ID   S2545_HUMAN             Reviewed;         288 AA.
AC   Q8N413; Q6PL49; Q8IW29;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 2.
DT   27-MAR-2024, entry version 149.
DE   RecName: Full=Solute carrier family 25 member 45;
GN   Name=SLC25A45;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), AND VARIANT VAL-224.
RA   Lin L., Zhong G., Ke R., Li H., Zhou G., Shen C., Yang S.;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), AND VARIANT
RP   VAL-224.
RC   TISSUE=Pancreas, and Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=16949250; DOI=10.1016/j.ygeno.2006.06.016;
RA   Haitina T., Lindblom J., Renstroem T., Fredriksson R.;
RT   "Fourteen novel human members of mitochondrial solute carrier family 25
RT   (SLC25) widely expressed in the central nervous system.";
RL   Genomics 88:779-790(2006).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=Q8N413-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8N413-2; Sequence=VSP_026246;
CC       Name=3;
CC         IsoId=Q8N413-3; Sequence=VSP_026246, VSP_026248;
CC       Name=4;
CC         IsoId=Q8N413-4; Sequence=VSP_026247;
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION: [Isoform 4]:
CC       Sequence=BC041100; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AY597807; AAT09000.1; -; mRNA.
DR   EMBL; AP000944; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC036869; AAH36869.1; -; mRNA.
DR   EMBL; BC041100; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS41670.1; -. [Q8N413-1]
DR   CCDS; CCDS41671.1; -. [Q8N413-2]
DR   CCDS; CCDS60850.1; -. [Q8N413-4]
DR   RefSeq; NP_001070709.2; NM_001077241.2. [Q8N413-2]
DR   RefSeq; NP_001265179.2; NM_001278250.2. [Q8N413-4]
DR   RefSeq; NP_001265180.2; NM_001278251.2. [Q8N413-2]
DR   RefSeq; NP_001287749.1; NM_001300820.1.
DR   RefSeq; NP_872362.3; NM_182556.3. [Q8N413-1]
DR   RefSeq; XP_006718572.1; XM_006718509.3.
DR   RefSeq; XP_006718573.1; XM_006718510.3.
DR   RefSeq; XP_011543245.1; XM_011544943.2.
DR   RefSeq; XP_011543246.1; XM_011544944.2.
DR   RefSeq; XP_011543251.1; XM_011544949.2.
DR   RefSeq; XP_016873052.1; XM_017017563.1.
DR   RefSeq; XP_016873053.1; XM_017017564.1.
DR   RefSeq; XP_016873054.1; XM_017017565.1.
DR   RefSeq; XP_016873055.1; XM_017017566.1.
DR   RefSeq; XP_016873056.1; XM_017017567.1.
DR   RefSeq; XP_016873057.1; XM_017017568.1.
DR   RefSeq; XP_016873058.1; XM_017017569.1.
DR   RefSeq; XP_016873059.1; XM_017017570.1.
DR   RefSeq; XP_016873060.1; XM_017017571.1.
DR   AlphaFoldDB; Q8N413; -.
DR   SMR; Q8N413; -.
DR   BioGRID; 129470; 1.
DR   STRING; 9606.ENSP00000381782; -.
DR   TCDB; 2.A.29.8.7; the mitochondrial carrier (mc) family.
DR   BioMuta; SLC25A45; -.
DR   DMDM; 150416125; -.
DR   MassIVE; Q8N413; -.
DR   PaxDb; 9606-ENSP00000381782; -.
DR   PeptideAtlas; Q8N413; -.
DR   ProteomicsDB; 71861; -. [Q8N413-1]
DR   ProteomicsDB; 71862; -. [Q8N413-2]
DR   Antibodypedia; 7360; 47 antibodies from 20 providers.
DR   DNASU; 283130; -.
DR   Ensembl; ENST00000294187.10; ENSP00000294187.6; ENSG00000162241.13. [Q8N413-2]
DR   Ensembl; ENST00000398802.6; ENSP00000381782.1; ENSG00000162241.13. [Q8N413-1]
DR   Ensembl; ENST00000527174.5; ENSP00000435489.1; ENSG00000162241.13. [Q8N413-1]
DR   Ensembl; ENST00000534028.5; ENSP00000431769.1; ENSG00000162241.13. [Q8N413-4]
DR   GeneID; 283130; -.
DR   KEGG; hsa:283130; -.
DR   MANE-Select; ENST00000398802.6; ENSP00000381782.1; NM_182556.4; NP_872362.4.
DR   UCSC; uc001odq.3; human. [Q8N413-1]
DR   AGR; HGNC:27442; -.
DR   CTD; 283130; -.
DR   DisGeNET; 283130; -.
DR   GeneCards; SLC25A45; -.
DR   HGNC; HGNC:27442; SLC25A45.
DR   HPA; ENSG00000162241; Tissue enhanced (pancreas).
DR   MIM; 610825; gene.
DR   neXtProt; NX_Q8N413; -.
DR   OpenTargets; ENSG00000162241; -.
DR   PharmGKB; PA162403718; -.
DR   VEuPathDB; HostDB:ENSG00000162241; -.
DR   eggNOG; KOG0758; Eukaryota.
DR   GeneTree; ENSGT00940000161002; -.
DR   InParanoid; Q8N413; -.
DR   OMA; QLFAGGC; -.
DR   OrthoDB; 4064096at2759; -.
DR   PhylomeDB; Q8N413; -.
DR   TreeFam; TF351739; -.
DR   PathwayCommons; Q8N413; -.
DR   BioGRID-ORCS; 283130; 17 hits in 1151 CRISPR screens.
DR   ChiTaRS; SLC25A45; human.
DR   GenomeRNAi; 283130; -.
DR   Pharos; Q8N413; Tdark.
DR   PRO; PR:Q8N413; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8N413; Protein.
DR   Bgee; ENSG00000162241; Expressed in body of pancreas and 135 other cell types or tissues.
DR   ExpressionAtlas; Q8N413; baseline and differential.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   PANTHER; PTHR45624; MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED; 1.
DR   PANTHER; PTHR45624:SF6; SOLUTE CARRIER FAMILY 25 MEMBER 45; 1.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
DR   Genevisible; Q8N413; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..288
FT                   /note="Solute carrier family 25 member 45"
FT                   /id="PRO_0000291826"
FT   TRANSMEM        6..26
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        266..286
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          1..83
FT                   /note="Solcar 1"
FT   REPEAT          97..191
FT                   /note="Solcar 2"
FT   REPEAT          199..286
FT                   /note="Solcar 3"
FT   VAR_SEQ         1..42
FT                   /note="Missing (in isoform 2 and isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT                   /id="VSP_026246"
FT   VAR_SEQ         28..51
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_026247"
FT   VAR_SEQ         52..113
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_026248"
FT   VARIANT         224
FT                   /note="M -> V (in dbSNP:rs624307)"
FT                   /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT                   /id="VAR_032866"
FT   VARIANT         251
FT                   /note="R -> Q (in dbSNP:rs7108281)"
FT                   /id="VAR_050135"
FT   CONFLICT        153
FT                   /note="S -> P (in Ref. 1; AAT09000)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   288 AA;  31906 MW;  BD8EF1D8A2BFB296 CRC64;
     MPVEEFVAGW ISGALGLVLG HPFDTVKVRL QTQTTYRGIV DCMVKIYRHE SLLGFFKGMS
     FPIASIAVVN SVLFGVYSNT LLVLTATSHQ ERRAQPPSYM HIFLAGCTGG FLQAYCLAPF
     DLIKVRLQNQ TEPRAQPGSP PPRYQGPVHC AASIFREEGP RGLFRGAWAL TLRDTPTVGI
     YFITYEGLCR QYTPEGQNPS SATVLVAGGF AGIASWVAAT PLDMIKSRMQ MDGLRRRVYQ
     GMLDCMVSSI RQEGLGVFFR GVTINSARAF PVNAVTFLSY EYLLRWWG
//