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Q8N3Y1

- FBXW8_HUMAN

UniProt

Q8N3Y1 - FBXW8_HUMAN

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Protein
F-box/WD repeat-containing protein 8
Gene
FBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (1 Publication). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (1 Publication). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (1 Publication). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (1 Publication).

Pathwayi

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. Golgi organization Source: UniProtKB
  2. labyrinthine layer blood vessel development Source: Ensembl
  3. positive regulation of dendrite morphogenesis Source: UniProtKB
  4. spongiotrophoblast layer development Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinkiQ8N3Y1.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/WD repeat-containing protein 8
Alternative name(s):
F-box and WD-40 domain-containing protein 8
F-box only protein 29
Gene namesi
Name:FBXW8
Synonyms:FBW6, FBW8, FBX29, FBXO29, FBXW6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:13597. FBXW8.

Subcellular locationi

Cytoplasmperinuclear region. Golgi apparatus
Note: Colocalizes with CUL7 at the Golgi apparatus in neurons By similarity.1 Publication

GO - Cellular componenti

  1. Cul7-RING ubiquitin ligase complex Source: UniProtKB
  2. Golgi apparatus Source: UniProtKB
  3. SCF ubiquitin ligase complex Source: Ensembl
  4. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28039.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 598598F-box/WD repeat-containing protein 8
PRO_0000050997Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8N3Y1.
PaxDbiQ8N3Y1.
PRIDEiQ8N3Y1.

PTM databases

PhosphoSiteiQ8N3Y1.

Expressioni

Gene expression databases

BgeeiQ8N3Y1.
CleanExiHS_FBXW8.
GenevestigatoriQ8N3Y1.

Organism-specific databases

HPAiHPA038851.

Interactioni

Subunit structurei

Part of a Cul7-RING ubiquitin-protein ligase complex, consisting of CUL7, RBX1, SKP1 and FBXW8. Interacts with GLMN isoform 1. Interacts with CUL7. Interacts with OBSL1, CUL1, CUL2, SKP1, CCT6B, PFDN5, CCT2, CCT3, CCT6A, CCT7, VBP1, CCDC8, ARF1, TRIP13, PDCD5 and GORASP1. Interacts with IRS1 (when phosphorylated). Interacts with MAP4K1/HPK1 (when autophosphorylated). Associated component of the 3M complex.

Binary interactionsi

WithEntry#Exp.IntActNotes
MYCP011063EBI-914770,EBI-447544

Protein-protein interaction databases

BioGridi117645. 38 interactions.
DIPiDIP-37970N.
IntActiQ8N3Y1. 3 interactions.
MINTiMINT-8415331.
STRINGi9606.ENSP00000310686.

Structurei

3D structure databases

ProteinModelPortaliQ8N3Y1.
SMRiQ8N3Y1. Positions 119-558.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini113 – 15947F-box
Add
BLAST
Repeati197 – 24549WD 1
Add
BLAST
Repeati254 – 29441WD 2
Add
BLAST
Repeati297 – 33640WD 3
Add
BLAST
Repeati430 – 47041WD 4
Add
BLAST
Repeati473 – 51038WD 5
Add
BLAST

Sequence similaritiesi

Contains 1 F-box domain.
Contains 5 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG115403.
HOGENOMiHOG000112555.
HOVERGENiHBG051597.
InParanoidiQ8N3Y1.
KOiK10264.
OMAiNIFQYLD.
OrthoDBiEOG7N8ZV2.
PhylomeDBiQ8N3Y1.
TreeFamiTF332593.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR011047. Quinonprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50998. SSF50998. 2 hits.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N3Y1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDDYSLDEFR RRWQEELAQA QAPKKRRRPE AAERRARRPE VGSGRGEQAS    50
GDPALAQRLL EGAGRPPAAR ATRAEGQDVA SRSRSPLARE GAGGGEQLVD 100
QLIRDLNEMN DVPFFDIQLP YELAINIFQY LDRKELGRCA QVSKTWKVIA 150
EDEVLWYRLC QQEGHLPDSS ISDYSCWKLI FQECRAKEHM LRTNWKNRKG 200
AVSELEHVPD TVLCDVHSHD GVVIAGYTSG DVRVWDTRTW DYVAPFLESE 250
DEEDEPGMQP NVSFVRINSS LAVAAYEDGF LNIWDLRTGK YPVHRFEHDA 300
RIQALALSQD DATVATASAF DVVMLSPNEE GYWQIAAEFE VPKLVQYLEI 350
VPETRRYPVA VAAAGDLMYL LKAEDSARTL LYAHGPPVTC LDVSANQVAF 400
GVQGLGWVYE GSKILVYSLE AGRRLLKLGN VLRDFTCVNL SDSPPNLMVS 450
GNMDGRVRIH DLRSGNIALS LSAHQLRVSA VQMDDWKIVS GGEEGLVSVW 500
DYRMNQKLWE VYSGHPVQHI SFSSHSLITA NVPYQTVMRN ADLDSFTTHR 550
RHRGLIRAYE FAVDQLAFQS PLPVCRSSCD AMATHYYDLA LAFPYNHV 598
Length:598
Mass (Da):67,394
Last modified:May 18, 2010 - v2
Checksum:i03B3C283BA46DB6B
GO
Isoform 2 (identifier: Q8N3Y1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-106: Missing.

Show »
Length:532
Mass (Da):60,705
Checksum:i921550273E26D2F2
GO

Sequence cautioni

The sequence AAF03129.1 differs from that shown. Reason: Frameshift at positions 282 and 295.
The sequence AAF03129.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti192 – 1921R → Q.2 Publications
Corresponds to variant rs4076700 [ dbSNP | Ensembl ].
VAR_060326
Natural varianti211 – 2111T → A.
Corresponds to variant rs36021180 [ dbSNP | Ensembl ].
VAR_057597
Natural varianti536 – 5361T → M.
Corresponds to variant rs3741466 [ dbSNP | Ensembl ].
VAR_057598
Natural varianti563 – 5631V → M.
Corresponds to variant rs56350562 [ dbSNP | Ensembl ].
VAR_062096

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei41 – 10666Missing in isoform 2.
VSP_008501Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461G → S in AAH37296. 1 Publication
Sequence conflicti58 – 581R → G in AAH37296. 1 Publication
Sequence conflicti380 – 3801L → I in AAH37296. 1 Publication
Sequence conflicti510 – 5101E → K in AAF03129. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF176707 mRNA. Translation: AAF03129.1. Sequence problems.
AC026368 Genomic DNA. No translation available.
AC083806 Genomic DNA. No translation available.
AC127164 Genomic DNA. No translation available.
BC037296 mRNA. Translation: AAH37296.1.
CCDSiCCDS44988.1. [Q8N3Y1-2]
CCDS9182.1. [Q8N3Y1-1]
RefSeqiNP_036306.1. NM_012174.1. [Q8N3Y1-2]
NP_699179.2. NM_153348.2. [Q8N3Y1-1]
UniGeneiHs.624537.
Hs.696428.

Genome annotation databases

EnsembliENST00000309909; ENSP00000310686; ENSG00000174989. [Q8N3Y1-1]
ENST00000455858; ENSP00000389144; ENSG00000174989. [Q8N3Y1-2]
GeneIDi26259.
KEGGihsa:26259.
UCSCiuc001twf.1. human. [Q8N3Y1-2]
uc001twg.1. human. [Q8N3Y1-1]

Polymorphism databases

DMDMi296434513.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF176707 mRNA. Translation: AAF03129.1 . Sequence problems.
AC026368 Genomic DNA. No translation available.
AC083806 Genomic DNA. No translation available.
AC127164 Genomic DNA. No translation available.
BC037296 mRNA. Translation: AAH37296.1 .
CCDSi CCDS44988.1. [Q8N3Y1-2 ]
CCDS9182.1. [Q8N3Y1-1 ]
RefSeqi NP_036306.1. NM_012174.1. [Q8N3Y1-2 ]
NP_699179.2. NM_153348.2. [Q8N3Y1-1 ]
UniGenei Hs.624537.
Hs.696428.

3D structure databases

ProteinModelPortali Q8N3Y1.
SMRi Q8N3Y1. Positions 119-558.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117645. 38 interactions.
DIPi DIP-37970N.
IntActi Q8N3Y1. 3 interactions.
MINTi MINT-8415331.
STRINGi 9606.ENSP00000310686.

PTM databases

PhosphoSitei Q8N3Y1.

Polymorphism databases

DMDMi 296434513.

Proteomic databases

MaxQBi Q8N3Y1.
PaxDbi Q8N3Y1.
PRIDEi Q8N3Y1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000309909 ; ENSP00000310686 ; ENSG00000174989 . [Q8N3Y1-1 ]
ENST00000455858 ; ENSP00000389144 ; ENSG00000174989 . [Q8N3Y1-2 ]
GeneIDi 26259.
KEGGi hsa:26259.
UCSCi uc001twf.1. human. [Q8N3Y1-2 ]
uc001twg.1. human. [Q8N3Y1-1 ]

Organism-specific databases

CTDi 26259.
GeneCardsi GC12P117348.
H-InvDB HIX0026457.
HIX0037115.
HGNCi HGNC:13597. FBXW8.
HPAi HPA038851.
MIMi 609073. gene.
neXtProti NX_Q8N3Y1.
PharmGKBi PA28039.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG115403.
HOGENOMi HOG000112555.
HOVERGENi HBG051597.
InParanoidi Q8N3Y1.
KOi K10264.
OMAi NIFQYLD.
OrthoDBi EOG7N8ZV2.
PhylomeDBi Q8N3Y1.
TreeFami TF332593.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinki Q8N3Y1.

Miscellaneous databases

ChiTaRSi FBXW8. human.
GeneWikii FBXW8.
GenomeRNAii 26259.
NextBioi 48503.
PROi Q8N3Y1.
SOURCEi Search...

Gene expression databases

Bgeei Q8N3Y1.
CleanExi HS_FBXW8.
Genevestigatori Q8N3Y1.

Family and domain databases

Gene3Di 2.130.10.10. 2 hits.
InterProi IPR001810. F-box_dom.
IPR011047. Quinonprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00646. F-box. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view ]
SMARTi SM00256. FBOX. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view ]
SUPFAMi SSF50998. SSF50998. 2 hits.
SSF81383. SSF81383. 1 hit.
PROSITEi PS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT GLN-192.
  2. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-192.
    Tissue: Brain.
  4. "CUL7: a DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex."
    Dias D.C., Dolios G., Wang R., Pan Z.Q.
    Proc. Natl. Acad. Sci. U.S.A. 99:16601-16606(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN SCF-LIKE COMPLEX.
  5. "Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis."
    Arai T., Kasper J.S., Skaar J.R., Ali S.H., Takahashi C., DeCaprio J.A.
    Proc. Natl. Acad. Sci. U.S.A. 100:9855-9860(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH CUL7; SKP1; RBX1 AND GLMN.
  6. Cited for: INTERACTION WITH CUL7.
  7. "The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation."
    Xu X., Sarikas A., Dias-Santagata D.C., Dolios G., Lafontant P.J., Tsai S.C., Zhu W., Nakajima H., Nakajima H.O., Field L.J., Wang R., Pan Z.Q.
    Mol. Cell 30:403-414(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH IRS1.
  8. "An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning."
    Litterman N., Ikeuchi Y., Gallardo G., O'Connell B.C., Sowa M.E., Gygi S.P., Harper J.W., Bonni A.
    PLoS Biol. 9:E1001060-E1001060(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH OBSL1; CUL1; CUL2; CUL7; SKP1; CCT6B; PFDN5; CCT2; CCT3; CCT6A; CCT7; VBP1; CCDC8; ARF1; TRIP13; PDCD5 AND GORASP1, SUBCELLULAR LOCATION.
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1."
    Wang H., Chen Y., Lin P., Li L., Zhou G., Liu G., Logsdon C., Jin J., Abbruzzese J.L., Tan T.H., Wang H.
    J. Biol. Chem. 289:4009-4017(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CUL7 AND MAP4K1.
  11. Cited for: FUNCTION.

Entry informationi

Entry nameiFBXW8_HUMAN
AccessioniPrimary (citable) accession number: Q8N3Y1
Secondary accession number(s): Q9UK95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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