ID   LRC18_HUMAN             Reviewed;         261 AA.
AC   Q8N456; Q6UY02;
DT   27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 2.
DT   27-MAR-2024, entry version 169.
DE   RecName: Full=Leucine-rich repeat-containing protein 18;
GN   Name=LRRC18; ORFNames=UNQ9338/PRO34010;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in the regulation of spermatogenesis and
CC       sperm maturation. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q8N456; O43559: FRS3; NbExp=3; IntAct=EBI-751373, EBI-725515;
CC       Q8N456; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-751373, EBI-16439278;
CC       Q8N456; O43167: ZBTB24; NbExp=3; IntAct=EBI-751373, EBI-744471;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8N456-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8N456-2; Sequence=VSP_015740;
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DR   EMBL; AY358137; AAQ88504.1; -; mRNA.
DR   EMBL; BC036722; AAH36722.1; -; mRNA.
DR   CCDS; CCDS31197.1; -. [Q8N456-1]
DR   RefSeq; NP_001006940.3; NM_001006939.3. [Q8N456-1]
DR   RefSeq; XP_006717930.1; XM_006717867.2.
DR   RefSeq; XP_011538124.1; XM_011539822.1. [Q8N456-1]
DR   RefSeq; XP_011538125.1; XM_011539823.1. [Q8N456-1]
DR   RefSeq; XP_011538128.1; XM_011539826.2. [Q8N456-1]
DR   RefSeq; XP_011538130.1; XM_011539828.2. [Q8N456-1]
DR   RefSeq; XP_011538131.1; XM_011539829.2.
DR   RefSeq; XP_016871765.1; XM_017016276.1. [Q8N456-1]
DR   RefSeq; XP_016871766.1; XM_017016277.1. [Q8N456-1]
DR   AlphaFoldDB; Q8N456; -.
DR   SMR; Q8N456; -.
DR   BioGRID; 138880; 7.
DR   IntAct; Q8N456; 8.
DR   STRING; 9606.ENSP00000363275; -.
DR   iPTMnet; Q8N456; -.
DR   PhosphoSitePlus; Q8N456; -.
DR   BioMuta; LRRC18; -.
DR   DMDM; 116242619; -.
DR   MassIVE; Q8N456; -.
DR   MaxQB; Q8N456; -.
DR   PaxDb; 9606-ENSP00000298124; -.
DR   PeptideAtlas; Q8N456; -.
DR   ProteomicsDB; 71886; -. [Q8N456-1]
DR   ProteomicsDB; 71887; -. [Q8N456-2]
DR   Antibodypedia; 49932; 115 antibodies from 20 providers.
DR   DNASU; 474354; -.
DR   Ensembl; ENST00000374160.8; ENSP00000363275.3; ENSG00000165383.12. [Q8N456-1]
DR   GeneID; 474354; -.
DR   KEGG; hsa:474354; -.
DR   MANE-Select; ENST00000374160.8; ENSP00000363275.3; NM_001378102.1; NP_001365031.1.
DR   UCSC; uc001jhd.4; human. [Q8N456-1]
DR   AGR; HGNC:23199; -.
DR   CTD; 474354; -.
DR   DisGeNET; 474354; -.
DR   GeneCards; LRRC18; -.
DR   HGNC; HGNC:23199; LRRC18.
DR   HPA; ENSG00000165383; Group enriched (choroid plexus, fallopian tube, testis).
DR   MIM; 619002; gene.
DR   neXtProt; NX_Q8N456; -.
DR   OpenTargets; ENSG00000165383; -.
DR   PharmGKB; PA134898691; -.
DR   VEuPathDB; HostDB:ENSG00000165383; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   GeneTree; ENSGT00940000156026; -.
DR   HOGENOM; CLU_000288_18_15_1; -.
DR   InParanoid; Q8N456; -.
DR   OMA; DSQEDWR; -.
DR   OrthoDB; 5346394at2759; -.
DR   PhylomeDB; Q8N456; -.
DR   TreeFam; TF331129; -.
DR   PathwayCommons; Q8N456; -.
DR   SignaLink; Q8N456; -.
DR   BioGRID-ORCS; 474354; 5 hits in 1132 CRISPR screens.
DR   GenomeRNAi; 474354; -.
DR   Pharos; Q8N456; Tdark.
DR   PRO; PR:Q8N456; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   RNAct; Q8N456; Protein.
DR   Bgee; ENSG00000165383; Expressed in bronchial epithelial cell and 74 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR48051; -; 1.
DR   PANTHER; PTHR48051:SF1; ZGC:77287; 1.
DR   Pfam; PF13855; LRR_8; 1.
DR   SMART; SM00369; LRR_TYP; 4.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS51450; LRR; 5.
DR   Genevisible; Q8N456; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cytoplasm; Leucine-rich repeat; Reference proteome;
KW   Repeat.
FT   CHAIN           1..261
FT                   /note="Leucine-rich repeat-containing protein 18"
FT                   /id="PRO_0000084472"
FT   REPEAT          28..49
FT                   /note="LRR 1"
FT   REPEAT          51..72
FT                   /note="LRR 2"
FT   REPEAT          74..95
FT                   /note="LRR 3"
FT   REPEAT          97..118
FT                   /note="LRR 4"
FT   REPEAT          122..144
FT                   /note="LRR 5"
FT   REPEAT          145..167
FT                   /note="LRR 6"
FT   REPEAT          168..189
FT                   /note="LRR 7"
FT   VAR_SEQ         256..261
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:12975309"
FT                   /id="VSP_015740"
FT   VARIANT         7
FT                   /note="G -> V (in dbSNP:rs7094610)"
FT                   /id="VAR_028161"
FT   VARIANT         31
FT                   /note="R -> H (in dbSNP:rs17772611)"
FT                   /id="VAR_028162"
FT   CONFLICT        137
FT                   /note="P -> S (in Ref. 2; AAH36722)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   261 AA;  29737 MW;  209F1CFC422B1701 CRC64;
     MVKGEKGPKG KKITLKVARN CIKITFDGKK RLDLSKMGIT TFPKCILRLS DMDELDLSRN
     LIRKIPDSIS KFQNLRWLDL HSNYIDKLPE SIGQMTSLLY LNVSNNRLTS NGLPVELKQL
     KNIRAVNLGL NHLDSVPTTL GALKELHEVG LHDNLLNNIP VSISKLPKLK KLNIKRNPFP
     KPGESEIFID SIRRLENLYV VEEKDLCAAC LRKCQNARDN LNRIKNMATT TPRKTIFPNL
     ISPNSMAKDS WEDWRIRLTS S
//