Reviewed,
UniProtKB/Swiss-Prot Q8N488 (RYBP_HUMAN)
Last modified
June 16, 2009.
Version 57.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: RING1 and YY1-binding protein Alternative name(s): Death effector domain-associated factor Short name=DED-associated factor YY1 and E4TF1-associated factor 1 Apoptin-associating protein 1 Short name=APAP-1 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 228 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. In tumor cell lines, may induce apoptosis. Ref.1 Ref.2 Ref.3 |
| Subunit structure | Interacts with CBX2, YAF2, IFT57, RING1 and RNF2 By similarity. Interacts with apoptin, DEDD, FADD, CASP8, CASP10, YY1 and E4TF1B. Together with E4TF1B and YY1, it forms a ternary complex, probably being the bridge factor between these two transcription factors. Component of repressive BCOR complex containing Polycomb group subcomplex at least composed of BCOR, PCGF1, RING1 and RNF2/RING2. |
| Subcellular location | Nucleus. Cytoplasm. Note: Primarily found in the nucleus. Ref.1 Ref.2 Ref.3 |
| Tissue specificity | Widely expressed with highest levels in lymphoid tissues and placenta. Ref.1 Ref.2 Ref.3 |
| Sequence similarities | Contains 1 RanBP2-type zinc finger. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Apoptosis Transcription Transcription regulation |
| Cellular component | Cytoplasm Nucleus |
| Domain | Zinc-finger |
| Ligand | DNA-binding Metal-binding Zinc |
| Molecular function | Repressor |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | apoptosis Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal developmentTraceable author statement. Source: ProtInc negative regulation of transcription from RNA polymerase II promoterTraceable author statement. Source: ProtInc transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | DNA binding Inferred from electronic annotation. Source: UniProtKB-KW transcription corepressor activityTraceable author statement. Source: ProtInc zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 228 | 228 | RING1 and YY1-binding protein | PRO_0000097550 | |||||
Regions | |||||||||
| Zinc finger | 21 – 50 | 30 | RanBP2-type | ||||||
| Region | 143 – 226 | 84 | Interaction with E4TF1B | ||||||
| Compositional bias | 73 – 76 | 4 | Poly-Pro | ||||||
| Compositional bias | 77 – 119 | 43 | Lys-rich | ||||||
| Compositional bias | 179 – 214 | 36 | Ser-rich | ||||||
Amino acid modifications | |||||||||
| Modified residue | 127 | 1 | Phosphoserine Ref.7 | ||||||
| Modified residue | 130 | 1 | Phosphoserine Ref.7 | ||||||
Experimental info | |||||||||
| Sequence conflict | 20 | 1 | A → T in AAH36459. Ref.5 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm." Zheng L., Schickling O., Peter M.E., Lenardo M.J. J. Biol. Chem. 276:31945-31952(2001) [PubMed: 11395500] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH DEDD; FADD; CASP8 AND CASP10. |
| [2] | "YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors." Sawa C., Yoshikawa T., Matsuda-Suzuki F., Delehouzee S., Goto M., Watanabe H., Sawada J., Kataoka K., Handa H. J. Biol. Chem. 277:22484-22490(2002) [PubMed: 11953439] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH YY1 AND E4TF1B. |
| [3] | "Human death effector domain-associated factor interacts with the viral apoptosis agonist Apoptin and exerts tumor-preferential cell killing." Danen-van Oorschot A.A.M.M., Voskamp P., Seelen M.C.M.J., van Miltenburg M.H.A.M., Bolk M.W., Tait S.W., Boesen-de Cock J.G.R., Rohn J.L., Borst J., Noteborn M.H.M. Cell Death Differ. 11:564-573(2004) [PubMed: 14765135] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH APOPTIN. |
| [4] | "The chicken anemia virus protein apoptin is associated with a human apoptotic protein, APAP1." Cheng C.M., Yuo C.Y. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Muscle. |
| [6] | "Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets." Gearhart M.D., Corcoran C.M., Wamstad J.A., Bardwell V.J. Mol. Cell. Biol. 26:6880-6889(2006) [PubMed: 16943429] [Abstract] Cited for: INTERACTION WITH BCOR, PCGF1, RING1, RNF2. |
| [7] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127 AND SER-130, MASS SPECTROMETRY. |
| [8] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF179286 mRNA. Translation: AAD51858.1. AB029551 mRNA. Translation: BAA89486.1. Different initiation. AY228125 mRNA. Translation: AAO73587.1. Different initiation. AF227959 mRNA. Translation: AAK63197.1. Different initiation. BC014959 mRNA. Translation: AAH14959.1. BC036459 mRNA. Translation: AAH36459.1. | |
| IPI | IPI00296594. |
| RefSeq | NP_036366.3. |
| UniGene | Hs.712596 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q8N488. 1 interaction. |
PTM databases | |
| PhosphoSite | Q8N488. |
Proteomic databases | |
| PRIDE | Q8N488. |
Genome annotation databases | |
| Ensembl | ENSG00000163602. Homo sapiens. [Contig view] |
| GeneID | 23429. |
| KEGG | hsa:23429. |
Organism-specific databases | |
| GeneCards | GC03M072506. |
| H-InvDB | HIX0003460. |
| HGNC | HGNC:10480. RYBP. |
| MIM | 607535. gene. |
| PharmGKB | PA34893. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q8N488. |
| HOVERGEN | Q8N488. |
Gene expression databases | |
| ArrayExpress | Q8N488. |
| Bgee | Q8N488. |
| CleanEx | HS_RYBP. |
| GermOnline | ENSG00000163602. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001876. Znf_RanBP2. [Graphical view] |
| Pfam | PF00641. zf-RanBP. 1 hit. [Graphical view] |
| SMART | SM00547. ZnF_RBZ. 1 hit. [Graphical view] |
| PROSITE | PS01358. ZF_RANBP2_1. 1 hit. PS50199. ZF_RANBP2_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 45669. |
| SOURCE | Search... |
Entry information
| Entry name | RYBP_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8N488 Secondary accession number(s): Q9P2W5, Q9UMW4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 3 Human chromosome 3: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


