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Protein

Leukocyte immunoglobulin-like receptor subfamily B member 2

Gene

LILRB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.4 Publications

GO - Molecular functioni

  • cell adhesion molecule binding Source: BHF-UCL
  • inhibitory MHC class I receptor activity Source: BHF-UCL
  • MHC class Ib protein binding Source: BHF-UCL
  • MHC class I protein binding Source: UniProtKB
  • protein phosphatase 1 binding Source: UniProtKB
  • receptor activity Source: ProtInc

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • cell-cell signaling Source: ProtInc
  • cell surface receptor signaling pathway Source: ProtInc
  • cellular defense response Source: ProtInc
  • cellular response to lipopolysaccharide Source: BHF-UCL
  • Fc receptor mediated inhibitory signaling pathway Source: UniProtKB
  • heterotypic cell-cell adhesion Source: BHF-UCL
  • immune response Source: ProtInc
  • immune response-inhibiting cell surface receptor signaling pathway Source: BHF-UCL
  • negative regulation of antigen processing and presentation Source: BHF-UCL
  • negative regulation of calcium ion transport Source: UniProtKB
  • negative regulation of immune response Source: UniProtKB
  • negative regulation of T cell proliferation Source: BHF-UCL
  • positive regulation of interleukin-6 production Source: BHF-UCL
  • positive regulation of regulatory T cell differentiation Source: BHF-UCL
  • positive regulation of T cell proliferation Source: BHF-UCL
  • positive regulation of T cell tolerance induction Source: BHF-UCL
  • positive regulation of tolerance induction Source: UniProtKB
  • regulation of dendritic cell differentiation Source: BHF-UCL
  • regulation of immune response Source: Reactome
  • signal transduction Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte immunoglobulin-like receptor subfamily B member 2
Short name:
LIR-2
Short name:
Leukocyte immunoglobulin-like receptor 2
Alternative name(s):
CD85 antigen-like family member D
Immunoglobulin-like transcript 4
Short name:
ILT-4
Monocyte/macrophage immunoglobulin-like receptor 10
Short name:
MIR-10
CD_antigen: CD85d
Gene namesi
Name:LILRB2
Synonyms:ILT4, LIR2, MIR10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6606. LILRB2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 461ExtracellularSequence analysisAdd BLAST440
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Topological domaini483 – 598CytoplasmicSequence analysisAdd BLAST116

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • cytoplasm Source: BHF-UCL
  • extracellular space Source: BHF-UCL
  • integral component of plasma membrane Source: BHF-UCL
  • membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10288.
OpenTargetsiENSG00000275463.
PharmGKBiPA30380.

Polymorphism and mutation databases

BioMutaiLILRB2.
DMDMi311033485.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001482122 – 598Leukocyte immunoglobulin-like receptor subfamily B member 2Add BLAST577

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 98PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi144 ↔ 196PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi156 ↔ 166PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi245 ↔ 296PROSITE-ProRule annotation
Glycosylationi280N-linked (GlcNAc...)Sequence analysis1
Glycosylationi301N-linked (GlcNAc...)Sequence analysis1
Glycosylationi340N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi345 ↔ 396PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8N423.
PeptideAtlasiQ8N423.
PRIDEiQ8N423.

PTM databases

iPTMnetiQ8N423.
PhosphoSitePlusiQ8N423.

Expressioni

Tissue specificityi

Expressed on monocytes and B-cells, and at lower levels on dendritic cells. Detected at low levels in natural killer (NK) cells.2 Publications

Gene expression databases

BgeeiENSG00000131042.
CleanExiHS_LILRB2.
ExpressionAtlasiQ8N423. baseline and differential.
GenevisibleiQ8N423. HS.

Organism-specific databases

HPAiCAB025797.

Interactioni

Subunit structurei

Binds PTPN6 when phosphorylated. Binds FCGR1A.

Binary interactionsi

WithEntry#Exp.IntActNotes
NOTCH1P465318EBI-2816428,EBI-636374

GO - Molecular functioni

  • cell adhesion molecule binding Source: BHF-UCL
  • MHC class Ib protein binding Source: BHF-UCL
  • MHC class I protein binding Source: UniProtKB
  • protein phosphatase 1 binding Source: UniProtKB

Protein-protein interaction databases

DIPiDIP-59888N.
IntActiQ8N423. 4 interactors.
STRINGi9606.ENSP00000375629.

Structurei

Secondary structure

1598
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 35Combined sources6
Beta strandi37 – 40Combined sources4
Beta strandi45 – 50Combined sources6
Beta strandi57 – 63Combined sources7
Beta strandi71 – 73Combined sources3
Helixi75 – 77Combined sources3
Helixi78 – 80Combined sources3
Beta strandi82 – 87Combined sources6
Turni90 – 92Combined sources3
Beta strandi94 – 102Combined sources9
Beta strandi113 – 118Combined sources6
Beta strandi125 – 130Combined sources6
Beta strandi140 – 158Combined sources19
Beta strandi166 – 168Combined sources3
Beta strandi176 – 183Combined sources8
Beta strandi188 – 190Combined sources3
Beta strandi193 – 199Combined sources7
Beta strandi226 – 231Combined sources6
Beta strandi233 – 235Combined sources3
Beta strandi241 – 249Combined sources9
Beta strandi252 – 258Combined sources7
Beta strandi264 – 268Combined sources5
Beta strandi277 – 283Combined sources7
Helixi288 – 290Combined sources3
Beta strandi292 – 299Combined sources8
Beta strandi313 – 317Combined sources5
Beta strandi326 – 331Combined sources6
Beta strandi333 – 335Combined sources3
Beta strandi342 – 349Combined sources8
Beta strandi352 – 361Combined sources10
Beta strandi366 – 369Combined sources4
Beta strandi371 – 373Combined sources3
Beta strandi376 – 382Combined sources7
Helixi388 – 390Combined sources3
Beta strandi392 – 400Combined sources9
Beta strandi403 – 407Combined sources5
Beta strandi414 – 418Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DYPX-ray2.50D24-219[»]
2GW5X-ray1.80A24-219[»]
4LLAX-ray2.50A/B/C222-419[»]
ProteinModelPortaliQ8N423.
SMRiQ8N423.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8N423.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 110Ig-like C2-type 1Add BLAST84
Domaini111 – 229Ig-like C2-type 2Add BLAST119
Domaini230 – 318Ig-like C2-type 3Add BLAST89
Domaini330 – 419Ig-like C2-type 4Add BLAST90

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi531 – 536ITIM motif 16
Motifi560 – 565ITIM motif 26
Motifi590 – 595ITIM motif 36

Domaini

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKJD. Eukaryota.
ENOG41116BR. LUCA.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiQ8N423.
OrthoDBiEOG091G0D6W.
PhylomeDBiQ8N423.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N423-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPIVTVLIC LGLSLGPRTH VQTGTIPKPT LWAEPDSVIT QGSPVTLSCQ
60 70 80 90 100
GSLEAQEYRL YREKKSASWI TRIRPELVKN GQFHIPSITW EHTGRYGCQY
110 120 130 140 150
YSRARWSELS DPLVLVMTGA YPKPTLSAQP SPVVTSGGRV TLQCESQVAF
160 170 180 190 200
GGFILCKEGE EEHPQCLNSQ PHARGSSRAI FSVGPVSPNR RWSHRCYGYD
210 220 230 240 250
LNSPYVWSSP SDLLELLVPG VSKKPSLSVQ PGPVVAPGES LTLQCVSDVG
260 270 280 290 300
YDRFVLYKEG ERDLRQLPGR QPQAGLSQAN FTLGPVSRSY GGQYRCYGAH
310 320 330 340 350
NLSSECSAPS DPLDILITGQ IRGTPFISVQ PGPTVASGEN VTLLCQSWRQ
360 370 380 390 400
FHTFLLTKAG AADAPLRLRS IHEYPKYQAE FPMSPVTSAH AGTYRCYGSL
410 420 430 440 450
NSDPYLLSHP SEPLELVVSG PSMGSSPPPT GPISTPAGPE DQPLTPTGSD
460 470 480 490 500
PQSGLGRHLG VVIGILVAVV LLLLLLLLLF LILRHRRQGK HWTSTQRKAD
510 520 530 540 550
FQHPAGAVGP EPTDRGLQWR SSPAADAQEE NLYAAVKDTQ PEDGVEMDTR
560 570 580 590
AAASEAPQDV TYAQLHSLTL RRKATEPPPS QEREPPAEPS IYATLAIH
Length:598
Mass (Da):65,039
Last modified:November 2, 2010 - v4
Checksum:i33E9737AFCAFCE2D
GO
Isoform 2 (identifier: Q8N423-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     437-437: Missing.

Note: Alternative use of an acceptor site. No experimental confirmation available.
Show »
Length:597
Mass (Da):64,968
Checksum:iE6C0FDA134C5F3C3
GO
Isoform 3 (identifier: Q8N423-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     495-510: TQRKADFQHPAGAVGP → SPAQLPTPRKKTSMLP
     511-598: Missing.

Show »
Length:510
Mass (Da):55,458
Checksum:iCFD221E533DBC3F7
GO
Isoform 4 (identifier: Q8N423-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.

Note: Gene prediction based on cDNA data.
Show »
Length:482
Mass (Da):51,959
Checksum:iD8A3DCC118CB7A06
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti583R → G in AAH36827 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01699720H → R.Corresponds to variant rs383369dbSNPEnsembl.1
Natural variantiVAR_016998161E → D.4 PublicationsCorresponds to variant rs373032dbSNPEnsembl.1
Natural variantiVAR_047432235V → M.Corresponds to variant rs386056dbSNPEnsembl.1
Natural variantiVAR_016999300H → Y.4 PublicationsCorresponds to variant rs7247538dbSNPEnsembl.1
Natural variantiVAR_017000306C → W.4 PublicationsCorresponds to variant rs7247451dbSNPEnsembl.1
Natural variantiVAR_061314322R → H.4 PublicationsCorresponds to variant rs1128646dbSNPEnsembl.1
Natural variantiVAR_047433324T → R.Corresponds to variant rs7247055dbSNPEnsembl.1
Natural variantiVAR_047434326F → S.Corresponds to variant rs7246737dbSNPEnsembl.1
Natural variantiVAR_047435349R → G.Corresponds to variant rs7247025dbSNPEnsembl.1
Natural variantiVAR_061315403D → N.Corresponds to variant rs4993133dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0557181 – 116Missing in isoform 4. CuratedAdd BLAST116
Alternative sequenceiVSP_008458437Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_055719495 – 510TQRKA…GAVGP → SPAQLPTPRKKTSMLP in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_055720511 – 598Missing in isoform 3. 1 PublicationAdd BLAST88

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025528 mRNA. Translation: AAB87662.1.
AF283986 mRNA. Translation: AAL36990.1.
AF283987 mRNA. Translation: AAL36991.1.
AC010518 Genomic DNA. No translation available.
BC036827 mRNA. Translation: AAH36827.1.
CCDSiCCDS12886.1. [Q8N423-1]
CCDS42612.1. [Q8N423-2]
CCDS62791.1. [Q8N423-4]
CCDS62792.1. [Q8N423-3]
UniGeneiHs.655652.

Genome annotation databases

EnsembliENST00000314446; ENSP00000319960; ENSG00000131042.
ENST00000391746; ENSP00000375626; ENSG00000131042.
ENST00000391748; ENSP00000375628; ENSG00000131042.
ENST00000391749; ENSP00000375629; ENSG00000131042.
ENST00000434421; ENSP00000410117; ENSG00000131042.
ENST00000610886; ENSP00000482933; ENSG00000276146.
ENST00000614225; ENSP00000480841; ENSG00000275463. [Q8N423-4]
ENST00000617341; ENSP00000484373; ENSG00000276146.
ENST00000617886; ENSP00000483553; ENSG00000276146.
ENST00000618392; ENSP00000480302; ENSG00000274513.
ENST00000618705; ENSP00000481208; ENSG00000275463. [Q8N423-1]
ENST00000619122; ENSP00000483478; ENSG00000275463. [Q8N423-3]
ENST00000621020; ENSP00000483014; ENSG00000275463. [Q8N423-2]
UCSCiuc010eri.4. human. [Q8N423-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025528 mRNA. Translation: AAB87662.1.
AF283986 mRNA. Translation: AAL36990.1.
AF283987 mRNA. Translation: AAL36991.1.
AC010518 Genomic DNA. No translation available.
BC036827 mRNA. Translation: AAH36827.1.
CCDSiCCDS12886.1. [Q8N423-1]
CCDS42612.1. [Q8N423-2]
CCDS62791.1. [Q8N423-4]
CCDS62792.1. [Q8N423-3]
UniGeneiHs.655652.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DYPX-ray2.50D24-219[»]
2GW5X-ray1.80A24-219[»]
4LLAX-ray2.50A/B/C222-419[»]
ProteinModelPortaliQ8N423.
SMRiQ8N423.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59888N.
IntActiQ8N423. 4 interactors.
STRINGi9606.ENSP00000375629.

PTM databases

iPTMnetiQ8N423.
PhosphoSitePlusiQ8N423.

Polymorphism and mutation databases

BioMutaiLILRB2.
DMDMi311033485.

Proteomic databases

PaxDbiQ8N423.
PeptideAtlasiQ8N423.
PRIDEiQ8N423.

Protocols and materials databases

DNASUi10288.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314446; ENSP00000319960; ENSG00000131042.
ENST00000391746; ENSP00000375626; ENSG00000131042.
ENST00000391748; ENSP00000375628; ENSG00000131042.
ENST00000391749; ENSP00000375629; ENSG00000131042.
ENST00000434421; ENSP00000410117; ENSG00000131042.
ENST00000610886; ENSP00000482933; ENSG00000276146.
ENST00000614225; ENSP00000480841; ENSG00000275463. [Q8N423-4]
ENST00000617341; ENSP00000484373; ENSG00000276146.
ENST00000617886; ENSP00000483553; ENSG00000276146.
ENST00000618392; ENSP00000480302; ENSG00000274513.
ENST00000618705; ENSP00000481208; ENSG00000275463. [Q8N423-1]
ENST00000619122; ENSP00000483478; ENSG00000275463. [Q8N423-3]
ENST00000621020; ENSP00000483014; ENSG00000275463. [Q8N423-2]
UCSCiuc010eri.4. human. [Q8N423-1]

Organism-specific databases

DisGeNETi10288.
GeneCardsiLILRB2.
HGNCiHGNC:6606. LILRB2.
HPAiCAB025797.
MIMi604815. gene.
neXtProtiNX_Q8N423.
OpenTargetsiENSG00000275463.
PharmGKBiPA30380.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKJD. Eukaryota.
ENOG41116BR. LUCA.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiQ8N423.
OrthoDBiEOG091G0D6W.
PhylomeDBiQ8N423.
TreeFamiTF336644.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

EvolutionaryTraceiQ8N423.
PROiQ8N423.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131042.
CleanExiHS_LILRB2.
ExpressionAtlasiQ8N423. baseline and differential.
GenevisibleiQ8N423. HS.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIRB2_HUMAN
AccessioniPrimary (citable) accession number: Q8N423
Secondary accession number(s): A8MU67
, C9JF29, O75017, Q8NHJ7, Q8NHJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 2, 2010
Last modified: November 30, 2016
This is version 143 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.