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Q8N3X6

- LCORL_HUMAN

UniProt

Q8N3X6 - LCORL_HUMAN

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Protein

Ligand-dependent nuclear receptor corepressor-like protein

Gene
LCORL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi544 – 56421H-T-H motif By similarityAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription from RNA polymerase II promoter Source: Ensembl
  2. transcription from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ligand-dependent nuclear receptor corepressor-like protein
Short name:
LCoR-like protein
Gene namesi
Name:LCORL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:30776. LCORL.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148507.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 602602Ligand-dependent nuclear receptor corepressor-like proteinPRO_0000310463Add
BLAST

Proteomic databases

MaxQBiQ8N3X6.
PaxDbiQ8N3X6.
PRIDEiQ8N3X6.

PTM databases

PhosphoSiteiQ8N3X6.

Expressioni

Gene expression databases

ArrayExpressiQ8N3X6.
BgeeiQ8N3X6.
CleanExiHS_LCORL.
GenevestigatoriQ8N3X6.

Organism-specific databases

HPAiHPA028794.
HPA028795.

Interactioni

Protein-protein interaction databases

BioGridi129025. 2 interactions.
IntActiQ8N3X6. 1 interaction.
MINTiMINT-8247449.
STRINGi9606.ENSP00000317566.

Structurei

3D structure databases

ProteinModelPortaliQ8N3X6.
SMRiQ8N3X6. Positions 522-579.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini516 – 56853HTH psq-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi9 – 3123Ala-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG77197.
HOGENOMiHOG000253915.
HOVERGENiHBG108084.
InParanoidiQ8N3X6.
OMAiASICNIE.
OrthoDBiEOG7VHSXQ.
PhylomeDBiQ8N3X6.
TreeFamiTF319589.

Family and domain databases

InterProiIPR009057. Homeodomain-like.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF05225. HTH_psq. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS50960. HTH_PSQ. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N3X6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDKGRERMAA AAAAAAAAAA AAQCRSPRCA AERRGFRREL DSWRHRLMHC    50
VGFESILEGL YGPRLRRDLS LFEDCEPEEL TDWSMDEKCS FCNLQREAVS 100
DCIPSLDSSQ STPTEELSSQ GQSNTDKIEC QAENYLNALF RKKDLPQNCD 150
PNIPLVAQEL MKKMIRQFAI EYISKSGKTQ ENRNGSIGPS IVCKSIQMNQ 200
AENSLQEEQE GPLDLTVNRM QEQNTQQGDG VLDLSTKKTS IKSEESSICD 250
PSSENSVAGR LHRNREDYVE RSAEFADGLL SKALKDIQSG ALDINKAGIL 300
YGIPQKTLLL HLEALPAGKP ASFKNKTRDF HDSYSYKDSK ETCAVLQKVA 350
LWARAQAERT EKSKLNLLET SEIKFPTAST YLHQLTLQKM VTQFKEKNES 400
LQYETSNPTV QLKIPQLRVS SVSKSQPDGS GLLDVMYQVS KTSSVLEGSA 450
LQKLKNILPK QNKIECSGPV THSSVDSYFL HGDLSPLCLN SKNGTVDGTS 500
ENTEDGLDRK DSKQPRKKRG RYRQYDHEIM EEAIAMVMSG KMSVSKAQGI 550
YGVPHSTLEY KVKERSGTLK TPPKKKLRLP DTGLYNMTDS GTGSCKNSSK 600
PV 602
Length:602
Mass (Da):66,964
Last modified:November 13, 2007 - v4
Checksum:i05245F999E5A61D7
GO
Isoform 2 (identifier: Q8N3X6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-389: Missing.

Show »
Length:213
Mass (Da):23,504
Checksum:iF466768931A99290
GO
Isoform 3 (identifier: Q8N3X6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-318: RLHRNREDYV...LLHLEALPAG → MLQVKTDEKL...HNQNLKSEEK
     319-602: Missing.

Show »
Length:318
Mass (Da):35,408
Checksum:iA793EDAC37D7BEA7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 389389Missing in isoform 2. VSP_029287Add
BLAST
Alternative sequencei260 – 31859RLHRN…ALPAG → MLQVKTDEKLNVSDENTASC PLSPIKMCLNRPIEWNLNLT TASLTSCTVHNQNLKSEEK in isoform 3. VSP_029288Add
BLAST
Alternative sequencei319 – 602284Missing in isoform 3. VSP_029289Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti407 – 4071N → S in BAB70892. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK055258 mRNA. Translation: BAB70892.1.
AC005768 Genomic DNA. No translation available.
AC079399 Genomic DNA. No translation available.
CH471069 Genomic DNA. Translation: EAW92786.1.
BC037322 mRNA. Translation: AAH37322.3.
CCDSiCCDS3425.1. [Q8N3X6-3]
CCDS54749.1. [Q8N3X6-1]
RefSeqiNP_001159611.1. NM_001166139.1. [Q8N3X6-1]
NP_710153.2. NM_153686.7. [Q8N3X6-3]
UniGeneiHs.446201.
Hs.677572.

Genome annotation databases

EnsembliENST00000326877; ENSP00000317566; ENSG00000178177. [Q8N3X6-3]
ENST00000382226; ENSP00000371661; ENSG00000178177. [Q8N3X6-1]
GeneIDi254251.
KEGGihsa:254251.
UCSCiuc003gpq.3. human. [Q8N3X6-3]
uc021xmr.1. human. [Q8N3X6-1]

Polymorphism databases

DMDMi160395582.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK055258 mRNA. Translation: BAB70892.1 .
AC005768 Genomic DNA. No translation available.
AC079399 Genomic DNA. No translation available.
CH471069 Genomic DNA. Translation: EAW92786.1 .
BC037322 mRNA. Translation: AAH37322.3 .
CCDSi CCDS3425.1. [Q8N3X6-3 ]
CCDS54749.1. [Q8N3X6-1 ]
RefSeqi NP_001159611.1. NM_001166139.1. [Q8N3X6-1 ]
NP_710153.2. NM_153686.7. [Q8N3X6-3 ]
UniGenei Hs.446201.
Hs.677572.

3D structure databases

ProteinModelPortali Q8N3X6.
SMRi Q8N3X6. Positions 522-579.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 129025. 2 interactions.
IntActi Q8N3X6. 1 interaction.
MINTi MINT-8247449.
STRINGi 9606.ENSP00000317566.

PTM databases

PhosphoSitei Q8N3X6.

Polymorphism databases

DMDMi 160395582.

Proteomic databases

MaxQBi Q8N3X6.
PaxDbi Q8N3X6.
PRIDEi Q8N3X6.

Protocols and materials databases

DNASUi 254251.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000326877 ; ENSP00000317566 ; ENSG00000178177 . [Q8N3X6-3 ]
ENST00000382226 ; ENSP00000371661 ; ENSG00000178177 . [Q8N3X6-1 ]
GeneIDi 254251.
KEGGi hsa:254251.
UCSCi uc003gpq.3. human. [Q8N3X6-3 ]
uc021xmr.1. human. [Q8N3X6-1 ]

Organism-specific databases

CTDi 254251.
GeneCardsi GC04M017844.
HGNCi HGNC:30776. LCORL.
HPAi HPA028794.
HPA028795.
MIMi 611799. gene.
neXtProti NX_Q8N3X6.
PharmGKBi PA145148507.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG77197.
HOGENOMi HOG000253915.
HOVERGENi HBG108084.
InParanoidi Q8N3X6.
OMAi ASICNIE.
OrthoDBi EOG7VHSXQ.
PhylomeDBi Q8N3X6.
TreeFami TF319589.

Miscellaneous databases

ChiTaRSi LCORL. human.
GenomeRNAii 254251.
NextBioi 92303.
PROi Q8N3X6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8N3X6.
Bgeei Q8N3X6.
CleanExi HS_LCORL.
Genevestigatori Q8N3X6.

Family and domain databases

InterProi IPR009057. Homeodomain-like.
IPR007889. HTH_Psq.
[Graphical view ]
Pfami PF05225. HTH_psq. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 2 hits.
PROSITEi PS50960. HTH_PSQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  5. Cited for: IDENTIFICATION.

Entry informationi

Entry nameiLCORL_HUMAN
AccessioniPrimary (citable) accession number: Q8N3X6
Secondary accession number(s): Q96NK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: July 9, 2014
This is version 92 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

A report observed N-glycosylation at Asn-493 (1 Publication). However, as the protein is predicted to act as a DNA-binding transcription activator, additional evidences are required to confirm this result.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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