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Q8N456 (LRC18_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine-rich repeat-containing protein 18
Gene names
Name:LRRC18
ORF Names:UNQ9338/PRO34010
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in the regulation of spermatogenesis and sperm maturation By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Contains 7 LRR (leucine-rich) repeats.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainLeucine-rich repeat
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N456-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N456-2)

The sequence of this isoform differs from the canonical sequence as follows:
     256-261: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Leucine-rich repeat-containing protein 18
PRO_0000084472

Regions

Repeat28 – 4922LRR 1
Repeat51 – 7222LRR 2
Repeat74 – 9522LRR 3
Repeat97 – 11822LRR 4
Repeat122 – 14423LRR 5
Repeat145 – 16723LRR 6
Repeat168 – 18922LRR 7

Natural variations

Alternative sequence256 – 2616Missing in isoform 2.
VSP_015740
Natural variant71G → V.
Corresponds to variant rs7094610 [ dbSNP | Ensembl ].
VAR_028161
Natural variant311R → H.
Corresponds to variant rs17772611 [ dbSNP | Ensembl ].
VAR_028162

Experimental info

Sequence conflict1371P → S in AAH36722. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 209F1CFC422B1701

FASTA26129,737
        10         20         30         40         50         60 
MVKGEKGPKG KKITLKVARN CIKITFDGKK RLDLSKMGIT TFPKCILRLS DMDELDLSRN 

        70         80         90        100        110        120 
LIRKIPDSIS KFQNLRWLDL HSNYIDKLPE SIGQMTSLLY LNVSNNRLTS NGLPVELKQL 

       130        140        150        160        170        180 
KNIRAVNLGL NHLDSVPTTL GALKELHEVG LHDNLLNNIP VSISKLPKLK KLNIKRNPFP 

       190        200        210        220        230        240 
KPGESEIFID SIRRLENLYV VEEKDLCAAC LRKCQNARDN LNRIKNMATT TPRKTIFPNL 

       250        260 
ISPNSMAKDS WEDWRIRLTS S 

« Hide

Isoform 2 [UniParc].

Checksum: 47016B445DD74D82
Show »

FASTA25529,079

References

[1]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY358137 mRNA. Translation: AAQ88504.1.
BC036722 mRNA. Translation: AAH36722.1.
RefSeqNP_001006940.3. NM_001006939.3.
UniGeneHs.202438.

3D structure databases

ProteinModelPortalQ8N456.
SMRQ8N456. Positions 27-234.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid138880. 1 interaction.
IntActQ8N456. 1 interaction.
MINTMINT-1485571.
STRING9606.ENSP00000298124.

PTM databases

PhosphoSiteQ8N456.

Polymorphism databases

DMDM116242619.

Proteomic databases

PaxDbQ8N456.
PRIDEQ8N456.

Protocols and materials databases

DNASU474354.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000298124; ENSP00000298124; ENSG00000165383. [Q8N456-2]
ENST00000374160; ENSP00000363275; ENSG00000165383. [Q8N456-1]
GeneID474354.
KEGGhsa:474354.
UCSCuc001jhd.3. human. [Q8N456-1]

Organism-specific databases

CTD474354.
GeneCardsGC10M050117.
H-InvDBHIX0026080.
HGNCHGNC:23199. LRRC18.
HPAHPA039256.
neXtProtNX_Q8N456.
PharmGKBPA134898691.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4886.
HOGENOMHOG000113366.
HOVERGENHBG056513.
InParanoidQ8N456.
OMAKRNPFPK.
OrthoDBEOG79W960.
PhylomeDBQ8N456.
TreeFamTF331129.

Gene expression databases

BgeeQ8N456.
CleanExHS_LRRC18.
GenevestigatorQ8N456.

Family and domain databases

InterProIPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
[Graphical view]
PfamPF00560. LRR_1. 1 hit.
PF12799. LRR_4. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi474354.
NextBio111696.
PROQ8N456.

Entry information

Entry nameLRC18_HUMAN
AccessionPrimary (citable) accession number: Q8N456
Secondary accession number(s): Q6UY02
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: October 17, 2006
Last modified: April 16, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM