Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 843

Gene

ZNF843

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri33 – 5523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri145 – 16723C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 843
Gene namesi
Name:ZNF843
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:28710. ZNF843.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410853.

Polymorphism and mutation databases

BioMutaiZNF843.
DMDMi74759868.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Zinc finger protein 843PRO_0000343750Add
BLAST

Proteomic databases

PaxDbiQ8N446.
PRIDEiQ8N446.

PTM databases

iPTMnetiQ8N446.
PhosphoSiteiQ8N446.

Expressioni

Gene expression databases

BgeeiQ8N446.
CleanExiHS_ZNF843.
ExpressionAtlasiQ8N446. baseline and differential.
GenevisibleiQ8N446. HS.

Organism-specific databases

HPAiHPA030912.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC37Q165432EBI-6428016,EBI-295634

Protein-protein interaction databases

BioGridi129710. 5 interactions.
IntActiQ8N446. 2 interactions.
STRINGi9606.ENSP00000322899.

Structurei

3D structure databases

ProteinModelPortaliQ8N446.
SMRiQ8N446. Positions 22-63, 144-174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi210 – 25950Pro-richAdd
BLAST

Sequence similaritiesi

Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri33 – 5523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri145 – 16723C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000067643.
HOGENOMiHOG000205472.
InParanoidiQ8N446.
PhylomeDBiQ8N446.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR007087. Znf_C2H2.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N446-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSLPFALTV ESVSARAPTC CSTGRFTQGR QPCKCKACGR GFTQSASLLQ
60 70 80 90 100
HWRVHSDWRE TLSLSPVRQD LLWPLQPHQA PASPLGRSHS SAGVRQGFSG
110 120 130 140 150
QLCCWLTKEH TLAEALRLSP VPAGFWGPVE ADRPPANSHR RVCPFCCCSC
160 170 180 190 200
GDSVNEKTSL SQRVLPHPGE KTCRGGSVES VSLAPSSVAP DSTSGLRPCG
210 220 230 240 250
SPGSFLQHLP PSTLLPRPPF LYPGPPLSLQ PLVPSGLPAV PAVPLGGLEV
260 270 280 290 300
AQVPPATQPA AQQEGAMGPR SCASAGRDSR EAVQAPGYPE PARKASQHRA
310 320 330 340
AGPLGEARAR LQRQCRAPPP PSNPHWRGAL PVFPVWKASS RRSNLARH
Length:348
Mass (Da):37,065
Last modified:October 1, 2002 - v1
Checksum:i34BC7ED6E61438A7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti284 – 2841Q → L in BAF83752 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291063 mRNA. Translation: BAF83752.1.
BC036762 mRNA. Translation: AAH36762.1.
CCDSiCCDS45471.1.
RefSeqiNP_001129981.1. NM_001136509.1.
UniGeneiHs.722243.

Genome annotation databases

EnsembliENST00000315678; ENSP00000322899; ENSG00000176723.
ENST00000618063; ENSP00000483573; ENSG00000176723.
GeneIDi283933.
KEGGihsa:283933.
UCSCiuc010vfm.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291063 mRNA. Translation: BAF83752.1.
BC036762 mRNA. Translation: AAH36762.1.
CCDSiCCDS45471.1.
RefSeqiNP_001129981.1. NM_001136509.1.
UniGeneiHs.722243.

3D structure databases

ProteinModelPortaliQ8N446.
SMRiQ8N446. Positions 22-63, 144-174.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129710. 5 interactions.
IntActiQ8N446. 2 interactions.
STRINGi9606.ENSP00000322899.

PTM databases

iPTMnetiQ8N446.
PhosphoSiteiQ8N446.

Polymorphism and mutation databases

BioMutaiZNF843.
DMDMi74759868.

Proteomic databases

PaxDbiQ8N446.
PRIDEiQ8N446.

Protocols and materials databases

DNASUi283933.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315678; ENSP00000322899; ENSG00000176723.
ENST00000618063; ENSP00000483573; ENSG00000176723.
GeneIDi283933.
KEGGihsa:283933.
UCSCiuc010vfm.2. human.

Organism-specific databases

CTDi283933.
GeneCardsiZNF843.
HGNCiHGNC:28710. ZNF843.
HPAiHPA030912.
neXtProtiNX_Q8N446.
PharmGKBiPA162410853.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000067643.
HOGENOMiHOG000205472.
InParanoidiQ8N446.
PhylomeDBiQ8N446.

Miscellaneous databases

ChiTaRSiZNF843. human.
GenomeRNAii283933.
NextBioi94375.
PROiQ8N446.

Gene expression databases

BgeeiQ8N446.
CleanExiHS_ZNF843.
ExpressionAtlasiQ8N446. baseline and differential.
GenevisibleiQ8N446. HS.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR007087. Znf_C2H2.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiZN843_HUMAN
AccessioniPrimary (citable) accession number: Q8N446
Secondary accession number(s): A8K4U8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: October 1, 2002
Last modified: May 11, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.