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Protein

Fibroblast growth factor receptor-like 1

Gene

FGFRL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a negative effect on cell proliferation.By similarity

GO - Molecular functioni

  • fibroblast growth factor-activated receptor activity Source: UniProtKB
  • heparin binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-HSA-5658623. FGFRL1 modulation of FGFR1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptor-like 1
Short name:
FGF receptor-like protein 1
Alternative name(s):
FGF homologous factor receptor
FGFR-like protein
Fibroblast growth factor receptor 5
Short name:
FGFR-5
Gene namesi
Name:FGFRL1
Synonyms:FGFR5, FHFR
ORF Names:UNQ480/PRO943
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:3693. FGFRL1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 378ExtracellularSequence analysisAdd BLAST354
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Topological domaini400 – 504CytoplasmicSequence analysisAdd BLAST105

GO - Cellular componenti

  • cell-cell contact zone Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB
  • transport vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi53834.
OpenTargetsiENSG00000127418.
PharmGKBiPA28132.

Polymorphism and mutation databases

BioMutaiFGFRL1.
DMDMi68052359.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000002125025 – 504Fibroblast growth factor receptor-like 1Add BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 99PROSITE-ProRule annotation
Glycosylationi111N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi172 ↔ 221PROSITE-ProRule annotation
Glycosylationi231N-linked (GlcNAc...)Sequence analysis1
Glycosylationi255N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi268 ↔ 338PROSITE-ProRule annotation
Glycosylationi293N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8N441.
PaxDbiQ8N441.
PeptideAtlasiQ8N441.
PRIDEiQ8N441.

PTM databases

iPTMnetiQ8N441.
PhosphoSitePlusiQ8N441.

Expressioni

Tissue specificityi

Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen.3 Publications

Gene expression databases

BgeeiENSG00000127418.
CleanExiHS_FGFRL1.
ExpressionAtlasiQ8N441. baseline and differential.
GenevisibleiQ8N441. HS.

Organism-specific databases

HPAiCAB026019.
HPA068828.

Interactioni

Subunit structurei

Interacts with FGF2 with a low affinity.By similarity

Protein-protein interaction databases

BioGridi119806. 23 interactors.
STRINGi9606.ENSP00000264748.

Structurei

3D structure databases

ProteinModelPortaliQ8N441.
SMRiQ8N441.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 115Ig-like C2-type 1Add BLAST87
Domaini147 – 237Ig-like C2-type 2Add BLAST91
Domaini246 – 354Ig-like C2-type 3Add BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi479 – 501His-richAdd BLAST23

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00390000008504.
HOGENOMiHOG000112576.
HOVERGENiHBG056473.
InParanoidiQ8N441.
OMAiKRVEYGT.
OrthoDBiEOG091G0985.
PhylomeDBiQ8N441.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N441-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPSPLLLLL LPPLLLGAFP PAAAARGPPK MADKVVPRQV ARLGRTVRLQ
60 70 80 90 100
CPVEGDPPPL TMWTKDGRTI HSGWSRFRVL PQGLKVKQVE REDAGVYVCK
110 120 130 140 150
ATNGFGSLSV NYTLVVLDDI SPGKESLGPD SSSGGQEDPA SQQWARPRFT
160 170 180 190 200
QPSKMRRRVI ARPVGSSVRL KCVASGHPRP DITWMKDDQA LTRPEAAEPR
210 220 230 240 250
KKKWTLSLKN LRPEDSGKYT CRVSNRAGAI NATYKVDVIQ RTRSKPVLTG
260 270 280 290 300
THPVNTTVDF GGTTSFQCKV RSDVKPVIQW LKRVEYGAEG RHNSTIDVGG
310 320 330 340 350
QKFVVLPTGD VWSRPDGSYL NKLLITRARQ DDAGMYICLG ANTMGYSFRS
360 370 380 390 400
AFLTVLPDPK PPGPPVASSS SATSLPWPVV IGIPAGAVFI LGTLLLWLCQ
410 420 430 440 450
AQKKPCTPAP APPLPGHRPP GTARDRSGDK DLPSLAALSA GPGVGLCEEH
460 470 480 490 500
GSPAAPQHLL GPGPVAGPKL YPKLYTDIHT HTHTHSHTHS HVEGKVHQHI

HYQC
Length:504
Mass (Da):54,537
Last modified:October 1, 2002 - v1
Checksum:i56E35E57D5FC141B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti374 – 380Missing in AAK15273 (Ref. 3) Curated7

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022642362P → Q.3 PublicationsCorresponds to variant rs4647930dbSNPEnsembl.1
Natural variantiVAR_024316464P → L.Corresponds to variant rs4647932dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277437 mRNA. Translation: CAC14171.1.
AF279689 mRNA. Translation: AAK26742.1.
AF312678 mRNA. Translation: AAK15273.1.
AY358303 mRNA. Translation: AAQ88670.1.
AK314365 mRNA. Translation: BAG36996.1.
BC036769 mRNA. Translation: AAH36769.1.
CCDSiCCDS3344.1.
RefSeqiNP_001004356.1. NM_001004356.2.
NP_001004358.1. NM_001004358.1.
NP_068742.2. NM_021923.3.
XP_011511788.1. XM_011513486.1.
UniGeneiHs.193326.

Genome annotation databases

EnsembliENST00000264748; ENSP00000264748; ENSG00000127418.
ENST00000398484; ENSP00000381498; ENSG00000127418.
ENST00000504138; ENSP00000423091; ENSG00000127418.
ENST00000510644; ENSP00000425025; ENSG00000127418.
GeneIDi53834.
KEGGihsa:53834.
UCSCiuc003gcf.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277437 mRNA. Translation: CAC14171.1.
AF279689 mRNA. Translation: AAK26742.1.
AF312678 mRNA. Translation: AAK15273.1.
AY358303 mRNA. Translation: AAQ88670.1.
AK314365 mRNA. Translation: BAG36996.1.
BC036769 mRNA. Translation: AAH36769.1.
CCDSiCCDS3344.1.
RefSeqiNP_001004356.1. NM_001004356.2.
NP_001004358.1. NM_001004358.1.
NP_068742.2. NM_021923.3.
XP_011511788.1. XM_011513486.1.
UniGeneiHs.193326.

3D structure databases

ProteinModelPortaliQ8N441.
SMRiQ8N441.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119806. 23 interactors.
STRINGi9606.ENSP00000264748.

PTM databases

iPTMnetiQ8N441.
PhosphoSitePlusiQ8N441.

Polymorphism and mutation databases

BioMutaiFGFRL1.
DMDMi68052359.

Proteomic databases

MaxQBiQ8N441.
PaxDbiQ8N441.
PeptideAtlasiQ8N441.
PRIDEiQ8N441.

Protocols and materials databases

DNASUi53834.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264748; ENSP00000264748; ENSG00000127418.
ENST00000398484; ENSP00000381498; ENSG00000127418.
ENST00000504138; ENSP00000423091; ENSG00000127418.
ENST00000510644; ENSP00000425025; ENSG00000127418.
GeneIDi53834.
KEGGihsa:53834.
UCSCiuc003gcf.4. human.

Organism-specific databases

CTDi53834.
DisGeNETi53834.
GeneCardsiFGFRL1.
H-InvDBHIX0163986.
HGNCiHGNC:3693. FGFRL1.
HPAiCAB026019.
HPA068828.
MIMi605830. gene.
neXtProtiNX_Q8N441.
OpenTargetsiENSG00000127418.
PharmGKBiPA28132.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00390000008504.
HOGENOMiHOG000112576.
HOVERGENiHBG056473.
InParanoidiQ8N441.
OMAiKRVEYGT.
OrthoDBiEOG091G0985.
PhylomeDBiQ8N441.

Enzyme and pathway databases

ReactomeiR-HSA-5658623. FGFRL1 modulation of FGFR1 signaling.

Miscellaneous databases

GeneWikiiFGFRL1.
GenomeRNAii53834.
PROiQ8N441.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127418.
CleanExiHS_FGFRL1.
ExpressionAtlasiQ8N441. baseline and differential.
GenevisibleiQ8N441. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFGRL1_HUMAN
AccessioniPrimary (citable) accession number: Q8N441
Secondary accession number(s): B2RAU9
, Q6PJN1, Q9BXN7, Q9H4D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.