PGBD5

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: PiggyBac transposable element-derived protein 5
Gene namesⁱ	Name:PGBD5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19405. PGBD5.

HGNCⁱ

HGNC:19405. PGBD5.

Subcellular locationⁱ

Membrane Curated; Single-pass membrane protein Curated

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	405 – 421	HelicalSequence analysisAdd BLAST		17

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	79605.
Open Targets More...OpenTargetsⁱ	ENSG00000177614.
PharmGKBⁱ	PA134905621.

Polymorphism and mutation databases

BioMutaⁱ	PGBD5.
DMDMⁱ	300669682.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000288056	1 – 455	PiggyBac transposable element-derived protein 5Add BLAST		455

Proteomic databases

EPDⁱ	Q8N414.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N414.
PaxDbⁱ	Q8N414.
PeptideAtlas More...PeptideAtlasⁱ	Q8N414.
PRIDEⁱ	Q8N414.

PTM databases

iPTMnetⁱ	Q8N414.
PhosphoSitePlusⁱ	Q8N414.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000177614.
CleanExⁱ	HS_PGBD5.
ExpressionAtlasⁱ	Q8N414. baseline and differential.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA065010.

HPAⁱ

HPA065010.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	122741. 1 interactor.
STRINGⁱ	9606.ENSP00000322530.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N414.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IJ9Y. Eukaryota. ENOG410XP35. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000047893.
HOGENOMⁱ	HOG000115519.
HOVERGENⁱ	HBG053995.
InParanoidⁱ	Q8N414.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0684.
PhylomeDBⁱ	Q8N414.
TreeFamⁱ	TF332005.

Family and domain databases

InterProⁱ	View protein in InterPro IPR029526. PGBD.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13843. DDE_Tnp_1_7. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8N414-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPDYRTRALF VQSTLGDSAG PELQLLSIVP GRDLQPSDSF TGPTRKMPPS 
        60         70         80         90        100
ASAVDFFQLF VPDNVLKNMV VQTNMYAKKF QERFGSDGAW VEVTLTEMKA 
       110        120        130        140        150
FLGYMISTSI SHCESVLSIW SGGFYSNRSL ALVMSQARFE KILKYFHVVA 
       160        170        180        190        200
FRSSQTTHGL YKVQPFLDSL QNSFDSAFRP SQTQVLHEPL IDEDPVFIAT 
       210        220        230        240        250
CTERELRKRK KRKFSLWVRQ CSSTGFIIQI YVHLKEGGGP DGLDALKNKP 
       260        270        280        290        300
QLHSMVARSL CRNAAGKNYI IFTGPSITSL TLFEEFEKQG IYCCGLLRAR 
       310        320        330        340        350
KSDCTGLPLS MLTNPATPPA RGQYQIKMKG NMSLICWYNK GHFRFLTNAY 
       360        370        380        390        400
SPVQQGVIIK RKSGEIPCPL AVEAFAAHLS YICRYDDKYS KYFISHKPNK 
       410        420        430        440        450
TWQQVFWFAI SIAINNAYIL YKMSDAYHVK RYSRAQFGER LVRELLGLED 

ASPTH

Length:455

Mass (Da):51,642

Last modified:July 13, 2010 - v3

Checksum:ⁱDF3393BFADC6F5F0

GO

Sequence cautionⁱ

The sequence CAI13996 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	245	A → V in AAI50639 (PubMed:15489334).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL691479 Genomic DNA. Translation: CAI13996.2. Sequence problems. BC013901 mRNA. Translation: AAH13901.1. BC027466 mRNA. Translation: AAH27466.1. BC036865 mRNA. Translation: AAH36865.1. BC150638 mRNA. Translation: AAI50639.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001245240.1. NM_001258311.1.
UniGeneⁱ	Hs.520463.

Genome annotation databases

Ensemblⁱ	ENST00000525115; ENSP00000431404; ENSG00000177614.
GeneIDⁱ	79605.
KEGGⁱ	hsa:79605.
UCSC genome browser More...UCSCⁱ	uc057qgx.1. human.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL691479 Genomic DNA. Translation: CAI13996.2. Sequence problems. BC013901 mRNA. Translation: AAH13901.1. BC027466 mRNA. Translation: AAH27466.1. BC036865 mRNA. Translation: AAH36865.1. BC150638 mRNA. Translation: AAI50639.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001245240.1. NM_001258311.1.
UniGeneⁱ	Hs.520463.

3D structure databases

ProteinModelPortalⁱ	Q8N414.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122741. 1 interactor.
STRINGⁱ	9606.ENSP00000322530.

PTM databases

iPTMnetⁱ	Q8N414.
PhosphoSitePlusⁱ	Q8N414.

Polymorphism and mutation databases

BioMutaⁱ	PGBD5.
DMDMⁱ	300669682.

Proteomic databases

EPDⁱ	Q8N414.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N414.
PaxDbⁱ	Q8N414.
PeptideAtlas More...PeptideAtlasⁱ	Q8N414.
PRIDEⁱ	Q8N414.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000525115; ENSP00000431404; ENSG00000177614.
GeneIDⁱ	79605.
KEGGⁱ	hsa:79605.
UCSC genome browser More...UCSCⁱ	uc057qgx.1. human.

Organism-specific databases

CTDⁱ	79605.
DisGeNET More...DisGeNETⁱ	79605.
GeneCardsⁱ	PGBD5.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19405. PGBD5.
Human Protein Atlas More...HPAⁱ	HPA065010.
neXtProtⁱ	NX_Q8N414.
Open Targets More...OpenTargetsⁱ	ENSG00000177614.
PharmGKBⁱ	PA134905621.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJ9Y. Eukaryota. ENOG410XP35. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000047893.
HOGENOMⁱ	HOG000115519.
HOVERGENⁱ	HBG053995.
InParanoidⁱ	Q8N414.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0684.
PhylomeDBⁱ	Q8N414.
TreeFamⁱ	TF332005.

Miscellaneous databases

ChiTaRSⁱ	PGBD5. human.
GenomeRNAiⁱ	79605.
Protein Ontology More...PROⁱ	PR:Q8N414.

Gene expression databases

Bgeeⁱ	ENSG00000177614.
CleanExⁱ	HS_PGBD5.
ExpressionAtlasⁱ	Q8N414. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR029526. PGBD.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13843. DDE_Tnp_1_7. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PGBD5_HUMAN
Accessionⁱ	Q8N414Primary (citable) accession number: Q8N414 Secondary accession number(s): A0PJF3 , B9EK58, Q5SR37, Q6PJN2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
	Last sequence update:	July 13, 2010
	Last modified:	June 7, 2017
	This is version 85 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8N414 (PGBD5_HUMAN)

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PiggyBac transposable element-derived protein 5

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ