Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sesquipedalian-1

Gene

PHETA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.1 Publication

Miscellaneous

Was named after 'sesquipedalian', an unnecessarily long description of a simple thing.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • endosome organization Source: UniProtKB
  • receptor recycling Source: UniProtKB
  • retrograde transport, endosome to Golgi Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Sesquipedalian-11 Publication
Short name:
Ses1
Alternative name(s):
27 kDa inositol polyphosphate phosphatase-interacting protein A
Short name:
IPIP27A
PH domain-containing endocytic trafficking adaptor 1Curated
Gene namesi
Name:PHETA1Imported
Synonyms:FAM109AImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000198324.13
HGNCiHGNC:26509 PHETA1
neXtProtiNX_Q8N4B1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi224F → A: Loss of OCRL-binding. Drastically reduces membrane targeting. 2 Publications1
Mutagenesisi228H → A: Loss of OCRL-binding. 2 Publications1
Mutagenesisi234 – 235EI → AA: Loss of OCRL-binding. 1 Publication2

Organism-specific databases

DisGeNETi144717
OpenTargetsiENSG00000198324
PharmGKBiPA143485466

Polymorphism and mutation databases

BioMutaiFAM109A
DMDMi74728832

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002545721 – 249Sesquipedalian-1Add BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei213PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N4B1
MaxQBiQ8N4B1
PaxDbiQ8N4B1
PeptideAtlasiQ8N4B1
PRIDEiQ8N4B1
ProteomicsDBi71901
71902 [Q8N4B1-2]
71903 [Q8N4B1-3]

PTM databases

iPTMnetiQ8N4B1
PhosphoSitePlusiQ8N4B1

Expressioni

Gene expression databases

BgeeiENSG00000198324
CleanExiHS_FAM109A
ExpressionAtlasiQ8N4B1 baseline and differential
GenevisibleiQ8N4B1 HS

Interactioni

Subunit structurei

Forms homodimers and heterodimers with PHETA2 (PubMed:21233288). Interacts with OCRL and INPP5B (PubMed:20133602, PubMed:21233288, PubMed:21666675). Interaction with OCRL may be important for endosomal morphology and function (By similarity).By similarity3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi126873, 7 interactors
ELMiQ8N4B1
IntActiQ8N4B1, 13 interactors
MINTiQ8N4B1
STRINGi9606.ENSP00000354461

Structurei

Secondary structure

1249
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi224 – 231Combined sources8
Turni232 – 234Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QISX-ray2.30B223-235[»]
ProteinModelPortaliQ8N4B1
SMRiQ8N4B1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 113PHPROSITE-ProRule annotationAdd BLAST97

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi223 – 235F&HAdd BLAST13

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi139 – 223Pro-richAdd BLAST85

Domaini

The F&H motif, an approximately 12-13 amino-acid sequence centered around Phe and His residues, is essential for binding to OCRL and INPP5B.1 Publication

Sequence similaritiesi

Belongs to the sesquipedalian family.Curated

Phylogenomic databases

eggNOGiENOG410IH44 Eukaryota
ENOG4111J7G LUCA
GeneTreeiENSGT00440000034671
HOVERGENiHBG061708
InParanoidiQ8N4B1
OMAiTRARTYV
OrthoDBiEOG091G0IU5
PhylomeDBiQ8N4B1
TreeFamiTF326731

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N4B1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLNERSLAF YATCDAPVDN AGFLYKKGGR HAAYHRRWFV LRGNMLFYFE
60 70 80 90 100
DAASREPVGV IILEGCTVEL VEAAEEFAFA VRFAGTRART YVLAAESQDA
110 120 130 140 150
MEGWVKALSR ASFDYLRLVV RELEQQLAAV RGGGGMALPQ PQPQSLPLPP
160 170 180 190 200
SLPSALAPVP SLPSAPAPVP ALPLPRRPSA LPPKENGCAV WSTEATFRPG
210 220 230 240
PEPPPPPPRR RASAPHGPLD MAPFARLHEC YGQEIRALRG QWLSSRVQP
Length:249
Mass (Da):27,215
Last modified:October 1, 2002 - v1
Checksum:i73410C946DA6113A
GO
Isoform 2 (identifier: Q8N4B1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.
     124-138: EQQLAAVRGGGGMAL → MQKQRPREMNSLPGV

Note: No experimental confirmation available.
Show »
Length:126
Mass (Da):13,610
Checksum:i8AAF24512D83EDF9
GO
Isoform 3 (identifier: Q8N4B1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     64-88: EGCTVELVEAAEEFAFAVRFAGTRA → VAVALWPRALSVSPWWLSQGSPDTP
     89-249: Missing.

Note: No experimental confirmation available.
Show »
Length:88
Mass (Da):9,957
Checksum:iA855A284B01643EF
GO
Isoform 4 (identifier: Q8N4B1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAPGSPPGPAIATM

Note: No experimental confirmation available.
Show »
Length:262
Mass (Da):28,364
Checksum:i5886034B521FFCA4
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0212391 – 123Missing in isoform 2. 1 PublicationAdd BLAST123
Alternative sequenceiVSP_0448361M → MAPGSPPGPAIATM in isoform 4. 1 Publication1
Alternative sequenceiVSP_02124164 – 88EGCTV…AGTRA → VAVALWPRALSVSPWWLSQG SPDTP in isoform 3. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_02124289 – 249Missing in isoform 3. 1 PublicationAdd BLAST161
Alternative sequenceiVSP_021240124 – 138EQQLA…GGMAL → MQKQRPREMNSLPGV in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056918 mRNA Translation: BAB71310.1
AC005805 Genomic DNA No translation available.
BC014091 mRNA Translation: AAH14091.1
BC034809 mRNA Translation: AAH34809.1
CX758147 mRNA No translation available.
CCDSiCCDS53833.1 [Q8N4B1-4]
CCDS9152.1 [Q8N4B1-1]
RefSeqiNP_001171467.1, NM_001177996.1 [Q8N4B1-4]
NP_001171468.1, NM_001177997.1 [Q8N4B1-1]
NP_653272.2, NM_144671.4 [Q8N4B1-1]
XP_006719320.1, XM_006719257.3 [Q8N4B1-1]
XP_011536278.1, XM_011537976.2 [Q8N4B1-1]
XP_016874372.1, XM_017018883.1 [Q8N4B1-1]
UniGeneiHs.173088

Genome annotation databases

EnsembliENST00000361483; ENSP00000354461; ENSG00000198324 [Q8N4B1-4]
ENST00000547838; ENSP00000447353; ENSG00000198324 [Q8N4B1-1]
ENST00000548163; ENSP00000449994; ENSG00000198324 [Q8N4B1-1]
GeneIDi144717
KEGGihsa:144717
UCSCiuc021rdy.1 human [Q8N4B1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSESQ1_HUMAN
AccessioniPrimary (citable) accession number: Q8N4B1
Secondary accession number(s): J3KP50, Q6PJL9, Q96MH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health