Q8N461 (FXL16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
F-box/LRR-repeat protein 16

Alternative name(s):
F-box and leucine-rich repeat protein 16

Gene names

Name:	FBXL16
Synonyms:	C16orf22, FBL16

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	479 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex By similarity.
Subunit structure	Interacts with SKP1 and CUL1 By similarity.
Sequence similarities	Contains 1 F-box domain. Contains 7 LRR (leucine-rich) repeats.
Sequence caution	The sequence AAK61245.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Coding sequence diversity	Polymorphism
Domain	Leucine-rich repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 479	479	F-box/LRR-repeat protein 16		PRO_0000119863
Regions
	Domain	94 – 139	46	F-box
	Repeat	244 – 266	23	LRR 1
	Repeat	267 – 290	24	LRR 2
	Repeat	319 – 343	25	LRR 3
	Repeat	345 – 369	25	LRR 4
	Repeat	371 – 395	25	LRR 5
	Repeat	396 – 420	25	LRR 6
	Repeat	446 – 470	25	LRR 7
	Compositional bias	10 – 94	85	Pro-rich
Natural variations
	Natural variant	429	1	L → P. Ref.1 Ref.4 Corresponds to variant rs17855603 [ dbSNP | Ensembl ].		VAR_028163

Sequences

	Sequence		Length	Mass (Da)
	Q8N461 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: BC5E2EF407142A5A	FASTA	479	51,658
	10 20 30 40 50 60 MSSPGIDGDP KPPCLPRNGL VKLPGQPNGL GAASITKGTP ATKNRPCQPP PPPTLPPPSL 70 80 90 100 110 120 AAPLSRAALA GGPCTPAGGP ASALAPGHPA ERPPLATDEK ILNGLFWYFS ACEKCVLAQV 130 140 150 160 170 180 CKAWRRVLYQ PKFWAGLTPV LHAKELYNVL PGGEKEFVNL QGFAARGFEG FCLVGVSDLD 190 200 210 220 230 240 ICEFIDNYAL SKKGVKAMSL KRSTITDAGL EVMLEQMQGV VRLELSGCND FTEAGLWSSL 250 260 270 280 290 300 SARITSLSVS DCINVADDAI AAISQLLPNL AELSLQAYHV TDTALAYFTA RQGHSTHTLR 310 320 330 340 350 360 LLSCWEITNH GVVNVVHSLP NLTALSLSGC SKVTDDGVEL VAENLRKLRS LDLSWCPRIT 370 380 390 400 410 420 DMALEYVACD LHRLEELVLD RCVRITDTGL SYLSTMSSLR SLYLRWCCQV QDFGLKHLLA 430 440 450 460 470 LGSLRLLSLA GCPLLTTTGL SGLVQLQELE ELELTNCPGA TPELFKYFSQ HLPRCLVIE

References

[1]	"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16." Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R. Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-429.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-429. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006464 Genomic DNA. Translation: AAK61245.1. Sequence problems. Z97653 Genomic DNA. Translation: CAJ55832.1. CH471112 Genomic DNA. Translation: EAW85749.1. CH471112 Genomic DNA. Translation: EAW85750.1. BC036680 mRNA. Translation: AAH36680.1.
IPI	IPI00181733.
RefSeq	NP_699181.2. NM_153350.3.
UniGene	Hs.513244.
3D structure databases
ProteinModelPortal	Q8N461.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000318674.
PTM databases
PhosphoSite	Q8N461.
Polymorphism databases
DMDM	116242480.
Proteomic databases
PaxDb	Q8N461.
PeptideAtlas	Q8N461.
PRIDE	Q8N461.
Protocols and materials databases
DNASU	146330.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000324361; ENSP00000318674; ENSG00000127585. ENST00000397621; ENSP00000380746; ENSG00000127585.
GeneID	146330.
KEGG	hsa:146330.
UCSC	uc002cjb.3. human.
Organism-specific databases
CTD	146330.
GeneCards	GC16M000742.
HGNC	HGNC:14150. FBXL16.
HPA	HPA039504.
MIM	609082. gene.
neXtProt	NX_Q8N461.
PharmGKB	PA25536.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG279509.
HOGENOM	HOG000060108.
HOVERGEN	HBG051675.
InParanoid	Q8N461.
KO	K10282.
OMA	AGLEVML.
OrthoDB	EOG4PRSQR.
Gene expression databases
ArrayExpress	Q8N461.
Bgee	Q8N461.
CleanEx	HS_FBXL16.
Genevestigator	Q8N461.
GermOnline	ENSG00000127585. Homo sapiens.
Family and domain databases
InterPro	IPR001810. F-box_dom_cyclin-like. [Graphical view]
SUPFAM	SSF81383. F-box_dom_Skp2-like. 1 hit.
PROSITE	PS50181. FBOX. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FBXL16. human.
GenomeRNAi	146330.
NextBio	85333.
SOURCE	Search...

Entry information

Entry name

FXL16_HUMAN

Accession

Primary (citable) accession number: Q8N461
Secondary accession number(s): D3DU60 , Q2MHR2, Q96S14, Q9UJI0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	October 17, 2006
Last modified:	May 1, 2013
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.