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Protein

Zinc finger CCHC domain-containing protein 7

Gene

ZCCHC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri241 – 258CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri263 – 280CCHC-type 2PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri304 – 321CCHC-type 3PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri348 – 365CCHC-type 4PROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCHC domain-containing protein 7
Alternative name(s):
TRAMP-like complex RNA-binding factor ZCCHC7
Gene namesi
Name:ZCCHC7
ORF Names:HSPC086
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000147905.17.
HGNCiHGNC:26209. ZCCHC7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000147905.
PharmGKBiPA128394734.

Polymorphism and mutation databases

BioMutaiZCCHC7.
DMDMi226693603.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001509591 – 543Zinc finger CCHC domain-containing protein 7Add BLAST543

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki131Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki139Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki141Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki239Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki339Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki412Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki417Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki435Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki478Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei482PhosphoserineCombined sources1
Modified residuei485PhosphoserineCombined sources1
Cross-linki487Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki490Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki493Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki537Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8N3Z6.
MaxQBiQ8N3Z6.
PaxDbiQ8N3Z6.
PeptideAtlasiQ8N3Z6.
PRIDEiQ8N3Z6.

PTM databases

iPTMnetiQ8N3Z6.
PhosphoSitePlusiQ8N3Z6.

Expressioni

Gene expression databases

BgeeiENSG00000147905.
CleanExiHS_ZCCHC7.
ExpressionAtlasiQ8N3Z6. baseline and differential.
GenevisibleiQ8N3Z6. HS.

Organism-specific databases

HPAiHPA020600.
HPA021088.
HPA029522.

Interactioni

Subunit structurei

Component of a nucleolar TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of a helicase (SKIV2L2/MTR4), an oligadenylate polymerase (PAPD5 or PAPD7), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi123934. 28 interactors.
ELMiQ8N3Z6.
IntActiQ8N3Z6. 13 interactors.
MINTiMINT-1182798.
STRINGi9606.ENSP00000337839.

Structurei

3D structure databases

ProteinModelPortaliQ8N3Z6.
SMRiQ8N3Z6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri241 – 258CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri263 – 280CCHC-type 2PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri304 – 321CCHC-type 3PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri348 – 365CCHC-type 4PROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IUGX. Eukaryota.
ENOG41123PW. LUCA.
GeneTreeiENSGT00510000048226.
HOVERGENiHBG094757.
InParanoidiQ8N3Z6.
KOiK12597.
OMAiDACTEIW.
OrthoDBiEOG091G06HR.
PhylomeDBiQ8N3Z6.
TreeFamiTF329448.

Family and domain databases

Gene3Di4.10.60.10. 5 hits.
InterProiView protein in InterPro
IPR001878. Znf_CCHC.
PfamiView protein in Pfam
PF00098. zf-CCHC. 1 hit.
SMARTiView protein in SMART
SM00343. ZnF_C2HC. 4 hits.
SUPFAMiSSF57756. SSF57756. 1 hit.
PROSITEiView protein in PROSITE
PS50158. ZF_CCHC. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N3Z6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMFGGYETIE AYEDDLYRDE SSSELSVDSE VEFQLYSQIH YAQDLDDVIR
60 70 80 90 100
EEEHEEKNSG NSESSSSKPN QKKLIVLSDS EVIQLSDGSE VITLSDEDSI
110 120 130 140 150
YRCKGKNVRV QAQENAHGLS SSLQSNELVD KKCKSDIEKP KSEERSGVIR
160 170 180 190 200
EVMIIEVSSS EEEESTISEG DNVESWMLLG CEVDDKDDDI LLNLVGCENS
210 220 230 240 250
VTEGEDGINW SISDKDIEAQ IANNRTPGRW TQRYYSANKN IICRNCDKRG
260 270 280 290 300
HLSKNCPLPR KVRRCFLCSR RGHLLYSCPA PLCEYCPVPK MLDHSCLFRH
310 320 330 340 350
SWDKQCDRCH MLGHYTDACT EIWRQYHLTT KPGPPKKPKT PSRPSALAYC
360 370 380 390 400
YHCAQKGHYG HECPEREVYD PSPVSPFICY YDDKYEIQER EKRLKQKIKV
410 420 430 440 450
LKKNGVIPEP SKLPYIKAAN ENPHHDIRKG RASWKSNRWP QENKETQKEM
460 470 480 490 500
KNKNRNWEKH RKADRHREVD EDFPRGPKTY SSPGSFKTQK PSKPFHRSSH
510 520 530 540
YHTSREDKSP KEGKRGKQKK KERCWEDDDN DNLFLIKQRK KKS
Length:543
Mass (Da):63,052
Last modified:April 14, 2009 - v2
Checksum:i1EDB6DD168C28EE6
GO
Isoform 2 (identifier: Q8N3Z6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-206: ED → QE
     207-543: Missing.

Show »
Length:206
Mass (Da):23,094
Checksum:i8066E398C03F4A26
GO

Sequence cautioni

The sequence AAH36940 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15418 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAC11087 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG37581 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI12726 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3F → L in BAB15418 (PubMed:14702039).Curated1
Sequence conflicti65S → P in AAH22434 (PubMed:15489334).Curated1
Sequence conflicti214D → G in BAC11087 (PubMed:14702039).Curated1
Sequence conflicti233R → W in BAC11087 (PubMed:14702039).Curated1
Sequence conflicti443N → D in BAC11087 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054958118G → D. Corresponds to variant dbSNP:rs35119826Ensembl.1
Natural variantiVAR_054959539R → K. Corresponds to variant dbSNP:rs1051465Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013841205 – 206ED → QE in isoform 2. 1 Publication2
Alternative sequenceiVSP_013842207 – 543Missing in isoform 2. 1 PublicationAdd BLAST337

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026264 mRNA. Translation: BAB15418.1. Sequence problems.
AK074608 mRNA. Translation: BAC11087.1. Different initiation.
AK315128 mRNA. Translation: BAG37581.1. Different initiation.
AL512604, AL158155 Genomic DNA. Translation: CAI12725.2.
AL512604 Genomic DNA. Translation: CAI12726.1. Different initiation.
AL158155, AL512604 Genomic DNA. Translation: CAI13846.2.
CH471071 Genomic DNA. Translation: EAW58288.1.
CH471071 Genomic DNA. Translation: EAW58289.1.
BC022434 mRNA. Translation: AAH22434.1.
BC036940 mRNA. Translation: AAH36940.1. Different initiation.
AF161349 mRNA. Translation: AAF28909.1.
CCDSiCCDS6608.2. [Q8N3Z6-1]
RefSeqiNP_001276048.1. NM_001289119.1. [Q8N3Z6-1]
NP_001276049.1. NM_001289120.1. [Q8N3Z6-1]
NP_001276050.1. NM_001289121.1. [Q8N3Z6-1]
NP_115602.2. NM_032226.2. [Q8N3Z6-1]
XP_005251665.1. XM_005251608.4. [Q8N3Z6-1]
XP_005251669.1. XM_005251612.2. [Q8N3Z6-1]
UniGeneiHs.654700.

Genome annotation databases

EnsembliENST00000336755; ENSP00000337839; ENSG00000147905. [Q8N3Z6-1]
ENST00000534928; ENSP00000443113; ENSG00000147905. [Q8N3Z6-1]
GeneIDi84186.
KEGGihsa:84186.
UCSCiuc003zzq.4. human. [Q8N3Z6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZCHC7_HUMAN
AccessioniPrimary (citable) accession number: Q8N3Z6
Secondary accession number(s): B2RCI4
, D3DRQ0, Q5T0Q8, Q5T0Q9, Q5T0R0, Q8N2M1, Q8N4J2, Q8TBK8, Q9H648, Q9P0F0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: April 14, 2009
Last modified: September 27, 2017
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations