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Q8N423

- LIRB2_HUMAN

UniProt

Q8N423 - LIRB2_HUMAN

Protein

Leukocyte immunoglobulin-like receptor subfamily B member 2

Gene

LILRB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 4 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.4 Publications

    GO - Molecular functioni

    1. cell adhesion molecule binding Source: BHF-UCL
    2. inhibitory MHC class I receptor activity Source: BHF-UCL
    3. MHC class Ib protein binding Source: BHF-UCL
    4. MHC class I protein binding Source: UniProtKB
    5. protein binding Source: UniProtKB
    6. protein phosphatase 1 binding Source: UniProtKB
    7. receptor activity Source: ProtInc

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. cell surface receptor signaling pathway Source: ProtInc
    3. cellular defense response Source: ProtInc
    4. cellular response to lipopolysaccharide Source: BHF-UCL
    5. Fc receptor mediated inhibitory signaling pathway Source: UniProtKB
    6. heterotypic cell-cell adhesion Source: BHF-UCL
    7. immune response Source: ProtInc
    8. immune response-inhibiting cell surface receptor signaling pathway Source: BHF-UCL
    9. negative regulation of antigen processing and presentation Source: BHF-UCL
    10. negative regulation of calcium ion transport Source: UniProtKB
    11. negative regulation of T cell proliferation Source: BHF-UCL
    12. positive regulation of interleukin-6 production Source: BHF-UCL
    13. positive regulation of regulatory T cell differentiation Source: BHF-UCL
    14. positive regulation of T cell proliferation Source: BHF-UCL
    15. positive regulation of T cell tolerance induction Source: BHF-UCL
    16. regulation of dendritic cell differentiation Source: BHF-UCL
    17. regulation of immune response Source: Reactome
    18. signal transduction Source: BHF-UCL

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Adaptive immunity, Immunity

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily B member 2
    Short name:
    LIR-2
    Short name:
    Leukocyte immunoglobulin-like receptor 2
    Alternative name(s):
    CD85 antigen-like family member D
    Immunoglobulin-like transcript 4
    Short name:
    ILT-4
    Monocyte/macrophage immunoglobulin-like receptor 10
    Short name:
    MIR-10
    CD_antigen: CD85d
    Gene namesi
    Name:LILRB2
    Synonyms:ILT4, LIR2, MIR10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6606. LILRB2.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: BHF-UCL
    2. cytoplasm Source: BHF-UCL
    3. extracellular space Source: BHF-UCL
    4. integral component of plasma membrane Source: BHF-UCL
    5. membrane Source: ProtInc
    6. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30380.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 598577Leukocyte immunoglobulin-like receptor subfamily B member 2PRO_0000014821Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 98PROSITE-ProRule annotation
    Disulfide bondi144 ↔ 196PROSITE-ProRule annotation
    Disulfide bondi156 ↔ 166PROSITE-ProRule annotation
    Disulfide bondi245 ↔ 296PROSITE-ProRule annotation
    Glycosylationi280 – 2801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi340 – 3401N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi345 ↔ 396PROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ8N423.
    PRIDEiQ8N423.

    PTM databases

    PhosphoSiteiQ8N423.

    Expressioni

    Tissue specificityi

    Expressed on monocytes and B-cells, and at lower levels on dendritic cells. Detected at low levels in natural killer (NK) cells.2 Publications

    Gene expression databases

    ArrayExpressiQ8N423.
    BgeeiQ8N423.
    CleanExiHS_LILRB2.
    GenevestigatoriQ8N423.

    Interactioni

    Subunit structurei

    Binds PTPN6 when phosphorylated. Binds FCGR1A.

    Protein-protein interaction databases

    BioGridi115577. 5 interactions.
    DIPiDIP-59888N.
    IntActiQ8N423. 3 interactions.
    STRINGi9606.ENSP00000375629.

    Structurei

    Secondary structure

    1
    598
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi30 – 356
    Beta strandi37 – 404
    Beta strandi45 – 506
    Beta strandi57 – 637
    Beta strandi71 – 733
    Helixi75 – 773
    Helixi78 – 803
    Beta strandi82 – 876
    Turni90 – 923
    Beta strandi94 – 1029
    Beta strandi113 – 1186
    Beta strandi125 – 1306
    Beta strandi140 – 15819
    Beta strandi166 – 1683
    Beta strandi176 – 1838
    Beta strandi188 – 1903
    Beta strandi193 – 1997
    Beta strandi226 – 2316
    Beta strandi233 – 2353
    Beta strandi241 – 2499
    Beta strandi252 – 2587
    Beta strandi264 – 2685
    Beta strandi277 – 2837
    Helixi288 – 2903
    Beta strandi292 – 2998
    Beta strandi313 – 3175
    Beta strandi326 – 3316
    Beta strandi333 – 3353
    Beta strandi342 – 3498
    Beta strandi352 – 36110
    Beta strandi366 – 3694
    Beta strandi371 – 3733
    Beta strandi376 – 3827
    Helixi388 – 3903
    Beta strandi392 – 4009
    Beta strandi403 – 4075
    Beta strandi414 – 4185

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DYPX-ray2.50D24-219[»]
    2GW5X-ray1.80A24-219[»]
    4LLAX-ray2.50A/B/C222-419[»]
    ProteinModelPortaliQ8N423.
    SMRiQ8N423. Positions 26-419.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8N423.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 461440ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini483 – 598116CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei462 – 48221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 11084Ig-like C2-type 1Add
    BLAST
    Domaini111 – 229119Ig-like C2-type 2Add
    BLAST
    Domaini230 – 31889Ig-like C2-type 3Add
    BLAST
    Domaini330 – 41990Ig-like C2-type 4Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi531 – 5366ITIM motif 1
    Motifi560 – 5656ITIM motif 2
    Motifi590 – 5956ITIM motif 3

    Domaini

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG25855.
    HOGENOMiHOG000234395.
    HOVERGENiHBG074353.
    InParanoidiQ8N423.
    KOiK06512.
    OMAiKWIPREL.
    OrthoDBiEOG7R56S3.
    PhylomeDBiQ8N423.
    TreeFamiTF336644.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view]
    SMARTiSM00409. IG. 3 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N423-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTPIVTVLIC LGLSLGPRTH VQTGTIPKPT LWAEPDSVIT QGSPVTLSCQ    50
    GSLEAQEYRL YREKKSASWI TRIRPELVKN GQFHIPSITW EHTGRYGCQY 100
    YSRARWSELS DPLVLVMTGA YPKPTLSAQP SPVVTSGGRV TLQCESQVAF 150
    GGFILCKEGE EEHPQCLNSQ PHARGSSRAI FSVGPVSPNR RWSHRCYGYD 200
    LNSPYVWSSP SDLLELLVPG VSKKPSLSVQ PGPVVAPGES LTLQCVSDVG 250
    YDRFVLYKEG ERDLRQLPGR QPQAGLSQAN FTLGPVSRSY GGQYRCYGAH 300
    NLSSECSAPS DPLDILITGQ IRGTPFISVQ PGPTVASGEN VTLLCQSWRQ 350
    FHTFLLTKAG AADAPLRLRS IHEYPKYQAE FPMSPVTSAH AGTYRCYGSL 400
    NSDPYLLSHP SEPLELVVSG PSMGSSPPPT GPISTPAGPE DQPLTPTGSD 450
    PQSGLGRHLG VVIGILVAVV LLLLLLLLLF LILRHRRQGK HWTSTQRKAD 500
    FQHPAGAVGP EPTDRGLQWR SSPAADAQEE NLYAAVKDTQ PEDGVEMDTR 550
    AAASEAPQDV TYAQLHSLTL RRKATEPPPS QEREPPAEPS IYATLAIH 598
    Length:598
    Mass (Da):65,039
    Last modified:November 2, 2010 - v4
    Checksum:i33E9737AFCAFCE2D
    GO
    Isoform 2 (identifier: Q8N423-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         437-437: Missing.

    Note: Alternative use of an acceptor site. No experimental confirmation available.

    Show »
    Length:597
    Mass (Da):64,968
    Checksum:iE6C0FDA134C5F3C3
    GO
    Isoform 3 (identifier: Q8N423-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         495-510: TQRKADFQHPAGAVGP → SPAQLPTPRKKTSMLP
         511-598: Missing.

    Show »
    Length:510
    Mass (Da):55,458
    Checksum:iCFD221E533DBC3F7
    GO
    Isoform 4 (identifier: Q8N423-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-116: Missing.

    Note: Gene prediction based on cDNA data.

    Show »
    Length:482
    Mass (Da):51,959
    Checksum:iD8A3DCC118CB7A06
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti583 – 5831R → G in AAH36827. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti20 – 201H → R.
    Corresponds to variant rs383369 [ dbSNP | Ensembl ].
    VAR_016997
    Natural varianti161 – 1611E → D.4 Publications
    Corresponds to variant rs373032 [ dbSNP | Ensembl ].
    VAR_016998
    Natural varianti235 – 2351V → M.
    Corresponds to variant rs386056 [ dbSNP | Ensembl ].
    VAR_047432
    Natural varianti300 – 3001H → Y.4 Publications
    Corresponds to variant rs7247538 [ dbSNP | Ensembl ].
    VAR_016999
    Natural varianti306 – 3061C → W.4 Publications
    Corresponds to variant rs7247451 [ dbSNP | Ensembl ].
    VAR_017000
    Natural varianti322 – 3221R → H.4 Publications
    Corresponds to variant rs1128646 [ dbSNP | Ensembl ].
    VAR_061314
    Natural varianti324 – 3241T → R.
    Corresponds to variant rs7247055 [ dbSNP | Ensembl ].
    VAR_047433
    Natural varianti326 – 3261F → S.
    Corresponds to variant rs7246737 [ dbSNP | Ensembl ].
    VAR_047434
    Natural varianti349 – 3491R → G.
    Corresponds to variant rs7247025 [ dbSNP | Ensembl ].
    VAR_047435
    Natural varianti403 – 4031D → N.
    Corresponds to variant rs4993133 [ dbSNP | Ensembl ].
    VAR_061315

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 116116Missing in isoform 4. CuratedVSP_055718Add
    BLAST
    Alternative sequencei437 – 4371Missing in isoform 2. 1 PublicationVSP_008458
    Alternative sequencei495 – 51016TQRKA…GAVGP → SPAQLPTPRKKTSMLP in isoform 3. 1 PublicationVSP_055719Add
    BLAST
    Alternative sequencei511 – 59888Missing in isoform 3. 1 PublicationVSP_055720Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF025528 mRNA. Translation: AAB87662.1.
    AF283986 mRNA. Translation: AAL36990.1.
    AF283987 mRNA. Translation: AAL36991.1.
    AC010518 Genomic DNA. No translation available.
    BC036827 mRNA. Translation: AAH36827.1.
    CCDSiCCDS12886.1. [Q8N423-1]
    CCDS42612.1. [Q8N423-2]
    UniGeneiHs.655652.

    Genome annotation databases

    EnsembliENST00000314446; ENSP00000319960; ENSG00000131042. [Q8N423-2]
    ENST00000391746; ENSP00000375626; ENSG00000131042. [Q8N423-3]
    ENST00000391748; ENSP00000375628; ENSG00000131042. [Q8N423-2]
    ENST00000391749; ENSP00000375629; ENSG00000131042. [Q8N423-1]
    ENST00000434421; ENSP00000410117; ENSG00000131042. [Q8N423-4]
    KEGGihsa:10288.
    UCSCiuc002qfb.3. human. [Q8N423-1]
    uc002qfc.3. human. [Q8N423-2]

    Polymorphism databases

    DMDMi311033485.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF025528 mRNA. Translation: AAB87662.1 .
    AF283986 mRNA. Translation: AAL36990.1 .
    AF283987 mRNA. Translation: AAL36991.1 .
    AC010518 Genomic DNA. No translation available.
    BC036827 mRNA. Translation: AAH36827.1 .
    CCDSi CCDS12886.1. [Q8N423-1 ]
    CCDS42612.1. [Q8N423-2 ]
    UniGenei Hs.655652.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DYP X-ray 2.50 D 24-219 [» ]
    2GW5 X-ray 1.80 A 24-219 [» ]
    4LLA X-ray 2.50 A/B/C 222-419 [» ]
    ProteinModelPortali Q8N423.
    SMRi Q8N423. Positions 26-419.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115577. 5 interactions.
    DIPi DIP-59888N.
    IntActi Q8N423. 3 interactions.
    STRINGi 9606.ENSP00000375629.

    PTM databases

    PhosphoSitei Q8N423.

    Polymorphism databases

    DMDMi 311033485.

    Proteomic databases

    PaxDbi Q8N423.
    PRIDEi Q8N423.

    Protocols and materials databases

    DNASUi 10288.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000314446 ; ENSP00000319960 ; ENSG00000131042 . [Q8N423-2 ]
    ENST00000391746 ; ENSP00000375626 ; ENSG00000131042 . [Q8N423-3 ]
    ENST00000391748 ; ENSP00000375628 ; ENSG00000131042 . [Q8N423-2 ]
    ENST00000391749 ; ENSP00000375629 ; ENSG00000131042 . [Q8N423-1 ]
    ENST00000434421 ; ENSP00000410117 ; ENSG00000131042 . [Q8N423-4 ]
    KEGGi hsa:10288.
    UCSCi uc002qfb.3. human. [Q8N423-1 ]
    uc002qfc.3. human. [Q8N423-2 ]

    Organism-specific databases

    CTDi 10288.
    GeneCardsi GC19M054777.
    HGNCi HGNC:6606. LILRB2.
    MIMi 604815. gene.
    neXtProti NX_Q8N423.
    PharmGKBi PA30380.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG25855.
    HOGENOMi HOG000234395.
    HOVERGENi HBG074353.
    InParanoidi Q8N423.
    KOi K06512.
    OMAi KWIPREL.
    OrthoDBi EOG7R56S3.
    PhylomeDBi Q8N423.
    TreeFami TF336644.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Miscellaneous databases

    EvolutionaryTracei Q8N423.
    GenomeRNAii 10288.
    NextBioi 38982.
    PROi Q8N423.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N423.
    Bgeei Q8N423.
    CleanExi HS_LILRB2.
    Genevestigatori Q8N423.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view ]
    SMARTi SM00409. IG. 3 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells."
      Colonna M., Navarro F., Bellon T., Llano M., Garcia P., Samaridis J., Angman L., Cella M., Lopez-Botet M.
      J. Exp. Med. 186:1809-1818(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANTS ASP-161; TYR-300; TRP-306 AND HIS-322.
    2. "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules."
      Borges L., Hsu M.-L., Fanger N., Kubin M., Cosman D.
      J. Immunol. 159:5192-5196(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION, VARIANTS ASP-161; TYR-300; TRP-306 AND HIS-322.
      Tissue: Dendritic cell and Peripheral blood monocyte.
    3. Canavez F.C.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS ASP-161; TYR-300; TRP-306 AND HIS-322.
    4. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ASP-161; TYR-300; TRP-306 AND HIS-322.
      Tissue: Peripheral blood leukocyte.
    6. "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes."
      Fanger N.A., Cosman D., Peterson L., Braddy S.C., Maliszewski C.R., Borges L.
      Eur. J. Immunol. 28:3423-3434(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PTPN6 AND FCGR1A, PHOSPHORYLATION, TISSUE SPECIFICITY, FUNCTION.
    7. "Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4."
      Chang C.C., Ciubotariu R., Manavalan J.S., Yuan J., Colovai A.I., Piazza F., Lederman S., Colonna M., Cortesini R., Dalla-Favera R., Suciu-Foca N.
      Nat. Immunol. 3:237-243(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G."
      Shiroishi M., Tsumoto K., Amano K., Shirakihara Y., Colonna M., Braud V.M., Allan D.S.J., Makadzange A., Rowland-Jones S., Willcox B.E., Jones E.Y., van der Merwe P.A., Kumagai I., Maenaka K.
      Proc. Natl. Acad. Sci. U.S.A. 100:8856-8861(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TYPE I MHC ALLELES, FUNCTION.
    9. "Crystal structure of LIR-2 (ILT4) at 1.8 A: differences from LIR-1 (ILT2) in regions implicated in the binding of the human cytomegalovirus class I MHC homolog UL18."
      Willcox B.E., Thomas L.M., Chapman T.L., Heikema A.P., West A.P. Jr., Bjorkman P.J.
      BMC Struct. Biol. 2:6-6(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 22-219.

    Entry informationi

    Entry nameiLIRB2_HUMAN
    AccessioniPrimary (citable) accession number: Q8N423
    Secondary accession number(s): A8MU67
    , C9JF29, O75017, Q8NHJ7, Q8NHJ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2003
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 124 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3