ID   LCORL_HUMAN             Reviewed;         602 AA.
AC   Q8N3X6; Q96NK1;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 4.
DT   27-MAR-2024, entry version 156.
DE   RecName: Full=Ligand-dependent nuclear receptor corepressor-like protein;
DE            Short=LCoR-like protein;
GN   Name=LCORL;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=19139490; DOI=10.1074/mcp.m800504-mcp200;
RA   Jia W., Lu Z., Fu Y., Wang H.P., Wang L.H., Chi H., Yuan Z.F., Zheng Z.B.,
RA   Song L.N., Han H.H., Liang Y.M., Wang J.L., Cai Y., Zhang Y.K., Deng Y.L.,
RA   Ying W.T., He S.M., Qian X.H.;
RT   "A strategy for precise and large scale identification of core fucosylated
RT   glycoproteins.";
RL   Mol. Cell. Proteomics 8:913-923(2009).
RN   [6]
RP   SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-242; LYS-319; LYS-340 AND
RP   LYS-397, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=28112733; DOI=10.1038/nsmb.3366;
RA   Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA   Nielsen M.L.;
RT   "Site-specific mapping of the human SUMO proteome reveals co-modification
RT   with phosphorylation.";
RL   Nat. Struct. Mol. Biol. 24:325-336(2017).
CC   -!- FUNCTION: May act as transcription activator that binds DNA elements
CC       with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in
CC       spermatogenesis (By similarity). {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q8N3X6; Q13363: CTBP1; NbExp=6; IntAct=EBI-7138654, EBI-908846;
CC       Q8N3X6; P43360: MAGEA6; NbExp=3; IntAct=EBI-7138654, EBI-1045155;
CC       Q8N3X6-3; P56545-3: CTBP2; NbExp=3; IntAct=EBI-12111580, EBI-10171902;
CC       Q8N3X6-3; P43360: MAGEA6; NbExp=3; IntAct=EBI-12111580, EBI-1045155;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q8N3X6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8N3X6-2; Sequence=VSP_029287;
CC       Name=3;
CC         IsoId=Q8N3X6-3; Sequence=VSP_029288, VSP_029289;
CC   -!- CAUTION: A report observed N-glycosylation at Asn-493
CC       (PubMed:19139490). However, as the protein is predicted to act as a
CC       DNA-binding transcription activator, additional evidence is required to
CC       confirm this result. {ECO:0000305|PubMed:19139490}.
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DR   EMBL; AK055258; BAB70892.1; -; mRNA.
DR   EMBL; AC005768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC079399; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471069; EAW92786.1; -; Genomic_DNA.
DR   EMBL; BC037322; AAH37322.3; -; mRNA.
DR   CCDS; CCDS3425.1; -. [Q8N3X6-3]
DR   CCDS; CCDS54749.1; -. [Q8N3X6-1]
DR   RefSeq; NP_001159611.1; NM_001166139.2. [Q8N3X6-1]
DR   RefSeq; NP_710153.2; NM_153686.8. [Q8N3X6-3]
DR   AlphaFoldDB; Q8N3X6; -.
DR   SMR; Q8N3X6; -.
DR   BioGRID; 129025; 13.
DR   IntAct; Q8N3X6; 5.
DR   MINT; Q8N3X6; -.
DR   STRING; 9606.ENSP00000371661; -.
DR   GlyConnect; 2054; 1 N-Linked glycan (1 site).
DR   GlyCosmos; Q8N3X6; 1 site, 2 glycans.
DR   GlyGen; Q8N3X6; 1 site, 2 N-linked glycans (1 site).
DR   iPTMnet; Q8N3X6; -.
DR   PhosphoSitePlus; Q8N3X6; -.
DR   BioMuta; LCORL; -.
DR   DMDM; 160395582; -.
DR   EPD; Q8N3X6; -.
DR   jPOST; Q8N3X6; -.
DR   MassIVE; Q8N3X6; -.
DR   MaxQB; Q8N3X6; -.
DR   PaxDb; 9606-ENSP00000371661; -.
DR   PeptideAtlas; Q8N3X6; -.
DR   ProteomicsDB; 71844; -. [Q8N3X6-1]
DR   ProteomicsDB; 71845; -. [Q8N3X6-2]
DR   ProteomicsDB; 71846; -. [Q8N3X6-3]
DR   Antibodypedia; 23115; 153 antibodies from 23 providers.
DR   DNASU; 254251; -.
DR   Ensembl; ENST00000326877.8; ENSP00000317566.3; ENSG00000178177.17. [Q8N3X6-3]
DR   Ensembl; ENST00000382226.5; ENSP00000371661.5; ENSG00000178177.17. [Q8N3X6-1]
DR   GeneID; 254251; -.
DR   KEGG; hsa:254251; -.
DR   UCSC; uc003gpq.4; human. [Q8N3X6-1]
DR   AGR; HGNC:30776; -.
DR   CTD; 254251; -.
DR   DisGeNET; 254251; -.
DR   GeneCards; LCORL; -.
DR   HGNC; HGNC:30776; LCORL.
DR   HPA; ENSG00000178177; Low tissue specificity.
DR   MIM; 611799; gene.
DR   neXtProt; NX_Q8N3X6; -.
DR   OpenTargets; ENSG00000178177; -.
DR   PharmGKB; PA145148507; -.
DR   VEuPathDB; HostDB:ENSG00000178177; -.
DR   eggNOG; KOG4565; Eukaryota.
DR   GeneTree; ENSGT00940000154965; -.
DR   HOGENOM; CLU_076618_1_0_1; -.
DR   InParanoid; Q8N3X6; -.
DR   OMA; SLQYETH; -.
DR   OrthoDB; 5350333at2759; -.
DR   PhylomeDB; Q8N3X6; -.
DR   TreeFam; TF319589; -.
DR   PathwayCommons; Q8N3X6; -.
DR   SignaLink; Q8N3X6; -.
DR   BioGRID-ORCS; 254251; 6 hits in 1178 CRISPR screens.
DR   ChiTaRS; LCORL; human.
DR   GenomeRNAi; 254251; -.
DR   Pharos; Q8N3X6; Tbio.
DR   PRO; PR:Q8N3X6; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; Q8N3X6; Protein.
DR   Bgee; ENSG00000178177; Expressed in buccal mucosa cell and 184 other cell types or tissues.
DR   ExpressionAtlas; Q8N3X6; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:1990226; F:histone methyltransferase binding; IPI:ARUK-UCL.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR007889; HTH_Psq.
DR   PANTHER; PTHR21545:SF14; LIGAND-DEPENDENT COREPRESSOR; 1.
DR   PANTHER; PTHR21545; TRANSCRIPTION FACTOR MLR1/2; 1.
DR   Pfam; PF05225; HTH_psq; 2.
DR   SUPFAM; SSF46689; Homeodomain-like; 2.
DR   PROSITE; PS50960; HTH_PSQ; 1.
DR   Genevisible; Q8N3X6; HS.
PE   1: Evidence at protein level;
KW   Activator; Alternative splicing; DNA-binding; Isopeptide bond; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation;
KW   Ubl conjugation.
FT   CHAIN           1..602
FT                   /note="Ligand-dependent nuclear receptor corepressor-like
FT                   protein"
FT                   /id="PRO_0000310463"
FT   DOMAIN          516..568
FT                   /note="HTH psq-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT   DNA_BIND        544..564
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT   REGION          104..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          495..521
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          564..602
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        585..602
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CROSSLNK        242
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0007744|PubMed:28112733"
FT   CROSSLNK        319
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0007744|PubMed:28112733"
FT   CROSSLNK        340
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0007744|PubMed:28112733"
FT   CROSSLNK        397
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0007744|PubMed:28112733"
FT   VAR_SEQ         1..389
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_029287"
FT   VAR_SEQ         260..318
FT                   /note="RLHRNREDYVERSAEFADGLLSKALKDIQSGALDINKAGILYGIPQKTLLLH
FT                   LEALPAG -> MLQVKTDEKLNVSDENTASCPLSPIKMCLNRPIEWNLNLTTASLTSCT
FT                   VHNQNLKSEEK (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_029288"
FT   VAR_SEQ         319..602
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_029289"
FT   CONFLICT        407
FT                   /note="N -> S (in Ref. 1; BAB70892)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   602 AA;  66964 MW;  05245F999E5A61D7 CRC64;
     MDKGRERMAA AAAAAAAAAA AAQCRSPRCA AERRGFRREL DSWRHRLMHC VGFESILEGL
     YGPRLRRDLS LFEDCEPEEL TDWSMDEKCS FCNLQREAVS DCIPSLDSSQ STPTEELSSQ
     GQSNTDKIEC QAENYLNALF RKKDLPQNCD PNIPLVAQEL MKKMIRQFAI EYISKSGKTQ
     ENRNGSIGPS IVCKSIQMNQ AENSLQEEQE GPLDLTVNRM QEQNTQQGDG VLDLSTKKTS
     IKSEESSICD PSSENSVAGR LHRNREDYVE RSAEFADGLL SKALKDIQSG ALDINKAGIL
     YGIPQKTLLL HLEALPAGKP ASFKNKTRDF HDSYSYKDSK ETCAVLQKVA LWARAQAERT
     EKSKLNLLET SEIKFPTAST YLHQLTLQKM VTQFKEKNES LQYETSNPTV QLKIPQLRVS
     SVSKSQPDGS GLLDVMYQVS KTSSVLEGSA LQKLKNILPK QNKIECSGPV THSSVDSYFL
     HGDLSPLCLN SKNGTVDGTS ENTEDGLDRK DSKQPRKKRG RYRQYDHEIM EEAIAMVMSG
     KMSVSKAQGI YGVPHSTLEY KVKERSGTLK TPPKKKLRLP DTGLYNMTDS GTGSCKNSSK
     PV
//