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Protein

Follistatin-related protein 5

Gene

FSTL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi188 – 2001PROSITE-ProRule annotationAdd BLAST13
Calcium bindingi226 – 2382PROSITE-ProRule annotationAdd BLAST13

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding

Protein family/group databases

MEROPSiI01.977

Names & Taxonomyi

Protein namesi
Recommended name:
Follistatin-related protein 5
Alternative name(s):
Follistatin-like protein 5
Gene namesi
Name:FSTL5
Synonyms:KIAA1263
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000168843.13
HGNCiHGNC:21386 FSTL5
neXtProtiNX_Q8N475

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi56884
OpenTargetsiENSG00000168843
PharmGKBiPA134978045

Polymorphism and mutation databases

BioMutaiFSTL5
DMDMi62510692

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001011821 – 847Follistatin-related protein 5Add BLAST827

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi89 ↔ 119PROSITE-ProRule annotation
Disulfide bondi93 ↔ 112PROSITE-ProRule annotation
Disulfide bondi101 ↔ 133PROSITE-ProRule annotation
Disulfide bondi270 ↔ 321By similarity
Glycosylationi318N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi362 ↔ 413By similarity
Glycosylationi394N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8N475
MaxQBiQ8N475
PaxDbiQ8N475
PeptideAtlasiQ8N475
PRIDEiQ8N475

PTM databases

iPTMnetiQ8N475
PhosphoSitePlusiQ8N475

Expressioni

Gene expression databases

BgeeiENSG00000168843
CleanExiHS_FSTL5
GenevisibleiQ8N475 HS

Organism-specific databases

HPAiHPA045909
HPA046724

Interactioni

Protein-protein interaction databases

BioGridi121216, 2 interactors
IntActiQ8N475, 1 interactor
STRINGi9606.ENSP00000305334

Structurei

3D structure databases

ProteinModelPortaliQ8N475
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 135Kazal-likePROSITE-ProRule annotationAdd BLAST53
Domaini175 – 210EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini211 – 246EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini250 – 337Ig-like 1Add BLAST88
Domaini341 – 426Ig-like 2Add BLAST86

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IEEJ Eukaryota
ENOG410YBHC LUCA
GeneTreeiENSGT00530000063333
HOGENOMiHOG000236319
HOVERGENiHBG051667
InParanoidiQ8N475
OMAiFGSCENK
OrthoDBiEOG091G0C29
PhylomeDBiQ8N475
TreeFamiTF350473

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SM00280 KAZAL, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF47473 SSF47473, 1 hit
SSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 1 hit
PS50835 IG_LIKE, 2 hits
PS51465 KAZAL_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N475-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFKCWSVVLV LGFIFLESEG RPTKEGGYGL KSYQPLMRLR HKQEKNQESS
60 70 80 90 100
RVKGFMIQDG PFGSCENKYC GLGRHCVTSR ETGQAECACM DLCKRHYKPV
110 120 130 140 150
CGSDGEFYEN HCEVHRAACL KKQKITIVHN EDCFFKGDKC KTTEYSKMKN
160 170 180 190 200
MLLDLQNQKY IMQENENPNG DDISRKKLLV DQMFKYFDAD SNGLVDINEL
210 220 230 240 250
TQVIKQEELG KDLFDCTLYV LLKYDDFNAD KHLALEEFYR AFQVIQLSLP
260 270 280 290 300
EDQKLSITAA TVGQSAVLSC AIQGTLRPPI IWKRNNIILN NLDLEDINDF
310 320 330 340 350
GDDGSLYITK VTTTHVGNYT CYADGYEQVY QTHIFQVNVP PVIRVYPESQ
360 370 380 390 400
AREPGVTASL RCHAEGIPKP QLGWLKNGID ITPKLSKQLT LQANGSEVHI
410 420 430 440 450
SNVRYEDTGA YTCIAKNEAG VDEDISSLFV EDSARKTLAN ILWREEGLGI
460 470 480 490 500
GNMFYVFYED GIKVIQPIEC EFQRHIKPSE KLLGFQDEVC PKAEGDEVQR
510 520 530 540 550
CVWASAVNVK DKFIYVAQPT LDRVLIVDVQ SQKVVQAVST DPVPVKLHYD
560 570 580 590 600
KSHDQVWVLS WGTLEKTSPT LQVITLASGN VPHHTIHTQP VGKQFDRVDD
610 620 630 640 650
FFIPTTTLII THMRFGFILH KDEAALQKID LETMSYIKTI NLKDYKCVPQ
660 670 680 690 700
SLAYTHLGGY YFIGCKPDST GAVSPQVMVD GVTDSVIGFN SDVTGTPYVS
710 720 730 740 750
PDGHYLVSIN DVKGLVRVQY ITIRGEIQEA FDIYTNLHIS DLAFQPSFTE
760 770 780 790 800
AHQYNIYGSS STQTDVLFVE LSSGKVKMIK SLKEPLKAEE WPWNRKNRQI
810 820 830 840
QDSGLFGQYL MTPSKDSLFI LDGRLNKLNC EITEVEKGNT VIWVGDA
Length:847
Mass (Da):95,751
Last modified:April 12, 2005 - v2
Checksum:iAA8ECA182FF6CDB6
GO
Isoform 2 (identifier: Q8N475-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-43: Missing.

Note: No experimental confirmation available.
Show »
Length:846
Mass (Da):95,623
Checksum:i254D3EBC85178C61
GO
Isoform 3 (identifier: Q8N475-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-43: Missing.
     438-447: LANILWREEG → R

Note: No experimental confirmation available.
Show »
Length:837
Mass (Da):94,597
Checksum:iEF11265F82EB6139
GO

Sequence cautioni

The sequence BAA86577 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti145Y → C in CAB70877 (PubMed:17974005).Curated1
Sequence conflicti159K → R in CAB70877 (PubMed:17974005).Curated1
Sequence conflicti193G → D in CAB70877 (PubMed:17974005).Curated1
Sequence conflicti293D → G in CAB70877 (PubMed:17974005).Curated1
Sequence conflicti492K → I in CAB70877 (PubMed:17974005).Curated1
Sequence conflicti560S → G in AK315152 (PubMed:14702039).Curated1
Sequence conflicti567T → S in AAH36502 (PubMed:15489334).Curated1
Sequence conflicti631L → I in AAH36502 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03613592L → I in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs747628234Ensembl.1
Natural variantiVAR_049092711D → Y. Corresponds to variant dbSNP:rs3749598Ensembl.1
Natural variantiVAR_049093815K → E. Corresponds to variant dbSNP:rs17040982Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04621543Missing in isoform 2 and isoform 3. 2 Publications1
Alternative sequenceiVSP_046216438 – 447LANILWREEG → R in isoform 3. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033089 mRNA Translation: BAA86577.1 Different initiation.
AK315152 mRNA No translation available.
AC023136 Genomic DNA No translation available.
AC079227 Genomic DNA No translation available.
AC084281 Genomic DNA No translation available.
AC096717 Genomic DNA No translation available.
AC104793 Genomic DNA No translation available.
AC105251 Genomic DNA No translation available.
AC108163 Genomic DNA No translation available.
BC036502 mRNA Translation: AAH36502.1
AL137695 mRNA Translation: CAB70877.1
CCDSiCCDS3802.1 [Q8N475-1]
CCDS47157.1 [Q8N475-3]
CCDS47158.1 [Q8N475-2]
PIRiT46283
RefSeqiNP_001121899.1, NM_001128427.2 [Q8N475-2]
NP_001121900.1, NM_001128428.2 [Q8N475-3]
NP_064501.2, NM_020116.4 [Q8N475-1]
UniGeneiHs.32452

Genome annotation databases

EnsembliENST00000306100; ENSP00000305334; ENSG00000168843 [Q8N475-1]
ENST00000379164; ENSP00000368462; ENSG00000168843 [Q8N475-2]
ENST00000427802; ENSP00000389270; ENSG00000168843 [Q8N475-3]
GeneIDi56884
KEGGihsa:56884
UCSCiuc003iqh.5 human [Q8N475-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFSTL5_HUMAN
AccessioniPrimary (citable) accession number: Q8N475
Secondary accession number(s): E9PCP6, Q9NSW7, Q9ULF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: April 12, 2005
Last modified: May 23, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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