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Protein

F-box/LRR-repeat protein 16

Gene

FBXL16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 16
Alternative name(s):
F-box and leucine-rich repeat protein 16
Gene namesi
Name:FBXL16
Synonyms:C16orf22, FBL16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:14150. FBXL16.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000127585.
PharmGKBiPA25536.

Polymorphism and mutation databases

BioMutaiFBXL16.
DMDMi116242480.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198631 – 479F-box/LRR-repeat protein 16Add BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei92Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiQ8N461.
PaxDbiQ8N461.
PeptideAtlasiQ8N461.
PRIDEiQ8N461.

PTM databases

iPTMnetiQ8N461.
PhosphoSitePlusiQ8N461.

Expressioni

Gene expression databases

BgeeiENSG00000127585.
CleanExiHS_FBXL16.
GenevisibleiQ8N461. HS.

Organism-specific databases

HPAiHPA039504.
HPA056354.

Interactioni

Subunit structurei

Interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridi126979. 12 interactors.
IntActiQ8N461. 8 interactors.
MINTiMINT-8247545.
STRINGi9606.ENSP00000318674.

Structurei

3D structure databases

ProteinModelPortaliQ8N461.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 139F-boxAdd BLAST46
Repeati244 – 266LRR 1Add BLAST23
Repeati267 – 290LRR 2Add BLAST24
Repeati319 – 343LRR 3Add BLAST25
Repeati345 – 369LRR 4Add BLAST25
Repeati371 – 395LRR 5Add BLAST25
Repeati396 – 420LRR 6Add BLAST25
Repeati446 – 470LRR 7Add BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 94Pro-richAdd BLAST85

Sequence similaritiesi

Contains 1 F-box domain.Curated
Contains 7 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IT21. Eukaryota.
ENOG410XQRM. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000060108.
HOVERGENiHBG051675.
InParanoidiQ8N461.
KOiK10282.
OMAiNCPGATA.
OrthoDBiEOG091G0NN8.
PhylomeDBiQ8N461.
TreeFamiTF324260.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
[Graphical view]
SMARTiSM00367. LRR_CC. 8 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N461-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSPGIDGDP KPPCLPRNGL VKLPGQPNGL GAASITKGTP ATKNRPCQPP
60 70 80 90 100
PPPTLPPPSL AAPLSRAALA GGPCTPAGGP ASALAPGHPA ERPPLATDEK
110 120 130 140 150
ILNGLFWYFS ACEKCVLAQV CKAWRRVLYQ PKFWAGLTPV LHAKELYNVL
160 170 180 190 200
PGGEKEFVNL QGFAARGFEG FCLVGVSDLD ICEFIDNYAL SKKGVKAMSL
210 220 230 240 250
KRSTITDAGL EVMLEQMQGV VRLELSGCND FTEAGLWSSL SARITSLSVS
260 270 280 290 300
DCINVADDAI AAISQLLPNL AELSLQAYHV TDTALAYFTA RQGHSTHTLR
310 320 330 340 350
LLSCWEITNH GVVNVVHSLP NLTALSLSGC SKVTDDGVEL VAENLRKLRS
360 370 380 390 400
LDLSWCPRIT DMALEYVACD LHRLEELVLD RCVRITDTGL SYLSTMSSLR
410 420 430 440 450
SLYLRWCCQV QDFGLKHLLA LGSLRLLSLA GCPLLTTTGL SGLVQLQELE
460 470
ELELTNCPGA TPELFKYFSQ HLPRCLVIE
Length:479
Mass (Da):51,658
Last modified:October 17, 2006 - v2
Checksum:iBC5E2EF407142A5A
GO
Isoform 2 (identifier: Q8N461-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-212: Missing.

Note: No experimental confirmation available.
Show »
Length:267
Mass (Da):29,423
Checksum:i657FB1C6B0077BEB
GO

Sequence cautioni

The sequence AAK61245 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028163429L → P.2 PublicationsCorresponds to variant rs17855603dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0569961 – 212Missing in isoform 2. 1 PublicationAdd BLAST212

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091054 mRNA. Translation: BAG52271.1.
AE006464 Genomic DNA. Translation: AAK61245.1. Sequence problems.
Z92544 Genomic DNA. No translation available.
Z97653 Genomic DNA. Translation: CAJ55832.1.
CH471112 Genomic DNA. Translation: EAW85749.1.
CH471112 Genomic DNA. Translation: EAW85750.1.
BC036680 mRNA. Translation: AAH36680.1.
CCDSiCCDS10421.1. [Q8N461-1]
RefSeqiNP_699181.2. NM_153350.3. [Q8N461-1]
UniGeneiHs.513244.

Genome annotation databases

EnsembliENST00000324361; ENSP00000318674; ENSG00000127585. [Q8N461-1]
ENST00000397621; ENSP00000380746; ENSG00000127585. [Q8N461-1]
ENST00000562563; ENSP00000455217; ENSG00000127585. [Q8N461-2]
GeneIDi146330.
KEGGihsa:146330.
UCSCiuc002cjb.4. human. [Q8N461-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091054 mRNA. Translation: BAG52271.1.
AE006464 Genomic DNA. Translation: AAK61245.1. Sequence problems.
Z92544 Genomic DNA. No translation available.
Z97653 Genomic DNA. Translation: CAJ55832.1.
CH471112 Genomic DNA. Translation: EAW85749.1.
CH471112 Genomic DNA. Translation: EAW85750.1.
BC036680 mRNA. Translation: AAH36680.1.
CCDSiCCDS10421.1. [Q8N461-1]
RefSeqiNP_699181.2. NM_153350.3. [Q8N461-1]
UniGeneiHs.513244.

3D structure databases

ProteinModelPortaliQ8N461.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126979. 12 interactors.
IntActiQ8N461. 8 interactors.
MINTiMINT-8247545.
STRINGi9606.ENSP00000318674.

PTM databases

iPTMnetiQ8N461.
PhosphoSitePlusiQ8N461.

Polymorphism and mutation databases

BioMutaiFBXL16.
DMDMi116242480.

Proteomic databases

MaxQBiQ8N461.
PaxDbiQ8N461.
PeptideAtlasiQ8N461.
PRIDEiQ8N461.

Protocols and materials databases

DNASUi146330.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324361; ENSP00000318674; ENSG00000127585. [Q8N461-1]
ENST00000397621; ENSP00000380746; ENSG00000127585. [Q8N461-1]
ENST00000562563; ENSP00000455217; ENSG00000127585. [Q8N461-2]
GeneIDi146330.
KEGGihsa:146330.
UCSCiuc002cjb.4. human. [Q8N461-1]

Organism-specific databases

CTDi146330.
GeneCardsiFBXL16.
HGNCiHGNC:14150. FBXL16.
HPAiHPA039504.
HPA056354.
MIMi609082. gene.
neXtProtiNX_Q8N461.
OpenTargetsiENSG00000127585.
PharmGKBiPA25536.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IT21. Eukaryota.
ENOG410XQRM. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000060108.
HOVERGENiHBG051675.
InParanoidiQ8N461.
KOiK10282.
OMAiNCPGATA.
OrthoDBiEOG091G0NN8.
PhylomeDBiQ8N461.
TreeFamiTF324260.

Enzyme and pathway databases

ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiFBXL16. human.
GenomeRNAii146330.
PROiQ8N461.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127585.
CleanExiHS_FBXL16.
GenevisibleiQ8N461. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
[Graphical view]
SMARTiSM00367. LRR_CC. 8 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFXL16_HUMAN
AccessioniPrimary (citable) accession number: Q8N461
Secondary accession number(s): B3KR59
, D3DU60, Q2MHR2, Q96S14, Q9UJI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.