Q8N441 (FGRL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fibroblast growth factor receptor-like 1
Short name=FGF receptor-like protein 1

Alternative name(s):
FGF homologous factor receptor
FGFR-like protein
Fibroblast growth factor receptor 5
Short name=FGFR-5

Gene names

Name:	FGFRL1
Synonyms:	FGFR5, FHFR
ORF Names:	UNQ480/PRO943

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	504 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has a negative effect on cell proliferation By similarity.
Subunit structure	Interacts with FGF2 with a low affinity By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein. Note: Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles. Ref.9
Tissue specificity	Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen. Ref.1 Ref.2 Ref.8
Sequence similarities	Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	diaphragm development Inferred from electronic annotation. Source: Compara heart valve morphogenesis Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara regulation of cell growth Non-traceable author statement. Source: UniProtKB skeletal system development Inferred from electronic annotation. Source: Compara ventricular septum morphogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay Ref.9. Source: UniProtKB
Molecular_function	fibroblast growth factor-activated receptor activity Inferred from direct assay Ref.9. Source: UniProtKB heparin binding Inferred from direct assay Ref.9. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Ref.7
	Chain	25 – 504	480	Fibroblast growth factor receptor-like 1		PRO_0000021250
Regions
	Topological domain	25 – 378	354	Extracellular Potential
	Transmembrane	379 – 399	21	Helical; Potential
	Topological domain	400 – 504	105	Cytoplasmic Potential
	Domain	29 – 115	87	Ig-like C2-type 1
	Domain	147 – 237	91	Ig-like C2-type 2
	Domain	246 – 354	109	Ig-like C2-type 3
	Compositional bias	479 – 501	23	His-rich
Amino acid modifications
	Glycosylation	111	1	N-linked (GlcNAc...) Potential
	Glycosylation	231	1	N-linked (GlcNAc...) Potential
	Glycosylation	255	1	N-linked (GlcNAc...) Potential
	Glycosylation	293	1	N-linked (GlcNAc...) Potential
	Disulfide bond	51 ↔ 99		By similarity
	Disulfide bond	172 ↔ 221		By similarity
	Disulfide bond	268 ↔ 338		By similarity
Natural variations
	Natural variant	362	1	P → Q. Ref.1 Ref.2 Ref.6 Corresponds to variant rs4647930 [ dbSNP | Ensembl ].		VAR_022642
	Natural variant	464	1	P → L. Corresponds to variant rs4647932 [ dbSNP | Ensembl ].		VAR_024316
Experimental info
	Sequence conflict	374 – 380	7	Missing in AAK15273. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q8N441 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 56E35E57D5FC141B	FASTA	504	54,537
	10 20 30 40 50 60 MTPSPLLLLL LPPLLLGAFP PAAAARGPPK MADKVVPRQV ARLGRTVRLQ CPVEGDPPPL 70 80 90 100 110 120 TMWTKDGRTI HSGWSRFRVL PQGLKVKQVE REDAGVYVCK ATNGFGSLSV NYTLVVLDDI 130 140 150 160 170 180 SPGKESLGPD SSSGGQEDPA SQQWARPRFT QPSKMRRRVI ARPVGSSVRL KCVASGHPRP 190 200 210 220 230 240 DITWMKDDQA LTRPEAAEPR KKKWTLSLKN LRPEDSGKYT CRVSNRAGAI NATYKVDVIQ 250 260 270 280 290 300 RTRSKPVLTG THPVNTTVDF GGTTSFQCKV RSDVKPVIQW LKRVEYGAEG RHNSTIDVGG 310 320 330 340 350 360 QKFVVLPTGD VWSRPDGSYL NKLLITRARQ DDAGMYICLG ANTMGYSFRS AFLTVLPDPK 370 380 390 400 410 420 PPGPPVASSS SATSLPWPVV IGIPAGAVFI LGTLLLWLCQ AQKKPCTPAP APPLPGHRPP 430 440 450 460 470 480 GTARDRSGDK DLPSLAALSA GPGVGLCEEH GSPAAPQHLL GPGPVAGPKL YPKLYTDIHT 490 500 HTHTHSHTHS HVEGKVHQHI HYQC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors." Wiedemann M., Trueb B. Genomics 69:275-279(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT GLN-362. Tissue: Cartilage.
[2]	"A novel fibroblast growth factor receptor-5 preferentially expressed in the pancreas." Kim I., Moon S.-O., Yu K.-H., Kim U.-H., Koh G.Y. Biochim. Biophys. Acta 1518:152-156(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT GLN-362.
[3]	"FHFR, a novel fibroblast growth factor receptor that uniquely binds the fibroblast growth factor homologous factors." Aggarwal S., Xie M.-H., Foster J., Frantz G., Stinson J., Corpuz R.T., Simmons L., Hillan K., Yansura D.G., Vandlen R.L., Goddard A.D., Gurney A.L. Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-362. Tissue: Brain.
[7]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 25-39.
[8]	"Identification of a new fibroblast growth factor receptor, FGFR5." Sleeman M., Fraser J., McDonald M., Yuan S., White D., Grandison P., Kumble K., Watson J.D., Murison J.G. Gene 271:171-182(2001) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[9]	"Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues." Trueb B., Zhuang L., Taeschler S., Wiedemann M. J. Biol. Chem. 278:33857-33865(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION. Tissue: Cartilage.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ277437 mRNA. Translation: CAC14171.1. AF279689 mRNA. Translation: AAK26742.1. AF312678 mRNA. Translation: AAK15273.1. AY358303 mRNA. Translation: AAQ88670.1. AK314365 mRNA. Translation: BAG36996.1. BC036769 mRNA. Translation: AAH36769.1.
IPI	IPI00296561.
RefSeq	NP_001004356.1. NM_001004356.2. NP_001004358.1. NM_001004358.1. NP_068742.2. NM_021923.3.
UniGene	Hs.193326.
3D structure databases
ProteinModelPortal	Q8N441.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000264748.
Protein family/group databases
MEROPS	I43.001.
PTM databases
PhosphoSite	Q8N441.
Polymorphism databases
DMDM	68052359.
Proteomic databases
PaxDb	Q8N441.
PeptideAtlas	Q8N441.
PRIDE	Q8N441.
Protocols and materials databases
DNASU	53834.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264748; ENSP00000264748; ENSG00000127418. ENST00000398484; ENSP00000381498; ENSG00000127418. ENST00000504138; ENSP00000423091; ENSG00000127418. ENST00000510644; ENSP00000425025; ENSG00000127418.
GeneID	53834.
KEGG	hsa:53834.
UCSC	uc003gce.3. human.
Organism-specific databases
CTD	53834.
GeneCards	GC04P001003.
H-InvDB	HIX0163986.
HGNC	HGNC:3693. FGFRL1.
HPA	CAB026019.
MIM	605830. gene.
neXtProt	NX_Q8N441.
PharmGKB	PA28132.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG289609.
HOGENOM	HOG000112576.
HOVERGEN	HBG056473.
InParanoid	Q8N441.
OMA	SQQWARP.
OrthoDB	EOG44XJGS.
Gene expression databases
ArrayExpress	Q8N441.
Bgee	Q8N441.
CleanEx	HS_FGFRL1.
Genevestigator	Q8N441.
GermOnline	ENSG00000127418. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 3 hits.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. [Graphical view]
Pfam	PF07679. I-set. 3 hits. [Graphical view]
SMART	SM00409. IG. 1 hit. SM00408. IGc2. 2 hits. [Graphical view]
PROSITE	PS50835. IG_LIKE. 3 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	53834.
NextBio	56170.
SOURCE	Search...

Entry information

Entry name

FGRL1_HUMAN

Accession

Primary (citable) accession number: Q8N441
Secondary accession number(s): B2RAU9 , Q6PJN1, Q9BXN7, Q9H4D7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.