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Q8N413

- S2545_HUMAN

UniProt

Q8N413 - S2545_HUMAN

Protein

Solute carrier family 25 member 45

Gene

SLC25A45

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (26 Jun 2007)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. transmembrane transport Source: InterPro

    Keywords - Biological processi

    Transport

    Protein family/group databases

    TCDBi2.A.29.8.7. the mitochondrial carrier (mc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 25 member 45
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:27442. SLC25A45.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162403718.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Solute carrier family 25 member 45PRO_0000291826Add
    BLAST

    Proteomic databases

    PaxDbiQ8N413.
    PRIDEiQ8N413.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N413.
    BgeeiQ8N413.
    CleanExiHS_SLC25A45.
    GenevestigatoriQ8N413.

    Organism-specific databases

    HPAiHPA050821.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000381782.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N413.
    SMRiQ8N413. Positions 5-285.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei63 – 8321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei166 – 18621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei202 – 22221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei266 – 28621Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati1 – 8383Solcar 1Add
    BLAST
    Repeati97 – 19195Solcar 2Add
    BLAST
    Repeati199 – 28688Solcar 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG274957.
    HOGENOMiHOG000168307.
    HOVERGENiHBG003500.
    KOiK15123.
    OMAiYRHESIL.
    OrthoDBiEOG77DJ6R.
    PhylomeDBiQ8N413.
    TreeFamiTF351739.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    PRINTSiPR00926. MITOCARRIER.
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N413-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPVEEFVAGW ISGALGLVLG HPFDTVKVRL QTQTTYRGIV DCMVKIYRHE    50
    SLLGFFKGMS FPIASIAVVN SVLFGVYSNT LLVLTATSHQ ERRAQPPSYM 100
    HIFLAGCTGG FLQAYCLAPF DLIKVRLQNQ TEPRAQPGSP PPRYQGPVHC 150
    AASIFREEGP RGLFRGAWAL TLRDTPTVGI YFITYEGLCR QYTPEGQNPS 200
    SATVLVAGGF AGIASWVAAT PLDMIKSRMQ MDGLRRRVYQ GMLDCMVSSI 250
    RQEGLGVFFR GVTINSARAF PVNAVTFLSY EYLLRWWG 288
    Length:288
    Mass (Da):31,906
    Last modified:June 26, 2007 - v2
    Checksum:iBD8EF1D8A2BFB296
    GO
    Isoform 2 (identifier: Q8N413-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-42: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:246
    Mass (Da):27,319
    Checksum:i3DD46F818E36CA50
    GO
    Isoform 3 (identifier: Q8N413-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-42: Missing.
         52-113: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:184
    Mass (Da):20,631
    Checksum:i603EA67772E2A639
    GO
    Isoform 4 (identifier: Q8N413-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         28-51: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:264
    Mass (Da):29,027
    Checksum:i05876BDB4AA7A1C7
    GO

    Sequence cautioni

    Isoform 4 : The sequence BC041100 differs from that shown. Reason: Frameshift at position 208.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti153 – 1531S → P in AAT09000. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti224 – 2241M → V.2 Publications
    Corresponds to variant rs624307 [ dbSNP | Ensembl ].
    VAR_032866
    Natural varianti251 – 2511R → Q.
    Corresponds to variant rs7108281 [ dbSNP | Ensembl ].
    VAR_050135

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4242Missing in isoform 2 and isoform 3. 2 PublicationsVSP_026246Add
    BLAST
    Alternative sequencei28 – 5124Missing in isoform 4. 1 PublicationVSP_026247Add
    BLAST
    Alternative sequencei52 – 11362Missing in isoform 3. 1 PublicationVSP_026248Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY597807 mRNA. Translation: AAT09000.1.
    AP000944 Genomic DNA. No translation available.
    BC036869 mRNA. Translation: AAH36869.1.
    BC041100 mRNA. No translation available.
    CCDSiCCDS41670.1. [Q8N413-1]
    CCDS41671.1. [Q8N413-2]
    CCDS60850.1. [Q8N413-4]
    RefSeqiNP_001070709.1. NM_001077241.1. [Q8N413-2]
    NP_001265179.1. NM_001278250.1. [Q8N413-4]
    NP_872362.2. NM_182556.2. [Q8N413-1]
    XP_006718570.1. XM_006718507.1. [Q8N413-1]
    XP_006718571.1. XM_006718508.1. [Q8N413-2]
    XP_006718572.1. XM_006718509.1. [Q8N413-2]
    XP_006718573.1. XM_006718510.1. [Q8N413-2]
    XP_006718575.1. XM_006718512.1. [Q8N413-2]
    XP_006718576.1. XM_006718513.1. [Q8N413-2]
    UniGeneiHs.661604.

    Genome annotation databases

    EnsembliENST00000294187; ENSP00000294187; ENSG00000162241. [Q8N413-2]
    ENST00000398802; ENSP00000381782; ENSG00000162241. [Q8N413-1]
    ENST00000527174; ENSP00000435489; ENSG00000162241. [Q8N413-1]
    ENST00000534028; ENSP00000431769; ENSG00000162241. [Q8N413-4]
    GeneIDi283130.
    KEGGihsa:283130.
    UCSCiuc001odq.2. human. [Q8N413-4]
    uc001odr.1. human. [Q8N413-1]

    Polymorphism databases

    DMDMi150416125.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY597807 mRNA. Translation: AAT09000.1 .
    AP000944 Genomic DNA. No translation available.
    BC036869 mRNA. Translation: AAH36869.1 .
    BC041100 mRNA. No translation available.
    CCDSi CCDS41670.1. [Q8N413-1 ]
    CCDS41671.1. [Q8N413-2 ]
    CCDS60850.1. [Q8N413-4 ]
    RefSeqi NP_001070709.1. NM_001077241.1. [Q8N413-2 ]
    NP_001265179.1. NM_001278250.1. [Q8N413-4 ]
    NP_872362.2. NM_182556.2. [Q8N413-1 ]
    XP_006718570.1. XM_006718507.1. [Q8N413-1 ]
    XP_006718571.1. XM_006718508.1. [Q8N413-2 ]
    XP_006718572.1. XM_006718509.1. [Q8N413-2 ]
    XP_006718573.1. XM_006718510.1. [Q8N413-2 ]
    XP_006718575.1. XM_006718512.1. [Q8N413-2 ]
    XP_006718576.1. XM_006718513.1. [Q8N413-2 ]
    UniGenei Hs.661604.

    3D structure databases

    ProteinModelPortali Q8N413.
    SMRi Q8N413. Positions 5-285.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000381782.

    Protein family/group databases

    TCDBi 2.A.29.8.7. the mitochondrial carrier (mc) family.

    Polymorphism databases

    DMDMi 150416125.

    Proteomic databases

    PaxDbi Q8N413.
    PRIDEi Q8N413.

    Protocols and materials databases

    DNASUi 283130.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000294187 ; ENSP00000294187 ; ENSG00000162241 . [Q8N413-2 ]
    ENST00000398802 ; ENSP00000381782 ; ENSG00000162241 . [Q8N413-1 ]
    ENST00000527174 ; ENSP00000435489 ; ENSG00000162241 . [Q8N413-1 ]
    ENST00000534028 ; ENSP00000431769 ; ENSG00000162241 . [Q8N413-4 ]
    GeneIDi 283130.
    KEGGi hsa:283130.
    UCSCi uc001odq.2. human. [Q8N413-4 ]
    uc001odr.1. human. [Q8N413-1 ]

    Organism-specific databases

    CTDi 283130.
    GeneCardsi GC11M065142.
    HGNCi HGNC:27442. SLC25A45.
    HPAi HPA050821.
    MIMi 610825. gene.
    neXtProti NX_Q8N413.
    PharmGKBi PA162403718.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG274957.
    HOGENOMi HOG000168307.
    HOVERGENi HBG003500.
    KOi K15123.
    OMAi YRHESIL.
    OrthoDBi EOG77DJ6R.
    PhylomeDBi Q8N413.
    TreeFami TF351739.

    Miscellaneous databases

    GenomeRNAii 283130.
    NextBioi 93640.
    PROi Q8N413.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N413.
    Bgeei Q8N413.
    CleanExi HS_SLC25A45.
    Genevestigatori Q8N413.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    PRINTSi PR00926. MITOCARRIER.
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Lin L., Zhong G., Ke R., Li H., Zhou G., Shen C., Yang S.
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT VAL-224.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), VARIANT VAL-224.
      Tissue: Pancreas and Prostate.
    4. "Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system."
      Haitina T., Lindblom J., Renstroem T., Fredriksson R.
      Genomics 88:779-790(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiS2545_HUMAN
    AccessioniPrimary (citable) accession number: Q8N413
    Secondary accession number(s): Q6PL49, Q8IW29
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: June 26, 2007
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3