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Protein

Putative transporter SVOPL

Gene

SVOPL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157703-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative transporter SVOPL
Alternative name(s):
SV2-related protein-like
SVOP-like protein
Gene namesi
Name:SVOPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:27034. SVOPL.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Transmembranei383 – 403HelicalSequence analysisAdd BLAST21
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Transmembranei458 – 478HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000157703.
PharmGKBiPA162405089.

Polymorphism and mutation databases

BioMutaiSVOPL.
DMDMi152112307.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002944611 – 492Putative transporter SVOPLAdd BLAST492

Proteomic databases

PaxDbiQ8N434.
PeptideAtlasiQ8N434.
PRIDEiQ8N434.

PTM databases

iPTMnetiQ8N434.
PhosphoSitePlusiQ8N434.

Expressioni

Gene expression databases

BgeeiENSG00000157703.
CleanExiHS_SVOPL.
ExpressionAtlasiQ8N434. baseline and differential.
GenevisibleiQ8N434. HS.

Organism-specific databases

HPAiHPA018035.

Interactioni

Protein-protein interaction databases

BioGridi126453. 1 interactor.
IntActiQ8N434. 1 interactor.
STRINGi9606.ENSP00000405482.

Structurei

3D structure databases

ProteinModelPortaliQ8N434.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0253. Eukaryota.
ENOG410ZVDQ. LUCA.
GeneTreeiENSGT00550000074384.
HOGENOMiHOG000114543.
HOVERGENiHBG108527.
InParanoidiQ8N434.
OMAiESHSPCH.
OrthoDBiEOG091G04VD.
PhylomeDBiQ8N434.
TreeFamiTF313465.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N434-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATKPTEPVT ILSLRKLSLG TAEPQVKEPK TFTVEDAVET IGFGRFHIAL
60 70 80 90 100
FLIMGSTGVV EAMEIMLIAV VSPVIRCEWQ LENWQVALVT TMVFFGYMVF
110 120 130 140 150
SILFGLLADR YGRWKILLIS FLWGAYFSLL TSFAPSYIWF VFLRTMVGCG
160 170 180 190 200
VSGHSQGLII KTEFLPTKYR GYMLPLSQVF WLAGSLLIIG LASVIIPTIG
210 220 230 240 250
WRWLIRVASI PGIILIVAFK FIPESARFNV STGNTRAALA TLERVAKMNR
260 270 280 290 300
SVMPEGKLVE PVLEKRGRFA DLLDAKYLRT TLQIWVIWLG ISFAYYGVIL
310 320 330 340 350
ASAELLERDL VCGSKSDSAV VVTGGDSGES QSPCYCHMFA PSDYRTMIIS
360 370 380 390 400
TIGEIALNPL NILGINFLGR RLSLSITMGC TALFFLLLNI CTSSAGLIGF
410 420 430 440 450
LFMLRALVAA NFNTVYIYTA EVYPTTMRAL GMGTSGSLCR IGAMVAPFIS
460 470 480 490
QVLMSASILG ALCLFSSVCV VCAISAFTLP IETKGRALQQ IK
Note: No experimental confirmation available.
Length:492
Mass (Da):53,991
Last modified:July 10, 2007 - v2
Checksum:iAB0460AAEEEC5F04
GO
Isoform 2 (identifier: Q8N434-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-152: Missing.
     153-157: GHSQG → MAAGR

Note: No experimental confirmation available.
Show »
Length:340
Mass (Da):36,911
Checksum:i7F0CD663D9A44DCF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033188385F → C.Corresponds to variant rs2305816dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0266511 – 152Missing in isoform 2. 1 PublicationAdd BLAST152
Alternative sequenceiVSP_026652153 – 157GHSQG → MAAGR in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013429 Genomic DNA. No translation available.
AC020983 Genomic DNA. No translation available.
BC036796 mRNA. Translation: AAH36796.1.
CCDSiCCDS47721.1. [Q8N434-1]
CCDS5848.1. [Q8N434-2]
RefSeqiNP_001132928.1. NM_001139456.1. [Q8N434-1]
NP_777619.1. NM_174959.3. [Q8N434-2]
XP_005250200.1. XM_005250143.3. [Q8N434-1]
XP_011514099.1. XM_011515797.2. [Q8N434-2]
XP_016867236.1. XM_017011747.1. [Q8N434-2]
XP_016867237.1. XM_017011748.1. [Q8N434-2]
UniGeneiHs.99414.

Genome annotation databases

EnsembliENST00000288513; ENSP00000288513; ENSG00000157703. [Q8N434-2]
ENST00000419765; ENSP00000405482; ENSG00000157703. [Q8N434-1]
ENST00000436657; ENSP00000417018; ENSG00000157703. [Q8N434-2]
GeneIDi136306.
KEGGihsa:136306.
UCSCiuc003vue.4. human. [Q8N434-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013429 Genomic DNA. No translation available.
AC020983 Genomic DNA. No translation available.
BC036796 mRNA. Translation: AAH36796.1.
CCDSiCCDS47721.1. [Q8N434-1]
CCDS5848.1. [Q8N434-2]
RefSeqiNP_001132928.1. NM_001139456.1. [Q8N434-1]
NP_777619.1. NM_174959.3. [Q8N434-2]
XP_005250200.1. XM_005250143.3. [Q8N434-1]
XP_011514099.1. XM_011515797.2. [Q8N434-2]
XP_016867236.1. XM_017011747.1. [Q8N434-2]
XP_016867237.1. XM_017011748.1. [Q8N434-2]
UniGeneiHs.99414.

3D structure databases

ProteinModelPortaliQ8N434.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126453. 1 interactor.
IntActiQ8N434. 1 interactor.
STRINGi9606.ENSP00000405482.

PTM databases

iPTMnetiQ8N434.
PhosphoSitePlusiQ8N434.

Polymorphism and mutation databases

BioMutaiSVOPL.
DMDMi152112307.

Proteomic databases

PaxDbiQ8N434.
PeptideAtlasiQ8N434.
PRIDEiQ8N434.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288513; ENSP00000288513; ENSG00000157703. [Q8N434-2]
ENST00000419765; ENSP00000405482; ENSG00000157703. [Q8N434-1]
ENST00000436657; ENSP00000417018; ENSG00000157703. [Q8N434-2]
GeneIDi136306.
KEGGihsa:136306.
UCSCiuc003vue.4. human. [Q8N434-1]

Organism-specific databases

CTDi136306.
GeneCardsiSVOPL.
HGNCiHGNC:27034. SVOPL.
HPAiHPA018035.
MIMi611700. gene.
neXtProtiNX_Q8N434.
OpenTargetsiENSG00000157703.
PharmGKBiPA162405089.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0253. Eukaryota.
ENOG410ZVDQ. LUCA.
GeneTreeiENSGT00550000074384.
HOGENOMiHOG000114543.
HOVERGENiHBG108527.
InParanoidiQ8N434.
OMAiESHSPCH.
OrthoDBiEOG091G04VD.
PhylomeDBiQ8N434.
TreeFamiTF313465.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157703-MONOMER.

Miscellaneous databases

GenomeRNAii136306.
PROiQ8N434.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157703.
CleanExiHS_SVOPL.
ExpressionAtlasiQ8N434. baseline and differential.
GenevisibleiQ8N434. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSVOPL_HUMAN
AccessioniPrimary (citable) accession number: Q8N434
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: November 30, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.