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Q8N441

- FGRL1_HUMAN

UniProt

Q8N441 - FGRL1_HUMAN

Protein

Fibroblast growth factor receptor-like 1

Gene

FGFRL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Has a negative effect on cell proliferation.By similarity

    GO - Molecular functioni

    1. fibroblast growth factor-activated receptor activity Source: UniProtKB
    2. heparin binding Source: UniProtKB

    GO - Biological processi

    1. diaphragm development Source: Ensembl
    2. fibroblast growth factor receptor signaling pathway Source: GOC
    3. heart valve morphogenesis Source: Ensembl
    4. negative regulation of cell proliferation Source: Ensembl
    5. skeletal system development Source: Ensembl
    6. ventricular septum morphogenesis Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor receptor-like 1
    Short name:
    FGF receptor-like protein 1
    Alternative name(s):
    FGF homologous factor receptor
    FGFR-like protein
    Fibroblast growth factor receptor 5
    Short name:
    FGFR-5
    Gene namesi
    Name:FGFRL1
    Synonyms:FGFR5, FHFR
    ORF Names:UNQ480/PRO943
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:3693. FGFRL1.

    Subcellular locationi

    Membrane 1 Publication; Single-pass type I membrane protein 1 Publication
    Note: Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28132.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 24241 PublicationAdd
    BLAST
    Chaini25 – 504480Fibroblast growth factor receptor-like 1PRO_0000021250Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi51 ↔ 99PROSITE-ProRule annotation
    Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi172 ↔ 221PROSITE-ProRule annotation
    Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi268 ↔ 338PROSITE-ProRule annotation
    Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ8N441.
    PaxDbiQ8N441.
    PeptideAtlasiQ8N441.
    PRIDEiQ8N441.

    PTM databases

    PhosphoSiteiQ8N441.

    Expressioni

    Tissue specificityi

    Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen.3 Publications

    Gene expression databases

    ArrayExpressiQ8N441.
    BgeeiQ8N441.
    CleanExiHS_FGFRL1.
    GenevestigatoriQ8N441.

    Organism-specific databases

    HPAiCAB026019.

    Interactioni

    Subunit structurei

    Interacts with FGF2 with a low affinity.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000264748.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N441.
    SMRiQ8N441. Positions 25-359.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 378354ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini400 – 504105CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei379 – 39921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 11587Ig-like C2-type 1Add
    BLAST
    Domaini147 – 23791Ig-like C2-type 2Add
    BLAST
    Domaini246 – 354109Ig-like C2-type 3Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi479 – 50123His-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG289609.
    HOGENOMiHOG000112576.
    HOVERGENiHBG056473.
    InParanoidiQ8N441.
    OMAiKQWARPR.
    OrthoDBiEOG79KPF3.
    PhylomeDBiQ8N441.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view]
    PfamiPF07679. I-set. 3 hits.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    SM00408. IGc2. 2 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8N441-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTPSPLLLLL LPPLLLGAFP PAAAARGPPK MADKVVPRQV ARLGRTVRLQ    50
    CPVEGDPPPL TMWTKDGRTI HSGWSRFRVL PQGLKVKQVE REDAGVYVCK 100
    ATNGFGSLSV NYTLVVLDDI SPGKESLGPD SSSGGQEDPA SQQWARPRFT 150
    QPSKMRRRVI ARPVGSSVRL KCVASGHPRP DITWMKDDQA LTRPEAAEPR 200
    KKKWTLSLKN LRPEDSGKYT CRVSNRAGAI NATYKVDVIQ RTRSKPVLTG 250
    THPVNTTVDF GGTTSFQCKV RSDVKPVIQW LKRVEYGAEG RHNSTIDVGG 300
    QKFVVLPTGD VWSRPDGSYL NKLLITRARQ DDAGMYICLG ANTMGYSFRS 350
    AFLTVLPDPK PPGPPVASSS SATSLPWPVV IGIPAGAVFI LGTLLLWLCQ 400
    AQKKPCTPAP APPLPGHRPP GTARDRSGDK DLPSLAALSA GPGVGLCEEH 450
    GSPAAPQHLL GPGPVAGPKL YPKLYTDIHT HTHTHSHTHS HVEGKVHQHI 500
    HYQC 504
    Length:504
    Mass (Da):54,537
    Last modified:October 1, 2002 - v1
    Checksum:i56E35E57D5FC141B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti374 – 3807Missing in AAK15273. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti362 – 3621P → Q.3 Publications
    Corresponds to variant rs4647930 [ dbSNP | Ensembl ].
    VAR_022642
    Natural varianti464 – 4641P → L.
    Corresponds to variant rs4647932 [ dbSNP | Ensembl ].
    VAR_024316

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ277437 mRNA. Translation: CAC14171.1.
    AF279689 mRNA. Translation: AAK26742.1.
    AF312678 mRNA. Translation: AAK15273.1.
    AY358303 mRNA. Translation: AAQ88670.1.
    AK314365 mRNA. Translation: BAG36996.1.
    BC036769 mRNA. Translation: AAH36769.1.
    CCDSiCCDS3344.1.
    RefSeqiNP_001004356.1. NM_001004356.2.
    NP_001004358.1. NM_001004358.1.
    NP_068742.2. NM_021923.3.
    UniGeneiHs.193326.

    Genome annotation databases

    EnsembliENST00000264748; ENSP00000264748; ENSG00000127418.
    ENST00000398484; ENSP00000381498; ENSG00000127418.
    ENST00000504138; ENSP00000423091; ENSG00000127418.
    ENST00000510644; ENSP00000425025; ENSG00000127418.
    GeneIDi53834.
    KEGGihsa:53834.
    UCSCiuc003gce.3. human.

    Polymorphism databases

    DMDMi68052359.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ277437 mRNA. Translation: CAC14171.1 .
    AF279689 mRNA. Translation: AAK26742.1 .
    AF312678 mRNA. Translation: AAK15273.1 .
    AY358303 mRNA. Translation: AAQ88670.1 .
    AK314365 mRNA. Translation: BAG36996.1 .
    BC036769 mRNA. Translation: AAH36769.1 .
    CCDSi CCDS3344.1.
    RefSeqi NP_001004356.1. NM_001004356.2.
    NP_001004358.1. NM_001004358.1.
    NP_068742.2. NM_021923.3.
    UniGenei Hs.193326.

    3D structure databases

    ProteinModelPortali Q8N441.
    SMRi Q8N441. Positions 25-359.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000264748.

    Protein family/group databases

    MEROPSi I43.001.

    PTM databases

    PhosphoSitei Q8N441.

    Polymorphism databases

    DMDMi 68052359.

    Proteomic databases

    MaxQBi Q8N441.
    PaxDbi Q8N441.
    PeptideAtlasi Q8N441.
    PRIDEi Q8N441.

    Protocols and materials databases

    DNASUi 53834.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264748 ; ENSP00000264748 ; ENSG00000127418 .
    ENST00000398484 ; ENSP00000381498 ; ENSG00000127418 .
    ENST00000504138 ; ENSP00000423091 ; ENSG00000127418 .
    ENST00000510644 ; ENSP00000425025 ; ENSG00000127418 .
    GeneIDi 53834.
    KEGGi hsa:53834.
    UCSCi uc003gce.3. human.

    Organism-specific databases

    CTDi 53834.
    GeneCardsi GC04P001003.
    H-InvDB HIX0163986.
    HGNCi HGNC:3693. FGFRL1.
    HPAi CAB026019.
    MIMi 605830. gene.
    neXtProti NX_Q8N441.
    PharmGKBi PA28132.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG289609.
    HOGENOMi HOG000112576.
    HOVERGENi HBG056473.
    InParanoidi Q8N441.
    OMAi KQWARPR.
    OrthoDBi EOG79KPF3.
    PhylomeDBi Q8N441.

    Miscellaneous databases

    GeneWikii FGFRL1.
    GenomeRNAii 53834.
    NextBioi 56170.
    PROi Q8N441.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N441.
    Bgeei Q8N441.
    CleanExi HS_FGFRL1.
    Genevestigatori Q8N441.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view ]
    Pfami PF07679. I-set. 3 hits.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    SM00408. IGc2. 2 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors."
      Wiedemann M., Trueb B.
      Genomics 69:275-279(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT GLN-362.
      Tissue: Cartilage.
    2. "A novel fibroblast growth factor receptor-5 preferentially expressed in the pancreas."
      Kim I., Moon S.-O., Yu K.-H., Kim U.-H., Koh G.Y.
      Biochim. Biophys. Acta 1518:152-156(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT GLN-362.
    3. "FHFR, a novel fibroblast growth factor receptor that uniquely binds the fibroblast growth factor homologous factors."
      Aggarwal S., Xie M.-H., Foster J., Frantz G., Stinson J., Corpuz R.T., Simmons L., Hillan K., Yansura D.G., Vandlen R.L., Goddard A.D., Gurney A.L.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-362.
      Tissue: Brain.
    7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-39.
    8. "Identification of a new fibroblast growth factor receptor, FGFR5."
      Sleeman M., Fraser J., McDonald M., Yuan S., White D., Grandison P., Kumble K., Watson J.D., Murison J.G.
      Gene 271:171-182(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    9. "Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues."
      Trueb B., Zhuang L., Taeschler S., Wiedemann M.
      J. Biol. Chem. 278:33857-33865(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
      Tissue: Cartilage.

    Entry informationi

    Entry nameiFGRL1_HUMAN
    AccessioniPrimary (citable) accession number: Q8N441
    Secondary accession number(s): B2RAU9
    , Q6PJN1, Q9BXN7, Q9H4D7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3