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Q8N413

- S2545_HUMAN

UniProt

Q8N413 - S2545_HUMAN

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Protein

Solute carrier family 25 member 45

Gene

SLC25A45

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.29.8.7. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 45
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:27442. SLC25A45.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162403718.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Solute carrier family 25 member 45PRO_0000291826Add
BLAST

Proteomic databases

PaxDbiQ8N413.
PRIDEiQ8N413.

Expressioni

Gene expression databases

BgeeiQ8N413.
CleanExiHS_SLC25A45.
ExpressionAtlasiQ8N413. baseline and differential.
GenevestigatoriQ8N413.

Organism-specific databases

HPAiHPA050821.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000381782.

Structurei

3D structure databases

ProteinModelPortaliQ8N413.
SMRiQ8N413. Positions 5-285.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei63 – 8321Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei166 – 18621Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei202 – 22221Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei266 – 28621Helical; Name=6Sequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1 – 8383Solcar 1Add
BLAST
Repeati97 – 19195Solcar 2Add
BLAST
Repeati199 – 28688Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG274957.
GeneTreeiENSGT00700000104295.
HOGENOMiHOG000168307.
HOVERGENiHBG003500.
InParanoidiQ8N413.
KOiK15123.
OMAiYRHESIL.
OrthoDBiEOG77DJ6R.
PhylomeDBiQ8N413.
TreeFamiTF351739.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N413-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVEEFVAGW ISGALGLVLG HPFDTVKVRL QTQTTYRGIV DCMVKIYRHE
60 70 80 90 100
SLLGFFKGMS FPIASIAVVN SVLFGVYSNT LLVLTATSHQ ERRAQPPSYM
110 120 130 140 150
HIFLAGCTGG FLQAYCLAPF DLIKVRLQNQ TEPRAQPGSP PPRYQGPVHC
160 170 180 190 200
AASIFREEGP RGLFRGAWAL TLRDTPTVGI YFITYEGLCR QYTPEGQNPS
210 220 230 240 250
SATVLVAGGF AGIASWVAAT PLDMIKSRMQ MDGLRRRVYQ GMLDCMVSSI
260 270 280
RQEGLGVFFR GVTINSARAF PVNAVTFLSY EYLLRWWG
Length:288
Mass (Da):31,906
Last modified:June 26, 2007 - v2
Checksum:iBD8EF1D8A2BFB296
GO
Isoform 2 (identifier: Q8N413-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Note: No experimental confirmation available.

Show »
Length:246
Mass (Da):27,319
Checksum:i3DD46F818E36CA50
GO
Isoform 3 (identifier: Q8N413-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     52-113: Missing.

Note: No experimental confirmation available.

Show »
Length:184
Mass (Da):20,631
Checksum:i603EA67772E2A639
GO
Isoform 4 (identifier: Q8N413-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-51: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:264
Mass (Da):29,027
Checksum:i05876BDB4AA7A1C7
GO

Sequence cautioni

Isoform 4 : The sequence BC041100 differs from that shown. Reason: Frameshift at position 208.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti153 – 1531S → P in AAT09000. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti224 – 2241M → V.2 Publications
Corresponds to variant rs624307 [ dbSNP | Ensembl ].
VAR_032866
Natural varianti251 – 2511R → Q.
Corresponds to variant rs7108281 [ dbSNP | Ensembl ].
VAR_050135

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4242Missing in isoform 2 and isoform 3. 2 PublicationsVSP_026246Add
BLAST
Alternative sequencei28 – 5124Missing in isoform 4. 1 PublicationVSP_026247Add
BLAST
Alternative sequencei52 – 11362Missing in isoform 3. 1 PublicationVSP_026248Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY597807 mRNA. Translation: AAT09000.1.
AP000944 Genomic DNA. No translation available.
BC036869 mRNA. Translation: AAH36869.1.
BC041100 mRNA. No translation available.
CCDSiCCDS41670.1. [Q8N413-1]
CCDS41671.1. [Q8N413-2]
CCDS60850.1. [Q8N413-4]
RefSeqiNP_001070709.2. NM_001077241.2. [Q8N413-2]
NP_001265179.2. NM_001278250.2. [Q8N413-4]
NP_001265180.2. NM_001278251.2. [Q8N413-2]
NP_872362.3. NM_182556.3. [Q8N413-1]
XP_006718570.1. XM_006718507.1. [Q8N413-1]
XP_006718571.1. XM_006718508.1. [Q8N413-2]
XP_006718572.1. XM_006718509.1. [Q8N413-2]
XP_006718573.1. XM_006718510.1. [Q8N413-2]
XP_006718575.1. XM_006718512.1. [Q8N413-2]
XP_006718576.1. XM_006718513.1. [Q8N413-2]
UniGeneiHs.661604.

Genome annotation databases

EnsembliENST00000294187; ENSP00000294187; ENSG00000162241. [Q8N413-2]
ENST00000398802; ENSP00000381782; ENSG00000162241. [Q8N413-1]
ENST00000527174; ENSP00000435489; ENSG00000162241. [Q8N413-1]
ENST00000534028; ENSP00000431769; ENSG00000162241. [Q8N413-4]
GeneIDi283130.
KEGGihsa:283130.
UCSCiuc001odq.2. human. [Q8N413-4]
uc001odr.1. human. [Q8N413-1]

Polymorphism databases

DMDMi150416125.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY597807 mRNA. Translation: AAT09000.1 .
AP000944 Genomic DNA. No translation available.
BC036869 mRNA. Translation: AAH36869.1 .
BC041100 mRNA. No translation available.
CCDSi CCDS41670.1. [Q8N413-1 ]
CCDS41671.1. [Q8N413-2 ]
CCDS60850.1. [Q8N413-4 ]
RefSeqi NP_001070709.2. NM_001077241.2. [Q8N413-2 ]
NP_001265179.2. NM_001278250.2. [Q8N413-4 ]
NP_001265180.2. NM_001278251.2. [Q8N413-2 ]
NP_872362.3. NM_182556.3. [Q8N413-1 ]
XP_006718570.1. XM_006718507.1. [Q8N413-1 ]
XP_006718571.1. XM_006718508.1. [Q8N413-2 ]
XP_006718572.1. XM_006718509.1. [Q8N413-2 ]
XP_006718573.1. XM_006718510.1. [Q8N413-2 ]
XP_006718575.1. XM_006718512.1. [Q8N413-2 ]
XP_006718576.1. XM_006718513.1. [Q8N413-2 ]
UniGenei Hs.661604.

3D structure databases

ProteinModelPortali Q8N413.
SMRi Q8N413. Positions 5-285.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000381782.

Protein family/group databases

TCDBi 2.A.29.8.7. the mitochondrial carrier (mc) family.

Polymorphism databases

DMDMi 150416125.

Proteomic databases

PaxDbi Q8N413.
PRIDEi Q8N413.

Protocols and materials databases

DNASUi 283130.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000294187 ; ENSP00000294187 ; ENSG00000162241 . [Q8N413-2 ]
ENST00000398802 ; ENSP00000381782 ; ENSG00000162241 . [Q8N413-1 ]
ENST00000527174 ; ENSP00000435489 ; ENSG00000162241 . [Q8N413-1 ]
ENST00000534028 ; ENSP00000431769 ; ENSG00000162241 . [Q8N413-4 ]
GeneIDi 283130.
KEGGi hsa:283130.
UCSCi uc001odq.2. human. [Q8N413-4 ]
uc001odr.1. human. [Q8N413-1 ]

Organism-specific databases

CTDi 283130.
GeneCardsi GC11M065142.
HGNCi HGNC:27442. SLC25A45.
HPAi HPA050821.
MIMi 610825. gene.
neXtProti NX_Q8N413.
PharmGKBi PA162403718.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG274957.
GeneTreei ENSGT00700000104295.
HOGENOMi HOG000168307.
HOVERGENi HBG003500.
InParanoidi Q8N413.
KOi K15123.
OMAi YRHESIL.
OrthoDBi EOG77DJ6R.
PhylomeDBi Q8N413.
TreeFami TF351739.

Miscellaneous databases

GenomeRNAii 283130.
NextBioi 93640.
PROi Q8N413.
SOURCEi Search...

Gene expression databases

Bgeei Q8N413.
CleanExi HS_SLC25A45.
ExpressionAtlasi Q8N413. baseline and differential.
Genevestigatori Q8N413.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
InterProi IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 3 hits.
[Graphical view ]
PRINTSi PR00926. MITOCARRIER.
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Lin L., Zhong G., Ke R., Li H., Zhou G., Shen C., Yang S.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT VAL-224.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), VARIANT VAL-224.
    Tissue: Pancreas and Prostate.
  4. "Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system."
    Haitina T., Lindblom J., Renstroem T., Fredriksson R.
    Genomics 88:779-790(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiS2545_HUMAN
AccessioniPrimary (citable) accession number: Q8N413
Secondary accession number(s): Q6PL49, Q8IW29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: October 29, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3