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Protein

Ras-GEF domain-containing family member 1C

Gene

RASGEF1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Guanine nucleotide exchange factor (GEF).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

SIGNORiQ8N431.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-GEF domain-containing family member 1C
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:27400. RASGEF1C.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134895897.

Polymorphism and mutation databases

BioMutaiRASGEF1C.
DMDMi156633613.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 466466Ras-GEF domain-containing family member 1CPRO_0000297643Add
BLAST

Proteomic databases

PaxDbiQ8N431.
PeptideAtlasiQ8N431.
PRIDEiQ8N431.

PTM databases

iPTMnetiQ8N431.
PhosphoSiteiQ8N431.

Expressioni

Gene expression databases

BgeeiQ8N431.
CleanExiHS_RASGEF1C.
ExpressionAtlasiQ8N431. baseline and differential.
GenevisibleiQ8N431. HS.

Organism-specific databases

HPAiHPA028242.

Interactioni

Protein-protein interaction databases

BioGridi129103. 4 interactions.
IntActiQ8N431. 1 interaction.
MINTiMINT-1388726.
STRINGi9606.ENSP00000354963.

Structurei

3D structure databases

ProteinModelPortaliQ8N431.
SMRiQ8N431. Positions 28-440.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 164131N-terminal Ras-GEFPROSITE-ProRule annotationAdd
BLAST
Domaini200 – 446247Ras-GEFPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3541. Eukaryota.
ENOG410XRE3. LUCA.
GeneTreeiENSGT00810000125357.
HOGENOMiHOG000018026.
HOVERGENiHBG055252.
InParanoidiQ8N431.
OMAiPCDEAYR.
OrthoDBiEOG72JWFQ.
PhylomeDBiQ8N431.
TreeFamiTF313379.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
InterProiIPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
[Graphical view]
PfamiPF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00147. RasGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
PROSITEiPS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N431-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPQTLSASDM VTPGSLSPPP TEPTDGEQAG QPLLDGAPSS ASLETLIQHL
60 70 80 90 100
VPTADYYPEK AYIFTFLLSS RLFIEPRELL ARVCHLCIEQ QQLDKPVLDK
110 120 130 140 150
ARVRKFGPKL LQLLAEWTET FPRDFQEEST IGHLKDVVGR IAPCDEAYRK
160 170 180 190 200
RMHQLLQALH QKLAALRQGP EGLVGADKPI SYRTKPPASI HRELLGVCSD
210 220 230 240 250
PYTLAQQLTH VELERLRHIG PEEFVQAFVN KDPLASTKPC FSDKTSNLEA
260 270 280 290 300
YVKWFNRLCY LVATEICMPA KKKQRAQVIE FFIDVARECF NIGNFNSLMA
310 320 330 340 350
IISGMNMSPV SRLKKTWAKV RTAKFFILEH QMDPTGNFCN YRTALRGAAH
360 370 380 390 400
RSLTAHSSRE KIVIPFFSLL IKDIYFLNEG CANRLPNGHV NFEKFLELAK
410 420 430 440 450
QVGEFITWKQ VECPFEQDAS ITHYLYTAPI FSEDGLYLAS YESESPENQT
460
EKERWKALRS SILGKT
Length:466
Mass (Da):52,870
Last modified:August 21, 2007 - v2
Checksum:iDDEFC900F30612B7
GO
Isoform 2 (identifier: Q8N431-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.

Show »
Length:315
Mass (Da):35,967
Checksum:i156D3B4D588D0651
GO

Sequence cautioni

The sequence AAH36802.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 151151Missing in isoform 2. 1 PublicationVSP_027316Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF449764 mRNA. Translation: AAP97676.1.
AK093160 mRNA. Translation: BAC04079.1.
CH471165 Genomic DNA. Translation: EAW53769.1.
CH471165 Genomic DNA. Translation: EAW53770.1.
BC036802 mRNA. Translation: AAH36802.1. Different initiation.
CCDSiCCDS4452.1. [Q8N431-1]
RefSeqiNP_778232.2. NM_175062.3. [Q8N431-1]
UniGeneiHs.190559.

Genome annotation databases

EnsembliENST00000361132; ENSP00000354963; ENSG00000146090. [Q8N431-1]
ENST00000393371; ENSP00000377037; ENSG00000146090. [Q8N431-1]
ENST00000522500; ENSP00000429114; ENSG00000146090. [Q8N431-2]
GeneIDi255426.
KEGGihsa:255426.
UCSCiuc003mlp.5. human. [Q8N431-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF449764 mRNA. Translation: AAP97676.1.
AK093160 mRNA. Translation: BAC04079.1.
CH471165 Genomic DNA. Translation: EAW53769.1.
CH471165 Genomic DNA. Translation: EAW53770.1.
BC036802 mRNA. Translation: AAH36802.1. Different initiation.
CCDSiCCDS4452.1. [Q8N431-1]
RefSeqiNP_778232.2. NM_175062.3. [Q8N431-1]
UniGeneiHs.190559.

3D structure databases

ProteinModelPortaliQ8N431.
SMRiQ8N431. Positions 28-440.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129103. 4 interactions.
IntActiQ8N431. 1 interaction.
MINTiMINT-1388726.
STRINGi9606.ENSP00000354963.

PTM databases

iPTMnetiQ8N431.
PhosphoSiteiQ8N431.

Polymorphism and mutation databases

BioMutaiRASGEF1C.
DMDMi156633613.

Proteomic databases

PaxDbiQ8N431.
PeptideAtlasiQ8N431.
PRIDEiQ8N431.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361132; ENSP00000354963; ENSG00000146090. [Q8N431-1]
ENST00000393371; ENSP00000377037; ENSG00000146090. [Q8N431-1]
ENST00000522500; ENSP00000429114; ENSG00000146090. [Q8N431-2]
GeneIDi255426.
KEGGihsa:255426.
UCSCiuc003mlp.5. human. [Q8N431-1]

Organism-specific databases

CTDi255426.
GeneCardsiRASGEF1C.
HGNCiHGNC:27400. RASGEF1C.
HPAiHPA028242.
neXtProtiNX_Q8N431.
PharmGKBiPA134895897.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3541. Eukaryota.
ENOG410XRE3. LUCA.
GeneTreeiENSGT00810000125357.
HOGENOMiHOG000018026.
HOVERGENiHBG055252.
InParanoidiQ8N431.
OMAiPCDEAYR.
OrthoDBiEOG72JWFQ.
PhylomeDBiQ8N431.
TreeFamiTF313379.

Enzyme and pathway databases

SIGNORiQ8N431.

Miscellaneous databases

GenomeRNAii255426.
PROiQ8N431.

Gene expression databases

BgeeiQ8N431.
CleanExiHS_RASGEF1C.
ExpressionAtlasiQ8N431. baseline and differential.
GenevisibleiQ8N431. HS.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
InterProiIPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
[Graphical view]
PfamiPF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00147. RasGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
PROSITEiPS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Homo sapiens cDNA, similar to Macaca fascicularis brain cDNA."
    Yu L., Guo J., She X.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiRGF1C_HUMAN
AccessioniPrimary (citable) accession number: Q8N431
Secondary accession number(s): D3DWQ7, Q7Z4T0, Q8NA49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: July 6, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.