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Protein

Solute carrier family 25 member 45

Gene

SLC25A45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.29.8.7. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 45
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:27442. SLC25A45.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei63 – 8321Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei166 – 18621Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei202 – 22221Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei266 – 28621Helical; Name=6Sequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162403718.

Polymorphism and mutation databases

BioMutaiSLC25A45.
DMDMi150416125.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Solute carrier family 25 member 45PRO_0000291826Add
BLAST

Proteomic databases

PaxDbiQ8N413.
PRIDEiQ8N413.

Expressioni

Gene expression databases

BgeeiQ8N413.
CleanExiHS_SLC25A45.
ExpressionAtlasiQ8N413. baseline and differential.
GenevisibleiQ8N413. HS.

Organism-specific databases

HPAiHPA050821.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000381782.

Structurei

3D structure databases

ProteinModelPortaliQ8N413.
SMRiQ8N413. Positions 5-285.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1 – 8383Solcar 1Add
BLAST
Repeati97 – 19195Solcar 2Add
BLAST
Repeati199 – 28688Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG274957.
GeneTreeiENSGT00700000104295.
HOGENOMiHOG000168307.
HOVERGENiHBG003500.
InParanoidiQ8N413.
KOiK15123.
OMAiGMLDCMV.
OrthoDBiEOG77DJ6R.
PhylomeDBiQ8N413.
TreeFamiTF351739.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N413-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVEEFVAGW ISGALGLVLG HPFDTVKVRL QTQTTYRGIV DCMVKIYRHE
60 70 80 90 100
SLLGFFKGMS FPIASIAVVN SVLFGVYSNT LLVLTATSHQ ERRAQPPSYM
110 120 130 140 150
HIFLAGCTGG FLQAYCLAPF DLIKVRLQNQ TEPRAQPGSP PPRYQGPVHC
160 170 180 190 200
AASIFREEGP RGLFRGAWAL TLRDTPTVGI YFITYEGLCR QYTPEGQNPS
210 220 230 240 250
SATVLVAGGF AGIASWVAAT PLDMIKSRMQ MDGLRRRVYQ GMLDCMVSSI
260 270 280
RQEGLGVFFR GVTINSARAF PVNAVTFLSY EYLLRWWG
Length:288
Mass (Da):31,906
Last modified:June 26, 2007 - v2
Checksum:iBD8EF1D8A2BFB296
GO
Isoform 2 (identifier: Q8N413-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Note: No experimental confirmation available.
Show »
Length:246
Mass (Da):27,319
Checksum:i3DD46F818E36CA50
GO
Isoform 3 (identifier: Q8N413-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     52-113: Missing.

Note: No experimental confirmation available.
Show »
Length:184
Mass (Da):20,631
Checksum:i603EA67772E2A639
GO
Isoform 4 (identifier: Q8N413-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-51: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:264
Mass (Da):29,027
Checksum:i05876BDB4AA7A1C7
GO

Sequence cautioni

Isoform 4 : The sequence BC041100 differs from that shown. Reason: Frameshift at position 208. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti153 – 1531S → P in AAT09000 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti224 – 2241M → V.2 Publications
Corresponds to variant rs624307 [ dbSNP | Ensembl ].
VAR_032866
Natural varianti251 – 2511R → Q.
Corresponds to variant rs7108281 [ dbSNP | Ensembl ].
VAR_050135

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4242Missing in isoform 2 and isoform 3. 2 PublicationsVSP_026246Add
BLAST
Alternative sequencei28 – 5124Missing in isoform 4. 1 PublicationVSP_026247Add
BLAST
Alternative sequencei52 – 11362Missing in isoform 3. 1 PublicationVSP_026248Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY597807 mRNA. Translation: AAT09000.1.
AP000944 Genomic DNA. No translation available.
BC036869 mRNA. Translation: AAH36869.1.
BC041100 mRNA. No translation available.
CCDSiCCDS41670.1. [Q8N413-1]
CCDS41671.1. [Q8N413-2]
CCDS60850.1. [Q8N413-4]
RefSeqiNP_001070709.2. NM_001077241.2.
NP_001265179.2. NM_001278250.2.
NP_001265180.2. NM_001278251.2.
NP_001287749.1. NM_001300820.1.
NP_872362.3. NM_182556.3.
XP_006718572.1. XM_006718509.2. [Q8N413-2]
XP_006718573.1. XM_006718510.2. [Q8N413-2]
UniGeneiHs.661604.

Genome annotation databases

EnsembliENST00000294187; ENSP00000294187; ENSG00000162241. [Q8N413-2]
ENST00000398802; ENSP00000381782; ENSG00000162241. [Q8N413-1]
ENST00000527174; ENSP00000435489; ENSG00000162241. [Q8N413-1]
ENST00000534028; ENSP00000431769; ENSG00000162241. [Q8N413-4]
GeneIDi283130.
KEGGihsa:283130.
UCSCiuc001odq.2. human. [Q8N413-4]
uc001odr.1. human. [Q8N413-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY597807 mRNA. Translation: AAT09000.1.
AP000944 Genomic DNA. No translation available.
BC036869 mRNA. Translation: AAH36869.1.
BC041100 mRNA. No translation available.
CCDSiCCDS41670.1. [Q8N413-1]
CCDS41671.1. [Q8N413-2]
CCDS60850.1. [Q8N413-4]
RefSeqiNP_001070709.2. NM_001077241.2.
NP_001265179.2. NM_001278250.2.
NP_001265180.2. NM_001278251.2.
NP_001287749.1. NM_001300820.1.
NP_872362.3. NM_182556.3.
XP_006718572.1. XM_006718509.2. [Q8N413-2]
XP_006718573.1. XM_006718510.2. [Q8N413-2]
UniGeneiHs.661604.

3D structure databases

ProteinModelPortaliQ8N413.
SMRiQ8N413. Positions 5-285.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000381782.

Protein family/group databases

TCDBi2.A.29.8.7. the mitochondrial carrier (mc) family.

Polymorphism and mutation databases

BioMutaiSLC25A45.
DMDMi150416125.

Proteomic databases

PaxDbiQ8N413.
PRIDEiQ8N413.

Protocols and materials databases

DNASUi283130.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294187; ENSP00000294187; ENSG00000162241. [Q8N413-2]
ENST00000398802; ENSP00000381782; ENSG00000162241. [Q8N413-1]
ENST00000527174; ENSP00000435489; ENSG00000162241. [Q8N413-1]
ENST00000534028; ENSP00000431769; ENSG00000162241. [Q8N413-4]
GeneIDi283130.
KEGGihsa:283130.
UCSCiuc001odq.2. human. [Q8N413-4]
uc001odr.1. human. [Q8N413-1]

Organism-specific databases

CTDi283130.
GeneCardsiGC11M065142.
HGNCiHGNC:27442. SLC25A45.
HPAiHPA050821.
MIMi610825. gene.
neXtProtiNX_Q8N413.
PharmGKBiPA162403718.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG274957.
GeneTreeiENSGT00700000104295.
HOGENOMiHOG000168307.
HOVERGENiHBG003500.
InParanoidiQ8N413.
KOiK15123.
OMAiGMLDCMV.
OrthoDBiEOG77DJ6R.
PhylomeDBiQ8N413.
TreeFamiTF351739.

Miscellaneous databases

ChiTaRSiSLC25A45. human.
GenomeRNAii283130.
NextBioi93640.
PROiQ8N413.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N413.
CleanExiHS_SLC25A45.
ExpressionAtlasiQ8N413. baseline and differential.
GenevisibleiQ8N413. HS.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Lin L., Zhong G., Ke R., Li H., Zhou G., Shen C., Yang S.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT VAL-224.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), VARIANT VAL-224.
    Tissue: Pancreas and Prostate.
  4. "Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system."
    Haitina T., Lindblom J., Renstroem T., Fredriksson R.
    Genomics 88:779-790(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiS2545_HUMAN
AccessioniPrimary (citable) accession number: Q8N413
Secondary accession number(s): Q6PL49, Q8IW29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: June 24, 2015
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.