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Protein

RIB43A-like with coiled-coils protein 1

Gene

RIBC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158423-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RIB43A-like with coiled-coils protein 1
Gene namesi
Name:RIBC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:26537. RIBC1.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000158423.
PharmGKBiPA134903330.

Polymorphism and mutation databases

DMDMi74762522.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002540931 – 379RIB43A-like with coiled-coils protein 1Add BLAST379

Proteomic databases

MaxQBiQ8N443.
PaxDbiQ8N443.
PeptideAtlasiQ8N443.
PRIDEiQ8N443.

PTM databases

PhosphoSitePlusiQ8N443.

Expressioni

Gene expression databases

BgeeiENSG00000158423.
CleanExiHS_RIBC1.
ExpressionAtlasiQ8N443. baseline and differential.
GenevisibleiQ8N443. HS.

Organism-specific databases

HPAiHPA021613.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EMILIN1Q9Y6C23EBI-10265323,EBI-744586
GOLGA2Q083793EBI-10265323,EBI-618309
KRT15P190123EBI-10265323,EBI-739566
KRT31Q153235EBI-10265323,EBI-948001
RINT1Q6NUQ15EBI-10265323,EBI-726876
TEX11Q8IYF33EBI-10265323,EBI-742397
TRIM27P143733EBI-10265323,EBI-719493

Protein-protein interaction databases

BioGridi127705. 22 interactors.
IntActiQ8N443. 13 interactors.
STRINGi9606.ENSP00000364476.

Structurei

3D structure databases

ProteinModelPortaliQ8N443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili82 – 111Sequence analysisAdd BLAST30
Coiled coili216 – 304Sequence analysisAdd BLAST89

Sequence similaritiesi

Belongs to the RIB43A family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE6I. Eukaryota.
ENOG410YKAG. LUCA.
GeneTreeiENSGT00390000010825.
HOGENOMiHOG000231390.
HOVERGENiHBG056758.
InParanoidiQ8N443.
OMAiMMSAMAN.
OrthoDBiEOG091G0J9X.
PhylomeDBiQ8N443.
TreeFamiTF324120.

Family and domain databases

InterProiIPR008805. RIB43A.
[Graphical view]
PANTHERiPTHR14517. PTHR14517. 1 hit.
PfamiPF05914. RIB43A. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N443-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYNIKQSTDT KEAAAIEARR NREKERQNRF FNVRNRVMGV DVQALNNQVG
60 70 80 90 100
DRKRREAAER SKEAAYGTSQ VQYDVVVQML EKEEADRTRQ LAKKVQEFRE
110 120 130 140 150
QKQQLKNGRE FSLWDPGQVW KGLPTYLSYS NTYPGPASLQ YFSGEDLDRD
160 170 180 190 200
TRLRMQQGQF RYNLERQQQE QQQAKVDENY TDALSNQLRL AMDAQATHLA
210 220 230 240 250
RLEESCRAAM MCAMANANKA QAAVQAGRQR CERQREQKAN LAEIQHQSTS
260 270 280 290 300
DLLTENPQVA QHPMAPYRVL PYCWKGMTPE QQAAIRKEQE VQRSKKQAHR
310 320 330 340 350
QAEKTLDTEW KSQTMSSAQA VLELEEQERE LCAVFQRGLG SFNQQLANEQ
360 370
KAQQDYLNSV IYTNQPTAQY HQQFNTSSR
Length:379
Mass (Da):44,015
Last modified:October 1, 2002 - v1
Checksum:iBAEF361A74D38EE9
GO
Isoform 2 (identifier: Q8N443-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-192: DALSNQLRLAM → GKQPGPPDSET
     193-379: Missing.

Show »
Length:192
Mass (Da):22,563
Checksum:iB0028FE3FC0E8FE6
GO
Isoform 3 (identifier: Q8N443-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-181: Missing.
     354-379: Missing.

Note: No experimental confirmation available.
Show »
Length:238
Mass (Da):27,246
Checksum:iE53288E2557744E7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66Y → C in BAG65059 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04483467 – 181Missing in isoform 3. 1 PublicationAdd BLAST115
Alternative sequenceiVSP_021178182 – 192DALSNQLRLAM → GKQPGPPDSET in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_021179193 – 379Missing in isoform 2. 1 PublicationAdd BLAST187
Alternative sequenceiVSP_044835354 – 379Missing in isoform 3. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057345 mRNA. Translation: BAB71438.1.
AK304179 mRNA. Translation: BAG65059.1.
Z97054 Genomic DNA. Translation: CAI42648.1.
Z97054 Genomic DNA. Translation: CAI42649.1.
Z97054 Genomic DNA. Translation: CAI42650.1.
BC036767 mRNA. Translation: AAH36767.1.
CCDSiCCDS14353.1. [Q8N443-2]
CCDS35299.1. [Q8N443-1]
CCDS59168.1. [Q8N443-3]
RefSeqiNP_001026915.1. NM_001031745.4. [Q8N443-1]
NP_001253982.1. NM_001267053.3. [Q8N443-3]
NP_659405.1. NM_144968.3. [Q8N443-2]
XP_005262045.1. XM_005261988.3. [Q8N443-1]
UniGeneiHs.351743.

Genome annotation databases

EnsembliENST00000375327; ENSP00000364476; ENSG00000158423. [Q8N443-1]
ENST00000414955; ENSP00000401463; ENSG00000158423. [Q8N443-3]
ENST00000457095; ENSP00000402080; ENSG00000158423. [Q8N443-2]
GeneIDi158787.
KEGGihsa:158787.
UCSCiuc004dsj.3. human. [Q8N443-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057345 mRNA. Translation: BAB71438.1.
AK304179 mRNA. Translation: BAG65059.1.
Z97054 Genomic DNA. Translation: CAI42648.1.
Z97054 Genomic DNA. Translation: CAI42649.1.
Z97054 Genomic DNA. Translation: CAI42650.1.
BC036767 mRNA. Translation: AAH36767.1.
CCDSiCCDS14353.1. [Q8N443-2]
CCDS35299.1. [Q8N443-1]
CCDS59168.1. [Q8N443-3]
RefSeqiNP_001026915.1. NM_001031745.4. [Q8N443-1]
NP_001253982.1. NM_001267053.3. [Q8N443-3]
NP_659405.1. NM_144968.3. [Q8N443-2]
XP_005262045.1. XM_005261988.3. [Q8N443-1]
UniGeneiHs.351743.

3D structure databases

ProteinModelPortaliQ8N443.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127705. 22 interactors.
IntActiQ8N443. 13 interactors.
STRINGi9606.ENSP00000364476.

PTM databases

PhosphoSitePlusiQ8N443.

Polymorphism and mutation databases

DMDMi74762522.

Proteomic databases

MaxQBiQ8N443.
PaxDbiQ8N443.
PeptideAtlasiQ8N443.
PRIDEiQ8N443.

Protocols and materials databases

DNASUi158787.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375327; ENSP00000364476; ENSG00000158423. [Q8N443-1]
ENST00000414955; ENSP00000401463; ENSG00000158423. [Q8N443-3]
ENST00000457095; ENSP00000402080; ENSG00000158423. [Q8N443-2]
GeneIDi158787.
KEGGihsa:158787.
UCSCiuc004dsj.3. human. [Q8N443-1]

Organism-specific databases

CTDi158787.
GeneCardsiRIBC1.
HGNCiHGNC:26537. RIBC1.
HPAiHPA021613.
neXtProtiNX_Q8N443.
OpenTargetsiENSG00000158423.
PharmGKBiPA134903330.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE6I. Eukaryota.
ENOG410YKAG. LUCA.
GeneTreeiENSGT00390000010825.
HOGENOMiHOG000231390.
HOVERGENiHBG056758.
InParanoidiQ8N443.
OMAiMMSAMAN.
OrthoDBiEOG091G0J9X.
PhylomeDBiQ8N443.
TreeFamiTF324120.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158423-MONOMER.

Miscellaneous databases

GenomeRNAii158787.
PROiQ8N443.

Gene expression databases

BgeeiENSG00000158423.
CleanExiHS_RIBC1.
ExpressionAtlasiQ8N443. baseline and differential.
GenevisibleiQ8N443. HS.

Family and domain databases

InterProiIPR008805. RIB43A.
[Graphical view]
PANTHERiPTHR14517. PTHR14517. 1 hit.
PfamiPF05914. RIB43A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRIBC1_HUMAN
AccessioniPrimary (citable) accession number: Q8N443
Secondary accession number(s): B4E297
, E9PDU2, Q5H931, Q96A80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.