Skip Header

 
Contribute Send feedback
Read comments (1) or add your own

Reviewed, UniProtKB/Swiss-Prot Q8N448 (LNX2_HUMAN)

Last modified June 16, 2009. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Ligand of Numb protein X 2
Alternative name(s):
    Numb-binding protein 2
    PDZ domain-containing RING finger protein 1
Gene names
Name: LNX2
Synonyms: PDZRN1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length690 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

Hide | Top

General annotation (Comments)

Subunit structure

Interacts with the phosphotyrosine interaction domain of NUMB By similarity.

Domain

The NPXY motif is required for the interaction with the PID domain of NUMB. It is however not sufficient.

Sequence similarities

Contains 4 PDZ (DHR) domains.

Contains 1 RING-type zinc finger.

Hide | Top

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainRepeat
Zinc-finger
   LigandMetal-binding
Zinc
   Technical term3D-structure
Gene Ontology (GO)
   Molecular functionzinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 690690Ligand of Numb protein X 2
PRO_0000055915

Regions

Domain233 – 31886PDZ 1
Domain339 – 42284PDZ 2
Domain468 – 55487PDZ 3
Domain600 – 68889PDZ 4
Zinc finger50 – 8839RING-type
Motif208 – 2114NPXY motif

Natural variations

Natural variant1981S → P: dbSNP rs8002697.
VAR_024612

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q8N448-1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: A3F941A477721F1D

FASTA69076,004
        10         20         30         40         50         60 
MGTTSDEMVS VEQTSSSSLN PLCFECGQQH WTRENHLYNY QNEVDDDLVC HICLQPLLQP 

        70         80         90        100        110        120 
LDTPCGHTFC YKCLRNFLQE KDFCPLDRKR LHFKLCKKSS ILVHKLLDKL LVLCPFSSVC 

       130        140        150        160        170        180 
KDVMQRCDLE AHLKNRCPGA SHRRVALERR KTSRTQAEIE NENGPTLLDP AGTLSPEADC 

       190        200        210        220        230        240 
LGTGAVPVER HLTSASLSTW SEEPGLDNPA FEESAGADTT QQPLSLPEGE ITTIEIHRSN 

       250        260        270        280        290        300 
PYIQLGISIV GGNETPLINI VIQEVYRDGV IARDGRLLAG DQILQVNNYN ISNVSHNYAR 

       310        320        330        340        350        360 
AVLSQPCNTL HLTVLRERRF GNRAHNHSDS NSPREEIFQV ALHKRDSGEQ LGIKLVRRTD 

       370        380        390        400        410        420 
EPGVFILDLL EGGLAAQDGR LSSNDRVLAI NGHDLKYGTP ELAAQIIQAS GERVNLTIAR 

       430        440        450        460        470        480 
PGKPQPGNTI REAGNHSSSS QHHTPPPYYS RPSSHKDLTQ CVTCQEKHIT VKKEPHESLG 

       490        500        510        520        530        540 
MTVAGGRGSK SGELPIFVTS VPPHGCLARD GRIKRGDVLL NINGIDLTNL SHSEAVAMLK 

       550        560        570        580        590        600 
ASAASPAVAL KALEVQIVEE ATQNAEEQPS TFSENEYDAS WSPSWVMWLG LPSTLHSCHD 

       610        620        630        640        650        660 
IVLRRSYLGS WGFSIVGGYE ENHTNQPFFI KTIVLGTPAY YDGRLKCGDM IVAVNGLSTV 

       670        680        690 
GMSHSALVPM LKEQRNKVTL TVICWPGSLV

« Hide

Hide | Top

References

[1]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed: 15057823] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Melanoma.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 522-690.
Tissue: Colon.

Hide | Top

Cross-references

Sequence databases

AL138699 Genomic DNA. Translation: CAH73446.1.
BC036755 mRNA. Translation: AAH36755.1.
AK172771 mRNA. Translation: BAD18754.1. Different initiation.
IPIIPI00171047.
RefSeqNP_699202.1.
UniGeneHs.132359

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2VWRX-ray1.30A336-424[»]
ModBaseSearch...

PTM databases

PhosphoSiteQ8N448.

Proteomic databases

PeptideAtlasQ8N448.
PRIDEQ8N448.

Genome annotation databases

EnsemblENSG00000139517. Homo sapiens. [Contig view]
GeneID222484.
KEGGhsa:222484.

Organism-specific databases

GeneCardsGC13M027018.
HGNCHGNC:20421. LNX2.
MIM609733. gene.
PharmGKBPA134899015.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ8N448.
HOVERGENQ8N448.
OMAQ8N448. ENHLYNY.

Gene expression databases

ArrayExpressQ8N448.
BgeeQ8N448.
CleanExHS_LNX2.
GermOnlineENSG00000139517. Homo sapiens.

Family and domain databases

InterProIPR001478. PDZ/DHR/GLGF.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF00595. PDZ. 4 hits.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTSM00228. PDZ. 4 hits.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEPS50106. PDZ. 4 hits.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio91602.
SOURCESearch...

Hide | Top

Entry information

Entry nameLNX2_HUMAN
AccessionPrimary (citable) accession number: Q8N448
Secondary accession number(s): Q5W0P0, Q6ZMH2, Q96SH4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: October 1, 2002
Last modified: June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Hide | Top

Relevant documents

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents