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Q8N3Z3 (GTPB8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP-binding protein 8
Gene names
Name:GTPBP8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   LigandGTP-binding
Magnesium
Metal-binding
Nucleotide-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbarrier septum assembly

Inferred from electronic annotation. Source: InterPro

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N3Z3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N3Z3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     113-145: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8N3Z3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     113-121: VCFIGRSNV → LEENIFISG
     122-284: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 284284GTP-binding protein 8 HAMAP-Rule MF_00321
PRO_0000338612

Regions

Domain109 – 282174EngB-type G
Nucleotide binding117 – 1248GTP By similarity
Nucleotide binding146 – 1505GTP By similarity
Nucleotide binding164 – 1674GTP By similarity
Nucleotide binding226 – 2294GTP By similarity
Nucleotide binding261 – 2633GTP By similarity

Sites

Metal binding1241Magnesium By similarity
Metal binding1481Magnesium By similarity

Natural variations

Alternative sequence113 – 14533Missing in isoform 2.
VSP_034055
Alternative sequence113 – 1219VCFIGRSNV → LEENIFISG in isoform 3.
VSP_034056
Alternative sequence122 – 284163Missing in isoform 3.
VSP_034057
Natural variant2421Q → H.
Corresponds to variant rs1054263 [ dbSNP | Ensembl ].
VAR_048934

Experimental info

Sequence conflict1011R → C in BAF82300. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 446AF4FFBC1E6E65

FASTA28432,147
        10         20         30         40         50         60 
MAAPGLRLGA GRLFEMPAVL ERLSRYNSTS QAFAEVLRLP KQQLRKLLYP LQEVERFLAP 

        70         80         90        100        110        120 
YGRQDLHLRI FDPSPEDIAR ADNIFTATER NRIDYVSSAV RIDHAPDLPR PEVCFIGRSN 

       130        140        150        160        170        180 
VGKSSLIKAL FSLAPEVEVR VSKKPGHTKK MNFFKVGKHF TVVDMPGYGF RAPEDFVDMV 

       190        200        210        220        230        240 
ETYLKERRNL KRTFLLVDSV VGIQKTDNIA IEMCEEFALP YVIVLTKIDK SSKGHLLKQV 

       250        260        270        280 
LQIQKFVNMK TQGCFPQLFP VSAVTFSGIH LLRCFIASVT GSLD 

« Hide

Isoform 2 [UniParc].

Checksum: D1031C4F4EF93895
Show »

FASTA25128,604
Isoform 3 [UniParc].

Checksum: 6705362389ED1379
Show »

FASTA12113,848

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain cortex and Thymus.
[2]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Tissue: Muscle and Skin.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK289611 mRNA. Translation: BAF82300.1.
AK292651 mRNA. Translation: BAF85340.1.
AC074044 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79655.1.
BC010137 mRNA. No translation available.
BC037163 mRNA. Translation: AAH37163.1.
CCDSCCDS33820.1. [Q8N3Z3-1]
CCDS33821.1. [Q8N3Z3-2]
RefSeqNP_054889.2. NM_014170.2. [Q8N3Z3-1]
NP_612494.1. NM_138485.1. [Q8N3Z3-2]
UniGeneHs.127496.

3D structure databases

ProteinModelPortalQ8N3Z3.
SMRQ8N3Z3. Positions 100-279.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118853. 2 interactions.
IntActQ8N3Z3. 1 interaction.
STRING9606.ENSP00000373176.

PTM databases

PhosphoSiteQ8N3Z3.

Polymorphism databases

DMDM74728797.

Proteomic databases

MaxQBQ8N3Z3.
PaxDbQ8N3Z3.
PRIDEQ8N3Z3.

Protocols and materials databases

DNASU29083.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295864; ENSP00000295864; ENSG00000163607. [Q8N3Z3-3]
ENST00000383677; ENSP00000373175; ENSG00000163607. [Q8N3Z3-2]
ENST00000383678; ENSP00000373176; ENSG00000163607. [Q8N3Z3-1]
ENST00000485330; ENSP00000418877; ENSG00000163607. [Q8N3Z3-2]
GeneID29083.
KEGGhsa:29083.
UCSCuc003dzn.3. human. [Q8N3Z3-1]
uc003dzo.3. human. [Q8N3Z3-2]

Organism-specific databases

CTD29083.
GeneCardsGC03P112709.
HGNCHGNC:25007. GTPBP8.
HPAHPA034831.
neXtProtNX_Q8N3Z3.
PharmGKBPA142671705.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0218.
HOGENOMHOG000009834.
HOVERGENHBG055007.
OMAVSKKPGH.
OrthoDBEOG7QVM4B.
PhylomeDBQ8N3Z3.
TreeFamTF331089.

Gene expression databases

ArrayExpressQ8N3Z3.
BgeeQ8N3Z3.
CleanExHS_GTPBP8.
GenevestigatorQ8N3Z3.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00321. GTPase_EngB.
InterProIPR019987. GTP-bd_ribosome_bio_YsxC.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01926. MMR_HSR1. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR03598. GTPase_YsxC. 1 hit.
PROSITEPS51706. G_ENGB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi29083.
NextBio52062.
PROQ8N3Z3.

Entry information

Entry nameGTPB8_HUMAN
AccessionPrimary (citable) accession number: Q8N3Z3
Secondary accession number(s): A6NE99 expand/collapse secondary AC list , A6NN11, A8K0P6, Q5I0Y4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM