Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8N441

- FGRL1_HUMAN

UniProt

Q8N441 - FGRL1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Fibroblast growth factor receptor-like 1

Gene

FGFRL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Has a negative effect on cell proliferation.By similarity

GO - Molecular functioni

  1. fibroblast growth factor-activated receptor activity Source: UniProtKB
  2. heparin binding Source: UniProtKB

GO - Biological processi

  1. diaphragm development Source: Ensembl
  2. heart valve morphogenesis Source: Ensembl
  3. negative regulation of cell proliferation Source: Ensembl
  4. skeletal system development Source: Ensembl
  5. ventricular septum morphogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptor-like 1
Short name:
FGF receptor-like protein 1
Alternative name(s):
FGF homologous factor receptor
FGFR-like protein
Fibroblast growth factor receptor 5
Short name:
FGFR-5
Gene namesi
Name:FGFRL1
Synonyms:FGFR5, FHFR
ORF Names:UNQ480/PRO943
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:3693. FGFRL1.

Subcellular locationi

Membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Note: Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles.

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28132.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Chaini25 – 504480Fibroblast growth factor receptor-like 1PRO_0000021250Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 99PROSITE-ProRule annotation
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi172 ↔ 221PROSITE-ProRule annotation
Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi268 ↔ 338PROSITE-ProRule annotation
Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8N441.
PaxDbiQ8N441.
PeptideAtlasiQ8N441.
PRIDEiQ8N441.

PTM databases

PhosphoSiteiQ8N441.

Expressioni

Tissue specificityi

Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen.3 Publications

Gene expression databases

BgeeiQ8N441.
CleanExiHS_FGFRL1.
ExpressionAtlasiQ8N441. baseline and differential.
GenevestigatoriQ8N441.

Organism-specific databases

HPAiCAB026019.

Interactioni

Subunit structurei

Interacts with FGF2 with a low affinity.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000264748.

Structurei

3D structure databases

ProteinModelPortaliQ8N441.
SMRiQ8N441. Positions 25-359.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 378354ExtracellularSequence AnalysisAdd
BLAST
Topological domaini400 – 504105CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei379 – 39921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 11587Ig-like C2-type 1Add
BLAST
Domaini147 – 23791Ig-like C2-type 2Add
BLAST
Domaini246 – 354109Ig-like C2-type 3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi479 – 50123His-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG289609.
GeneTreeiENSGT00390000008504.
HOGENOMiHOG000112576.
HOVERGENiHBG056473.
InParanoidiQ8N441.
OMAiKQWARPR.
OrthoDBiEOG79KPF3.
PhylomeDBiQ8N441.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N441-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTPSPLLLLL LPPLLLGAFP PAAAARGPPK MADKVVPRQV ARLGRTVRLQ
60 70 80 90 100
CPVEGDPPPL TMWTKDGRTI HSGWSRFRVL PQGLKVKQVE REDAGVYVCK
110 120 130 140 150
ATNGFGSLSV NYTLVVLDDI SPGKESLGPD SSSGGQEDPA SQQWARPRFT
160 170 180 190 200
QPSKMRRRVI ARPVGSSVRL KCVASGHPRP DITWMKDDQA LTRPEAAEPR
210 220 230 240 250
KKKWTLSLKN LRPEDSGKYT CRVSNRAGAI NATYKVDVIQ RTRSKPVLTG
260 270 280 290 300
THPVNTTVDF GGTTSFQCKV RSDVKPVIQW LKRVEYGAEG RHNSTIDVGG
310 320 330 340 350
QKFVVLPTGD VWSRPDGSYL NKLLITRARQ DDAGMYICLG ANTMGYSFRS
360 370 380 390 400
AFLTVLPDPK PPGPPVASSS SATSLPWPVV IGIPAGAVFI LGTLLLWLCQ
410 420 430 440 450
AQKKPCTPAP APPLPGHRPP GTARDRSGDK DLPSLAALSA GPGVGLCEEH
460 470 480 490 500
GSPAAPQHLL GPGPVAGPKL YPKLYTDIHT HTHTHSHTHS HVEGKVHQHI

HYQC
Length:504
Mass (Da):54,537
Last modified:October 1, 2002 - v1
Checksum:i56E35E57D5FC141B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti374 – 3807Missing in AAK15273. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti362 – 3621P → Q.3 Publications
Corresponds to variant rs4647930 [ dbSNP | Ensembl ].
VAR_022642
Natural varianti464 – 4641P → L.
Corresponds to variant rs4647932 [ dbSNP | Ensembl ].
VAR_024316

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ277437 mRNA. Translation: CAC14171.1.
AF279689 mRNA. Translation: AAK26742.1.
AF312678 mRNA. Translation: AAK15273.1.
AY358303 mRNA. Translation: AAQ88670.1.
AK314365 mRNA. Translation: BAG36996.1.
BC036769 mRNA. Translation: AAH36769.1.
CCDSiCCDS3344.1.
RefSeqiNP_001004356.1. NM_001004356.2.
NP_001004358.1. NM_001004358.1.
NP_068742.2. NM_021923.3.
UniGeneiHs.193326.

Genome annotation databases

EnsembliENST00000264748; ENSP00000264748; ENSG00000127418.
ENST00000398484; ENSP00000381498; ENSG00000127418.
ENST00000504138; ENSP00000423091; ENSG00000127418.
ENST00000510644; ENSP00000425025; ENSG00000127418.
GeneIDi53834.
KEGGihsa:53834.
UCSCiuc003gce.3. human.

Polymorphism databases

DMDMi68052359.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ277437 mRNA. Translation: CAC14171.1 .
AF279689 mRNA. Translation: AAK26742.1 .
AF312678 mRNA. Translation: AAK15273.1 .
AY358303 mRNA. Translation: AAQ88670.1 .
AK314365 mRNA. Translation: BAG36996.1 .
BC036769 mRNA. Translation: AAH36769.1 .
CCDSi CCDS3344.1.
RefSeqi NP_001004356.1. NM_001004356.2.
NP_001004358.1. NM_001004358.1.
NP_068742.2. NM_021923.3.
UniGenei Hs.193326.

3D structure databases

ProteinModelPortali Q8N441.
SMRi Q8N441. Positions 25-359.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000264748.

Protein family/group databases

MEROPSi I43.001.

PTM databases

PhosphoSitei Q8N441.

Polymorphism databases

DMDMi 68052359.

Proteomic databases

MaxQBi Q8N441.
PaxDbi Q8N441.
PeptideAtlasi Q8N441.
PRIDEi Q8N441.

Protocols and materials databases

DNASUi 53834.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264748 ; ENSP00000264748 ; ENSG00000127418 .
ENST00000398484 ; ENSP00000381498 ; ENSG00000127418 .
ENST00000504138 ; ENSP00000423091 ; ENSG00000127418 .
ENST00000510644 ; ENSP00000425025 ; ENSG00000127418 .
GeneIDi 53834.
KEGGi hsa:53834.
UCSCi uc003gce.3. human.

Organism-specific databases

CTDi 53834.
GeneCardsi GC04P001003.
H-InvDB HIX0163986.
HGNCi HGNC:3693. FGFRL1.
HPAi CAB026019.
MIMi 605830. gene.
neXtProti NX_Q8N441.
PharmGKBi PA28132.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG289609.
GeneTreei ENSGT00390000008504.
HOGENOMi HOG000112576.
HOVERGENi HBG056473.
InParanoidi Q8N441.
OMAi KQWARPR.
OrthoDBi EOG79KPF3.
PhylomeDBi Q8N441.

Miscellaneous databases

GeneWikii FGFRL1.
GenomeRNAii 53834.
NextBioi 56170.
PROi Q8N441.
SOURCEi Search...

Gene expression databases

Bgeei Q8N441.
CleanExi HS_FGFRL1.
ExpressionAtlasi Q8N441. baseline and differential.
Genevestigatori Q8N441.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view ]
Pfami PF07679. I-set. 3 hits.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors."
    Wiedemann M., Trueb B.
    Genomics 69:275-279(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT GLN-362.
    Tissue: Cartilage.
  2. "A novel fibroblast growth factor receptor-5 preferentially expressed in the pancreas."
    Kim I., Moon S.-O., Yu K.-H., Kim U.-H., Koh G.Y.
    Biochim. Biophys. Acta 1518:152-156(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT GLN-362.
  3. "FHFR, a novel fibroblast growth factor receptor that uniquely binds the fibroblast growth factor homologous factors."
    Aggarwal S., Xie M.-H., Foster J., Frantz G., Stinson J., Corpuz R.T., Simmons L., Hillan K., Yansura D.G., Vandlen R.L., Goddard A.D., Gurney A.L.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-362.
    Tissue: Brain.
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-39.
  8. "Identification of a new fibroblast growth factor receptor, FGFR5."
    Sleeman M., Fraser J., McDonald M., Yuan S., White D., Grandison P., Kumble K., Watson J.D., Murison J.G.
    Gene 271:171-182(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. "Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues."
    Trueb B., Zhuang L., Taeschler S., Wiedemann M.
    J. Biol. Chem. 278:33857-33865(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Tissue: Cartilage.

Entry informationi

Entry nameiFGRL1_HUMAN
AccessioniPrimary (citable) accession number: Q8N441
Secondary accession number(s): B2RAU9
, Q6PJN1, Q9BXN7, Q9H4D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3