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Q8N436

- CPXM2_HUMAN

UniProt

Q8N436 - CPXM2_HUMAN

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Protein
Inactive carboxypeptidase-like protein X2
Gene
CPXM2, UNQ676/PRO1310
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in cell-cell interactions.

GO - Molecular functioni

  1. metallocarboxypeptidase activity Source: InterPro
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell adhesion Source: InterPro
Complete GO annotation...

Protein family/group databases

MEROPSiM14.036.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive carboxypeptidase-like protein X2
Gene namesi
Name:CPXM2
ORF Names:UNQ676/PRO1310
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:26977. CPXM2.

Subcellular locationi

Secreted Inferred

GO - Cellular componenti

  1. extracellular space Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134866722.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 756731Inactive carboxypeptidase-like protein X2
PRO_0000004409Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi136 ↔ 293 By similarity
Glycosylationi231 – 2311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi241 – 2411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi281 – 2811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi337 – 3371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi491 – 4911N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8N436.
PRIDEiQ8N436.

PTM databases

PhosphoSiteiQ8N436.

Expressioni

Gene expression databases

BgeeiQ8N436.
CleanExiHS_CPXM2.
GenevestigatoriQ8N436.

Organism-specific databases

HPAiHPA048375.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000241305.

Structurei

3D structure databases

ProteinModelPortaliQ8N436.
SMRiQ8N436. Positions 135-293, 314-706.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini134 – 293160F5/8 type C
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi45 – 10157Pro-rich
Add
BLAST
Compositional biasi388 – 3925Poly-Leu

Sequence similaritiesi

Belongs to the peptidase M14 family.
Contains 1 F5/8 type C domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG322453.
HOGENOMiHOG000232185.
HOVERGENiHBG003410.
InParanoidiQ8N436.
KOiK08639.
OMAiGNSEKEI.
OrthoDBiEOG7B8S32.
PhylomeDBiQ8N436.
TreeFamiTF315592.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.1120. 1 hit.
InterProiIPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR008979. Galactose-bd-like.
IPR000834. Peptidase_M14.
[Graphical view]
PfamiPF00754. F5_F8_type_C. 1 hit.
PF00246. Peptidase_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00231. FA58C. 1 hit.
SM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF49464. SSF49464. 1 hit.
SSF49785. SSF49785. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N436-1 [UniParc]FASTAAdd to Basket

« Hide

MSRPGTATPA LALVLLAVTL AGVGAQGAAL EDPDYYGQEI WSREPYYARP    50
EPELETFSPP LPAGPGEEWE RRPQEPRPPK RATKPKKAPK REKSAPEPPP 100
PGKHSNKKVM RTKSSEKAAN DDHSVRVARE DVRESCPPLG LETLKITDFQ 150
LHASTVKRYG LGAHRGRLNI QAGINENDFY DGAWCAGRND LQQWIEVDAR 200
RLTRFTGVIT QGRNSLWLSD WVTSYKVMVS NDSHTWVTVK NGSGDMIFEG 250
NSEKEIPVLN ELPVPMVARY IRINPQSWFD NGSICMRMEI LGCPLPDPNN 300
YYHRRNEMTT TDDLDFKHHN YKEMRQLMKV VNEMCPNITR IYNIGKSHQG 350
LKLYAVEISD HPGEHEVGEP EFHYIAGAHG NEVLGRELLL LLVQFVCQEY 400
LARNARIVHL VEETRIHVLP SLNPDGYEKA YEGGSELGGW SLGRWTHDGI 450
DINNNFPDLN TLLWEAEDRQ NVPRKVPNHY IAIPEWFLSE NATVAAETRA 500
VIAWMEKIPF VLGGNLQGGE LVVAYPYDLV RSPWKTQEHT PTPDDHVFRW 550
LAYSYASTHR LMTDARRRVC HTEDFQKEEG TVNGASWHTV AGSLNDFSYL 600
HTNCFELSIY VGCDKYPHES QLPEEWENNR ESLIVFMEQV HRGIKGLVRD 650
SHGKGIPNAI ISVEGINHDI RTANDGDYWR LLNPGEYVVT AKAEGFTAST 700
KNCMVGYDMG ATRCDFTLSK TNMARIREIM EKFGKQPVSL PARRLKLRGQ 750
KRRQRG 756
Length:756
Mass (Da):85,870
Last modified:May 18, 2010 - v3
Checksum:i1A2F1A5BA7C1DCBE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti750 – 7501Q → R.4 Publications
Corresponds to variant rs7088479 [ dbSNP | Ensembl ].
VAR_048603

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358565 mRNA. Translation: AAQ88928.1.
AK304814 mRNA. Translation: BAG65564.1.
AC009987 Genomic DNA. No translation available.
AC068058 Genomic DNA. No translation available.
CH471066 Genomic DNA. Translation: EAW49279.1.
BC036789 mRNA. Translation: AAH36789.2.
BC137492 mRNA. Translation: AAI37493.1.
BC146862 mRNA. Translation: AAI46863.1.
CCDSiCCDS7637.1.
RefSeqiNP_937791.2. NM_198148.2.
UniGeneiHs.656887.
Hs.663647.

Genome annotation databases

EnsembliENST00000241305; ENSP00000241305; ENSG00000121898.
GeneIDi119587.
KEGGihsa:119587.
UCSCiuc001lhk.1. human.

Polymorphism databases

DMDMi296439384.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358565 mRNA. Translation: AAQ88928.1 .
AK304814 mRNA. Translation: BAG65564.1 .
AC009987 Genomic DNA. No translation available.
AC068058 Genomic DNA. No translation available.
CH471066 Genomic DNA. Translation: EAW49279.1 .
BC036789 mRNA. Translation: AAH36789.2 .
BC137492 mRNA. Translation: AAI37493.1 .
BC146862 mRNA. Translation: AAI46863.1 .
CCDSi CCDS7637.1.
RefSeqi NP_937791.2. NM_198148.2.
UniGenei Hs.656887.
Hs.663647.

3D structure databases

ProteinModelPortali Q8N436.
SMRi Q8N436. Positions 135-293, 314-706.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000241305.

Protein family/group databases

MEROPSi M14.036.

PTM databases

PhosphoSitei Q8N436.

Polymorphism databases

DMDMi 296439384.

Proteomic databases

PaxDbi Q8N436.
PRIDEi Q8N436.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000241305 ; ENSP00000241305 ; ENSG00000121898 .
GeneIDi 119587.
KEGGi hsa:119587.
UCSCi uc001lhk.1. human.

Organism-specific databases

CTDi 119587.
GeneCardsi GC10M125462.
H-InvDB HIX0009282.
HGNCi HGNC:26977. CPXM2.
HPAi HPA048375.
neXtProti NX_Q8N436.
PharmGKBi PA134866722.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG322453.
HOGENOMi HOG000232185.
HOVERGENi HBG003410.
InParanoidi Q8N436.
KOi K08639.
OMAi GNSEKEI.
OrthoDBi EOG7B8S32.
PhylomeDBi Q8N436.
TreeFami TF315592.

Miscellaneous databases

GenomeRNAii 119587.
NextBioi 35477597.
PROi Q8N436.

Gene expression databases

Bgeei Q8N436.
CleanExi HS_CPXM2.
Genevestigatori Q8N436.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
2.60.40.1120. 1 hit.
InterProi IPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR008979. Galactose-bd-like.
IPR000834. Peptidase_M14.
[Graphical view ]
Pfami PF00754. F5_F8_type_C. 1 hit.
PF00246. Peptidase_M14. 1 hit.
[Graphical view ]
PRINTSi PR00765. CRBOXYPTASEA.
SMARTi SM00231. FA58C. 1 hit.
SM00631. Zn_pept. 1 hit.
[Graphical view ]
SUPFAMi SSF49464. SSF49464. 1 hit.
SSF49785. SSF49785. 1 hit.
PROSITEi PS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-750.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-750.
    Tissue: Uterus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-750.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-750.
    Tissue: Brain, Lung and Testis.

Entry informationi

Entry nameiCPXM2_HUMAN
AccessioniPrimary (citable) accession number: Q8N436
Secondary accession number(s): B4E3Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Although related to peptidase M14 family, lacks the active sites residues and zinc-binding sites, suggesting that it has no carboxypeptidase activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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