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Protein

Ligand-dependent nuclear receptor corepressor-like protein

Gene

LCORL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi544 – 56421H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ligand-dependent nuclear receptor corepressor-like protein
Short name:
LCoR-like protein
Gene namesi
Name:LCORL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:30776. LCORL.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148507.

Polymorphism and mutation databases

BioMutaiLCORL.
DMDMi160395582.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 602602Ligand-dependent nuclear receptor corepressor-like proteinPRO_0000310463Add
BLAST

Proteomic databases

MaxQBiQ8N3X6.
PaxDbiQ8N3X6.
PRIDEiQ8N3X6.

PTM databases

PhosphoSiteiQ8N3X6.

Expressioni

Gene expression databases

BgeeiQ8N3X6.
CleanExiHS_LCORL.
ExpressionAtlasiQ8N3X6. baseline and differential.
GenevisibleiQ8N3X6. HS.

Organism-specific databases

HPAiHPA028794.
HPA028795.
HPA060033.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MAGEA6P433603EBI-7138654,EBI-1045155

Protein-protein interaction databases

BioGridi129025. 3 interactions.
IntActiQ8N3X6. 2 interactions.
MINTiMINT-8247449.
STRINGi9606.ENSP00000371661.

Structurei

3D structure databases

ProteinModelPortaliQ8N3X6.
SMRiQ8N3X6. Positions 522-579.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini516 – 56853HTH psq-typePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi9 – 3123Ala-richAdd
BLAST

Sequence similaritiesi

Contains 1 HTH psq-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG77197.
GeneTreeiENSGT00520000055615.
HOGENOMiHOG000253915.
HOVERGENiHBG108084.
InParanoidiQ8N3X6.
OMAiYKVKERS.
OrthoDBiEOG7VHSXQ.
PhylomeDBiQ8N3X6.
TreeFamiTF319589.

Family and domain databases

InterProiIPR009057. Homeodomain-like.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF05225. HTH_psq. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS50960. HTH_PSQ. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N3X6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDKGRERMAA AAAAAAAAAA AAQCRSPRCA AERRGFRREL DSWRHRLMHC
60 70 80 90 100
VGFESILEGL YGPRLRRDLS LFEDCEPEEL TDWSMDEKCS FCNLQREAVS
110 120 130 140 150
DCIPSLDSSQ STPTEELSSQ GQSNTDKIEC QAENYLNALF RKKDLPQNCD
160 170 180 190 200
PNIPLVAQEL MKKMIRQFAI EYISKSGKTQ ENRNGSIGPS IVCKSIQMNQ
210 220 230 240 250
AENSLQEEQE GPLDLTVNRM QEQNTQQGDG VLDLSTKKTS IKSEESSICD
260 270 280 290 300
PSSENSVAGR LHRNREDYVE RSAEFADGLL SKALKDIQSG ALDINKAGIL
310 320 330 340 350
YGIPQKTLLL HLEALPAGKP ASFKNKTRDF HDSYSYKDSK ETCAVLQKVA
360 370 380 390 400
LWARAQAERT EKSKLNLLET SEIKFPTAST YLHQLTLQKM VTQFKEKNES
410 420 430 440 450
LQYETSNPTV QLKIPQLRVS SVSKSQPDGS GLLDVMYQVS KTSSVLEGSA
460 470 480 490 500
LQKLKNILPK QNKIECSGPV THSSVDSYFL HGDLSPLCLN SKNGTVDGTS
510 520 530 540 550
ENTEDGLDRK DSKQPRKKRG RYRQYDHEIM EEAIAMVMSG KMSVSKAQGI
560 570 580 590 600
YGVPHSTLEY KVKERSGTLK TPPKKKLRLP DTGLYNMTDS GTGSCKNSSK

PV
Length:602
Mass (Da):66,964
Last modified:November 13, 2007 - v4
Checksum:i05245F999E5A61D7
GO
Isoform 2 (identifier: Q8N3X6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-389: Missing.

Show »
Length:213
Mass (Da):23,504
Checksum:iF466768931A99290
GO
Isoform 3 (identifier: Q8N3X6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-318: RLHRNREDYV...LLHLEALPAG → MLQVKTDEKL...HNQNLKSEEK
     319-602: Missing.

Show »
Length:318
Mass (Da):35,408
Checksum:iA793EDAC37D7BEA7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti407 – 4071N → S in BAB70892 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 389389Missing in isoform 2. 1 PublicationVSP_029287Add
BLAST
Alternative sequencei260 – 31859RLHRN…ALPAG → MLQVKTDEKLNVSDENTASC PLSPIKMCLNRPIEWNLNLT TASLTSCTVHNQNLKSEEK in isoform 3. 1 PublicationVSP_029288Add
BLAST
Alternative sequencei319 – 602284Missing in isoform 3. 1 PublicationVSP_029289Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055258 mRNA. Translation: BAB70892.1.
AC005768 Genomic DNA. No translation available.
AC079399 Genomic DNA. No translation available.
CH471069 Genomic DNA. Translation: EAW92786.1.
BC037322 mRNA. Translation: AAH37322.3.
CCDSiCCDS3425.1. [Q8N3X6-3]
CCDS54749.1. [Q8N3X6-1]
RefSeqiNP_001159611.1. NM_001166139.1. [Q8N3X6-1]
NP_710153.2. NM_153686.7. [Q8N3X6-3]
UniGeneiHs.446201.
Hs.677572.

Genome annotation databases

EnsembliENST00000326877; ENSP00000317566; ENSG00000178177. [Q8N3X6-3]
ENST00000382226; ENSP00000371661; ENSG00000178177. [Q8N3X6-1]
GeneIDi254251.
KEGGihsa:254251.
UCSCiuc003gpq.3. human. [Q8N3X6-3]
uc021xmr.1. human. [Q8N3X6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055258 mRNA. Translation: BAB70892.1.
AC005768 Genomic DNA. No translation available.
AC079399 Genomic DNA. No translation available.
CH471069 Genomic DNA. Translation: EAW92786.1.
BC037322 mRNA. Translation: AAH37322.3.
CCDSiCCDS3425.1. [Q8N3X6-3]
CCDS54749.1. [Q8N3X6-1]
RefSeqiNP_001159611.1. NM_001166139.1. [Q8N3X6-1]
NP_710153.2. NM_153686.7. [Q8N3X6-3]
UniGeneiHs.446201.
Hs.677572.

3D structure databases

ProteinModelPortaliQ8N3X6.
SMRiQ8N3X6. Positions 522-579.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129025. 3 interactions.
IntActiQ8N3X6. 2 interactions.
MINTiMINT-8247449.
STRINGi9606.ENSP00000371661.

PTM databases

PhosphoSiteiQ8N3X6.

Polymorphism and mutation databases

BioMutaiLCORL.
DMDMi160395582.

Proteomic databases

MaxQBiQ8N3X6.
PaxDbiQ8N3X6.
PRIDEiQ8N3X6.

Protocols and materials databases

DNASUi254251.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326877; ENSP00000317566; ENSG00000178177. [Q8N3X6-3]
ENST00000382226; ENSP00000371661; ENSG00000178177. [Q8N3X6-1]
GeneIDi254251.
KEGGihsa:254251.
UCSCiuc003gpq.3. human. [Q8N3X6-3]
uc021xmr.1. human. [Q8N3X6-1]

Organism-specific databases

CTDi254251.
GeneCardsiGC04M017844.
HGNCiHGNC:30776. LCORL.
HPAiHPA028794.
HPA028795.
HPA060033.
MIMi611799. gene.
neXtProtiNX_Q8N3X6.
PharmGKBiPA145148507.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG77197.
GeneTreeiENSGT00520000055615.
HOGENOMiHOG000253915.
HOVERGENiHBG108084.
InParanoidiQ8N3X6.
OMAiYKVKERS.
OrthoDBiEOG7VHSXQ.
PhylomeDBiQ8N3X6.
TreeFamiTF319589.

Miscellaneous databases

ChiTaRSiLCORL. human.
GenomeRNAii254251.
NextBioi92303.
PROiQ8N3X6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N3X6.
CleanExiHS_LCORL.
ExpressionAtlasiQ8N3X6. baseline and differential.
GenevisibleiQ8N3X6. HS.

Family and domain databases

InterProiIPR009057. Homeodomain-like.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF05225. HTH_psq. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS50960. HTH_PSQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  5. Cited for: IDENTIFICATION.

Entry informationi

Entry nameiLCORL_HUMAN
AccessioniPrimary (citable) accession number: Q8N3X6
Secondary accession number(s): Q96NK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: June 24, 2015
This is version 99 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

A report observed N-glycosylation at Asn-493 (PubMed:19139490). However, as the protein is predicted to act as a DNA-binding transcription activator, additional evidences are required to confirm this result.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.