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Q8N413 (S2545_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 25 member 45
Gene names
Name:SLC25A45
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]

Contains 3 Solcar repeats.

Sequence caution

Isoform 4: The sequence BC041100 differs from that shown. Reason: Frameshift at position 208.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Transmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransmembrane transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial inner membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N413-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N413-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8N413-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     52-113: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q8N413-4)

The sequence of this isoform differs from the canonical sequence as follows:
     28-51: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Solute carrier family 25 member 45
PRO_0000291826

Regions

Transmembrane6 – 2621Helical; Name=1; Potential
Transmembrane63 – 8321Helical; Name=2; Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Transmembrane166 – 18621Helical; Name=4; Potential
Transmembrane202 – 22221Helical; Name=5; Potential
Transmembrane266 – 28621Helical; Name=6; Potential
Repeat1 – 8383Solcar 1
Repeat97 – 19195Solcar 2
Repeat199 – 28688Solcar 3

Natural variations

Alternative sequence1 – 4242Missing in isoform 2 and isoform 3.
VSP_026246
Alternative sequence28 – 5124Missing in isoform 4.
VSP_026247
Alternative sequence52 – 11362Missing in isoform 3.
VSP_026248
Natural variant2241M → V. Ref.1 Ref.3
Corresponds to variant rs624307 [ dbSNP | Ensembl ].
VAR_032866
Natural variant2511R → Q.
Corresponds to variant rs7108281 [ dbSNP | Ensembl ].
VAR_050135

Experimental info

Sequence conflict1531S → P in AAT09000. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 26, 2007. Version 2.
Checksum: BD8EF1D8A2BFB296

FASTA28831,906
        10         20         30         40         50         60 
MPVEEFVAGW ISGALGLVLG HPFDTVKVRL QTQTTYRGIV DCMVKIYRHE SLLGFFKGMS 

        70         80         90        100        110        120 
FPIASIAVVN SVLFGVYSNT LLVLTATSHQ ERRAQPPSYM HIFLAGCTGG FLQAYCLAPF 

       130        140        150        160        170        180 
DLIKVRLQNQ TEPRAQPGSP PPRYQGPVHC AASIFREEGP RGLFRGAWAL TLRDTPTVGI 

       190        200        210        220        230        240 
YFITYEGLCR QYTPEGQNPS SATVLVAGGF AGIASWVAAT PLDMIKSRMQ MDGLRRRVYQ 

       250        260        270        280 
GMLDCMVSSI RQEGLGVFFR GVTINSARAF PVNAVTFLSY EYLLRWWG 

« Hide

Isoform 2 [UniParc].

Checksum: 3DD46F818E36CA50
Show »

FASTA24627,319
Isoform 3 [UniParc].

Checksum: 603EA67772E2A639
Show »

FASTA18420,631
Isoform 4 [UniParc].

Checksum: 05876BDB4AA7A1C7
Show »

FASTA26429,027

References

« Hide 'large scale' references
[1]Lin L., Zhong G., Ke R., Li H., Zhou G., Shen C., Yang S.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT VAL-224.
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), VARIANT VAL-224.
Tissue: Pancreas and Prostate.
[4]"Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system."
Haitina T., Lindblom J., Renstroem T., Fredriksson R.
Genomics 88:779-790(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY597807 mRNA. Translation: AAT09000.1.
AP000944 Genomic DNA. No translation available.
BC036869 mRNA. Translation: AAH36869.1.
BC041100 mRNA. No translation available.
RefSeqNP_001070709.1. NM_001077241.1.
NP_001265179.1. NM_001278250.1.
NP_872362.2. NM_182556.2.
UniGeneHs.661604.

3D structure databases

ProteinModelPortalQ8N413.
SMRQ8N413. Positions 5-287.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000381782.

Protein family/group databases

TCDB2.A.29.8.7. the mitochondrial carrier (mc) family.

Polymorphism databases

DMDM150416125.

Proteomic databases

PaxDbQ8N413.
PRIDEQ8N413.

Protocols and materials databases

DNASU283130.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000294187; ENSP00000294187; ENSG00000162241. [Q8N413-2]
ENST00000360662; ENSP00000353879; ENSG00000162241. [Q8N413-4]
ENST00000377152; ENSP00000366357; ENSG00000162241. [Q8N413-3]
ENST00000398802; ENSP00000381782; ENSG00000162241. [Q8N413-1]
ENST00000417511; ENSP00000407530; ENSG00000162241. [Q8N413-2]
ENST00000527174; ENSP00000435489; ENSG00000162241. [Q8N413-1]
ENST00000534028; ENSP00000431769; ENSG00000162241. [Q8N413-4]
GeneID283130.
KEGGhsa:283130.
UCSCuc001odq.2. human. [Q8N413-4]
uc001odr.1. human. [Q8N413-1]

Organism-specific databases

CTD283130.
GeneCardsGC11M065142.
HGNCHGNC:27442. SLC25A45.
HPAHPA050821.
MIM610825. gene.
neXtProtNX_Q8N413.
PharmGKBPA162403718.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG274957.
HOGENOMHOG000168307.
HOVERGENHBG003500.
KOK15123.
OMAKIYRHES.
OrthoDBEOG77DJ6R.
PhylomeDBQ8N413.
TreeFamTF351739.

Gene expression databases

ArrayExpressQ8N413.
BgeeQ8N413.
CleanExHS_SLC25A45.
GenevestigatorQ8N413.

Family and domain databases

Gene3D1.50.40.10. 1 hit.
InterProIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSPR00926. MITOCARRIER.
SUPFAMSSF103506. SSF103506. 1 hit.
PROSITEPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi283130.
NextBio93640.
PROQ8N413.
SOURCESearch...

Entry information

Entry nameS2545_HUMAN
AccessionPrimary (citable) accession number: Q8N413
Secondary accession number(s): Q6PL49, Q8IW29
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: April 16, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM