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Q8N461 (FXL16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
F-box/LRR-repeat protein 16
Alternative name(s):
F-box and leucine-rich repeat protein 16
Gene names
Name:FBXL16
Synonyms:C16orf22, FBL16
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length479 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex By similarity.

Subunit structure

Interacts with SKP1 and CUL1 By similarity.

Sequence similarities

Contains 1 F-box domain.

Contains 7 LRR (leucine-rich) repeats.

Sequence caution

The sequence AAK61245.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Coding sequence diversityPolymorphism
   DomainLeucine-rich repeat
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 479479F-box/LRR-repeat protein 16
PRO_0000119863

Regions

Domain94 – 13946F-box
Repeat244 – 26623LRR 1
Repeat267 – 29024LRR 2
Repeat319 – 34325LRR 3
Repeat345 – 36925LRR 4
Repeat371 – 39525LRR 5
Repeat396 – 42025LRR 6
Repeat446 – 47025LRR 7
Compositional bias10 – 9485Pro-rich

Natural variations

Natural variant4291L → P. Ref.1 Ref.4
Corresponds to variant rs17855603 [ dbSNP | Ensembl ].
VAR_028163

Sequences

Sequence LengthMass (Da)Tools
Q8N461 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: BC5E2EF407142A5A

FASTA47951,658
        10         20         30         40         50         60 
MSSPGIDGDP KPPCLPRNGL VKLPGQPNGL GAASITKGTP ATKNRPCQPP PPPTLPPPSL 

        70         80         90        100        110        120 
AAPLSRAALA GGPCTPAGGP ASALAPGHPA ERPPLATDEK ILNGLFWYFS ACEKCVLAQV 

       130        140        150        160        170        180 
CKAWRRVLYQ PKFWAGLTPV LHAKELYNVL PGGEKEFVNL QGFAARGFEG FCLVGVSDLD 

       190        200        210        220        230        240 
ICEFIDNYAL SKKGVKAMSL KRSTITDAGL EVMLEQMQGV VRLELSGCND FTEAGLWSSL 

       250        260        270        280        290        300 
SARITSLSVS DCINVADDAI AAISQLLPNL AELSLQAYHV TDTALAYFTA RQGHSTHTLR 

       310        320        330        340        350        360 
LLSCWEITNH GVVNVVHSLP NLTALSLSGC SKVTDDGVEL VAENLRKLRS LDLSWCPRIT 

       370        380        390        400        410        420 
DMALEYVACD LHRLEELVLD RCVRITDTGL SYLSTMSSLR SLYLRWCCQV QDFGLKHLLA 

       430        440        450        460        470 
LGSLRLLSLA GCPLLTTTGL SGLVQLQELE ELELTNCPGA TPELFKYFSQ HLPRCLVIE 

« Hide

References

[1]"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-429.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-429.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006464 Genomic DNA. Translation: AAK61245.1. Sequence problems.
Z97653 Genomic DNA. Translation: CAJ55832.1.
CH471112 Genomic DNA. Translation: EAW85749.1.
CH471112 Genomic DNA. Translation: EAW85750.1.
BC036680 mRNA. Translation: AAH36680.1.
CCDSCCDS10421.1.
RefSeqNP_699181.2. NM_153350.3.
XP_005255189.1. XM_005255132.1.
UniGeneHs.513244.

3D structure databases

ProteinModelPortalQ8N461.
SMRQ8N461. Positions 193-227, 318-479.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126979. 3 interactions.
IntActQ8N461. 2 interactions.
MINTMINT-8247545.
STRING9606.ENSP00000318674.

PTM databases

PhosphoSiteQ8N461.

Polymorphism databases

DMDM116242480.

Proteomic databases

MaxQBQ8N461.
PaxDbQ8N461.
PeptideAtlasQ8N461.
PRIDEQ8N461.

Protocols and materials databases

DNASU146330.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000324361; ENSP00000318674; ENSG00000127585.
ENST00000397621; ENSP00000380746; ENSG00000127585.
GeneID146330.
KEGGhsa:146330.
UCSCuc002cjb.3. human.

Organism-specific databases

CTD146330.
GeneCardsGC16M000742.
HGNCHGNC:14150. FBXL16.
HPAHPA039504.
MIM609082. gene.
neXtProtNX_Q8N461.
PharmGKBPA25536.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG279509.
HOGENOMHOG000060108.
HOVERGENHBG051675.
InParanoidQ8N461.
KOK10282.
OMARGFEGFC.
OrthoDBEOG75MVVV.
PhylomeDBQ8N461.
TreeFamTF324260.

Gene expression databases

ArrayExpressQ8N461.
BgeeQ8N461.
CleanExHS_FBXL16.
GenevestigatorQ8N461.

Family and domain databases

InterProIPR001810. F-box_dom.
[Graphical view]
SUPFAMSSF81383. SSF81383. 1 hit.
ProtoNetSearch...

Other

ChiTaRSFBXL16. human.
GenomeRNAi146330.
NextBio85333.
PROQ8N461.
SOURCESearch...

Entry information

Entry nameFXL16_HUMAN
AccessionPrimary (citable) accession number: Q8N461
Secondary accession number(s): D3DU60 expand/collapse secondary AC list , Q2MHR2, Q96S14, Q9UJI0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM