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Q8N441 (FGRL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor receptor-like 1

Short name=FGF receptor-like protein 1
Alternative name(s):
FGF homologous factor receptor
FGFR-like protein
Fibroblast growth factor receptor 5
Short name=FGFR-5
Gene names
Name:FGFRL1
Synonyms:FGFR5, FHFR
ORF Names:UNQ480/PRO943
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has a negative effect on cell proliferation By similarity.

Subunit structure

Interacts with FGF2 with a low affinity By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein. Note: Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles. Ref.9

Tissue specificity

Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen. Ref.1 Ref.2 Ref.8

Sequence similarities

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Ref.7
Chain25 – 504480Fibroblast growth factor receptor-like 1
PRO_0000021250

Regions

Topological domain25 – 378354Extracellular Potential
Transmembrane379 – 39921Helical; Potential
Topological domain400 – 504105Cytoplasmic Potential
Domain29 – 11587Ig-like C2-type 1
Domain147 – 23791Ig-like C2-type 2
Domain246 – 354109Ig-like C2-type 3
Compositional bias479 – 50123His-rich

Amino acid modifications

Glycosylation1111N-linked (GlcNAc...) Potential
Glycosylation2311N-linked (GlcNAc...) Potential
Glycosylation2551N-linked (GlcNAc...) Potential
Glycosylation2931N-linked (GlcNAc...) Potential
Disulfide bond51 ↔ 99 By similarity
Disulfide bond172 ↔ 221 By similarity
Disulfide bond268 ↔ 338 By similarity

Natural variations

Natural variant3621P → Q. Ref.1 Ref.2 Ref.6
Corresponds to variant rs4647930 [ dbSNP | Ensembl ].
VAR_022642
Natural variant4641P → L.
Corresponds to variant rs4647932 [ dbSNP | Ensembl ].
VAR_024316

Experimental info

Sequence conflict374 – 3807Missing in AAK15273. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8N441 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 56E35E57D5FC141B

FASTA50454,537
        10         20         30         40         50         60 
MTPSPLLLLL LPPLLLGAFP PAAAARGPPK MADKVVPRQV ARLGRTVRLQ CPVEGDPPPL 

        70         80         90        100        110        120 
TMWTKDGRTI HSGWSRFRVL PQGLKVKQVE REDAGVYVCK ATNGFGSLSV NYTLVVLDDI 

       130        140        150        160        170        180 
SPGKESLGPD SSSGGQEDPA SQQWARPRFT QPSKMRRRVI ARPVGSSVRL KCVASGHPRP 

       190        200        210        220        230        240 
DITWMKDDQA LTRPEAAEPR KKKWTLSLKN LRPEDSGKYT CRVSNRAGAI NATYKVDVIQ 

       250        260        270        280        290        300 
RTRSKPVLTG THPVNTTVDF GGTTSFQCKV RSDVKPVIQW LKRVEYGAEG RHNSTIDVGG 

       310        320        330        340        350        360 
QKFVVLPTGD VWSRPDGSYL NKLLITRARQ DDAGMYICLG ANTMGYSFRS AFLTVLPDPK 

       370        380        390        400        410        420 
PPGPPVASSS SATSLPWPVV IGIPAGAVFI LGTLLLWLCQ AQKKPCTPAP APPLPGHRPP 

       430        440        450        460        470        480 
GTARDRSGDK DLPSLAALSA GPGVGLCEEH GSPAAPQHLL GPGPVAGPKL YPKLYTDIHT 

       490        500 
HTHTHSHTHS HVEGKVHQHI HYQC 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors."
Wiedemann M., Trueb B.
Genomics 69:275-279(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT GLN-362.
Tissue: Cartilage.
[2]"A novel fibroblast growth factor receptor-5 preferentially expressed in the pancreas."
Kim I., Moon S.-O., Yu K.-H., Kim U.-H., Koh G.Y.
Biochim. Biophys. Acta 1518:152-156(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT GLN-362.
[3]"FHFR, a novel fibroblast growth factor receptor that uniquely binds the fibroblast growth factor homologous factors."
Aggarwal S., Xie M.-H., Foster J., Frantz G., Stinson J., Corpuz R.T., Simmons L., Hillan K., Yansura D.G., Vandlen R.L., Goddard A.D., Gurney A.L.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-362.
Tissue: Brain.
[7]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 25-39.
[8]"Identification of a new fibroblast growth factor receptor, FGFR5."
Sleeman M., Fraser J., McDonald M., Yuan S., White D., Grandison P., Kumble K., Watson J.D., Murison J.G.
Gene 271:171-182(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[9]"Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues."
Trueb B., Zhuang L., Taeschler S., Wiedemann M.
J. Biol. Chem. 278:33857-33865(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
Tissue: Cartilage.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ277437 mRNA. Translation: CAC14171.1.
AF279689 mRNA. Translation: AAK26742.1.
AF312678 mRNA. Translation: AAK15273.1.
AY358303 mRNA. Translation: AAQ88670.1.
AK314365 mRNA. Translation: BAG36996.1.
BC036769 mRNA. Translation: AAH36769.1.
CCDSCCDS3344.1.
RefSeqNP_001004356.1. NM_001004356.2.
NP_001004358.1. NM_001004358.1.
NP_068742.2. NM_021923.3.
UniGeneHs.193326.

3D structure databases

ProteinModelPortalQ8N441.
SMRQ8N441. Positions 25-359.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000264748.

Protein family/group databases

MEROPSI43.001.

PTM databases

PhosphoSiteQ8N441.

Polymorphism databases

DMDM68052359.

Proteomic databases

MaxQBQ8N441.
PaxDbQ8N441.
PeptideAtlasQ8N441.
PRIDEQ8N441.

Protocols and materials databases

DNASU53834.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264748; ENSP00000264748; ENSG00000127418.
ENST00000398484; ENSP00000381498; ENSG00000127418.
ENST00000504138; ENSP00000423091; ENSG00000127418.
ENST00000510644; ENSP00000425025; ENSG00000127418.
GeneID53834.
KEGGhsa:53834.
UCSCuc003gce.3. human.

Organism-specific databases

CTD53834.
GeneCardsGC04P001003.
H-InvDBHIX0163986.
HGNCHGNC:3693. FGFRL1.
HPACAB026019.
MIM605830. gene.
neXtProtNX_Q8N441.
PharmGKBPA28132.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG289609.
HOGENOMHOG000112576.
HOVERGENHBG056473.
InParanoidQ8N441.
OMAKQWARPR.
OrthoDBEOG79KPF3.
PhylomeDBQ8N441.

Gene expression databases

ArrayExpressQ8N441.
BgeeQ8N441.
CleanExHS_FGFRL1.
GenevestigatorQ8N441.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamPF07679. I-set. 3 hits.
[Graphical view]
SMARTSM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiFGFRL1.
GenomeRNAi53834.
NextBio56170.
PROQ8N441.
SOURCESearch...

Entry information

Entry nameFGRL1_HUMAN
AccessionPrimary (citable) accession number: Q8N441
Secondary accession number(s): B2RAU9 expand/collapse secondary AC list , Q6PJN1, Q9BXN7, Q9H4D7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM