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Protein

Inactive serine protease 35

Gene

PRSS35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Although related to peptidase S1 family, lacks the conserved active Ser residue in position 346 which is replaced by a Thr, suggesting that it has no protease activity.Curated

Keywordsi

Molecular functionSerine protease homolog

Protein family/group databases

MEROPSiS01.994

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive serine protease 35
Gene namesi
Name:PRSS35
Synonyms:C6orf158
ORF Names:UNQ522/PRO1057
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000146250.6
HGNCiHGNC:21387 PRSS35
neXtProtiNX_Q8N3Z0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi167681
OpenTargetsiENSG00000146250
PharmGKBiPA134974089

Polymorphism and mutation databases

BioMutaiPRSS35
DMDMi158563845

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000029935817 – 413Inactive serine protease 35Add BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi154 ↔ 170By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8N3Z0
PeptideAtlasiQ8N3Z0
PRIDEiQ8N3Z0
TopDownProteomicsiQ8N3Z0

PTM databases

iPTMnetiQ8N3Z0
PhosphoSitePlusiQ8N3Z0

Expressioni

Gene expression databases

BgeeiENSG00000146250
CleanExiHS_PRSS35
GenevisibleiQ8N3Z0 HS

Organism-specific databases

HPAiHPA038787
HPA038788

Interactioni

Protein-protein interaction databases

BioGridi127949, 5 interactors
STRINGi9606.ENSP00000358714

Structurei

3D structure databases

ProteinModelPortaliQ8N3Z0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 408Peptidase S1Add BLAST285

Sequence similaritiesi

Belongs to the peptidase S1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IF0G Eukaryota
ENOG410ZRQ7 LUCA
GeneTreeiENSGT00390000000155
HOGENOMiHOG000059661
HOVERGENiHBG053702
InParanoidiQ8N3Z0
OMAiFQWTRVK
OrthoDBiEOG091G0BVQ
PhylomeDBiQ8N3Z0
TreeFamiTF329011

Family and domain databases

InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
SUPFAMiSSF50494 SSF50494, 2 hits
PROSITEiView protein in PROSITE
PS00134 TRYPSIN_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N3Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENMLLWLIF FTPGWTLIDG SEMEWDFMWH LRKVPRIVSE RTFHLTSPAF
60 70 80 90 100
EADAKMMVNT VCGIECQKEL PTPSLSELED YLSYETVFEN GTRTLTRVKV
110 120 130 140 150
QDLVLEPTQN ITTKGVSVRR KRQVYGTDSR FSILDKRFLT NFPFSTAVKL
160 170 180 190 200
STGCSGILIS PQHVLTAAHC VHDGKDYVKG SKKLRVGLLK MRNKSGGKKR
210 220 230 240 250
RGSKRSRREA SGGDQREGTR EHLRERAKGG RRRKKSGRGQ RIAEGRPSFQ
260 270 280 290 300
WTRVKNTHIP KGWARGGMGD ATLDYDYALL ELKRAHKKKY MELGISPTIK
310 320 330 340 350
KMPGGMIHFS GFDNDRADQL VYRFCSVSDE SNDLLYQYCD AESGSTGSGV
360 370 380 390 400
YLRLKDPDKK NWKRKIIAVY SGHQWVDVHG VQKDYNVAVR ITPLKYAQIC
410
LWIHGNDANC AYG
Length:413
Mass (Da):47,098
Last modified:September 11, 2007 - v2
Checksum:i818D9C951BD2D6C1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034810224R → Q3 PublicationsCorresponds to variant dbSNP:rs504593Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358661 mRNA Translation: AAQ89024.1
AK291928 mRNA Translation: BAF84617.1
AL121939 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48663.1
BC037170 mRNA Translation: AAH37170.1
CCDSiCCDS4999.1
RefSeqiNP_001163894.1, NM_001170423.1
NP_699193.2, NM_153362.2
UniGeneiHs.98381

Genome annotation databases

EnsembliENST00000369700; ENSP00000358714; ENSG00000146250
GeneIDi167681
KEGGihsa:167681
UCSCiuc003pjz.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPRS35_HUMAN
AccessioniPrimary (citable) accession number: Q8N3Z0
Secondary accession number(s): A8K7B3, Q9BQP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: May 23, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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