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Protein

F-box only protein 39

Gene

FBXO39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177294-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 39
Gene namesi
Name:FBXO39
Synonyms:FBX39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28565. FBXO39.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177294.
PharmGKBiPA134889729.

Polymorphism and mutation databases

BioMutaiFBXO39.
DMDMi51701431.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199351 – 442F-box only protein 39Add BLAST442

Proteomic databases

PaxDbiQ8N4B4.
PRIDEiQ8N4B4.

PTM databases

iPTMnetiQ8N4B4.
PhosphoSitePlusiQ8N4B4.

Expressioni

Gene expression databases

BgeeiENSG00000177294.
CleanExiHS_FBXO39.
ExpressionAtlasiQ8N4B4. baseline and differential.
GenevisibleiQ8N4B4. HS.

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

IntActiQ8N4B4. 1 interactor.
STRINGi9606.ENSP00000321386.

Structurei

3D structure databases

ProteinModelPortaliQ8N4B4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 61F-boxAdd BLAST46

Sequence similaritiesi

Contains 1 F-box domain.Curated

Phylogenomic databases

eggNOGiENOG410IT1X. Eukaryota.
ENOG4111FS0. LUCA.
GeneTreeiENSGT00510000048837.
HOGENOMiHOG000112546.
HOVERGENiHBG051580.
InParanoidiQ8N4B4.
KOiK10314.
OMAiEGQCALR.
OrthoDBiEOG091G0NJN.
PhylomeDBiQ8N4B4.
TreeFamiTF321665.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS51450. LRR. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N4B4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEESELIQP QDQSCWAFLP DLCLCRVFWW LGDRDRSRAA LVCRKWNQMM
60 70 80 90 100
YSAELWRYRT ITFSGRPSRV HASEVESAVW YVKKFGRYLE HLEVKFMNPY
110 120 130 140 150
NAVLTKKFQV TMRGLLSCLS KSNNRLKSLS IQYLELDRLV WRNSIRSSFI
160 170 180 190 200
SSLSFFLKKM GKRLDYLNLK GARLTVEQGC QILDSLSYMR NENVISELNI
210 220 230 240 250
EDYFSHHLAV YNSPQFKKTM STFHNLVSLN LNYNCISDEL LENLCENAST
260 270 280 290 300
LRTINIKCHV HDPHGQVIWG MSWAKLARQA TNLKVNFFFE RIMKYERLAR
310 320 330 340 350
ILLQEIPIRS ISLRSCYFSD PDCSMRPTLI DLLPTFRHTL QKLTCEFNNN
360 370 380 390 400
HESLDEELHL LIISCRKLFY FKIWAFLDVS FVERILKSQK ERQCALRVFK
410 420 430 440
ARIYTNRYET NEEDKTLQEI YRKYRKLIES ELSYFVIVYS VM
Length:442
Mass (Da):52,646
Last modified:October 1, 2002 - v1
Checksum:i32A1E4D69FA29C71
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02444410P → S.Corresponds to variant rs4796555dbSNPEnsembl.1
Natural variantiVAR_049050166Y → C.Corresponds to variant rs16956264dbSNPEnsembl.1
Natural variantiVAR_049051221S → T.Corresponds to variant rs4143218dbSNPEnsembl.1
Natural variantiVAR_024445231L → F.Corresponds to variant rs1509123dbSNPEnsembl.1
Natural variantiVAR_024446363I → M.Corresponds to variant rs7213731dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034782 mRNA. Translation: AAH34782.1.
CCDSiCCDS11082.1.
RefSeqiNP_694962.1. NM_153230.2.
XP_011521999.1. XM_011523697.1.
UniGeneiHs.368364.

Genome annotation databases

EnsembliENST00000321535; ENSP00000321386; ENSG00000177294.
GeneIDi162517.
KEGGihsa:162517.
UCSCiuc010vtg.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034782 mRNA. Translation: AAH34782.1.
CCDSiCCDS11082.1.
RefSeqiNP_694962.1. NM_153230.2.
XP_011521999.1. XM_011523697.1.
UniGeneiHs.368364.

3D structure databases

ProteinModelPortaliQ8N4B4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8N4B4. 1 interactor.
STRINGi9606.ENSP00000321386.

PTM databases

iPTMnetiQ8N4B4.
PhosphoSitePlusiQ8N4B4.

Polymorphism and mutation databases

BioMutaiFBXO39.
DMDMi51701431.

Proteomic databases

PaxDbiQ8N4B4.
PRIDEiQ8N4B4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321535; ENSP00000321386; ENSG00000177294.
GeneIDi162517.
KEGGihsa:162517.
UCSCiuc010vtg.3. human.

Organism-specific databases

CTDi162517.
GeneCardsiFBXO39.
HGNCiHGNC:28565. FBXO39.
MIMi609106. gene.
neXtProtiNX_Q8N4B4.
OpenTargetsiENSG00000177294.
PharmGKBiPA134889729.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IT1X. Eukaryota.
ENOG4111FS0. LUCA.
GeneTreeiENSGT00510000048837.
HOGENOMiHOG000112546.
HOVERGENiHBG051580.
InParanoidiQ8N4B4.
KOiK10314.
OMAiEGQCALR.
OrthoDBiEOG091G0NJN.
PhylomeDBiQ8N4B4.
TreeFamiTF321665.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177294-MONOMER.

Miscellaneous databases

GenomeRNAii162517.
PROiQ8N4B4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177294.
CleanExiHS_FBXO39.
ExpressionAtlasiQ8N4B4. baseline and differential.
GenevisibleiQ8N4B4. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS51450. LRR. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBX39_HUMAN
AccessioniPrimary (citable) accession number: Q8N4B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.