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Q8N3X6

- LCORL_HUMAN

UniProt

Q8N3X6 - LCORL_HUMAN

Protein

Ligand-dependent nuclear receptor corepressor-like protein

Gene

LCORL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 4 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi544 – 56421H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription from RNA polymerase II promoter Source: Ensembl
    2. transcription from RNA polymerase II promoter Source: Ensembl

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ligand-dependent nuclear receptor corepressor-like protein
    Short name:
    LCoR-like protein
    Gene namesi
    Name:LCORL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:30776. LCORL.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145148507.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 602602Ligand-dependent nuclear receptor corepressor-like proteinPRO_0000310463Add
    BLAST

    Proteomic databases

    MaxQBiQ8N3X6.
    PaxDbiQ8N3X6.
    PRIDEiQ8N3X6.

    PTM databases

    PhosphoSiteiQ8N3X6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N3X6.
    BgeeiQ8N3X6.
    CleanExiHS_LCORL.
    GenevestigatoriQ8N3X6.

    Organism-specific databases

    HPAiHPA028794.
    HPA028795.

    Interactioni

    Protein-protein interaction databases

    BioGridi129025. 2 interactions.
    IntActiQ8N3X6. 1 interaction.
    MINTiMINT-8247449.
    STRINGi9606.ENSP00000317566.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N3X6.
    SMRiQ8N3X6. Positions 522-579.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini516 – 56853HTH psq-typePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi9 – 3123Ala-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HTH psq-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG77197.
    HOGENOMiHOG000253915.
    HOVERGENiHBG108084.
    InParanoidiQ8N3X6.
    OMAiASICNIE.
    OrthoDBiEOG7VHSXQ.
    PhylomeDBiQ8N3X6.
    TreeFamiTF319589.

    Family and domain databases

    InterProiIPR009057. Homeodomain-like.
    IPR007889. HTH_Psq.
    [Graphical view]
    PfamiPF05225. HTH_psq. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 2 hits.
    PROSITEiPS50960. HTH_PSQ. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N3X6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDKGRERMAA AAAAAAAAAA AAQCRSPRCA AERRGFRREL DSWRHRLMHC    50
    VGFESILEGL YGPRLRRDLS LFEDCEPEEL TDWSMDEKCS FCNLQREAVS 100
    DCIPSLDSSQ STPTEELSSQ GQSNTDKIEC QAENYLNALF RKKDLPQNCD 150
    PNIPLVAQEL MKKMIRQFAI EYISKSGKTQ ENRNGSIGPS IVCKSIQMNQ 200
    AENSLQEEQE GPLDLTVNRM QEQNTQQGDG VLDLSTKKTS IKSEESSICD 250
    PSSENSVAGR LHRNREDYVE RSAEFADGLL SKALKDIQSG ALDINKAGIL 300
    YGIPQKTLLL HLEALPAGKP ASFKNKTRDF HDSYSYKDSK ETCAVLQKVA 350
    LWARAQAERT EKSKLNLLET SEIKFPTAST YLHQLTLQKM VTQFKEKNES 400
    LQYETSNPTV QLKIPQLRVS SVSKSQPDGS GLLDVMYQVS KTSSVLEGSA 450
    LQKLKNILPK QNKIECSGPV THSSVDSYFL HGDLSPLCLN SKNGTVDGTS 500
    ENTEDGLDRK DSKQPRKKRG RYRQYDHEIM EEAIAMVMSG KMSVSKAQGI 550
    YGVPHSTLEY KVKERSGTLK TPPKKKLRLP DTGLYNMTDS GTGSCKNSSK 600
    PV 602
    Length:602
    Mass (Da):66,964
    Last modified:November 13, 2007 - v4
    Checksum:i05245F999E5A61D7
    GO
    Isoform 2 (identifier: Q8N3X6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-389: Missing.

    Show »
    Length:213
    Mass (Da):23,504
    Checksum:iF466768931A99290
    GO
    Isoform 3 (identifier: Q8N3X6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         260-318: RLHRNREDYV...LLHLEALPAG → MLQVKTDEKL...HNQNLKSEEK
         319-602: Missing.

    Show »
    Length:318
    Mass (Da):35,408
    Checksum:iA793EDAC37D7BEA7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti407 – 4071N → S in BAB70892. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 389389Missing in isoform 2. 1 PublicationVSP_029287Add
    BLAST
    Alternative sequencei260 – 31859RLHRN…ALPAG → MLQVKTDEKLNVSDENTASC PLSPIKMCLNRPIEWNLNLT TASLTSCTVHNQNLKSEEK in isoform 3. 1 PublicationVSP_029288Add
    BLAST
    Alternative sequencei319 – 602284Missing in isoform 3. 1 PublicationVSP_029289Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055258 mRNA. Translation: BAB70892.1.
    AC005768 Genomic DNA. No translation available.
    AC079399 Genomic DNA. No translation available.
    CH471069 Genomic DNA. Translation: EAW92786.1.
    BC037322 mRNA. Translation: AAH37322.3.
    CCDSiCCDS3425.1. [Q8N3X6-3]
    CCDS54749.1. [Q8N3X6-1]
    RefSeqiNP_001159611.1. NM_001166139.1. [Q8N3X6-1]
    NP_710153.2. NM_153686.7. [Q8N3X6-3]
    UniGeneiHs.446201.
    Hs.677572.

    Genome annotation databases

    EnsembliENST00000326877; ENSP00000317566; ENSG00000178177. [Q8N3X6-3]
    ENST00000382226; ENSP00000371661; ENSG00000178177. [Q8N3X6-1]
    GeneIDi254251.
    KEGGihsa:254251.
    UCSCiuc003gpq.3. human. [Q8N3X6-3]
    uc021xmr.1. human. [Q8N3X6-1]

    Polymorphism databases

    DMDMi160395582.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055258 mRNA. Translation: BAB70892.1 .
    AC005768 Genomic DNA. No translation available.
    AC079399 Genomic DNA. No translation available.
    CH471069 Genomic DNA. Translation: EAW92786.1 .
    BC037322 mRNA. Translation: AAH37322.3 .
    CCDSi CCDS3425.1. [Q8N3X6-3 ]
    CCDS54749.1. [Q8N3X6-1 ]
    RefSeqi NP_001159611.1. NM_001166139.1. [Q8N3X6-1 ]
    NP_710153.2. NM_153686.7. [Q8N3X6-3 ]
    UniGenei Hs.446201.
    Hs.677572.

    3D structure databases

    ProteinModelPortali Q8N3X6.
    SMRi Q8N3X6. Positions 522-579.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129025. 2 interactions.
    IntActi Q8N3X6. 1 interaction.
    MINTi MINT-8247449.
    STRINGi 9606.ENSP00000317566.

    PTM databases

    PhosphoSitei Q8N3X6.

    Polymorphism databases

    DMDMi 160395582.

    Proteomic databases

    MaxQBi Q8N3X6.
    PaxDbi Q8N3X6.
    PRIDEi Q8N3X6.

    Protocols and materials databases

    DNASUi 254251.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326877 ; ENSP00000317566 ; ENSG00000178177 . [Q8N3X6-3 ]
    ENST00000382226 ; ENSP00000371661 ; ENSG00000178177 . [Q8N3X6-1 ]
    GeneIDi 254251.
    KEGGi hsa:254251.
    UCSCi uc003gpq.3. human. [Q8N3X6-3 ]
    uc021xmr.1. human. [Q8N3X6-1 ]

    Organism-specific databases

    CTDi 254251.
    GeneCardsi GC04M017844.
    HGNCi HGNC:30776. LCORL.
    HPAi HPA028794.
    HPA028795.
    MIMi 611799. gene.
    neXtProti NX_Q8N3X6.
    PharmGKBi PA145148507.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG77197.
    HOGENOMi HOG000253915.
    HOVERGENi HBG108084.
    InParanoidi Q8N3X6.
    OMAi ASICNIE.
    OrthoDBi EOG7VHSXQ.
    PhylomeDBi Q8N3X6.
    TreeFami TF319589.

    Miscellaneous databases

    ChiTaRSi LCORL. human.
    GenomeRNAii 254251.
    NextBioi 92303.
    PROi Q8N3X6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N3X6.
    Bgeei Q8N3X6.
    CleanExi HS_LCORL.
    Genevestigatori Q8N3X6.

    Family and domain databases

    InterProi IPR009057. Homeodomain-like.
    IPR007889. HTH_Psq.
    [Graphical view ]
    Pfami PF05225. HTH_psq. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 2 hits.
    PROSITEi PS50960. HTH_PSQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    5. Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiLCORL_HUMAN
    AccessioniPrimary (citable) accession number: Q8N3X6
    Secondary accession number(s): Q96NK1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 93 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    A report observed N-glycosylation at Asn-493 (PubMed:19139490). However, as the protein is predicted to act as a DNA-binding transcription activator, additional evidences are required to confirm this result.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3