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Protein

GTP-binding protein 8

Gene

GTPBP8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi124 – 1241MagnesiumBy similarity
Metal bindingi148 – 1481MagnesiumBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi117 – 1248GTPBy similarity
Nucleotide bindingi146 – 1505GTPBy similarity
Nucleotide bindingi164 – 1674GTPBy similarity
Nucleotide bindingi226 – 2294GTPBy similarity
Nucleotide bindingi261 – 2633GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. barrier septum assembly Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein 8
Gene namesi
Name:GTPBP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:25007. GTPBP8.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: HPA
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671705.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284GTP-binding protein 8PRO_0000338612Add
BLAST

Proteomic databases

MaxQBiQ8N3Z3.
PaxDbiQ8N3Z3.
PRIDEiQ8N3Z3.

PTM databases

PhosphoSiteiQ8N3Z3.

Expressioni

Gene expression databases

BgeeiQ8N3Z3.
CleanExiHS_GTPBP8.
ExpressionAtlasiQ8N3Z3. baseline and differential.
GenevestigatoriQ8N3Z3.

Organism-specific databases

HPAiHPA034831.
HPA058631.

Interactioni

Protein-protein interaction databases

BioGridi118853. 1 interaction.
IntActiQ8N3Z3. 1 interaction.
STRINGi9606.ENSP00000373176.

Structurei

3D structure databases

ProteinModelPortaliQ8N3Z3.
SMRiQ8N3Z3. Positions 100-279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini109 – 282174EngB-type GAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0218.
GeneTreeiENSGT00390000001083.
HOGENOMiHOG000009834.
HOVERGENiHBG055007.
InParanoidiQ8N3Z3.
OMAiFIWASPS.
OrthoDBiEOG7QVM4B.
PhylomeDBiQ8N3Z3.
TreeFamiTF331089.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00321. GTPase_EngB.
InterProiIPR030393. G_ENGB_dom.
IPR019987. GTP-bd_ribosome_bio_YsxC.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03598. GTPase_YsxC. 1 hit.
PROSITEiPS51706. G_ENGB. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N3Z3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPGLRLGA GRLFEMPAVL ERLSRYNSTS QAFAEVLRLP KQQLRKLLYP
60 70 80 90 100
LQEVERFLAP YGRQDLHLRI FDPSPEDIAR ADNIFTATER NRIDYVSSAV
110 120 130 140 150
RIDHAPDLPR PEVCFIGRSN VGKSSLIKAL FSLAPEVEVR VSKKPGHTKK
160 170 180 190 200
MNFFKVGKHF TVVDMPGYGF RAPEDFVDMV ETYLKERRNL KRTFLLVDSV
210 220 230 240 250
VGIQKTDNIA IEMCEEFALP YVIVLTKIDK SSKGHLLKQV LQIQKFVNMK
260 270 280
TQGCFPQLFP VSAVTFSGIH LLRCFIASVT GSLD
Length:284
Mass (Da):32,147
Last modified:September 30, 2002 - v1
Checksum:i446AF4FFBC1E6E65
GO
Isoform 2 (identifier: Q8N3Z3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-145: Missing.

Note: No experimental confirmation available.

Show »
Length:251
Mass (Da):28,604
Checksum:iD1031C4F4EF93895
GO
Isoform 3 (identifier: Q8N3Z3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-121: VCFIGRSNV → LEENIFISG
     122-284: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.

Show »
Length:121
Mass (Da):13,848
Checksum:i6705362389ED1379
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti101 – 1011R → C in BAF82300 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti242 – 2421Q → H.
Corresponds to variant rs1054263 [ dbSNP | Ensembl ].
VAR_048934

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei113 – 14533Missing in isoform 2. 1 PublicationVSP_034055Add
BLAST
Alternative sequencei113 – 1219VCFIGRSNV → LEENIFISG in isoform 3. 1 PublicationVSP_034056
Alternative sequencei122 – 284163Missing in isoform 3. 1 PublicationVSP_034057Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289611 mRNA. Translation: BAF82300.1.
AK292651 mRNA. Translation: BAF85340.1.
AC074044 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79655.1.
BC010137 mRNA. No translation available.
BC037163 mRNA. Translation: AAH37163.1.
CCDSiCCDS33820.1. [Q8N3Z3-1]
CCDS33821.1. [Q8N3Z3-2]
RefSeqiNP_054889.2. NM_014170.2. [Q8N3Z3-1]
NP_612494.1. NM_138485.1. [Q8N3Z3-2]
UniGeneiHs.127496.

Genome annotation databases

EnsembliENST00000295864; ENSP00000295864; ENSG00000163607. [Q8N3Z3-3]
ENST00000383677; ENSP00000373175; ENSG00000163607. [Q8N3Z3-2]
ENST00000383678; ENSP00000373176; ENSG00000163607. [Q8N3Z3-1]
ENST00000485330; ENSP00000418877; ENSG00000163607. [Q8N3Z3-2]
GeneIDi29083.
KEGGihsa:29083.
UCSCiuc003dzn.3. human. [Q8N3Z3-1]
uc003dzo.3. human. [Q8N3Z3-2]

Polymorphism databases

DMDMi74728797.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289611 mRNA. Translation: BAF82300.1.
AK292651 mRNA. Translation: BAF85340.1.
AC074044 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79655.1.
BC010137 mRNA. No translation available.
BC037163 mRNA. Translation: AAH37163.1.
CCDSiCCDS33820.1. [Q8N3Z3-1]
CCDS33821.1. [Q8N3Z3-2]
RefSeqiNP_054889.2. NM_014170.2. [Q8N3Z3-1]
NP_612494.1. NM_138485.1. [Q8N3Z3-2]
UniGeneiHs.127496.

3D structure databases

ProteinModelPortaliQ8N3Z3.
SMRiQ8N3Z3. Positions 100-279.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118853. 1 interaction.
IntActiQ8N3Z3. 1 interaction.
STRINGi9606.ENSP00000373176.

PTM databases

PhosphoSiteiQ8N3Z3.

Polymorphism databases

DMDMi74728797.

Proteomic databases

MaxQBiQ8N3Z3.
PaxDbiQ8N3Z3.
PRIDEiQ8N3Z3.

Protocols and materials databases

DNASUi29083.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295864; ENSP00000295864; ENSG00000163607. [Q8N3Z3-3]
ENST00000383677; ENSP00000373175; ENSG00000163607. [Q8N3Z3-2]
ENST00000383678; ENSP00000373176; ENSG00000163607. [Q8N3Z3-1]
ENST00000485330; ENSP00000418877; ENSG00000163607. [Q8N3Z3-2]
GeneIDi29083.
KEGGihsa:29083.
UCSCiuc003dzn.3. human. [Q8N3Z3-1]
uc003dzo.3. human. [Q8N3Z3-2]

Organism-specific databases

CTDi29083.
GeneCardsiGC03P112709.
HGNCiHGNC:25007. GTPBP8.
HPAiHPA034831.
HPA058631.
neXtProtiNX_Q8N3Z3.
PharmGKBiPA142671705.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0218.
GeneTreeiENSGT00390000001083.
HOGENOMiHOG000009834.
HOVERGENiHBG055007.
InParanoidiQ8N3Z3.
OMAiFIWASPS.
OrthoDBiEOG7QVM4B.
PhylomeDBiQ8N3Z3.
TreeFamiTF331089.

Miscellaneous databases

GenomeRNAii29083.
NextBioi52062.
PROiQ8N3Z3.

Gene expression databases

BgeeiQ8N3Z3.
CleanExiHS_GTPBP8.
ExpressionAtlasiQ8N3Z3. baseline and differential.
GenevestigatoriQ8N3Z3.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00321. GTPase_EngB.
InterProiIPR030393. G_ENGB_dom.
IPR019987. GTP-bd_ribosome_bio_YsxC.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03598. GTPase_YsxC. 1 hit.
PROSITEiPS51706. G_ENGB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain cortex and Thymus.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Muscle and Skin.

Entry informationi

Entry nameiGTPB8_HUMAN
AccessioniPrimary (citable) accession number: Q8N3Z3
Secondary accession number(s): A6NE99
, A6NN11, A8K0P6, Q5I0Y4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 9, 2008
Last sequence update: September 30, 2002
Last modified: March 3, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.