ID   FXL16_HUMAN             Reviewed;         479 AA.
AC   Q8N461; B3KR59; D3DU60; Q2MHR2; Q96S14; Q9UJI0;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 2.
DT   27-MAR-2024, entry version 172.
DE   RecName: Full=F-box/LRR-repeat protein 16;
DE   AltName: Full=F-box and leucine-rich repeat protein 16;
GN   Name=FBXL16; Synonyms=C16orf22, FBL16;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT PRO-429.
RX   PubMed=11157797; DOI=10.1093/hmg/10.4.339;
RA   Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C.,
RA   Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.;
RT   "Sequence, structure and pathology of the fully annotated terminal 2 Mb of
RT   the short arm of human chromosome 16.";
RL   Hum. Mol. Genet. 10:339-352(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA   Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA   Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA   Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA   Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA   Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA   Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA   Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA   Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA   Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA   Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA   Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA   Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA   Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA   Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA   Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA   Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA   DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA   Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA   Myers R.M., Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT PRO-429.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SKP1 and CUL1. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q8N461; Q16665: HIF1A; NbExp=6; IntAct=EBI-7208098, EBI-447269;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8N461-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8N461-2; Sequence=VSP_056996;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK61245.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AK091054; BAG52271.1; -; mRNA.
DR   EMBL; AE006464; AAK61245.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; Z92544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; Z97653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471112; EAW85749.1; -; Genomic_DNA.
DR   EMBL; CH471112; EAW85750.1; -; Genomic_DNA.
DR   EMBL; BC036680; AAH36680.1; -; mRNA.
DR   CCDS; CCDS10421.1; -. [Q8N461-1]
DR   RefSeq; NP_699181.2; NM_153350.3. [Q8N461-1]
DR   AlphaFoldDB; Q8N461; -.
DR   SMR; Q8N461; -.
DR   BioGRID; 126979; 31.
DR   ComplexPortal; CPX-2343; SCF E3 ubiquitin ligase complex, FBXL16 variant.
DR   IntAct; Q8N461; 15.
DR   MINT; Q8N461; -.
DR   STRING; 9606.ENSP00000380746; -.
DR   iPTMnet; Q8N461; -.
DR   PhosphoSitePlus; Q8N461; -.
DR   BioMuta; FBXL16; -.
DR   DMDM; 116242480; -.
DR   EPD; Q8N461; -.
DR   jPOST; Q8N461; -.
DR   MassIVE; Q8N461; -.
DR   MaxQB; Q8N461; -.
DR   PaxDb; 9606-ENSP00000380746; -.
DR   PeptideAtlas; Q8N461; -.
DR   ProteomicsDB; 3581; -.
DR   ProteomicsDB; 71888; -. [Q8N461-1]
DR   Antibodypedia; 22839; 137 antibodies from 26 providers.
DR   DNASU; 146330; -.
DR   Ensembl; ENST00000397621.6; ENSP00000380746.1; ENSG00000127585.13. [Q8N461-1]
DR   Ensembl; ENST00000562563.1; ENSP00000455217.1; ENSG00000127585.13. [Q8N461-2]
DR   GeneID; 146330; -.
DR   KEGG; hsa:146330; -.
DR   MANE-Select; ENST00000397621.6; ENSP00000380746.1; NM_153350.4; NP_699181.2.
DR   UCSC; uc002cjb.4; human. [Q8N461-1]
DR   AGR; HGNC:14150; -.
DR   CTD; 146330; -.
DR   DisGeNET; 146330; -.
DR   GeneCards; FBXL16; -.
DR   HGNC; HGNC:14150; FBXL16.
DR   HPA; ENSG00000127585; Tissue enriched (brain).
DR   MIM; 609082; gene.
DR   neXtProt; NX_Q8N461; -.
DR   OpenTargets; ENSG00000127585; -.
DR   PharmGKB; PA25536; -.
DR   VEuPathDB; HostDB:ENSG00000127585; -.
DR   eggNOG; KOG1947; Eukaryota.
DR   GeneTree; ENSGT00940000159138; -.
DR   HOGENOM; CLU_027026_1_0_1; -.
DR   InParanoid; Q8N461; -.
DR   OMA; FWAGLMP; -.
DR   OrthoDB; 2938287at2759; -.
DR   PhylomeDB; Q8N461; -.
DR   TreeFam; TF324260; -.
DR   PathwayCommons; Q8N461; -.
DR   Reactome; R-HSA-8951664; Neddylation.
DR   Reactome; R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   SignaLink; Q8N461; -.
DR   BioGRID-ORCS; 146330; 15 hits in 1190 CRISPR screens.
DR   ChiTaRS; FBXL16; human.
DR   GenomeRNAi; 146330; -.
DR   Pharos; Q8N461; Tdark.
DR   PRO; PR:Q8N461; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   RNAct; Q8N461; Protein.
DR   Bgee; ENSG00000127585; Expressed in Brodmann (1909) area 46 and 168 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   CDD; cd22127; F-box_FBXL16; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR13382:SF74; F-BOX AND LEUCINE RICH REPEAT PROTEIN 16; 1.
DR   PANTHER; PTHR13382; MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B; 1.
DR   Pfam; PF13516; LRR_6; 2.
DR   SMART; SM00367; LRR_CC; 8.
DR   SUPFAM; SSF81383; F-box domain; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   Genevisible; Q8N461; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Leucine-rich repeat; Methylation; Reference proteome;
KW   Repeat; Ubl conjugation pathway.
FT   CHAIN           1..479
FT                   /note="F-box/LRR-repeat protein 16"
FT                   /id="PRO_0000119863"
FT   DOMAIN          94..139
FT                   /note="F-box"
FT   REPEAT          244..266
FT                   /note="LRR 1"
FT   REPEAT          267..290
FT                   /note="LRR 2"
FT   REPEAT          319..343
FT                   /note="LRR 3"
FT   REPEAT          345..369
FT                   /note="LRR 4"
FT   REPEAT          371..395
FT                   /note="LRR 5"
FT   REPEAT          396..420
FT                   /note="LRR 6"
FT   REPEAT          446..470
FT                   /note="LRR 7"
FT   REGION          1..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..60
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         92
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:A2RT62"
FT   VAR_SEQ         1..212
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_056996"
FT   VARIANT         429
FT                   /note="L -> P (in dbSNP:rs17855603)"
FT                   /evidence="ECO:0000269|PubMed:11157797,
FT                   ECO:0000269|PubMed:15489334"
FT                   /id="VAR_028163"
SQ   SEQUENCE   479 AA;  51658 MW;  BC5E2EF407142A5A CRC64;
     MSSPGIDGDP KPPCLPRNGL VKLPGQPNGL GAASITKGTP ATKNRPCQPP PPPTLPPPSL
     AAPLSRAALA GGPCTPAGGP ASALAPGHPA ERPPLATDEK ILNGLFWYFS ACEKCVLAQV
     CKAWRRVLYQ PKFWAGLTPV LHAKELYNVL PGGEKEFVNL QGFAARGFEG FCLVGVSDLD
     ICEFIDNYAL SKKGVKAMSL KRSTITDAGL EVMLEQMQGV VRLELSGCND FTEAGLWSSL
     SARITSLSVS DCINVADDAI AAISQLLPNL AELSLQAYHV TDTALAYFTA RQGHSTHTLR
     LLSCWEITNH GVVNVVHSLP NLTALSLSGC SKVTDDGVEL VAENLRKLRS LDLSWCPRIT
     DMALEYVACD LHRLEELVLD RCVRITDTGL SYLSTMSSLR SLYLRWCCQV QDFGLKHLLA
     LGSLRLLSLA GCPLLTTTGL SGLVQLQELE ELELTNCPGA TPELFKYFSQ HLPRCLVIE
//