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Protein

Follistatin-related protein 5

Gene

FSTL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi188 – 2001PROSITE-ProRule annotationAdd BLAST13
Calcium bindingi226 – 2382PROSITE-ProRule annotationAdd BLAST13

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Protein family/group databases

MEROPSiI01.977.

Names & Taxonomyi

Protein namesi
Recommended name:
Follistatin-related protein 5
Alternative name(s):
Follistatin-like protein 5
Gene namesi
Name:FSTL5
Synonyms:KIAA1263
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:21386. FSTL5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi56884.
OpenTargetsiENSG00000168843.
PharmGKBiPA134978045.

Polymorphism and mutation databases

BioMutaiFSTL5.
DMDMi62510692.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001011821 – 847Follistatin-related protein 5Add BLAST827

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi270 ↔ 321By similarity
Glycosylationi318N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi362 ↔ 413By similarity
Glycosylationi394N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8N475.
MaxQBiQ8N475.
PaxDbiQ8N475.
PeptideAtlasiQ8N475.
PRIDEiQ8N475.

PTM databases

iPTMnetiQ8N475.
PhosphoSitePlusiQ8N475.

Expressioni

Gene expression databases

BgeeiENSG00000168843.
CleanExiHS_FSTL5.
GenevisibleiQ8N475. HS.

Organism-specific databases

HPAiHPA045909.
HPA046724.

Interactioni

Protein-protein interaction databases

BioGridi121216. 2 interactors.
IntActiQ8N475. 1 interactor.
STRINGi9606.ENSP00000305334.

Structurei

3D structure databases

ProteinModelPortaliQ8N475.
SMRiQ8N475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 135Kazal-likePROSITE-ProRule annotationAdd BLAST53
Domaini175 – 210EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini211 – 246EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini250 – 337Ig-like 1Add BLAST88
Domaini341 – 426Ig-like 2Add BLAST86

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IEEJ. Eukaryota.
ENOG410YBHC. LUCA.
GeneTreeiENSGT00530000063333.
HOGENOMiHOG000236319.
HOVERGENiHBG051667.
InParanoidiQ8N475.
OMAiFGSCENK.
OrthoDBiEOG091G0C29.
PhylomeDBiQ8N475.
TreeFamiTF350473.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
2.130.10.10. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR002350. Kazal_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF07648. Kazal_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF48726. SSF48726. 2 hits.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 1 hit.
PS50835. IG_LIKE. 2 hits.
PS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N475-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFKCWSVVLV LGFIFLESEG RPTKEGGYGL KSYQPLMRLR HKQEKNQESS
60 70 80 90 100
RVKGFMIQDG PFGSCENKYC GLGRHCVTSR ETGQAECACM DLCKRHYKPV
110 120 130 140 150
CGSDGEFYEN HCEVHRAACL KKQKITIVHN EDCFFKGDKC KTTEYSKMKN
160 170 180 190 200
MLLDLQNQKY IMQENENPNG DDISRKKLLV DQMFKYFDAD SNGLVDINEL
210 220 230 240 250
TQVIKQEELG KDLFDCTLYV LLKYDDFNAD KHLALEEFYR AFQVIQLSLP
260 270 280 290 300
EDQKLSITAA TVGQSAVLSC AIQGTLRPPI IWKRNNIILN NLDLEDINDF
310 320 330 340 350
GDDGSLYITK VTTTHVGNYT CYADGYEQVY QTHIFQVNVP PVIRVYPESQ
360 370 380 390 400
AREPGVTASL RCHAEGIPKP QLGWLKNGID ITPKLSKQLT LQANGSEVHI
410 420 430 440 450
SNVRYEDTGA YTCIAKNEAG VDEDISSLFV EDSARKTLAN ILWREEGLGI
460 470 480 490 500
GNMFYVFYED GIKVIQPIEC EFQRHIKPSE KLLGFQDEVC PKAEGDEVQR
510 520 530 540 550
CVWASAVNVK DKFIYVAQPT LDRVLIVDVQ SQKVVQAVST DPVPVKLHYD
560 570 580 590 600
KSHDQVWVLS WGTLEKTSPT LQVITLASGN VPHHTIHTQP VGKQFDRVDD
610 620 630 640 650
FFIPTTTLII THMRFGFILH KDEAALQKID LETMSYIKTI NLKDYKCVPQ
660 670 680 690 700
SLAYTHLGGY YFIGCKPDST GAVSPQVMVD GVTDSVIGFN SDVTGTPYVS
710 720 730 740 750
PDGHYLVSIN DVKGLVRVQY ITIRGEIQEA FDIYTNLHIS DLAFQPSFTE
760 770 780 790 800
AHQYNIYGSS STQTDVLFVE LSSGKVKMIK SLKEPLKAEE WPWNRKNRQI
810 820 830 840
QDSGLFGQYL MTPSKDSLFI LDGRLNKLNC EITEVEKGNT VIWVGDA
Length:847
Mass (Da):95,751
Last modified:April 12, 2005 - v2
Checksum:iAA8ECA182FF6CDB6
GO
Isoform 2 (identifier: Q8N475-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-43: Missing.

Note: No experimental confirmation available.
Show »
Length:846
Mass (Da):95,623
Checksum:i254D3EBC85178C61
GO
Isoform 3 (identifier: Q8N475-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-43: Missing.
     438-447: LANILWREEG → R

Note: No experimental confirmation available.
Show »
Length:837
Mass (Da):94,597
Checksum:iEF11265F82EB6139
GO

Sequence cautioni

The sequence BAA86577 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti145Y → C in CAB70877 (PubMed:17974005).Curated1
Sequence conflicti159K → R in CAB70877 (PubMed:17974005).Curated1
Sequence conflicti193G → D in CAB70877 (PubMed:17974005).Curated1
Sequence conflicti293D → G in CAB70877 (PubMed:17974005).Curated1
Sequence conflicti492K → I in CAB70877 (PubMed:17974005).Curated1
Sequence conflicti560S → G in AK315152 (PubMed:14702039).Curated1
Sequence conflicti567T → S in AAH36502 (PubMed:15489334).Curated1
Sequence conflicti631L → I in AAH36502 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03613592L → I in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs747628234dbSNPEnsembl.1
Natural variantiVAR_049092711D → Y.Corresponds to variant rs3749598dbSNPEnsembl.1
Natural variantiVAR_049093815K → E.Corresponds to variant rs17040982dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04621543Missing in isoform 2 and isoform 3. 2 Publications1
Alternative sequenceiVSP_046216438 – 447LANILWREEG → R in isoform 3. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033089 mRNA. Translation: BAA86577.1. Different initiation.
AK315152 mRNA. No translation available.
AC023136 Genomic DNA. No translation available.
AC079227 Genomic DNA. No translation available.
AC084281 Genomic DNA. No translation available.
AC096717 Genomic DNA. No translation available.
AC104793 Genomic DNA. No translation available.
AC105251 Genomic DNA. No translation available.
AC108163 Genomic DNA. No translation available.
BC036502 mRNA. Translation: AAH36502.1.
AL137695 mRNA. Translation: CAB70877.1.
CCDSiCCDS3802.1. [Q8N475-1]
CCDS47157.1. [Q8N475-3]
CCDS47158.1. [Q8N475-2]
PIRiT46283.
RefSeqiNP_001121899.1. NM_001128427.2. [Q8N475-2]
NP_001121900.1. NM_001128428.2. [Q8N475-3]
NP_064501.2. NM_020116.4. [Q8N475-1]
UniGeneiHs.32452.

Genome annotation databases

EnsembliENST00000306100; ENSP00000305334; ENSG00000168843. [Q8N475-1]
ENST00000379164; ENSP00000368462; ENSG00000168843. [Q8N475-2]
ENST00000427802; ENSP00000389270; ENSG00000168843. [Q8N475-3]
GeneIDi56884.
KEGGihsa:56884.
UCSCiuc003iqh.5. human. [Q8N475-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033089 mRNA. Translation: BAA86577.1. Different initiation.
AK315152 mRNA. No translation available.
AC023136 Genomic DNA. No translation available.
AC079227 Genomic DNA. No translation available.
AC084281 Genomic DNA. No translation available.
AC096717 Genomic DNA. No translation available.
AC104793 Genomic DNA. No translation available.
AC105251 Genomic DNA. No translation available.
AC108163 Genomic DNA. No translation available.
BC036502 mRNA. Translation: AAH36502.1.
AL137695 mRNA. Translation: CAB70877.1.
CCDSiCCDS3802.1. [Q8N475-1]
CCDS47157.1. [Q8N475-3]
CCDS47158.1. [Q8N475-2]
PIRiT46283.
RefSeqiNP_001121899.1. NM_001128427.2. [Q8N475-2]
NP_001121900.1. NM_001128428.2. [Q8N475-3]
NP_064501.2. NM_020116.4. [Q8N475-1]
UniGeneiHs.32452.

3D structure databases

ProteinModelPortaliQ8N475.
SMRiQ8N475.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121216. 2 interactors.
IntActiQ8N475. 1 interactor.
STRINGi9606.ENSP00000305334.

Protein family/group databases

MEROPSiI01.977.

PTM databases

iPTMnetiQ8N475.
PhosphoSitePlusiQ8N475.

Polymorphism and mutation databases

BioMutaiFSTL5.
DMDMi62510692.

Proteomic databases

EPDiQ8N475.
MaxQBiQ8N475.
PaxDbiQ8N475.
PeptideAtlasiQ8N475.
PRIDEiQ8N475.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306100; ENSP00000305334; ENSG00000168843. [Q8N475-1]
ENST00000379164; ENSP00000368462; ENSG00000168843. [Q8N475-2]
ENST00000427802; ENSP00000389270; ENSG00000168843. [Q8N475-3]
GeneIDi56884.
KEGGihsa:56884.
UCSCiuc003iqh.5. human. [Q8N475-1]

Organism-specific databases

CTDi56884.
DisGeNETi56884.
GeneCardsiFSTL5.
H-InvDBHIX0004604.
HGNCiHGNC:21386. FSTL5.
HPAiHPA045909.
HPA046724.
neXtProtiNX_Q8N475.
OpenTargetsiENSG00000168843.
PharmGKBiPA134978045.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEEJ. Eukaryota.
ENOG410YBHC. LUCA.
GeneTreeiENSGT00530000063333.
HOGENOMiHOG000236319.
HOVERGENiHBG051667.
InParanoidiQ8N475.
OMAiFGSCENK.
OrthoDBiEOG091G0C29.
PhylomeDBiQ8N475.
TreeFamiTF350473.

Miscellaneous databases

ChiTaRSiFSTL5. human.
GenomeRNAii56884.
PROiQ8N475.

Gene expression databases

BgeeiENSG00000168843.
CleanExiHS_FSTL5.
GenevisibleiQ8N475. HS.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
2.130.10.10. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR002350. Kazal_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF07648. Kazal_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF48726. SSF48726. 2 hits.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 1 hit.
PS50835. IG_LIKE. 2 hits.
PS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFSTL5_HUMAN
AccessioniPrimary (citable) accession number: Q8N475
Secondary accession number(s): E9PCP6, Q9NSW7, Q9ULF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: April 12, 2005
Last modified: November 2, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.