010 2020 2030 2040 AWDLQLLQQQ ACPMVPREQF LQLQRQLLQA ERINQHLQEE LENRTSETNT PQGNQEQLVT 2050 2060 2070 2080 2090 VMEERMIEVE QKLKLVKRLL QEKVNQLKEQ VSLPGHLCSP TSHSSFNSSF TSLYCH
	Isoform 6 [UniParc]. Checksum: A34D34D74D9B861C	FASTA	1,275	147,799
	10 20 30 40 50 60 MDEVEQDQHE ARLKELFDSF DTTGTGSLGQ EELTDLCHML SLEEVAPVLQ QTLLQDNLLG 70 80 90 100 110 120 RVHFDQFKEA LILILSRTLS NEEHFQEPDC SLEAQPKYVR GGKRYGRRSL PEFQESVEEF 130 140 150 160 170 180 PEVTVIEPLD EEARPSHIPA GDCSEHWKTQ RSEEYEAEGQ LRFWNPDDLN ASQSGSSPPQ 190 200 210 220 230 240 DWIEEKLQEV CEDLGITRDG HLNRKKLVSI CEQYGLQNVD GEMLEEVFHN LDPDGTMSVE 250 260 270 280 290 300 DFFYGLFKNG KSLTPSASTP YRQLKRHLSM QSFDESGRRT TTSSAMTSTI GFRVFSCLDD 310 320 330 340 350 360 GMGHASVERI LDTWQEEGIE NSQEILKALD FSLDGNINLT ELTLALENEL LVTKNSIHQA 370 380 390 400 410 420 ALASFKAEIR HLLERVDQVV REKEKLRSDL DKAEKLKSLM ASEVDDHHAA IERRNEYNLR 430 440 450 460 470 480 KLDEEYKERI AALKNELRKE REQILQQAGK QRLELEQEIE KAKTEENYIR DRLALSLKEN 490 500 510 520 530 540 SRLENELLEN AEKLAEYENL TNKLQRNLEN VLAEKFGDLD PSSAEFFLQE ERLTQMRNEY 550 560 570 580 590 600 ERQCRVLQDQ VDELQSELEE YRAQGRVLRL PLKNSPSEEV EANSGGIEPE HGLGSEECNP 610 620 630 640 650 660 LNMSIEAELV IEQMKEQHHR DICCLRLELE DKVRHYEKQL DETVVSCKKA QENMKQRHEN 670 680 690 700 710 720 ETHTLEKQIS DLKNEIAELQ GQAAVLKEAH HEATCRHEEE KKQLQVKLEE EKTHLQEKLR 730 740 750 760 770 780 LQHEMELKAR LTQAQASFER EREGLQSSAW TEEKVRGLTQ ELEQFHQEQL TSLVEKHTLE 790 800 810 820 830 840 KEELRKELLE KHQRELQEGR YESEKLQQEN SILRNEITTL NEEDSISNLK LGTLNGSQEE 850 860 870 880 890 900 MQKTETVKQE NAAVQKMVEN LKKQISELKI KNQQLDLENT ELSQKNSQNQ EKLQELNQRL 910 920 930 940 950 960 TEMLCQKEKE PGNSALEERE QEKFNLKEEL ERCKVQSSTL VSSLEAELSE VKIQTHIVQQ 970 980 990 1000 1010 1020 ENHLLKDELE KMKQLHRCPD LSDFQQKISS VLSYNEKLLK EKEALSEELN SCVDKLAKSS 1030 1040 1050 1060 1070 1080 LLEHRIATMK QEQKSWEHQS ASLKSQLVAS QEKVQNLEDT VQNVNLQMSR MKSDLRVTQQ 1090 1100 1110 1120 1130 1140 EKEALKQEVM SLHKQLQNAG GKSWAPEIAT HPSGLHNQQK RLSWDKLDHL MNEEQQLLWQ 1150 1160 1170 1180 1190 1200 ENERLQTMVQ NTKAELTHSR EKVRQLESNL LPKHQKHLNP SGTMNPTEQE KLSLKRECDQ 1210 1220 1230 1240 1250 1260 FQKEQSPANR KVSQMNSLEQ ELETIHLENE GLKKKQVKLD EQLMENSVVG SSREGCSSLP 1270 EIVCEDAAPE VHCDA
	Isoform 7 (B) [UniParc]. Checksum: 7B4B1C5A69FD4424	FASTA	2,133	248,194
	10 20 30 40 50 60 MDEVEQDQHE ARLKELFDSF DTTGTGSLGQ EELTDLCHML SLEEVAPVLQ QTLLQDNLLG 70 80 90 100 110 120 RVHFDQFKEA LILILSRTLS NEEHFQEPDC SLEAQPKYVR GGKRYGRRSL PEFQESVEEF 130 140 150 160 170 180 PEVTVIEPLD EEARPSHIPA GDCSEHWKTQ RSEEYEAEGQ LRFWNPDDLN ASQSGSSPPQ 190 200 210 220 230 240 DWIEEKLQEV CEDLGITRDG HLNRKKLVSI CEQYGLQNVD GEMLEEVFHN LDPDGTMSVE 250 260 270 280 290 300 DFFYGLFKNG KSLTPSASTP YRQLKRHLSM QSFDESGRRT TTSSAMTSTI GFRVFSCLDD 310 320 330 340 350 360 GMGHASVERI LDTWQEEGIE NSQEILKALD FSLDGNINLT ELTLALENEL LVTKNSIHQA 370 380 390 400 410 420 ALASFKAEIR HLLERVDQVV REKEKLRSDL DKAEKLKSLM ASEVDDHHAA IERRNEYNLR 430 440 450 460 470 480 KLDEEYKERI AALKNELRKE REQILQQAGK QRLELEQEIE KAKTEENYIR DRLALSLKEN 490 500 510 520 530 540 SRLENELLEN AEKLAEYENL TNKLQRNLEN VLAEKFGDLD PSSAEFFLQE ERLTQMRNEY 550 560 570 580 590 600 ERQCRVLQDQ VDELQSELEE YRAQGRVLRL PLKNSPSEEV EANSGGIEPE HGLGSEECNP 610 620 630 640 650 660 LNMSIEAELV IEQMKEQHHR DICCLRLELE DKVRHYEKQL DETVVSCKKA QENMKQRHEN 670 680 690 700 710 720 ETHTLEKQIS DLKNEIAELQ GQAAVLKEAH HEATCRHEEE KKQLQVKLEE EKTHLQEKLR 730 740 750 760 770 780 LQHEMELKAR LTQAQASFER EREGLQSSAW TEEKVRGLTQ ELEQFHQEQL TSLVEKHTLE 790 800 810 820 830 840 KEELRKELLE KHQRELQEGR EKMETECNRR TSQIEAQFQS DCQKVTERCE SALQSLEGRY 850 860 870 880 890 900 RQELKDLQEQ QREEKSQWEF EKDELTQECA EAQELLKETL KREKTTSLVL TQEREMLEKT 910 920 930 940 950 960 YKEHLNSMVV ERQQLLQDLE DLRNVSETQQ SLLSDQILEL KSSHKRELRE REEVLCQAGA 970 980 990 1000 1010 1020 SEQLASQRLE RLEMEHDQER QEMMSKLLAM ENIHKATCET ADRERAEMST EISRLQSKIK 1030 1040 1050 1060 1070 1080 EMQQATSPLS MLQSGCQVIG EEEVEGDGAL SLLQQGEQLL EENGDVLLSL QRAHEQAVKE 1090 1100 1110 1120 1130 1140 NVKMATEISR LQQRLQKLEP GLVMSSCLDE PATEFFGNTA EQTEQFLQQN RTKQVEGVTR 1150 1160 1170 1180 1190 1200 RHVLSDLEDD EVRDLGSTGT SSVQRQEVKI EESEASVEGF SELENSEETR TESWELKNQI 1210 1220 1230 1240 1250 1260 SQLQEQLMML CADCDRASEK KQDLLFDVSV LKKKLKMLER IPEASPKYKL LYEDVSREND 1270 1280 1290 1300 1310 1320 CLQEELRMME TRYDEALENN KELTAEVFRL QDELKKMEEV TETFLSLEKS YDEVKIENEG 1330 1340 1350 1360 1370 1380 LNVLVLRLQG KIEKLQESVV QRCDCCLWEA SLENLEIEPD GNILQLNQTL EECVPRVRSV 1390 1400 1410 1420 1430 1440 HHVIEECKQE NQYLEGNTQL LEKVKAHEIA WLHGTIQTHQ ERPRVQNQVI LEENTTLLGF 1450 1460 1470 1480 1490 1500 QDKHFQHQAT IAELELEKTK LQELTRKLKE RVTILVKQKD VLSHGEKEEE LKAMMHDLQI 1510 1520 1530 1540 1550 1560 TCSEMQQKVE LLRYESEKLQ QENSILRNEI TTLNEEDSIS NLKLGTLNGS QEEMWQKTET 1570 1580 1590 1600 1610 1620 VKQENAAVQK MVENLKKQIS ELKIKNQQLD LENTELSQKN SQNQEKLQEL NQRLTEMLCQ 1630 1640 1650 1660 1670 1680 KEKEPGNSAL EEREQEKFNL KEELERCKVQ SSTLVSSLEA ELSEVKIQTH IVQQENHLLK 1690 1700 1710 1720 1730 1740 DELEKMKQLH RCPDLSDFQQ KISSVLSYNE KLLKEKEALS EELNSCVDKL AKSSLLEHRI 1750 1760 1770 1780 1790 1800 ATMKQEQKSW EHQSASLKSQ LVASQEKVQN LEDTVQNVNL QMSRMKSDLR VTQQEKEALK 1810 1820 1830 1840 1850 1860 QEVMSLHKQL QNAGGKSWAP EIATHPSGLH NQQKRLSWDK LDHLMNEEQQ LLWQENERLQ 1870 1880 1890 1900 1910 1920 TMVQNTKAEL THSREKVRQL ESNLLPKHQK HLNPSGTMNP TEQEKLSLKR ECDQFQKEQS 1930 1940 1950 1960 1970 1980 PANRKVSQMN SLEQELETIH LENEGLKKKQ VKLDEQLMEM QHLRSTATPS PSPHAWDLQL 1990 2000 2010 2020 2030 2040 LQQQACPMVP REQFLQLQRQ LLQAERINQH LQEELENRTS ETNTPQGNQE QLVTVMEERM 2050 2060 2070 2080 2090 2100 IEVEQKLKLV KRLLQEKVNQ LKEQLCKNTK ADAMVKDLYV ENAQLLKALE VTEQRQKTAE 2110 2120 2130 KKNYLLEEKI ASLSNIVRNL TPAPLTSTPP LRS
	Isoform 8 [UniParc]. Checksum: 77E187FF00857A7D	FASTA	2,052	238,941
	10 20 30 40 50 60 MLSLEEVAPV LQQTLLQDNL LGRVHFDQFK EALILILSRT LSNEEHFQEP DCSLEAQPKY 70 80 90 100 110 120 VRGGKRYGRR SLPEFQESVE EFPEVTVIEP LDEEARPSHI PAGDCSEHWK TQRSEEYEAE 130 140 150 160 170 180 GQLRFWNPDD LNASQSGSSP PQDWIEEKLQ EVCEDLGITR DGHLNRKKLV SICEQYGLQN 190 200 210 220 230 240 VDGEMLEEVF HNLDPDGTMS VEDFFYGLFK NGKSLTPSAS TPYRQLKRHL SMQSFDESGR 250 260 270 280 290 300 RTTTSSAMTS TIGFRVFSCL DDGMGHASVE RILDTWQEEG IENSQEILKA LDFSLDGNIN 310 320 330 340 350 360 LTELTLALEN ELLVTKNSIH QAALASFKAE IRHLLERVDQ VVREKEKLRS DLDKAEKLKS 370 380 390 400 410 420 LMASEVDDHH AAIERRNEYN LRKLDEEYKE RIAALKNELR KEREQILQQA GKQRLELEQE 430 440 450 460 470 480 IEKAKTEENY IRDRLALSLK ENSRLENELL ENAEKLAEYE NLTNKLQRNL ENVLAEKFGD 490 500 510 520 530 540 LDPSSAEFFL QEERLTQMRN EYERQCRVLQ DQVDELQSEL EEYRAQGRVL RLPLKNSPSE 550 560 570 580 590 600 EVEANSGGIE PEHGLGSEEC NPLNMSIEAE LVIEQMKEQH HRDICCLRLE LEDKVRHYEK 610 620 630 640 650 660 QLDETVVSCK KAQENMKQRH ENETHTLEKQ ISDLKNEIAE LQGQAAVLKE AHHEATCRHE 670 680 690 700 710 720 EEKKQLQVKL EEEKTHLQEK LRLQHEMELK ARLTQAQASF EREREGLQSS AWTEEKVRGL 730 740 750 760 770 780 TQELEQFHQE QLTSLVEKHT LEKEELRKEL LEKHQRELQE GREKMETECN RRTSQIEAQF 790 800 810 820 830 840 QSDCQKVTER CESALQSLEG RYRQELKDLQ EQQREEKSQW EFEKDELTQE CAEAQELLKE 850 860 870 880 890 900 TLKREKTTSL VLTQEREMLE KTYKEHLNSM VVERQQLLQD LEDLRNVSET QQSLLSDQIL 910 920 930 940 950 960 ELKSSHKREL REREEVLCQA GASEQLASQR LERLEMEHDQ ERQEMMSKLL AMENIHKATC 970 980 990 1000 1010 1020 ETADRERAEM STEISRLQSK IKEMQQATSP LSMLQSGCQV IGEEEVEGDG ALSLLQQGEQ 1030 1040 1050 1060 1070 1080 LLEENGDVLL SLQRAHEQAV KENVKMATEI SRLQQRLQKL EPGLVMSSCL DEPATEFFGN 1090 1100 1110 1120 1130 1140 TAEQTEQFLQ QNRTKQVEGV TRRHVLSDLE DDEVRDLGST GTSSVQRQEV KIEESEASVE 1150 1160 1170 1180 1190 1200 GFSELENSEE TRTESWELKN QISQLQEQLM MLCADCDRAS EKKQDLLFDV SVLKKKLKML 1210 1220 1230 1240 1250 1260 ERIPEASPKY KLLYEDVSRE NDCLQEELRM METRYDEALE NNKELTAEVF RLQDELKKME 1270 1280 1290 1300 1310 1320 EVTETFLSLE KSYDEVKIEN EGLNVLVLRL QGKIEKLQES VVQRCDCCLW EASLENLEIE 1330 1340 1350 1360 1370 1380 PDGNILQLNQ TLEECVPRVR SVHHVIEECK QENQYLEGNT QLLEKVKAHE IAWLHGTIQT 1390 1400 1410 1420 1430 1440 HQERPRVQNQ VILEENTTLL GFQDKHFQHQ ATIAELELEK TKLQELTRKL KERVTILVKQ 1450 1460 1470 1480 1490 1500 KDVLSHGEKE EELKAMMHDL QITCSEMQQK VELLRYESEK LQQENSILRN EITTLNEEDS 1510 1520 1530 1540 1550 1560 ISNLKLGTLN GSQEEMWQKT ETVKQENAAV QKMVENLKKQ ISELKIKNQQ LDLENTELSQ 1570 1580 1590 1600 1610 1620 KNSQNQEKLQ ELNQRLTEML CQKEKEPGNS ALEEREQEKF NLKEELERCK VQSSTLVSSL 1630 1640 1650 1660 1670 1680 EAELSEVKIQ THIVQQENHL LKDELEKMKQ LHRCPDLSDF QQKISSVLSY NEKLLKEKEA 1690 1700 1710 1720 1730 1740 LSEELNSCVD KLAKSSLLEH RIATMKQEQK SWEHQSASLK SQLVASQEKV QNLEDTVQNV 1750 1760 1770 1780 1790 1800 NLQMSRMKSD LRVTQQEKEA LKQEVMSLHK QLQNAGGKSW APEIATHPSG LHNQQKRLSW 1810 1820 1830 1840 1850 1860 DKLDHLMNEE QQLLWQENER LQTMVQNTKA ELTHSREKVR QLESNLLPKH QKHLNPSGTM 1870 1880 1890 1900 1910 1920 NPTEQEKLSL KRECDQFQKE QSPANRKVSQ MNSLEQELET IHLENEGLKK KQVKLDEQLM 1930 1940 1950 1960 1970 1980 EMQHLRSTAT PSPSPHAWDL QLLQQQACPM VPREQFLQLQ RQLLQAERIN QHLQEELENR 1990 2000 2010 2020 2030 2040 TSETNTPQGN QEQLVTVMEE RMIEVEQKLK LVKRLLQEKV NQLKEQVSLP GHLCSPTSHS 2050 SFNSSFTSLY CH
	Isoform 9 [UniParc]. Checksum: 19AE5E3800593B03	FASTA	1,377	160,136
	10 20 30 40 50 60 MDEVEQDQHE ARLKELFDSF DTTGTGSLGQ EELTDLCHML SLEEVAPVLQ QTLLQDNLLG 70 80 90 100 110 120 RVHFDQFKEA LILILSRTLS NEEHFQEPDC SLEAQPKYVR GGKRYGRRSL PEFQESVEEF 130 140 150 160 170 180 PEVTVIEPLD EEARPSHIPA GDCSEHWKTQ RSEEYEAEGQ LRFWNPDDLN ASQSGSSPPQ 190 200 210 220 230 240 DWIEEKLQEV CEDLGITRDG HLNRKKLVSI CEQYGLQNVD GEMLEEVFHN LDPDGTMSVE 250 260 270 280 290 300 DFFYGLFKNG KSLTPSASTP YRQLKRHLSM QSFDESGRRT TTSSAMTSTI GFRVFSCLDD 310 320 330 340 350 360 GMGHASVERI LDTWQEEGIE NSQEILKALD FSLDGNINLT ELTLALENEL LVTKNSIHQA 370 380 390 400 410 420 ALASFKAEIR HLLERVDQVV REKEKLRSDL DKAEKLKSLM ASEVDDHHAA IERRNEYNLR 430 440 450 460 470 480 KLDEEYKERI AALKNELRKE REQILQQAGK QRLELEQEIE KAKTEENYIR DRLALSLKEN 490 500 510 520 530 540 SRLENELLEN AEKLAEYENL TNKLQRNLEN VLAEKFGDLD PSSAEFFLQE ERLTQMRNEY 550 560 570 580 590 600 ERQCRVLQDQ VDELQSELEE YRAQGRVLRL PLKNSPSEEV EANSGGIEPE HGLGSEECNP 610 620 630 640 650 660 LNMSIEAELV IEQMKEQHHR DICCLRLELE DKVRHYEKQL DETVVSCKKA QENMKQRHEN 670 680 690 700 710 720 ETHTLEKQIS DLKNEIAELQ GQAAVLKEAH HEATCRHEEE KKQLQVKLEE EKTHLQEKLR 730 740 750 760 770 780 LQHEMELKAR LTQAQASFER EREGLQSSAW TEEKVRGLTQ ELEQFHQEQL TSLVEKHTLE 790 800 810 820 830 840 KEELRKELLE KHQRELQEGR YESEKLQQEN SILRNEITTL NEEDSISNLK LGTLNGSQEE 850 860 870 880 890 900 MWQKTETVKQ ENAAVQKMVE NLKKQISELK IKNQQLDLEN TELSQKNSQN QEKLQELNQR 910 920 930 940 950 960 LTEMLCQKEK EPGNSALEER EQEKFNLKEE LERCKVQSST LVSSLEAELS EVKIQTHIVQ 970 980 990 1000 1010 1020 QENHLLKDEL EKMKQLHRCP DLSDFQQKIS SVLSYNEKLL KEKEALSEEL NSCVDKLAKS 1030 1040 1050 1060 1070 1080 SLLEHRIATM KQEQKSWEHQ SASLKSQLVA SQEKVQNLED TVQNVNLQMS RMKSDLRVTQ 1090 1100 1110 1120 1130 1140 QEKEALKQEV MSLHKQLQNA GGKSWAPEIA THPSGLHNQQ KRLSWDKLDH LMNEEQQLLW 1150 1160 1170 1180 1190 1200 QENERLQTMV QNTKAELTHS REKVRQLESN LLPKHQKHLN PSGTMNPTEQ EKLSLKRECD 1210 1220 1230 1240 1250 1260 QFQKEQSPAN RKVSQMNSLE QELETIHLEN EGLKKKQVKL DEQLMEMQHL RSTATPSPSP 1270 1280 1290 1300 1310 1320 HAWDLQLLQQ QACPMVPREQ FLQLQRQLLQ AERINQHLQE ELENRTSETN TPQGNQEQLV 1330 1340 1350 1360 1370 TVMEERMIEV EQKLKLVKRL LQEKVNQLKE QVSLPGHLCS PTSHSSFNSS FTSLYCH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta." Hong Y.-R., Chen C.-H., Chang J.-H., Wang S.-K., Sy W.-D., Chou C.-K., Howng S.-L. Biochim. Biophys. Acta 1492:513-516(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH GSK3B, VARIANTS PRO-1125 AND GLU-1320. Tissue: Fetal liver.
[2]	"Genomic organization and molecular characterization of the human ninein gene." Hong Y.-R., Chen C.-H., Chuo M.-H., Liou S.-Y., Howng S.-L. Biochem. Biophys. Res. Commun. 279:989-995(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS PRO-1125 AND GLU-1320.
[3]	"Human ninein is a centrosomal autoantigen recognized by CREST patient sera and plays a regulatory role in microtubule nucleation." Stillwell E.E., Zhou J., Joshi H.C. Cell Cycle 3:923-930(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4), PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, VARIANTS PRO-1125 AND GLU-1320. Tissue: Thymus.
[4]	"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O. DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6). Tissue: Brain.
[5]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[6]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 9), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-434 (ISOFORM 8), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1877-2090 (ISOFORM 4). Tissue: Lymph.
[8]	"3' isoforms of human ninein." Choquette M.C., de Medicis E. Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1561-2090 (ISOFORMS 1 AND 7). Tissue: Bone marrow.
[9]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1928-2090 (ISOFORM 7). Tissue: Hepatoma.
[10]	"CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation." Ou Y.Y., Mack G.J., Zhang M., Rattner J.B. J. Cell Sci. 115:1825-1835(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[11]	"Assembly of centrosomal proteins and microtubule organization depends on PCM-1." Dammermann A., Merdes A. J. Cell Biol. 159:255-266(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[12]	"Molecular characterization of human ninein protein: two distinct subdomains required for centrosomal targeting and regulating signals in cell cycle." Chen C.-H., Howng S.-L., Cheng T.-S., Chou M.-H., Huang C.-Y., Hong Y.-R. Biochem. Biophys. Res. Commun. 308:975-983(2003) [PubMed] [Europe PMC] [Abstract] Cited for: HOMOOLIGOMERIZATION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, PHOSPHORYLATION.
[13]	"A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors." Howng S.-L., Hsu H.-C., Cheng T.-S., Lee Y.-L., Chang L.-K., Lu P.-J., Hong Y.-R. FEBS Lett. 566:162-168(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH C14ORF166.
[14]	"Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome." Mack G.J., Rees J., Sandblom O., Balczon R., Fritzler M.J., Rattner J.B. Arthritis Rheum. 41:551-558(1998) [PubMed] [Europe PMC] [Abstract] Cited for: AUTOANTIBODY.
[15]	"Spectrum of centrosome autoantibodies in childhood varicella and post-varicella acute cerebellar ataxia." Fritzler M.J., Zhang M., Stinton L.M., Rattner J.B. BMC Pediatr. 3:11-11(2003) [PubMed] [Europe PMC] [Abstract] Cited for: AUTOANTIBODY.
[16]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1550, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[17]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1550, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[18]	"Functional characterization of AIBp, a novel Aurora-A binding protein in centrosome structure and spindle formation." Lieu A.S., Cheng T.S., Chou C.H., Wu C.H., Hsu C.Y., Huang C.Y., Chang L.K., Loh J.K., Chang C.S., Hsu C.M., Howng S.L., Hong Y.R. Int. J. Oncol. 37:429-436(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH AUNIP.
[19]	"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome." Ley T.J., Mardis E.R., Ding L., Fulton B., McLellan M.D., Chen K., Dooling D., Dunford-Shore B.H., McGrath S., Hickenbotham M., Cook L., Abbott R., Larson D.E., Koboldt D.C., Pohl C., Smith S., Hawkins A., Abbott S. , Locke D., Hillier L.W., Miner T., Fulton L., Magrini V., Wylie T., Glasscock J., Conyers J., Sander N., Shi X., Osborne J.R., Minx P., Gordon D., Chinwalla A., Zhao Y., Ries R.E., Payton J.E., Westervelt P., Tomasson M.H., Watson M., Baty J., Ivanovich J., Heath S., Shannon W.D., Nagarajan R., Walter M.J., Link D.C., Graubert T.A., DiPersio J.F., Wilson R.K. Nature 456:66-72(2008) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-1320.
[20]	"Novel microcephalic primordial dwarfism disorder associated with variants in the centrosomal protein ninein." Dauber A., Lafranchi S.H., Maliga Z., Lui J.C., Moon J.E., McDeed C., Henke K., Zonana J., Kingman G.A., Pers T.H., Baron J., Rosenfeld R.G., Hirschhorn J.N., Harris M.P., Hwa V. J. Clin. Endocrinol. Metab. 97:E2140-E2151(2012) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS SCKL7 ARG-1222 AND SER-1709.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF212162 mRNA. Translation: AAF23015.2. AF302773 mRNA. Translation: AAG33512.2. AF223937 mRNA. Translation: AAK00628.1. Sequence problems. AF223938 mRNA. Translation: AAK00629.1. Sequence problems. AF223939 mRNA. Translation: AAK00630.1. Sequence problems. AB046785 mRNA. Translation: BAB13391.2. Different initiation. AL133485 Genomic DNA. No translation available. AL606834 Genomic DNA. No translation available. BC034708 mRNA. Translation: AAH34708.2. BC065521 mRNA. Translation: AAH65521.1. Sequence problems. BC090932 mRNA. Translation: AAH90932.1. AY027794 mRNA. Translation: AAK27375.1. AY027795 mRNA. Translation: AAK27376.1. AY027796 mRNA. Translation: AAK27377.1. AF186776 mRNA. Translation: AAG17027.1. AK027054 mRNA. Translation: BAB15640.1. Different initiation.
IPI	IPI00171791. IPI00329695. IPI00441952. IPI00441955. IPI00441959. IPI00883941. IPI00921003. IPI00971005.
RefSeq	NP_057434.4. NM_016350.4. NP_065972.3. NM_020921.3. NP_891989.2. NM_182944.2. NP_891991.1. NM_182946.1.
UniGene	Hs.310429. Hs.569387.
3D structure databases
ProteinModelPortal	Q8N4C6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8N4C6. 3 interactions.
MINT	MINT-1175275.
PTM databases
PhosphoSite	Q8N4C6.
Polymorphism databases
DMDM	311033487.
Proteomic databases
PaxDb	Q8N4C6.
PRIDE	Q8N4C6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000245441; ENSP00000245441; ENSG00000100503. ENST00000382041; ENSP00000371472; ENSG00000100503. ENST00000382043; ENSP00000371474; ENSG00000100503.
GeneID	51199.
KEGG	hsa:51199.
UCSC	uc001wyi.3. human. uc001wym.2. human.
Organism-specific databases
CTD	51199.
GeneCards	GC14M051187.
HGNC	HGNC:14906. NIN.
HPA	HPA005939.
MIM	608684. gene. 614851. phenotype.
neXtProt	NX_Q8N4C6.
PharmGKB	PA31630.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG124644.
HOGENOM	HOG000293170.
HOVERGEN	HBG052623.
KO	K16476.
OMA	AMMHDLQ.
OrthoDB	EOG45QHC9.
Gene expression databases
ArrayExpress	Q8N4C6.
Bgee	Q8N4C6.
Genevestigator	Q8N4C6.
GermOnline	ENSG00000100503. Homo sapiens.
Family and domain databases
Gene3D	1.10.238.10. 2 hits.
InterPro	IPR011992. EF-hand-like_dom. IPR002048. EF_hand_dom. [Graphical view]
PROSITE	PS50222. EF_HAND_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q8N4C6.
ChiTaRS	NIN. human.
GenomeRNAi	51199.
NextBio	54220.
SOURCE	Search...

Entry information

Entry name

NIN_HUMAN

Accession

Primary (citable) accession number: Q8N4C6
Secondary accession number(s): A6NDB8 , B7WPA3, C9JSB6, C9JSG2, C9JXL2, Q5BKU3, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	November 2, 2010
Last modified:	May 1, 2013
This is version 101 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.