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Q8N461

- FXL16_HUMAN

UniProt

Q8N461 - FXL16_HUMAN

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Protein
F-box/LRR-repeat protein 16
Gene
FBXL16, C16orf22, FBL16
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex By similarity.

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 16
Alternative name(s):
F-box and leucine-rich repeat protein 16
Gene namesi
Name:FBXL16
Synonyms:C16orf22, FBL16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:14150. FBXL16.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25536.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 479479F-box/LRR-repeat protein 16
PRO_0000119863Add
BLAST

Proteomic databases

MaxQBiQ8N461.
PaxDbiQ8N461.
PeptideAtlasiQ8N461.
PRIDEiQ8N461.

PTM databases

PhosphoSiteiQ8N461.

Expressioni

Gene expression databases

ArrayExpressiQ8N461.
BgeeiQ8N461.
CleanExiHS_FBXL16.
GenevestigatoriQ8N461.

Organism-specific databases

HPAiHPA039504.

Interactioni

Subunit structurei

Interacts with SKP1 and CUL1 By similarity.

Protein-protein interaction databases

BioGridi126979. 3 interactions.
IntActiQ8N461. 2 interactions.
MINTiMINT-8247545.
STRINGi9606.ENSP00000318674.

Structurei

3D structure databases

ProteinModelPortaliQ8N461.
SMRiQ8N461. Positions 193-227, 318-479.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 13946F-box
Add
BLAST
Repeati244 – 26623LRR 1
Add
BLAST
Repeati267 – 29024LRR 2
Add
BLAST
Repeati319 – 34325LRR 3
Add
BLAST
Repeati345 – 36925LRR 4
Add
BLAST
Repeati371 – 39525LRR 5
Add
BLAST
Repeati396 – 42025LRR 6
Add
BLAST
Repeati446 – 47025LRR 7
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi10 – 9485Pro-rich
Add
BLAST

Sequence similaritiesi

Contains 1 F-box domain.

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiNOG279509.
HOGENOMiHOG000060108.
HOVERGENiHBG051675.
InParanoidiQ8N461.
KOiK10282.
OMAiRGFEGFC.
OrthoDBiEOG75MVVV.
PhylomeDBiQ8N461.
TreeFamiTF324260.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8N461-1 [UniParc]FASTAAdd to Basket

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MSSPGIDGDP KPPCLPRNGL VKLPGQPNGL GAASITKGTP ATKNRPCQPP    50
PPPTLPPPSL AAPLSRAALA GGPCTPAGGP ASALAPGHPA ERPPLATDEK 100
ILNGLFWYFS ACEKCVLAQV CKAWRRVLYQ PKFWAGLTPV LHAKELYNVL 150
PGGEKEFVNL QGFAARGFEG FCLVGVSDLD ICEFIDNYAL SKKGVKAMSL 200
KRSTITDAGL EVMLEQMQGV VRLELSGCND FTEAGLWSSL SARITSLSVS 250
DCINVADDAI AAISQLLPNL AELSLQAYHV TDTALAYFTA RQGHSTHTLR 300
LLSCWEITNH GVVNVVHSLP NLTALSLSGC SKVTDDGVEL VAENLRKLRS 350
LDLSWCPRIT DMALEYVACD LHRLEELVLD RCVRITDTGL SYLSTMSSLR 400
SLYLRWCCQV QDFGLKHLLA LGSLRLLSLA GCPLLTTTGL SGLVQLQELE 450
ELELTNCPGA TPELFKYFSQ HLPRCLVIE 479
Length:479
Mass (Da):51,658
Last modified:October 17, 2006 - v2
Checksum:iBC5E2EF407142A5A
GO

Sequence cautioni

The sequence AAK61245.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti429 – 4291L → P.2 Publications
Corresponds to variant rs17855603 [ dbSNP | Ensembl ].
VAR_028163

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006464 Genomic DNA. Translation: AAK61245.1. Sequence problems.
Z97653 Genomic DNA. Translation: CAJ55832.1.
CH471112 Genomic DNA. Translation: EAW85749.1.
CH471112 Genomic DNA. Translation: EAW85750.1.
BC036680 mRNA. Translation: AAH36680.1.
CCDSiCCDS10421.1.
RefSeqiNP_699181.2. NM_153350.3.
XP_005255189.1. XM_005255132.1.
UniGeneiHs.513244.

Genome annotation databases

EnsembliENST00000324361; ENSP00000318674; ENSG00000127585.
ENST00000397621; ENSP00000380746; ENSG00000127585.
GeneIDi146330.
KEGGihsa:146330.
UCSCiuc002cjb.3. human.

Polymorphism databases

DMDMi116242480.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006464 Genomic DNA. Translation: AAK61245.1 . Sequence problems.
Z97653 Genomic DNA. Translation: CAJ55832.1 .
CH471112 Genomic DNA. Translation: EAW85749.1 .
CH471112 Genomic DNA. Translation: EAW85750.1 .
BC036680 mRNA. Translation: AAH36680.1 .
CCDSi CCDS10421.1.
RefSeqi NP_699181.2. NM_153350.3.
XP_005255189.1. XM_005255132.1.
UniGenei Hs.513244.

3D structure databases

ProteinModelPortali Q8N461.
SMRi Q8N461. Positions 193-227, 318-479.
ModBasei Search...

Protein-protein interaction databases

BioGridi 126979. 3 interactions.
IntActi Q8N461. 2 interactions.
MINTi MINT-8247545.
STRINGi 9606.ENSP00000318674.

PTM databases

PhosphoSitei Q8N461.

Polymorphism databases

DMDMi 116242480.

Proteomic databases

MaxQBi Q8N461.
PaxDbi Q8N461.
PeptideAtlasi Q8N461.
PRIDEi Q8N461.

Protocols and materials databases

DNASUi 146330.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000324361 ; ENSP00000318674 ; ENSG00000127585 .
ENST00000397621 ; ENSP00000380746 ; ENSG00000127585 .
GeneIDi 146330.
KEGGi hsa:146330.
UCSCi uc002cjb.3. human.

Organism-specific databases

CTDi 146330.
GeneCardsi GC16M000742.
HGNCi HGNC:14150. FBXL16.
HPAi HPA039504.
MIMi 609082. gene.
neXtProti NX_Q8N461.
PharmGKBi PA25536.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG279509.
HOGENOMi HOG000060108.
HOVERGENi HBG051675.
InParanoidi Q8N461.
KOi K10282.
OMAi RGFEGFC.
OrthoDBi EOG75MVVV.
PhylomeDBi Q8N461.
TreeFami TF324260.

Miscellaneous databases

ChiTaRSi FBXL16. human.
GenomeRNAii 146330.
NextBioi 85333.
PROi Q8N461.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8N461.
Bgeei Q8N461.
CleanExi HS_FBXL16.
Genevestigatori Q8N461.

Family and domain databases

InterProi IPR001810. F-box_dom.
[Graphical view ]
SUPFAMi SSF81383. SSF81383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
    Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
    Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-429.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-429.
    Tissue: Brain.

Entry informationi

Entry nameiFXL16_HUMAN
AccessioniPrimary (citable) accession number: Q8N461
Secondary accession number(s): D3DU60
, Q2MHR2, Q96S14, Q9UJI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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