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Q8N436

- CPXM2_HUMAN

UniProt

Q8N436 - CPXM2_HUMAN

Protein

Inactive carboxypeptidase-like protein X2

Gene

CPXM2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    May be involved in cell-cell interactions.

    GO - Molecular functioni

    1. metallocarboxypeptidase activity Source: InterPro
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cell adhesion Source: InterPro

    Protein family/group databases

    MEROPSiM14.036.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inactive carboxypeptidase-like protein X2
    Gene namesi
    Name:CPXM2
    ORF Names:UNQ676/PRO1310
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:26977. CPXM2.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular space Source: BHF-UCL

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134866722.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 756731Inactive carboxypeptidase-like protein X2PRO_0000004409Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi136 ↔ 293PROSITE-ProRule annotation
    Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi337 – 3371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi491 – 4911N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8N436.
    PRIDEiQ8N436.

    PTM databases

    PhosphoSiteiQ8N436.

    Expressioni

    Gene expression databases

    BgeeiQ8N436.
    CleanExiHS_CPXM2.
    GenevestigatoriQ8N436.

    Organism-specific databases

    HPAiHPA048375.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000241305.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N436.
    SMRiQ8N436. Positions 135-293, 314-706.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini134 – 293160F5/8 type CPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi45 – 10157Pro-richAdd
    BLAST
    Compositional biasi388 – 3925Poly-Leu

    Sequence similaritiesi

    Belongs to the peptidase M14 family.Curated
    Contains 1 F5/8 type C domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG322453.
    HOGENOMiHOG000232185.
    HOVERGENiHBG003410.
    InParanoidiQ8N436.
    KOiK08639.
    OMAiGNSEKEI.
    OrthoDBiEOG7B8S32.
    PhylomeDBiQ8N436.
    TreeFamiTF315592.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    2.60.40.1120. 1 hit.
    InterProiIPR008969. CarboxyPept-like_regulatory.
    IPR014766. CarboxyPept_regulatory_dom.
    IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR008979. Galactose-bd-like.
    IPR000834. Peptidase_M14.
    [Graphical view]
    PfamiPF00754. F5_F8_type_C. 1 hit.
    PF00246. Peptidase_M14. 1 hit.
    [Graphical view]
    PRINTSiPR00765. CRBOXYPTASEA.
    SMARTiSM00231. FA58C. 1 hit.
    SM00631. Zn_pept. 1 hit.
    [Graphical view]
    SUPFAMiSSF49464. SSF49464. 1 hit.
    SSF49785. SSF49785. 1 hit.
    PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
    PS01285. FA58C_1. 1 hit.
    PS01286. FA58C_2. 1 hit.
    PS50022. FA58C_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8N436-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRPGTATPA LALVLLAVTL AGVGAQGAAL EDPDYYGQEI WSREPYYARP    50
    EPELETFSPP LPAGPGEEWE RRPQEPRPPK RATKPKKAPK REKSAPEPPP 100
    PGKHSNKKVM RTKSSEKAAN DDHSVRVARE DVRESCPPLG LETLKITDFQ 150
    LHASTVKRYG LGAHRGRLNI QAGINENDFY DGAWCAGRND LQQWIEVDAR 200
    RLTRFTGVIT QGRNSLWLSD WVTSYKVMVS NDSHTWVTVK NGSGDMIFEG 250
    NSEKEIPVLN ELPVPMVARY IRINPQSWFD NGSICMRMEI LGCPLPDPNN 300
    YYHRRNEMTT TDDLDFKHHN YKEMRQLMKV VNEMCPNITR IYNIGKSHQG 350
    LKLYAVEISD HPGEHEVGEP EFHYIAGAHG NEVLGRELLL LLVQFVCQEY 400
    LARNARIVHL VEETRIHVLP SLNPDGYEKA YEGGSELGGW SLGRWTHDGI 450
    DINNNFPDLN TLLWEAEDRQ NVPRKVPNHY IAIPEWFLSE NATVAAETRA 500
    VIAWMEKIPF VLGGNLQGGE LVVAYPYDLV RSPWKTQEHT PTPDDHVFRW 550
    LAYSYASTHR LMTDARRRVC HTEDFQKEEG TVNGASWHTV AGSLNDFSYL 600
    HTNCFELSIY VGCDKYPHES QLPEEWENNR ESLIVFMEQV HRGIKGLVRD 650
    SHGKGIPNAI ISVEGINHDI RTANDGDYWR LLNPGEYVVT AKAEGFTAST 700
    KNCMVGYDMG ATRCDFTLSK TNMARIREIM EKFGKQPVSL PARRLKLRGQ 750
    KRRQRG 756
    Length:756
    Mass (Da):85,870
    Last modified:May 18, 2010 - v3
    Checksum:i1A2F1A5BA7C1DCBE
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti750 – 7501Q → R.4 Publications
    Corresponds to variant rs7088479 [ dbSNP | Ensembl ].
    VAR_048603

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358565 mRNA. Translation: AAQ88928.1.
    AK304814 mRNA. Translation: BAG65564.1.
    AC009987 Genomic DNA. No translation available.
    AC068058 Genomic DNA. No translation available.
    CH471066 Genomic DNA. Translation: EAW49279.1.
    BC036789 mRNA. Translation: AAH36789.2.
    BC137492 mRNA. Translation: AAI37493.1.
    BC146862 mRNA. Translation: AAI46863.1.
    CCDSiCCDS7637.1.
    RefSeqiNP_937791.2. NM_198148.2.
    UniGeneiHs.656887.
    Hs.663647.

    Genome annotation databases

    EnsembliENST00000241305; ENSP00000241305; ENSG00000121898.
    GeneIDi119587.
    KEGGihsa:119587.
    UCSCiuc001lhk.1. human.

    Polymorphism databases

    DMDMi296439384.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358565 mRNA. Translation: AAQ88928.1 .
    AK304814 mRNA. Translation: BAG65564.1 .
    AC009987 Genomic DNA. No translation available.
    AC068058 Genomic DNA. No translation available.
    CH471066 Genomic DNA. Translation: EAW49279.1 .
    BC036789 mRNA. Translation: AAH36789.2 .
    BC137492 mRNA. Translation: AAI37493.1 .
    BC146862 mRNA. Translation: AAI46863.1 .
    CCDSi CCDS7637.1.
    RefSeqi NP_937791.2. NM_198148.2.
    UniGenei Hs.656887.
    Hs.663647.

    3D structure databases

    ProteinModelPortali Q8N436.
    SMRi Q8N436. Positions 135-293, 314-706.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000241305.

    Protein family/group databases

    MEROPSi M14.036.

    PTM databases

    PhosphoSitei Q8N436.

    Polymorphism databases

    DMDMi 296439384.

    Proteomic databases

    PaxDbi Q8N436.
    PRIDEi Q8N436.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000241305 ; ENSP00000241305 ; ENSG00000121898 .
    GeneIDi 119587.
    KEGGi hsa:119587.
    UCSCi uc001lhk.1. human.

    Organism-specific databases

    CTDi 119587.
    GeneCardsi GC10M125462.
    H-InvDB HIX0009282.
    HGNCi HGNC:26977. CPXM2.
    HPAi HPA048375.
    neXtProti NX_Q8N436.
    PharmGKBi PA134866722.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG322453.
    HOGENOMi HOG000232185.
    HOVERGENi HBG003410.
    InParanoidi Q8N436.
    KOi K08639.
    OMAi GNSEKEI.
    OrthoDBi EOG7B8S32.
    PhylomeDBi Q8N436.
    TreeFami TF315592.

    Miscellaneous databases

    GenomeRNAii 119587.
    NextBioi 35477597.
    PROi Q8N436.

    Gene expression databases

    Bgeei Q8N436.
    CleanExi HS_CPXM2.
    Genevestigatori Q8N436.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    2.60.40.1120. 1 hit.
    InterProi IPR008969. CarboxyPept-like_regulatory.
    IPR014766. CarboxyPept_regulatory_dom.
    IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR008979. Galactose-bd-like.
    IPR000834. Peptidase_M14.
    [Graphical view ]
    Pfami PF00754. F5_F8_type_C. 1 hit.
    PF00246. Peptidase_M14. 1 hit.
    [Graphical view ]
    PRINTSi PR00765. CRBOXYPTASEA.
    SMARTi SM00231. FA58C. 1 hit.
    SM00631. Zn_pept. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49464. SSF49464. 1 hit.
    SSF49785. SSF49785. 1 hit.
    PROSITEi PS00132. CARBOXYPEPT_ZN_1. 1 hit.
    PS01285. FA58C_1. 1 hit.
    PS01286. FA58C_2. 1 hit.
    PS50022. FA58C_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-750.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-750.
      Tissue: Uterus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-750.
    4. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-750.
      Tissue: Brain, Lung and Testis.

    Entry informationi

    Entry nameiCPXM2_HUMAN
    AccessioniPrimary (citable) accession number: Q8N436
    Secondary accession number(s): B4E3Q2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 17, 2003
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 113 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Although related to peptidase M14 family, lacks the active sites residues and zinc-binding sites, suggesting that it has no carboxypeptidase activity.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Peptidase families
      Classification of peptidase families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3