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Protein

Inactive serine protease 35

Gene

PRSS35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Keywords - Molecular functioni

Serine protease homolog

Enzyme and pathway databases

BioCyciZFISH:ENSG00000146250-MONOMER.

Protein family/group databases

MEROPSiS01.994.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive serine protease 35
Gene namesi
Name:PRSS35
Synonyms:C6orf158
ORF Names:UNQ522/PRO1057
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21387. PRSS35.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi167681.
OpenTargetsiENSG00000146250.
PharmGKBiPA134974089.

Polymorphism and mutation databases

BioMutaiPRSS35.
DMDMi158563845.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000029935817 – 413Inactive serine protease 35Add BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi90N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi154 ↔ 170By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8N3Z0.
PeptideAtlasiQ8N3Z0.
PRIDEiQ8N3Z0.
TopDownProteomicsiQ8N3Z0.

PTM databases

iPTMnetiQ8N3Z0.
PhosphoSitePlusiQ8N3Z0.

Expressioni

Gene expression databases

BgeeiENSG00000146250.
CleanExiHS_PRSS35.
GenevisibleiQ8N3Z0. HS.

Organism-specific databases

HPAiHPA038787.
HPA038788.

Interactioni

Protein-protein interaction databases

BioGridi127949. 5 interactors.
STRINGi9606.ENSP00000358714.

Structurei

3D structure databases

ProteinModelPortaliQ8N3Z0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 408Peptidase S1Add BLAST285

Sequence similaritiesi

Belongs to the peptidase S1 family.Curated
Contains 1 peptidase S1 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IF0G. Eukaryota.
ENOG410ZRQ7. LUCA.
GeneTreeiENSGT00390000000155.
HOGENOMiHOG000059661.
HOVERGENiHBG053702.
InParanoidiQ8N3Z0.
OMAiHGVQKDY.
OrthoDBiEOG091G0BVQ.
PhylomeDBiQ8N3Z0.
TreeFamiTF329011.

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 2 hits.
PROSITEiPS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N3Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENMLLWLIF FTPGWTLIDG SEMEWDFMWH LRKVPRIVSE RTFHLTSPAF
60 70 80 90 100
EADAKMMVNT VCGIECQKEL PTPSLSELED YLSYETVFEN GTRTLTRVKV
110 120 130 140 150
QDLVLEPTQN ITTKGVSVRR KRQVYGTDSR FSILDKRFLT NFPFSTAVKL
160 170 180 190 200
STGCSGILIS PQHVLTAAHC VHDGKDYVKG SKKLRVGLLK MRNKSGGKKR
210 220 230 240 250
RGSKRSRREA SGGDQREGTR EHLRERAKGG RRRKKSGRGQ RIAEGRPSFQ
260 270 280 290 300
WTRVKNTHIP KGWARGGMGD ATLDYDYALL ELKRAHKKKY MELGISPTIK
310 320 330 340 350
KMPGGMIHFS GFDNDRADQL VYRFCSVSDE SNDLLYQYCD AESGSTGSGV
360 370 380 390 400
YLRLKDPDKK NWKRKIIAVY SGHQWVDVHG VQKDYNVAVR ITPLKYAQIC
410
LWIHGNDANC AYG
Length:413
Mass (Da):47,098
Last modified:September 11, 2007 - v2
Checksum:i818D9C951BD2D6C1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034810224R → Q.3 PublicationsCorresponds to variant rs504593dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358661 mRNA. Translation: AAQ89024.1.
AK291928 mRNA. Translation: BAF84617.1.
AL121939 Genomic DNA. Translation: CAC35071.1.
CH471051 Genomic DNA. Translation: EAW48663.1.
BC037170 mRNA. Translation: AAH37170.1.
CCDSiCCDS4999.1.
RefSeqiNP_001163894.1. NM_001170423.1.
NP_699193.2. NM_153362.2.
UniGeneiHs.98381.

Genome annotation databases

EnsembliENST00000369700; ENSP00000358714; ENSG00000146250.
GeneIDi167681.
KEGGihsa:167681.
UCSCiuc003pjz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358661 mRNA. Translation: AAQ89024.1.
AK291928 mRNA. Translation: BAF84617.1.
AL121939 Genomic DNA. Translation: CAC35071.1.
CH471051 Genomic DNA. Translation: EAW48663.1.
BC037170 mRNA. Translation: AAH37170.1.
CCDSiCCDS4999.1.
RefSeqiNP_001163894.1. NM_001170423.1.
NP_699193.2. NM_153362.2.
UniGeneiHs.98381.

3D structure databases

ProteinModelPortaliQ8N3Z0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127949. 5 interactors.
STRINGi9606.ENSP00000358714.

Protein family/group databases

MEROPSiS01.994.

PTM databases

iPTMnetiQ8N3Z0.
PhosphoSitePlusiQ8N3Z0.

Polymorphism and mutation databases

BioMutaiPRSS35.
DMDMi158563845.

Proteomic databases

PaxDbiQ8N3Z0.
PeptideAtlasiQ8N3Z0.
PRIDEiQ8N3Z0.
TopDownProteomicsiQ8N3Z0.

Protocols and materials databases

DNASUi167681.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369700; ENSP00000358714; ENSG00000146250.
GeneIDi167681.
KEGGihsa:167681.
UCSCiuc003pjz.4. human.

Organism-specific databases

CTDi167681.
DisGeNETi167681.
GeneCardsiPRSS35.
H-InvDBHIX0025211.
HGNCiHGNC:21387. PRSS35.
HPAiHPA038787.
HPA038788.
neXtProtiNX_Q8N3Z0.
OpenTargetsiENSG00000146250.
PharmGKBiPA134974089.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF0G. Eukaryota.
ENOG410ZRQ7. LUCA.
GeneTreeiENSGT00390000000155.
HOGENOMiHOG000059661.
HOVERGENiHBG053702.
InParanoidiQ8N3Z0.
OMAiHGVQKDY.
OrthoDBiEOG091G0BVQ.
PhylomeDBiQ8N3Z0.
TreeFamiTF329011.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000146250-MONOMER.

Miscellaneous databases

GenomeRNAii167681.
PROiQ8N3Z0.

Gene expression databases

BgeeiENSG00000146250.
CleanExiHS_PRSS35.
GenevisibleiQ8N3Z0. HS.

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 2 hits.
PROSITEiPS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRS35_HUMAN
AccessioniPrimary (citable) accession number: Q8N3Z0
Secondary accession number(s): A8K7B3, Q9BQP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Although related to peptidase S1 family, lacks the conserved active Ser residue in position 346 which is replaced by a Thr, suggesting that it has no protease activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.