Q8N413 (S2545_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 25 member 45

Gene names

Name:

SLC25A45

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification] Contains 3 Solcar repeats.
Sequence caution	Isoform 4: The sequence BC041100 differs from that shown. Reason: Frameshift at position 208.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N413-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N413-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8N413-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     52-113: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q8N413-4)

The sequence of this isoform differs from the canonical sequence as follows:
     28-51: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	Solute carrier family 25 member 45		PRO_0000291826
Regions
	Transmembrane	6 – 26	21	Helical; Name=1; Potential
	Transmembrane	63 – 83	21	Helical; Name=2; Potential
	Transmembrane	100 – 120	21	Helical; Name=3; Potential
	Transmembrane	166 – 186	21	Helical; Name=4; Potential
	Transmembrane	202 – 222	21	Helical; Name=5; Potential
	Transmembrane	266 – 286	21	Helical; Name=6; Potential
	Repeat	1 – 83	83	Solcar 1
	Repeat	97 – 191	95	Solcar 2
	Repeat	199 – 286	88	Solcar 3
Natural variations
	Alternative sequence	1 – 42	42	Missing in isoform 2 and isoform 3.		VSP_026246
	Alternative sequence	28 – 51	24	Missing in isoform 4.		VSP_026247
	Alternative sequence	52 – 113	62	Missing in isoform 3.		VSP_026248
	Natural variant	224	1	M → V. Ref.1 Ref.3 Corresponds to variant rs624307 [ dbSNP | Ensembl ].		VAR_032866
	Natural variant	251	1	R → Q. Corresponds to variant rs7108281 [ dbSNP | Ensembl ].		VAR_050135
Experimental info
	Sequence conflict	153	1	S → P in AAT09000. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 26, 2007. Version 2. Checksum: BD8EF1D8A2BFB296	FASTA	288	31,906
	10 20 30 40 50 60 MPVEEFVAGW ISGALGLVLG HPFDTVKVRL QTQTTYRGIV DCMVKIYRHE SLLGFFKGMS 70 80 90 100 110 120 FPIASIAVVN SVLFGVYSNT LLVLTATSHQ ERRAQPPSYM HIFLAGCTGG FLQAYCLAPF 130 140 150 160 170 180 DLIKVRLQNQ TEPRAQPGSP PPRYQGPVHC AASIFREEGP RGLFRGAWAL TLRDTPTVGI 190 200 210 220 230 240 YFITYEGLCR QYTPEGQNPS SATVLVAGGF AGIASWVAAT PLDMIKSRMQ MDGLRRRVYQ 250 260 270 280 GMLDCMVSSI RQEGLGVFFR GVTINSARAF PVNAVTFLSY EYLLRWWG
	Isoform 2 [UniParc]. Checksum: 3DD46F818E36CA50	FASTA	246	27,319
	10 20 30 40 50 60 MVKIYRHESL LGFFKGMSFP IASIAVVNSV LFGVYSNTLL VLTATSHQER RAQPPSYMHI 70 80 90 100 110 120 FLAGCTGGFL QAYCLAPFDL IKVRLQNQTE PRAQPGSPPP RYQGPVHCAA SIFREEGPRG 130 140 150 160 170 180 LFRGAWALTL RDTPTVGIYF ITYEGLCRQY TPEGQNPSSA TVLVAGGFAG IASWVAATPL 190 200 210 220 230 240 DMIKSRMQMD GLRRRVYQGM LDCMVSSIRQ EGLGVFFRGV TINSARAFPV NAVTFLSYEY LLRWWG
	Isoform 3 [UniParc]. Checksum: 603EA67772E2A639	FASTA	184	20,631
	10 20 30 40 50 60 MVKIYRHESA YCLAPFDLIK VRLQNQTEPR AQPGSPPPRY QGPVHCAASI FREEGPRGLF 70 80 90 100 110 120 RGAWALTLRD TPTVGIYFIT YEGLCRQYTP EGQNPSSATV LVAGGFAGIA SWVAATPLDM 130 140 150 160 170 180 IKSRMQMDGL RRRVYQGMLD CMVSSIRQEG LGVFFRGVTI NSARAFPVNA VTFLSYEYLL RWWG
	Isoform 4 [UniParc]. Checksum: 05876BDB4AA7A1C7	FASTA	264	29,027
	10 20 30 40 50 60 MPVEEFVAGW ISGALGLVLG HPFDTVKLLG FFKGMSFPIA SIAVVNSVLF GVYSNTLLVL 70 80 90 100 110 120 TATSHQERRA QPPSYMHIFL AGCTGGFLQA YCLAPFDLIK VRLQNQTEPR AQPGSPPPRY 130 140 150 160 170 180 QGPVHCAASI FREEGPRGLF RGAWALTLRD TPTVGIYFIT YEGLCRQYTP EGQNPSSATV 190 200 210 220 230 240 LVAGGFAGIA SWVAATPLDM IKSRMQMDGL RRRVYQGMLD CMVSSIRQEG LGVFFRGVTI 250 260 NSARAFPVNA VTFLSYEYLL RWWG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Lin L., Zhong G., Ke R., Li H., Zhou G., Shen C., Yang S. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT VAL-224.
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), VARIANT VAL-224. Tissue: Pancreas and Prostate.
[4]	"Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system." Haitina T., Lindblom J., Renstroem T., Fredriksson R. Genomics 88:779-790(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY597807 mRNA. Translation: AAT09000.1. AP000944 Genomic DNA. No translation available. BC036869 mRNA. Translation: AAH36869.1. BC041100 mRNA. No translation available.
IPI	IPI00217118. IPI00386186. IPI00793288. IPI00983806.
RefSeq	NP_001070709.1. NM_001077241.1. NP_872362.2. NM_182556.2.
UniGene	Hs.661604.
3D structure databases
ProteinModelPortal	Q8N413.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000381782.
Polymorphism databases
DMDM	150416125.
Proteomic databases
PaxDb	Q8N413.
PRIDE	Q8N413.
Protocols and materials databases
DNASU	283130.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000294187; ENSP00000294187; ENSG00000162241. ENST00000360662; ENSP00000353879; ENSG00000162241. ENST00000377152; ENSP00000366357; ENSG00000162241. ENST00000398802; ENSP00000381782; ENSG00000162241. ENST00000417511; ENSP00000407530; ENSG00000162241. ENST00000527174; ENSP00000435489; ENSG00000162241. ENST00000534028; ENSP00000431769; ENSG00000162241.
GeneID	283130.
KEGG	hsa:283130.
UCSC	uc001odq.1. human. uc001odr.1. human.
Organism-specific databases
CTD	283130.
GeneCards	GC11M065142.
HGNC	HGNC:27442. SLC25A45.
HPA	HPA050821.
MIM	610825. gene.
neXtProt	NX_Q8N413.
PharmGKB	PA162403718.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG274957.
HOGENOM	HOG000168307.
HOVERGEN	HBG003500.
KO	K15123.
OMA	SARAFPV.
Gene expression databases
ArrayExpress	Q8N413.
Bgee	Q8N413.
CleanEx	HS_SLC25A45.
Genevestigator	Q8N413.
Family and domain databases
Gene3D	1.50.40.10. 1 hit.
InterPro	IPR002067. Mit_carrier. IPR018108. Mitochondrial_sb/sol_carrier. IPR023395. Mt_carrier_dom. [Graphical view]
Pfam	PF00153. Mito_carr. 3 hits. [Graphical view]
PRINTS	PR00926. MITOCARRIER.
SUPFAM	SSF103506. Mitoch_carrier. 1 hit.
PROSITE	PS50920. SOLCAR. 3 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	283130.
NextBio	93640.
SOURCE	Search...

Entry information

Entry name

S2545_HUMAN

Accession

Primary (citable) accession number: Q8N413
Secondary accession number(s): Q6PL49, Q8IW29

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	June 26, 2007
Last modified:	May 1, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.