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Q8N461

- FXL16_HUMAN

UniProt

Q8N461 - FXL16_HUMAN

Protein

F-box/LRR-repeat protein 16

Gene

FBXL16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F-box/LRR-repeat protein 16
    Alternative name(s):
    F-box and leucine-rich repeat protein 16
    Gene namesi
    Name:FBXL16
    Synonyms:C16orf22, FBL16
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:14150. FBXL16.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25536.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 479479F-box/LRR-repeat protein 16PRO_0000119863Add
    BLAST

    Proteomic databases

    MaxQBiQ8N461.
    PaxDbiQ8N461.
    PeptideAtlasiQ8N461.
    PRIDEiQ8N461.

    PTM databases

    PhosphoSiteiQ8N461.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N461.
    BgeeiQ8N461.
    CleanExiHS_FBXL16.
    GenevestigatoriQ8N461.

    Organism-specific databases

    HPAiHPA039504.

    Interactioni

    Subunit structurei

    Interacts with SKP1 and CUL1.By similarity

    Protein-protein interaction databases

    BioGridi126979. 3 interactions.
    IntActiQ8N461. 2 interactions.
    MINTiMINT-8247545.
    STRINGi9606.ENSP00000318674.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N461.
    SMRiQ8N461. Positions 193-227, 318-479.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini94 – 13946F-boxAdd
    BLAST
    Repeati244 – 26623LRR 1Add
    BLAST
    Repeati267 – 29024LRR 2Add
    BLAST
    Repeati319 – 34325LRR 3Add
    BLAST
    Repeati345 – 36925LRR 4Add
    BLAST
    Repeati371 – 39525LRR 5Add
    BLAST
    Repeati396 – 42025LRR 6Add
    BLAST
    Repeati446 – 47025LRR 7Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi10 – 9485Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 F-box domain.Curated
    Contains 7 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG279509.
    HOGENOMiHOG000060108.
    HOVERGENiHBG051675.
    InParanoidiQ8N461.
    KOiK10282.
    OMAiRGFEGFC.
    OrthoDBiEOG75MVVV.
    PhylomeDBiQ8N461.
    TreeFamiTF324260.

    Family and domain databases

    InterProiIPR001810. F-box_dom.
    [Graphical view]
    SUPFAMiSSF81383. SSF81383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8N461-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSPGIDGDP KPPCLPRNGL VKLPGQPNGL GAASITKGTP ATKNRPCQPP    50
    PPPTLPPPSL AAPLSRAALA GGPCTPAGGP ASALAPGHPA ERPPLATDEK 100
    ILNGLFWYFS ACEKCVLAQV CKAWRRVLYQ PKFWAGLTPV LHAKELYNVL 150
    PGGEKEFVNL QGFAARGFEG FCLVGVSDLD ICEFIDNYAL SKKGVKAMSL 200
    KRSTITDAGL EVMLEQMQGV VRLELSGCND FTEAGLWSSL SARITSLSVS 250
    DCINVADDAI AAISQLLPNL AELSLQAYHV TDTALAYFTA RQGHSTHTLR 300
    LLSCWEITNH GVVNVVHSLP NLTALSLSGC SKVTDDGVEL VAENLRKLRS 350
    LDLSWCPRIT DMALEYVACD LHRLEELVLD RCVRITDTGL SYLSTMSSLR 400
    SLYLRWCCQV QDFGLKHLLA LGSLRLLSLA GCPLLTTTGL SGLVQLQELE 450
    ELELTNCPGA TPELFKYFSQ HLPRCLVIE 479
    Length:479
    Mass (Da):51,658
    Last modified:October 17, 2006 - v2
    Checksum:iBC5E2EF407142A5A
    GO

    Sequence cautioni

    The sequence AAK61245.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti429 – 4291L → P.2 Publications
    Corresponds to variant rs17855603 [ dbSNP | Ensembl ].
    VAR_028163

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006464 Genomic DNA. Translation: AAK61245.1. Sequence problems.
    Z97653 Genomic DNA. Translation: CAJ55832.1.
    CH471112 Genomic DNA. Translation: EAW85749.1.
    CH471112 Genomic DNA. Translation: EAW85750.1.
    BC036680 mRNA. Translation: AAH36680.1.
    CCDSiCCDS10421.1.
    RefSeqiNP_699181.2. NM_153350.3.
    XP_005255189.1. XM_005255132.1.
    UniGeneiHs.513244.

    Genome annotation databases

    EnsembliENST00000324361; ENSP00000318674; ENSG00000127585.
    ENST00000397621; ENSP00000380746; ENSG00000127585.
    GeneIDi146330.
    KEGGihsa:146330.
    UCSCiuc002cjb.3. human.

    Polymorphism databases

    DMDMi116242480.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006464 Genomic DNA. Translation: AAK61245.1 . Sequence problems.
    Z97653 Genomic DNA. Translation: CAJ55832.1 .
    CH471112 Genomic DNA. Translation: EAW85749.1 .
    CH471112 Genomic DNA. Translation: EAW85750.1 .
    BC036680 mRNA. Translation: AAH36680.1 .
    CCDSi CCDS10421.1.
    RefSeqi NP_699181.2. NM_153350.3.
    XP_005255189.1. XM_005255132.1.
    UniGenei Hs.513244.

    3D structure databases

    ProteinModelPortali Q8N461.
    SMRi Q8N461. Positions 193-227, 318-479.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126979. 3 interactions.
    IntActi Q8N461. 2 interactions.
    MINTi MINT-8247545.
    STRINGi 9606.ENSP00000318674.

    PTM databases

    PhosphoSitei Q8N461.

    Polymorphism databases

    DMDMi 116242480.

    Proteomic databases

    MaxQBi Q8N461.
    PaxDbi Q8N461.
    PeptideAtlasi Q8N461.
    PRIDEi Q8N461.

    Protocols and materials databases

    DNASUi 146330.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000324361 ; ENSP00000318674 ; ENSG00000127585 .
    ENST00000397621 ; ENSP00000380746 ; ENSG00000127585 .
    GeneIDi 146330.
    KEGGi hsa:146330.
    UCSCi uc002cjb.3. human.

    Organism-specific databases

    CTDi 146330.
    GeneCardsi GC16M000742.
    HGNCi HGNC:14150. FBXL16.
    HPAi HPA039504.
    MIMi 609082. gene.
    neXtProti NX_Q8N461.
    PharmGKBi PA25536.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG279509.
    HOGENOMi HOG000060108.
    HOVERGENi HBG051675.
    InParanoidi Q8N461.
    KOi K10282.
    OMAi RGFEGFC.
    OrthoDBi EOG75MVVV.
    PhylomeDBi Q8N461.
    TreeFami TF324260.

    Miscellaneous databases

    ChiTaRSi FBXL16. human.
    GenomeRNAii 146330.
    NextBioi 85333.
    PROi Q8N461.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N461.
    Bgeei Q8N461.
    CleanExi HS_FBXL16.
    Genevestigatori Q8N461.

    Family and domain databases

    InterProi IPR001810. F-box_dom.
    [Graphical view ]
    SUPFAMi SSF81383. SSF81383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
      Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
      Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-429.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-429.
      Tissue: Brain.

    Entry informationi

    Entry nameiFXL16_HUMAN
    AccessioniPrimary (citable) accession number: Q8N461
    Secondary accession number(s): D3DU60
    , Q2MHR2, Q96S14, Q9UJI0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3