Reviewed, UniProtKB/Swiss-Prot Q8N441 (FGRL1_HUMAN)

Names and origin

Protein names

Recommended name:
    Fibroblast growth factor receptor-like 1
      Short name=FGF receptor-like protein 1
Alternative name(s):
    Fibroblast growth factor receptor 5
    FGFR-like protein
    FGF homologous factor receptor

Gene names

Name:	FGFRL1
Synonyms:	FGFR5, FHFR
ORF Names:	UNQ480/PRO943

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	504 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Has a negative effect on cell proliferation By similarity.
Subunit structure	Interacts with FGF2 with a low affinity By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein. Note: Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles. Ref.9
Tissue specificity	Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen. Ref.1 Ref.2 Ref.8
Sequence similarities	Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Sequence caution	The sequence AAH13955.2 differs from that shown. Reason: Frameshift at position 149.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	regulation of cell growth Non-traceable author statement. Source: UniProtKB
Cellular component	integral to membrane Ref.1 Non-traceable author statement. Source: UniProtKB
Molecular function	fibroblast growth factor receptor activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Ref.7
	Chain	25 – 504	480	Fibroblast growth factor receptor-like 1		PRO_0000021250
Regions
	Topological domain	25 – 378	354	Extracellular Potential
	Transmembrane	379 – 399	21	Potential
	Topological domain	400 – 504	105	Cytoplasmic Potential
	Domain	29 – 115	87	Ig-like C2-type 1
	Domain	147 – 237	91	Ig-like C2-type 2
	Domain	246 – 354	109	Ig-like C2-type 3
	Compositional bias	479 – 501	23	His-rich
Amino acid modifications
	Glycosylation	111	1	N-linked (GlcNAc...) Potential
	Glycosylation	231	1	N-linked (GlcNAc...) Potential
	Glycosylation	255	1	N-linked (GlcNAc...) Potential
	Glycosylation	293	1	N-linked (GlcNAc...) Potential
	Disulfide bond	51 ↔ 99		By similarity
	Disulfide bond	172 ↔ 221		By similarity
	Disulfide bond	268 ↔ 338		By similarity
Natural variations
	Natural variant	362	1	P → Q: dbSNP rs4647930. Ref.1 Ref.2 Ref.6		VAR_022642
	Natural variant	464	1	P → L: dbSNP rs4647932.		VAR_024316
Experimental info
	Sequence conflict	374 – 380	7	Missing in AAK15273. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q8N441-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 56E35E57D5FC141B	FASTA	504	54,537
	10 20 30 40 50 60 MTPSPLLLLL LPPLLLGAFP PAAAARGPPK MADKVVPRQV ARLGRTVRLQ CPVEGDPPPL 70 80 90 100 110 120 TMWTKDGRTI HSGWSRFRVL PQGLKVKQVE REDAGVYVCK ATNGFGSLSV NYTLVVLDDI 130 140 150 160 170 180 SPGKESLGPD SSSGGQEDPA SQQWARPRFT QPSKMRRRVI ARPVGSSVRL KCVASGHPRP 190 200 210 220 230 240 DITWMKDDQA LTRPEAAEPR KKKWTLSLKN LRPEDSGKYT CRVSNRAGAI NATYKVDVIQ 250 260 270 280 290 300 RTRSKPVLTG THPVNTTVDF GGTTSFQCKV RSDVKPVIQW LKRVEYGAEG RHNSTIDVGG 310 320 330 340 350 360 QKFVVLPTGD VWSRPDGSYL NKLLITRARQ DDAGMYICLG ANTMGYSFRS AFLTVLPDPK 370 380 390 400 410 420 PPGPPVASSS SATSLPWPVV IGIPAGAVFI LGTLLLWLCQ AQKKPCTPAP APPLPGHRPP 430 440 450 460 470 480 GTARDRSGDK DLPSLAALSA GPGVGLCEEH GSPAAPQHLL GPGPVAGPKL YPKLYTDIHT 490 500 HTHTHSHTHS HVEGKVHQHI HYQC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors." Wiedemann M., Trueb B. Genomics 69:275-279(2000) [PubMed: 11031111] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT GLN-362. Tissue: Cartilage.
[2]	"A novel fibroblast growth factor receptor-5 preferentially expressed in the pancreas." Kim I., Moon S.-O., Yu K.-H., Kim U.-H., Koh G.Y. Biochim. Biophys. Acta 1518:152-156(2001) [PubMed: 11267671] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT GLN-362.
[3]	"FHFR, a novel fibroblast growth factor receptor that uniquely binds the fibroblast growth factor homologous factors." Aggarwal S., Xie M.-H., Foster J., Frantz G., Stinson J., Corpuz R.T., Simmons L., Hillan K., Yansura D.G., Vandlen R.L., Goddard A.D., Gurney A.L. Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-362. Tissue: Brain and Kidney.
[7]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 25-39.
[8]	"Identification of a new fibroblast growth factor receptor, FGFR5." Sleeman M., Fraser J., McDonald M., Yuan S., White D., Grandison P., Kumble K., Watson J.D., Murison J.G. Gene 271:171-182(2001) [PubMed: 11418238] [Abstract] Cited for: TISSUE SPECIFICITY.
[9]	"Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues." Trueb B., Zhuang L., Taeschler S., Wiedemann M. J. Biol. Chem. 278:33857-33865(2003) [PubMed: 12813049] [Abstract] Cited for: SUBCELLULAR LOCATION. Tissue: Cartilage.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ277437 mRNA. Translation: CAC14171.1. AF279689 mRNA. Translation: AAK26742.1. AF312678 mRNA. Translation: AAK15273.1. AY358303 mRNA. Translation: AAQ88670.1. AK314365 mRNA. Translation: BAG36996.1. BC013955 mRNA. Translation: AAH13955.2. Sequence problems. BC036769 mRNA. Translation: AAH36769.1.
IPI	IPI00296561.
RefSeq	NP_001004356.1. NP_001004358.1. NP_068742.2.
UniGene	Hs.193326
3D structure databases
HSSP	HSSP built from PDB template 1EV2 based on UniProtKB Q9UQH9.
ModBase	Search...
Proteomic databases
PeptideAtlas	Q8N441.
PRIDE	Q8N441.
Genome annotation databases
Ensembl	ENSG00000127418. Homo sapiens. [Contig view]
GeneID	53834.
KEGG	hsa:53834.
UCSC	uc003gce.1. human.
Organism-specific databases
GeneCards	GC04P000996.
H-InvDB	HIX0004011. HIX0060458.
HGNC	HGNC:3693. FGFRL1.
MIM	605830. gene.
PharmGKB	PA28132.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q8N441.
HOVERGEN	Q8N441.
OMA	Q8N441. TLIVMDD.
Gene expression databases
ArrayExpress	Q8N441.
Bgee	Q8N441.
CleanEx	HS_FGFRL1.
GermOnline	ENSG00000127418. Homo sapiens.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 3 hits.
Pfam	PF07679. I-set. 3 hits. [Graphical view]
SMART	SM00409. IG. 1 hit. SM00408. IGc2. 2 hits. [Graphical view]
PROSITE	PS50835. IG_LIKE. 3 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	56170.
SOURCE	Search...

Entry information

Entry name

FGRL1_HUMAN

Accession

Primary (citable) accession number: Q8N441
Secondary accession number(s): B2RAU9 , Q6PJN1, Q9BXN7, Q9H4D7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	October 1, 2002
Last modified:	July 7, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)