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Protein

Protein limb expression 1 homolog

Gene

LIX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145721-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein limb expression 1 homolog
Gene namesi
Name:LIX1
Synonyms:C5orf11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:18581. LIX1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi167410.
OpenTargetsiENSG00000145721.
PharmGKBiPA38353.

Polymorphism and mutation databases

BioMutaiLIX1.
DMDMi126302565.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002328691 – 282Protein limb expression 1 homologAdd BLAST282

Proteomic databases

PaxDbiQ8N485.
PRIDEiQ8N485.

PTM databases

PhosphoSitePlusiQ8N485.

Expressioni

Gene expression databases

BgeeiENSG00000145721.
CleanExiHS_LIX1.
ExpressionAtlasiQ8N485. baseline and differential.
GenevisibleiQ8N485. HS.

Organism-specific databases

HPAiHPA058426.

Interactioni

Protein-protein interaction databases

BioGridi127946. 2 interactors.
IntActiQ8N485. 2 interactors.
STRINGi9606.ENSP00000274382.

Structurei

3D structure databases

ProteinModelPortaliQ8N485.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LIX1 family.Curated

Phylogenomic databases

eggNOGiENOG410IH13. Eukaryota.
ENOG410XRZR. LUCA.
GeneTreeiENSGT00390000005869.
HOGENOMiHOG000237359.
HOVERGENiHBG079509.
InParanoidiQ8N485.
OMAiVNELPCR.
OrthoDBiEOG091G0KAJ.
PhylomeDBiQ8N485.
TreeFamiTF324035.

Family and domain databases

InterProiIPR029270. LIX1.
[Graphical view]
PfamiPF14954. LIX1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N485-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRTLESLRH IIAQVLPHRD PALVFKDLNV VSMLQEFWES KQQQKAAFPS
60 70 80 90 100
EGVVVYESLP APGPPFVSYV TLPGGSCFGN FQCCLSRAEA RRDAAKVALI
110 120 130 140 150
NSLFNELPSR RITKEFIMES VQEAVASTSG TLDDADDPST SVGAYHYMLE
160 170 180 190 200
SNMGKTMLEF QELMTIFQLL HWNGSLKALR ETKCSRQEVI SYYSQYSLDE
210 220 230 240 250
KMRSHMALDW IMKERDSPGI VSQELRMALR QLEEARKAGQ ELRFYKEKKE
260 270 280
ILSLALTQIC SDPDTSSPSD DQLSLTALCG YH
Length:282
Mass (Da):31,891
Last modified:February 20, 2007 - v2
Checksum:iB5642D1123C3CEF6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0260393R → I.1 PublicationCorresponds to variant rs11558079dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098400 mRNA. Translation: BAC05298.1.
AK291034 mRNA. Translation: BAF83723.1.
CH471084 Genomic DNA. Translation: EAW96087.1.
BC036467 mRNA. Translation: AAH36467.1.
CCDSiCCDS4088.1.
RefSeqiNP_694966.3. NM_153234.4.
UniGeneiHs.656702.

Genome annotation databases

EnsembliENST00000274382; ENSP00000274382; ENSG00000145721.
GeneIDi167410.
KEGGihsa:167410.
UCSCiuc003kmy.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098400 mRNA. Translation: BAC05298.1.
AK291034 mRNA. Translation: BAF83723.1.
CH471084 Genomic DNA. Translation: EAW96087.1.
BC036467 mRNA. Translation: AAH36467.1.
CCDSiCCDS4088.1.
RefSeqiNP_694966.3. NM_153234.4.
UniGeneiHs.656702.

3D structure databases

ProteinModelPortaliQ8N485.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127946. 2 interactors.
IntActiQ8N485. 2 interactors.
STRINGi9606.ENSP00000274382.

PTM databases

PhosphoSitePlusiQ8N485.

Polymorphism and mutation databases

BioMutaiLIX1.
DMDMi126302565.

Proteomic databases

PaxDbiQ8N485.
PRIDEiQ8N485.

Protocols and materials databases

DNASUi167410.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274382; ENSP00000274382; ENSG00000145721.
GeneIDi167410.
KEGGihsa:167410.
UCSCiuc003kmy.5. human.

Organism-specific databases

CTDi167410.
DisGeNETi167410.
GeneCardsiLIX1.
HGNCiHGNC:18581. LIX1.
HPAiHPA058426.
MIMi610466. gene.
neXtProtiNX_Q8N485.
OpenTargetsiENSG00000145721.
PharmGKBiPA38353.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH13. Eukaryota.
ENOG410XRZR. LUCA.
GeneTreeiENSGT00390000005869.
HOGENOMiHOG000237359.
HOVERGENiHBG079509.
InParanoidiQ8N485.
OMAiVNELPCR.
OrthoDBiEOG091G0KAJ.
PhylomeDBiQ8N485.
TreeFamiTF324035.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145721-MONOMER.

Miscellaneous databases

GenomeRNAii167410.
PROiQ8N485.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145721.
CleanExiHS_LIX1.
ExpressionAtlasiQ8N485. baseline and differential.
GenevisibleiQ8N485. HS.

Family and domain databases

InterProiIPR029270. LIX1.
[Graphical view]
PfamiPF14954. LIX1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIX1_HUMAN
AccessioniPrimary (citable) accession number: Q8N485
Secondary accession number(s): A8K4R9, Q8N7I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: February 20, 2007
Last modified: November 2, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.