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Protein

Leukocyte immunoglobulin-like receptor subfamily B member 2

Gene

LILRB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.4 Publications

GO - Molecular functioni

  1. cell adhesion molecule binding Source: BHF-UCL
  2. inhibitory MHC class I receptor activity Source: BHF-UCL
  3. MHC class Ib protein binding Source: BHF-UCL
  4. MHC class I protein binding Source: UniProtKB
  5. protein phosphatase 1 binding Source: UniProtKB
  6. receptor activity Source: ProtInc

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. cell surface receptor signaling pathway Source: ProtInc
  3. cellular defense response Source: ProtInc
  4. cellular response to lipopolysaccharide Source: BHF-UCL
  5. Fc receptor mediated inhibitory signaling pathway Source: UniProtKB
  6. heterotypic cell-cell adhesion Source: BHF-UCL
  7. immune response Source: ProtInc
  8. immune response-inhibiting cell surface receptor signaling pathway Source: BHF-UCL
  9. negative regulation of antigen processing and presentation Source: BHF-UCL
  10. negative regulation of calcium ion transport Source: UniProtKB
  11. negative regulation of immune response Source: UniProtKB
  12. negative regulation of T cell proliferation Source: BHF-UCL
  13. positive regulation of interleukin-6 production Source: BHF-UCL
  14. positive regulation of regulatory T cell differentiation Source: BHF-UCL
  15. positive regulation of T cell proliferation Source: BHF-UCL
  16. positive regulation of T cell tolerance induction Source: BHF-UCL
  17. positive regulation of tolerance induction Source: UniProtKB
  18. regulation of dendritic cell differentiation Source: BHF-UCL
  19. regulation of immune response Source: Reactome
  20. signal transduction Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte immunoglobulin-like receptor subfamily B member 2
Short name:
LIR-2
Short name:
Leukocyte immunoglobulin-like receptor 2
Alternative name(s):
CD85 antigen-like family member D
Immunoglobulin-like transcript 4
Short name:
ILT-4
Monocyte/macrophage immunoglobulin-like receptor 10
Short name:
MIR-10
CD_antigen: CD85d
Gene namesi
Name:LILRB2
Synonyms:ILT4, LIR2, MIR10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 19, Unplaced

Organism-specific databases

HGNCiHGNC:6606. LILRB2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 461440ExtracellularSequence AnalysisAdd
BLAST
Transmembranei462 – 48221HelicalSequence AnalysisAdd
BLAST
Topological domaini483 – 598116CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. cytoplasm Source: BHF-UCL
  3. extracellular space Source: BHF-UCL
  4. integral component of plasma membrane Source: BHF-UCL
  5. membrane Source: ProtInc
  6. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30380.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 598577Leukocyte immunoglobulin-like receptor subfamily B member 2PRO_0000014821Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 98PROSITE-ProRule annotation
Disulfide bondi144 ↔ 196PROSITE-ProRule annotation
Disulfide bondi156 ↔ 166PROSITE-ProRule annotation
Disulfide bondi245 ↔ 296PROSITE-ProRule annotation
Glycosylationi280 – 2801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi340 – 3401N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi345 ↔ 396PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8N423.
PRIDEiQ8N423.

PTM databases

PhosphoSiteiQ8N423.

Expressioni

Tissue specificityi

Expressed on monocytes and B-cells, and at lower levels on dendritic cells. Detected at low levels in natural killer (NK) cells.2 Publications

Gene expression databases

BgeeiQ8N423.
CleanExiHS_LILRB2.
ExpressionAtlasiQ8N423. baseline and differential.
GenevestigatoriQ8N423.

Interactioni

Subunit structurei

Binds PTPN6 when phosphorylated. Binds FCGR1A.

Protein-protein interaction databases

BioGridi115577. 6 interactions.
DIPiDIP-59888N.
IntActiQ8N423. 3 interactions.
STRINGi9606.ENSP00000375629.

Structurei

Secondary structure

1
598
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 356Combined sources
Beta strandi37 – 404Combined sources
Beta strandi45 – 506Combined sources
Beta strandi57 – 637Combined sources
Beta strandi71 – 733Combined sources
Helixi75 – 773Combined sources
Helixi78 – 803Combined sources
Beta strandi82 – 876Combined sources
Turni90 – 923Combined sources
Beta strandi94 – 1029Combined sources
Beta strandi113 – 1186Combined sources
Beta strandi125 – 1306Combined sources
Beta strandi140 – 15819Combined sources
Beta strandi166 – 1683Combined sources
Beta strandi176 – 1838Combined sources
Beta strandi188 – 1903Combined sources
Beta strandi193 – 1997Combined sources
Beta strandi226 – 2316Combined sources
Beta strandi233 – 2353Combined sources
Beta strandi241 – 2499Combined sources
Beta strandi252 – 2587Combined sources
Beta strandi264 – 2685Combined sources
Beta strandi277 – 2837Combined sources
Helixi288 – 2903Combined sources
Beta strandi292 – 2998Combined sources
Beta strandi313 – 3175Combined sources
Beta strandi326 – 3316Combined sources
Beta strandi333 – 3353Combined sources
Beta strandi342 – 3498Combined sources
Beta strandi352 – 36110Combined sources
Beta strandi366 – 3694Combined sources
Beta strandi371 – 3733Combined sources
Beta strandi376 – 3827Combined sources
Helixi388 – 3903Combined sources
Beta strandi392 – 4009Combined sources
Beta strandi403 – 4075Combined sources
Beta strandi414 – 4185Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DYPX-ray2.50D24-219[»]
2GW5X-ray1.80A24-219[»]
4LLAX-ray2.50A/B/C222-419[»]
ProteinModelPortaliQ8N423.
SMRiQ8N423. Positions 26-444.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8N423.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 11084Ig-like C2-type 1Add
BLAST
Domaini111 – 229119Ig-like C2-type 2Add
BLAST
Domaini230 – 31889Ig-like C2-type 3Add
BLAST
Domaini330 – 41990Ig-like C2-type 4Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi531 – 5366ITIM motif 1
Motifi560 – 5656ITIM motif 2
Motifi590 – 5956ITIM motif 3

Domaini

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG25855.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiQ8N423.
OMAiKWIPREL.
OrthoDBiEOG7R56S3.
PhylomeDBiQ8N423.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N423-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPIVTVLIC LGLSLGPRTH VQTGTIPKPT LWAEPDSVIT QGSPVTLSCQ
60 70 80 90 100
GSLEAQEYRL YREKKSASWI TRIRPELVKN GQFHIPSITW EHTGRYGCQY
110 120 130 140 150
YSRARWSELS DPLVLVMTGA YPKPTLSAQP SPVVTSGGRV TLQCESQVAF
160 170 180 190 200
GGFILCKEGE EEHPQCLNSQ PHARGSSRAI FSVGPVSPNR RWSHRCYGYD
210 220 230 240 250
LNSPYVWSSP SDLLELLVPG VSKKPSLSVQ PGPVVAPGES LTLQCVSDVG
260 270 280 290 300
YDRFVLYKEG ERDLRQLPGR QPQAGLSQAN FTLGPVSRSY GGQYRCYGAH
310 320 330 340 350
NLSSECSAPS DPLDILITGQ IRGTPFISVQ PGPTVASGEN VTLLCQSWRQ
360 370 380 390 400
FHTFLLTKAG AADAPLRLRS IHEYPKYQAE FPMSPVTSAH AGTYRCYGSL
410 420 430 440 450
NSDPYLLSHP SEPLELVVSG PSMGSSPPPT GPISTPAGPE DQPLTPTGSD
460 470 480 490 500
PQSGLGRHLG VVIGILVAVV LLLLLLLLLF LILRHRRQGK HWTSTQRKAD
510 520 530 540 550
FQHPAGAVGP EPTDRGLQWR SSPAADAQEE NLYAAVKDTQ PEDGVEMDTR
560 570 580 590
AAASEAPQDV TYAQLHSLTL RRKATEPPPS QEREPPAEPS IYATLAIH
Length:598
Mass (Da):65,039
Last modified:November 2, 2010 - v4
Checksum:i33E9737AFCAFCE2D
GO
Isoform 2 (identifier: Q8N423-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     437-437: Missing.

Note: Alternative use of an acceptor site. No experimental confirmation available.

Show »
Length:597
Mass (Da):64,968
Checksum:iE6C0FDA134C5F3C3
GO
Isoform 3 (identifier: Q8N423-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     495-510: TQRKADFQHPAGAVGP → SPAQLPTPRKKTSMLP
     511-598: Missing.

Show »
Length:510
Mass (Da):55,458
Checksum:iCFD221E533DBC3F7
GO
Isoform 4 (identifier: Q8N423-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.

Note: Gene prediction based on cDNA data.

Show »
Length:482
Mass (Da):51,959
Checksum:iD8A3DCC118CB7A06
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti583 – 5831R → G in AAH36827 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201H → R.
Corresponds to variant rs383369 [ dbSNP | Ensembl ].
VAR_016997
Natural varianti161 – 1611E → D.4 Publications
Corresponds to variant rs373032 [ dbSNP | Ensembl ].
VAR_016998
Natural varianti235 – 2351V → M.
Corresponds to variant rs386056 [ dbSNP | Ensembl ].
VAR_047432
Natural varianti300 – 3001H → Y.4 Publications
Corresponds to variant rs7247538 [ dbSNP | Ensembl ].
VAR_016999
Natural varianti306 – 3061C → W.4 Publications
Corresponds to variant rs7247451 [ dbSNP | Ensembl ].
VAR_017000
Natural varianti322 – 3221R → H.4 Publications
Corresponds to variant rs1128646 [ dbSNP | Ensembl ].
VAR_061314
Natural varianti324 – 3241T → R.
Corresponds to variant rs7247055 [ dbSNP | Ensembl ].
VAR_047433
Natural varianti326 – 3261F → S.
Corresponds to variant rs7246737 [ dbSNP | Ensembl ].
VAR_047434
Natural varianti349 – 3491R → G.
Corresponds to variant rs7247025 [ dbSNP | Ensembl ].
VAR_047435
Natural varianti403 – 4031D → N.
Corresponds to variant rs4993133 [ dbSNP | Ensembl ].
VAR_061315

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 116116Missing in isoform 4. CuratedVSP_055718Add
BLAST
Alternative sequencei437 – 4371Missing in isoform 2. 1 PublicationVSP_008458
Alternative sequencei495 – 51016TQRKA…GAVGP → SPAQLPTPRKKTSMLP in isoform 3. 1 PublicationVSP_055719Add
BLAST
Alternative sequencei511 – 59888Missing in isoform 3. 1 PublicationVSP_055720Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025528 mRNA. Translation: AAB87662.1.
AF283986 mRNA. Translation: AAL36990.1.
AF283987 mRNA. Translation: AAL36991.1.
AC010518 Genomic DNA. No translation available.
BC036827 mRNA. Translation: AAH36827.1.
CCDSiCCDS12886.1. [Q8N423-1]
CCDS42612.1. [Q8N423-2]
CCDS62791.1. [Q8N423-4]
CCDS62792.1. [Q8N423-3]
UniGeneiHs.655652.

Genome annotation databases

EnsembliENST00000314446; ENSP00000319960; ENSG00000131042.
ENST00000391746; ENSP00000375626; ENSG00000131042.
ENST00000391748; ENSP00000375628; ENSG00000131042.
ENST00000391749; ENSP00000375629; ENSG00000131042.
ENST00000434421; ENSP00000410117; ENSG00000131042.
ENST00000610886; ENSP00000482933; ENSG00000276146.
ENST00000614225; ENSP00000480841; ENSG00000275463. [Q8N423-4]
ENST00000617341; ENSP00000484373; ENSG00000276146.
ENST00000617886; ENSP00000483553; ENSG00000276146.
ENST00000618392; ENSP00000480302; ENSG00000274513.
ENST00000618705; ENSP00000481208; ENSG00000275463. [Q8N423-1]
ENST00000619122; ENSP00000483478; ENSG00000275463. [Q8N423-3]
ENST00000621020; ENSP00000483014; ENSG00000275463. [Q8N423-2]
UCSCiuc002qfb.3. human. [Q8N423-1]
uc002qfc.3. human. [Q8N423-2]

Polymorphism databases

DMDMi311033485.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025528 mRNA. Translation: AAB87662.1.
AF283986 mRNA. Translation: AAL36990.1.
AF283987 mRNA. Translation: AAL36991.1.
AC010518 Genomic DNA. No translation available.
BC036827 mRNA. Translation: AAH36827.1.
CCDSiCCDS12886.1. [Q8N423-1]
CCDS42612.1. [Q8N423-2]
CCDS62791.1. [Q8N423-4]
CCDS62792.1. [Q8N423-3]
UniGeneiHs.655652.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DYPX-ray2.50D24-219[»]
2GW5X-ray1.80A24-219[»]
4LLAX-ray2.50A/B/C222-419[»]
ProteinModelPortaliQ8N423.
SMRiQ8N423. Positions 26-444.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115577. 6 interactions.
DIPiDIP-59888N.
IntActiQ8N423. 3 interactions.
STRINGi9606.ENSP00000375629.

PTM databases

PhosphoSiteiQ8N423.

Polymorphism databases

DMDMi311033485.

Proteomic databases

PaxDbiQ8N423.
PRIDEiQ8N423.

Protocols and materials databases

DNASUi10288.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314446; ENSP00000319960; ENSG00000131042.
ENST00000391746; ENSP00000375626; ENSG00000131042.
ENST00000391748; ENSP00000375628; ENSG00000131042.
ENST00000391749; ENSP00000375629; ENSG00000131042.
ENST00000434421; ENSP00000410117; ENSG00000131042.
ENST00000610886; ENSP00000482933; ENSG00000276146.
ENST00000614225; ENSP00000480841; ENSG00000275463. [Q8N423-4]
ENST00000617341; ENSP00000484373; ENSG00000276146.
ENST00000617886; ENSP00000483553; ENSG00000276146.
ENST00000618392; ENSP00000480302; ENSG00000274513.
ENST00000618705; ENSP00000481208; ENSG00000275463. [Q8N423-1]
ENST00000619122; ENSP00000483478; ENSG00000275463. [Q8N423-3]
ENST00000621020; ENSP00000483014; ENSG00000275463. [Q8N423-2]
UCSCiuc002qfb.3. human. [Q8N423-1]
uc002qfc.3. human. [Q8N423-2]

Organism-specific databases

GeneCardsiGC19M054777.
HGNCiHGNC:6606. LILRB2.
MIMi604815. gene.
neXtProtiNX_Q8N423.
PharmGKBiPA30380.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG25855.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiQ8N423.
OMAiKWIPREL.
OrthoDBiEOG7R56S3.
PhylomeDBiQ8N423.
TreeFamiTF336644.

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

EvolutionaryTraceiQ8N423.
GenomeRNAii10288.
NextBioi35464883.
PROiQ8N423.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N423.
CleanExiHS_LILRB2.
ExpressionAtlasiQ8N423. baseline and differential.
GenevestigatoriQ8N423.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells."
    Colonna M., Navarro F., Bellon T., Llano M., Garcia P., Samaridis J., Angman L., Cella M., Lopez-Botet M.
    J. Exp. Med. 186:1809-1818(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANTS ASP-161; TYR-300; TRP-306 AND HIS-322.
  2. "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules."
    Borges L., Hsu M.-L., Fanger N., Kubin M., Cosman D.
    J. Immunol. 159:5192-5196(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION, VARIANTS ASP-161; TYR-300; TRP-306 AND HIS-322.
    Tissue: Dendritic cell and Peripheral blood monocyte.
  3. Canavez F.C.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS ASP-161; TYR-300; TRP-306 AND HIS-322.
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ASP-161; TYR-300; TRP-306 AND HIS-322.
    Tissue: Peripheral blood leukocyte.
  6. "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes."
    Fanger N.A., Cosman D., Peterson L., Braddy S.C., Maliszewski C.R., Borges L.
    Eur. J. Immunol. 28:3423-3434(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PTPN6 AND FCGR1A, PHOSPHORYLATION, TISSUE SPECIFICITY, FUNCTION.
  7. "Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4."
    Chang C.C., Ciubotariu R., Manavalan J.S., Yuan J., Colovai A.I., Piazza F., Lederman S., Colonna M., Cortesini R., Dalla-Favera R., Suciu-Foca N.
    Nat. Immunol. 3:237-243(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G."
    Shiroishi M., Tsumoto K., Amano K., Shirakihara Y., Colonna M., Braud V.M., Allan D.S.J., Makadzange A., Rowland-Jones S., Willcox B.E., Jones E.Y., van der Merwe P.A., Kumagai I., Maenaka K.
    Proc. Natl. Acad. Sci. U.S.A. 100:8856-8861(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TYPE I MHC ALLELES, FUNCTION.
  9. "Crystal structure of LIR-2 (ILT4) at 1.8 A: differences from LIR-1 (ILT2) in regions implicated in the binding of the human cytomegalovirus class I MHC homolog UL18."
    Willcox B.E., Thomas L.M., Chapman T.L., Heikema A.P., West A.P. Jr., Bjorkman P.J.
    BMC Struct. Biol. 2:6-6(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 22-219.

Entry informationi

Entry nameiLIRB2_HUMAN
AccessioniPrimary (citable) accession number: Q8N423
Secondary accession number(s): A8MU67
, C9JF29, O75017, Q8NHJ7, Q8NHJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 2, 2010
Last modified: April 1, 2015
This is version 128 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.